Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer.

, Huh, Jung Wook; , Kim, Hyeong Rok; , Cho, Sang Hyuk; , Kim, Young Jin

doi:2009.25.2.107

Original Article

Journal of the Korean Society of Coloproctology 2009;25(2):107-112.
DOI: https://doi.org/10.3393/jksc.2009.25.2.107

Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer.

Huh, Jung Wook , Kim, Hyeong Rok , Cho, Sang Hyuk , Kim, Young Jin

Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea. drkhr@chonnam.ac.kr

Abstract

PURPOSE
This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.
METHODS
Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined.
Results
were correlated with clinical and pathological parameters.
RESULTS
Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables. Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).
CONCLUSIONS
Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.

Key Words: p53; Ki-67; Colorectal cancer