| Prognostic Factors after Hepatic Resection for Metastatic Colorectal Cancer. |
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Kim, Hee Cheol , Kim, Chang Nam , Hong, Hyoun Kee , Lee, Dong Hee , Yu, Chang Sik , Lee, Je Hwan , Kim, Tae Won , Kim, Jin Cheon |
1Colorectal Clinic, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Korea.
2Colorectal Clinic, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Korea.
3Department of Surgery, University of Ulji School of Medicine, Korea. |
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| Abstract |
Metastases to the liver from carcinoma of the colon and rectum occur as many as 80% of cases. As resection of metastases is proven to enhance survival and to reduce hepatic recurrence, the criteria for selection of patients and surgery type appear to be indispensable. Purpose
The aim of this study was to assess the prognostic factors after hepatic resection for metastatic colorectal cancer and propose the optimal surgical principles for resection of metastatic colorectal cancer.
Methods
Sixty-three patients who underwent initial hepatic resection for liver metastases from colorectal cancer between 1989 and 1998 were analyzed regarding clinical and pathologic parameters.
Results
Overall 5-year survival rate was 32%. Preoperative serum CEA level and resection margin of metastatic tumors were found to be significant predictors for poor long-term outcome.
Resection margin of greater than 5 mm was closely associated with better survival. In multivariate analysis, resection margin alone was an independent prognostic factor.
Conclusions
Preoperative serum CEA level and surgical resection margin may affect the outcome for the patients who underwent hepatic resection for metastatic colorectal cancer. Surgical resection margin must be kept enough to avoid re-recurrence or metastasis during hepatic resection for metastatic colorectal cancer. |
| Key Words:
Colorectal cancer; Hepatic metastasis; Prognostic factors; Serum CEA; Resection margin |
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