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A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire Hall, Louise Clarke, Atanu Pal, Pamela Buchwald, Tim Eglinton, Chris Wakeman, Frank Frizelle
Ann Coloproctol. 2019;35(6):294-305.   Published online December 31, 2019
DOI: https://doi.org/10.3393/ac.2019.11.13
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  • 155 Citations
AbstractAbstract PDF
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.

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    European Journal of Surgical Oncology.2025; 51(6): 109706.     CrossRef
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    Ping Cai, Qingzhen Yang, Jiaqi Lu, Xiaoyu Dai, Jinbo Xiong, Nicholas Chia
    mSystems.2025;[Epub]     CrossRef
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    Meifang Wang, Hongying Bu, Weijia Luo, Xi Zeng, Guodong Chen, Yingchun He, Deliang Cao
    Clinical Biochemistry.2025; 137: 110902.     CrossRef
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    Sensing and Bio-Sensing Research.2025; 47: 100771.     CrossRef
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    Dae-Hyun Kim, Seung-Wan Hong, Naeun Park
    Tobacco Induced Diseases.2025; 23(March): 1.     CrossRef
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    Jacklyn Liu, Helen Bewicke‐Copley, Shruti Patel, Oscar Emanuel, Nicholas Counsell, Shachi J. Sharma, Volker Schartinger, Oliver Siefer, Ulrike Wieland, Nora Würdemann, Rocio Garcia‐Marin, Jozsef Dudas, Dominic Patel, David Allen, Naomi Guppy, Josep Linare
    Clinical and Translational Medicine.2025;[Epub]     CrossRef
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    Talanta.2025; 292: 127925.     CrossRef
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    Materials Today Bio.2025; 32: 101768.     CrossRef
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    Journal of Extracellular Vesicles.2025;[Epub]     CrossRef
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    Journal of Clinical Medicine.2025; 14(9): 3189.     CrossRef
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    Food Bioscience.2025; 69: 106973.     CrossRef
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    Cancers.2024; 16(24): 4213.     CrossRef
  • The Past, Present, and Future of Biomarkers for the Early Diagnosis of Pancreatic Cancer
    Federica Vitale, Lorenzo Zileri Dal Verme, Mattia Paratore, Marcantonio Negri, Enrico Celestino Nista, Maria Elena Ainora, Giorgio Esposto, Irene Mignini, Raffaele Borriello, Linda Galasso, Sergio Alfieri, Antonio Gasbarrini, Maria Assunta Zocco, Alberto
    Biomedicines.2024; 12(12): 2840.     CrossRef
  • Elevated CA19-9 within the normal range suggests poorer prognosis in stage II CRC: A retrospective analysis of a large sample in a single center
    Ruoxin Zhang, Fan Chen, Junyong Weng, Zilan Ye, Xinxiang Li
    Journal of Cancer Research and Therapeutics.2024; 20(7): 2013.     CrossRef
  • Serum cytokines in astrocytic brain tumors: a prospective study
    Tariq Ansari, Gautam Dutta, Arvind Kumar Srivastava, Anita Jagetia, Daljit Singh, Hukum Singh, Rohit Bharti, Anand Prakash, Anil Kumar
    British Journal of Neurosurgery.2023; 37(1): 35.     CrossRef
  • Recent advancement in sensitive detection of carcinoembryonic antigen using nanomaterials based immunosensors
    Bazilah Awang Abd Manaf, Shyang Pei Hong, Mohammad Rizwan, Fareeha Arshad, Christopher Gwenin, Minhaz Uddin Ahmed
    Surfaces and Interfaces.2023; 36: 102596.     CrossRef
  • A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers
    Jian-Xia Xu, Jin-Bao Hu, Xiao-Yan Yang, Na Feng, Xiao-Shan Huang, Xiao-Zhong Zheng, Qin-Pan Rao, Yu-Guo Wei, Ri-Sheng Yu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment
    Karolina Grzesik, Marcelina Janik, Dorota Hoja-Łukowicz
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(3): 188889.     CrossRef
  • Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer
    Kaisa Lehtomäki, Eetu Heervä, Pirkko-Liisa Kellokumpu-Lehtinen, Harri Mustonen, Tapio Salminen, Heikki Joensuu, Kethe Hermunen, Mogens Karsbøl Boisen, Julia Sidenius Johansen, Caj Haglund, Pia Osterlund
    International Journal of Molecular Sciences.2023; 24(7): 6753.     CrossRef
  • Unexplained increase of serum carcinoembryonic antigen: don’t forget the thyroid!
    Filipe Miguel Montes de Jesus, Luca Giovanella
    Clinical Chemistry and Laboratory Medicine (CCLM).2023; 61(10): e203.     CrossRef
  • The Clinical Significance of Serum Free Light Chains in Bladder Cancer
    Monika Gudowska-Sawczuk, Jacek Kudelski, Michał Olkowicz, Grzegorz Młynarczyk, Piotr Chłosta, Barbara Mroczko
    Journal of Clinical Medicine.2023; 12(9): 3294.     CrossRef
  • Target selection and clinical chimeric antigen receptor T cell activity against solid tumors
    Eric von Hofe, Yanping Yang, Moonsoo M. Jin
    iLABMED.2023; 1(1): 29.     CrossRef
  • Sequence of colorectal and liver resection in patients with surgically-treatable stage IV colorectal cancer
    Calista Harbaugh, Aneel Damle
    Seminars in Colon and Rectal Surgery.2023; 34(3): 100969.     CrossRef
  • CXC ELR-Positive Chemokines as Diagnostic and Prognostic Markers for Breast Cancer Patients
    Joanna Motyka, Aleksandra Kicman, Monika Kulesza, Sławomir Ławicki
    Cancers.2023; 15(12): 3118.     CrossRef
  • Impedimetric aptasensor based on MOF based composite for measuring of carcinoembryonic antigen as a tumor biomarker
    Ping He, Qiang Zhang, Qiwei Liu
    Chemosphere.2023; 338: 139339.     CrossRef
  • Two-dimensional substrate assisted SERS immunosensor for accurate detection of carcinoembryonic antigen
    Dechan Lu, Cairou Chen, PeiPei Xu, Ruiyun You, Zhenzhen Lu, Yudong Lu
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2023; 302: 123142.     CrossRef
  • The Significance of CXCL1 and CXCR1 as Potential Biomarkers of Colorectal Cancer
    Marta Łukaszewicz-Zając, Monika Zajkowska, Sara Pączek, Agnieszka Kulczyńska-Przybik, Kamil Safiejko, Marcin Juchimiuk, Leszek Kozłowski, Barbara Mroczko
    Biomedicines.2023; 11(7): 1933.     CrossRef
  • New luminescent hydrophilic iridium(III) nanoflower at low potential for electrochemiluminescence immunosensing
    Li Song, Guangrong Kuang, Gui Zhang, Jiang Guo, Yingzi Fu
    Chemical Engineering Journal.2023; 472: 144923.     CrossRef
  • MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review
    May R. Ibrahim, Yaser E. Greish
    Molecules.2023; 28(16): 5970.     CrossRef
  • Proteomics-Driven Biomarkers in Pancreatic Cancer
    Luís Ramalhete, Emanuel Vigia, Rúben Araújo, Hugo Pinto Marques
    Proteomes.2023; 11(3): 24.     CrossRef
  • Clinicopathologic Significance of Heat Shock Protein 60 as a Survival Predictor in Colorectal Cancer
    Myunghee Kang, Soyeon Jeong, Jungsuk An, Sungjin Park, Seungyoon Nam, Kwang An Kwon, Debashis Sahoo, Pradipta Ghosh, Jung Ho Kim
    Cancers.2023; 15(16): 4052.     CrossRef
  • Colorimetric immunoassay of carcinoembryonic antigen based on the glucose oxidase/MnO2 nanosheet cascade reaction with self-supplying oxygen
    Yuanzhi Yao, Jinhong Wang, Ziqi Wang, Shenghua Li, Hongliang Tan
    Analytical Methods.2023; 15(40): 5351.     CrossRef
  • Combined effect of serum carcinoembryonic antigen and hepatic steatosis on new-onset ischemic heart disease among middle-aged and older Korean adults: a cohort study
    Ji Won Kwak, Yong Jae Lee, Byoungjin Park, Dong Hyuk Jung
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Digestive cancer surgery in low-mid income countries: analysis of postoperative mortality and complications in a single-center study
    Hamza Sekkat, Hassan Agouzoul, Zineb Loudyi, Jaouad Naddouri, Jihane El Hamzaoui, Samira El Fakir, Mohammed Omari, Youness Bakali, Mouna Mhamdi Alaoui, Mohammed Raiss, Abdelmalek Hrora, Farid Sabbah
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Exploring the Role of Biomarkers Associated with Alveolar Damage and Dysfunction in Idiopathic Pulmonary Fibrosis—A Systematic Review
    Alexandra-Simona Zamfir, Mihai Lucian Zabara, Raluca Ioana Arcana, Tudor Andrei Cernomaz, Andreea Zabara-Antal, Marius Traian Dragoș Marcu, Antigona Trofor, Carmen Lăcrămioara Zamfir, Radu Crișan-Dabija
    Journal of Personalized Medicine.2023; 13(11): 1607.     CrossRef
  • CEA vaccines
    Anchit Bhagat, Herbert K. Lyerly, Michael A. Morse, Zachary C. Hartman
    Human Vaccines & Immunotherapeutics.2023;[Epub]     CrossRef
  • Biomarkers in Cancer Detection, Diagnosis, and Prognosis
    Sreyashi Das, Mohan Kumar Dey, Ram Devireddy, Manas Ranjan Gartia
    Sensors.2023; 24(1): 37.     CrossRef
  • Disparities in post-operative surveillance testing for metastatic recurrence among colorectal cancer survivors
    Janeth I. Sanchez, Veena Shankaran, Joseph M. Unger, Margaret M. Madeleine, Noah Espinoza, Beti Thompson
    Journal of Cancer Survivorship.2022; 16(3): 638.     CrossRef
  • T‐cell surface generation of dual bivalent, bispecific T‐cell engaging, RNA duplex cross‐linked antibodies (dbBiTERs) for re‐directed tumor cell lysis
    Maciej Kujawski, Lin Li, Harry Li, Paul J. Yazaki, Piotr Swiderski, John E. Shively
    Biotechnology Journal.2022;[Epub]     CrossRef
  • Application of Proteomics in Pancreatic Ductal Adenocarcinoma Biomarker Investigations: A Review
    Christina Jane Vellan, Jaime Jacqueline Jayapalan, Boon-Koon Yoong, Azlina Abdul-Aziz, Sarni Mat-Junit, Perumal Subramanian
    International Journal of Molecular Sciences.2022; 23(4): 2093.     CrossRef
  • Biomarkers and Genetic Markers of Hepatocellular Carcinoma and Cholangiocarcinoma—What Do We Already Know
    Jacek Baj, Łukasz Bryliński, Filip Woliński, Michał Granat, Katarzyna Kostelecka, Piotr Duda, Jolanta Flieger, Grzegorz Teresiński, Grzegorz Buszewicz, Marzena Furtak-Niczyporuk, Piero Portincasa
    Cancers.2022; 14(6): 1493.     CrossRef
  • Preparation of a disposable electrochemiluminescence sensor chip based on an MXene-loaded ruthenium luminescent agent and its application in the detection of carcinoembryonic antigens
    Weiwei Luo, Zhuoxin Ye, Pinyi Ma, Qiong Wu, Daqian Song
    The Analyst.2022; 147(9): 1986.     CrossRef
  • Circulating Nucleic Acids as Novel Biomarkers for Pancreatic Ductal Adenocarcinoma
    Ryan McGowan, Áine Sally, Anthony McCabe, Brian Michael Moran, Karen Finn
    Cancers.2022; 14(8): 2027.     CrossRef
  • Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection
    Siew Suan Ng, Hooi Ling Lee, Pandian Bothi Raja, Ruey‐an Doong
    Chemistry – An Asian Journal.2022;[Epub]     CrossRef
  • Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors
    Renyuan Ma, Subash C. B. Gopinath, Thangavel Lakshmipriya, Yeng Chen, Larisa Lvova
    Journal of Analytical Methods in Chemistry.2022; 2022: 1.     CrossRef
  • CEA-regulated Oncolytic Virus Anticancer Therapy: A Promising Strategy for Rare Solid Tumors
    Yuqi Yang, Shuhang Wang, Peiwen Ma, Qiyu Tang, Yandong Li, Yuan Fang, Qi Zhu, Wei Tao, Yan Zha, Ning Li
    Current Cancer Drug Targets.2022; 22(2): 126.     CrossRef
  • Nomogram for Predicting Occult Locally Advanced Esophageal Squamous Cell Carcinoma Before Surgery
    Zhixin Huang, Zhinuan Hong, Ling Chen, Mingqiang Kang
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Predicting the benefit of stereotactic body radiotherapy of colorectal cancer metastases
    Sara Lindberg, Eva Onjukka, Peter Wersäll, Caroline Staff, Rolf Lewensohn, Giuseppe Masucci, Karin Lindberg
    Clinical and Translational Radiation Oncology.2022; 36: 91.     CrossRef
  • Prognostic Value of Carcinoembryonic Antigen Changes Before and After Operation for Esophageal Squamous Cell Carcinoma
    Zhinuan Hong, Zhixin Huang, Zhen Chen, Mingqiang Kang
    World Journal of Surgery.2022; 46(11): 2725.     CrossRef
  • Toxic metals in cement induced hematological and DNA damage as well as carcinogenesis in occupationally-Exposed block-factory workers in Lagos, Nigeria
    Tajudeen Yahaya, Esther Oladele, Titilola Salisu, Esther Orji, Zafira Zakari, Umar Usman Liman, Clement Boniface Gomo, Mustapha Abdullahi
    Egyptian Journal of Basic and Applied Sciences.2022; 9(1): 499.     CrossRef
  • Identification of a Five-MiRNA Expression Assay to Aid Colorectal Cancer Diagnosis
    Matthew G. Davey, Gerard Feeney, Heidi Annuk, Maxwell Paganga, Emma Holian, Aoife J. Lowery, Michael J. Kerin, Nicola Miller
    Gastrointestinal Disorders.2022; 4(3): 190.     CrossRef
  • Label-Free Immunosensor Based on Polyaniline-Loaded MXene and Gold-Decorated β-Cyclodextrin for Efficient Detection of Carcinoembryonic Antigen
    Qi Wang, Huaqian Xin, Zhou Wang
    Biosensors.2022; 12(8): 657.     CrossRef
  • The tumor microenvironment of hepatocellular carcinoma and its targeting strategy by CAR-T cell immunotherapy
    Zhang Guizhen, Ji Guanchang, Liu Liwen, Wang Huifen, Ren Zhigang, Sun Ranran, Yu Zujiang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study
    Chul-Hyun Park, Antonio Diaz Lizarraga, Yong-Taek Lee, Kyung-Jae Yoon, Tae-Kyung Yoo
    Journal of Clinical Medicine.2022; 11(17): 5009.     CrossRef
  • Preoperative albumin–bilirubin score as a prognostic indicator in patients with stage III colon cancer
    Hyun Gu Lee, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Jin Cheon Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • A Novel, Quick, and Reliable Smartphone-Based Method for Serum PSA Quantification: Original Design of a Portable Microfluidic Immunosensor-Based System
    Francisco Gabriel Ortega, Germán E. Gómez, Coral González-Martinez, Teresa Valero, José Expósito-Hernández, Ignacio Puche, Alba Rodriguez-Martinez, María José Serrano, José Antonio Lorente, Martín A. Fernández-Baldo
    Cancers.2022; 14(18): 4483.     CrossRef
  • Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends
    Yanping Wang, Yanfeng Gao, Yujun Song
    ChemMedChem.2022;[Epub]     CrossRef
  • Combined hepatocellular carcinoma-cholangiocarcinoma with a predominant HCC component: better survival and MRI-based prediction
    Yuyao Xiao, Xinde Zheng, Changwu Zhou, Peng Huang, Fei Wu, Chun Yang, Mengsu Zeng
    European Radiology.2022; 33(2): 1412.     CrossRef
  • The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
    Hossein Kamali, Shiva Golmohammadzadeh, Hamed Zare, Rahim Nosrati, Mohammad Fereidouni, Hossein Safarpour
    Journal of Nanobiotechnology.2022;[Epub]     CrossRef
  • The Indicative Value of Serum Tumor Markers for Metastasis and Stage of Non-Small Cell Lung Cancer
    Chunyang Jiang, Mengyao Zhao, Shaohui Hou, Xiaoli Hu, Jinchao Huang, Hongci Wang, Changhao Ren, Xiaoying Pan, Ti Zhang, Shengnan Wu, Shun Zhang, Bingsheng Sun
    Cancers.2022; 14(20): 5064.     CrossRef
  • Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis
    Georgia M. Lorentzen, Paweł Łaniewski, Haiyan Cui, Denise J. Roe, Jamal Mourad, Nichole D. Mahnert, Leslie V. Farland, Melissa M. Herbst-Kralovetz
    iScience.2022; 25(12): 105508.     CrossRef
  • Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer
    Jeesoo Choi, Ho Yeon Cho, Jeongseok Jeon, Kyung-A Kim, Yoon Dae Han, Joong Bae Ahn, Inbal Wortzel, David Lyden, Han Sang Kim
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Old and New Blood Markers in Human Colorectal Cancer
    Jean-Luc Wautier, Marie-Paule Wautier
    International Journal of Molecular Sciences.2022; 23(21): 12968.     CrossRef
  • Adnexal masses in patients with colorectal cancer
    Utku Akgor, Oguzhan Kuru, Burcu Soyak, Ali Can Gunes, Esra Uyanık, Murat Gultekin, Nejat Ozgul, Coskun Salman
    Journal of Gynecology Obstetrics and Human Reproduction.2021; 50(5): 101898.     CrossRef
  • Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Upper Gastrointestinal Cancers: A Systematic Review
    Natalia Calanzani, Paige E. Druce, Claudia Snudden, Kristi M. Milley, Rachel Boscott, Dawnya Behiyat, Smiji Saji, Javiera Martinez-Gutierrez, Jasmeen Oberoi, Garth Funston, Mike Messenger, Jon Emery, Fiona M. Walter
    Advances in Therapy.2021; 38(2): 793.     CrossRef
  • Prognostic value of carcinoembryonic antigen levels before and after curative surgery in colon cancer patients
    Hyun Ryung Kim, Jeong Il Joo, Sang Woo Lim, Bo Young Oh
    Annals of Surgical Treatment and Research.2021; 100(1): 33.     CrossRef
  • Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry
    Laura Pont, Valeriia Kuzyk, Fernando Benavente, Victoria Sanz-Nebot, Oleg A. Mayboroda, Manfred Wuhrer, Guinevere S. M. Lageveen-Kammeijer
    Journal of Proteome Research.2021; 20(3): 1666.     CrossRef
  • A two-tiered targeted proteomics approach to identify pre-diagnostic biomarkers of colorectal cancer risk
    Sophia Harlid, Justin Harbs, Robin Myte, Carl Brunius, Marc J. Gunter, Richard Palmqvist, Xijia Liu, Bethany Van Guelpen
    Scientific Reports.2021;[Epub]     CrossRef
  • The Roadmap of Colorectal Cancer Screening
    Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
    Cancers.2021; 13(5): 1101.     CrossRef
  • Optimizing the diagnosis and management of ductal prostate cancer
    Weranja Ranasinghe, Daniel D. Shapiro, Miao Zhang, Tharakeswara Bathala, Nora Navone, Timothy C. Thompson, Bradley Broom, Ana Aparicio, Shi-Ming Tu, Chad Tang, John W. Davis, Louis Pisters, Brian F. Chapin
    Nature Reviews Urology.2021; 18(6): 337.     CrossRef
  • Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis
    Paige Druce, Natalia Calanzani, Claudia Snudden, Kristi Milley, Rachel Boscott, Dawnya Behiyat, Javiera Martinez-Gutierrez, Smiji Saji, Jasmeen Oberoi, Garth Funston, Mike Messenger, Fiona M. Walter, Jon Emery
    Advances in Therapy.2021; 38(6): 3032.     CrossRef
  • Metachronous pulmonary and pancreatic metastases arising from sigmoid colon cancer: A case report
    Jian Yang, Yu-Chen Tang, Ni Yin, Wei Liu, Zhi-Fei Cao, Xi Li, Xiao Zou, Zi-Xiang Zhang, Jian Zhou
    World Journal of Clinical Cases.2021; 9(15): 3668.     CrossRef
  • Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?
    Robert S O'Neill, Alina Stoita
    World Journal of Gastroenterology.2021; 27(26): 4045.     CrossRef
  • Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression
    Ruidan Xu, Yongfeng Yang, Xiaofeng Zheng
    FEBS Letters.2021; 595(16): 2071.     CrossRef
  • Has the COVID-19 Pandemic Caused Upshifting in Colorectal Cancer Stage?
    Ji Ha Lim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin
    Annals of Coloproctology.2021; 37(4): 253.     CrossRef
  • SERS liquid biopsy: An emerging tool for medical diagnosis
    Vlad Moisoiu, Stefania D. Iancu, Andrei Stefancu, Tudor Moisoiu, Barbara Pardini, Mihnea P. Dragomir, Nicolae Crisan, Lucretia Avram, Dana Crisan, Iulia Andras, Daniela Fodor, Loredana F. Leopold, Carmen Socaciu, Zoltán Bálint, Ciprian Tomuleasa, Florin E
    Colloids and Surfaces B: Biointerfaces.2021; 208: 112064.     CrossRef
  • Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings
    Sophia Harlid, Marc J. Gunter, Bethany Van Guelpen
    Cancers.2021; 13(17): 4406.     CrossRef
  • The Level of Preoperative Plasma KRAS Mutations and CEA Predict Survival of Patients Undergoing Surgery for Colorectal Cancer Liver Metastases
    Jiri Polivka, Jindra Windrichova, Martin Pesta, Katerina Houfkova, Hana Rezackova, Tereza Macanova, Ondrej Vycital, Radek Kucera, David Slouka, Ondrej Topolcan
    Cancers.2020; 12(9): 2434.     CrossRef
  • Thionine-doped nanometer-sized silica conjugated with phenylboronic acid: An innovative recognition/signal element for voltammetric aptasensing of colorectal cancer-related carcinoembryonic antigen
    Liangjie Chi, Chao Xu, Shuyuan Li, Xiangyu Wang, Dianping Tang, Fangqin Xue
    Analytica Chimica Acta.2020; 1136: 91.     CrossRef
  • Molecularly Imprinted Polymers in Biological Applications
    Zahra El-Schich, Yuecheng Zhang, Marek Feith, Sarah Beyer, Louise Sternbæk, Lars Ohlsson, Maria Stollenwerk, Anette Gjörloff Wingren
    BioTechniques.2020; 69(6): 407.     CrossRef
  • Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort
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    Diagnostics.2020; 10(12): 1036.     CrossRef
Pelvic Floor Rehabilitation to Improve Functional Outcome After a Low Anterior Resection: A Systematic Review
Wilhelmina S Visser, Wouter W te Riele, Djamila Boerma, Bert van Ramshorst, Henderik L van Westreenen
Ann Coloproctol. 2014;30(3):109-114.   Published online June 23, 2014
DOI: https://doi.org/10.3393/ac.2014.30.3.109
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AbstractAbstract PDF
Purpose

Impaired functional outcome is common after a low anterior resection (LAR). Pelvic floor rehabilitation (PFR) might improve functional outcome after a LAR. The aim of this systematic review is to evaluate the effectiveness of PFR in improving functional outcome.

Methods

PubMed, Embase, and the Cochrane Library were searched using the terms fecal incontinence, colorectal neoplasm/surgery, LAR, rectal cancer, anterior resection syndrome, bowel habit, pelvic floor, training, therapy, physical therapy, rehabilitation and biofeedback. Of the 125 identified records, 5 articles were included.

Results

The 5 included studies reported on 321 patients, of which 286 patients (89%) underwent pelvic floor training. Three studies included patients with anterior resection syndrome after a LAR while the remaining studies included a series of patients after a LAR. Functional outcome was mostly assessed by using the Wexner incontinence scale. Quality of life was assessed in one study, and in three studies, rectal manometry was performed. After PFR, the functional outcome was improved in four studies, as was the quality of life.

Conclusion

This systematic review demonstrated that PFR is useful for improving the functional outcome after a LAR. The data are extracted from studies of limited quality, but the available evidence points to the effectiveness of the procedure.

Citations

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  • Pelvic floor muscle training for the prevention and management of low anterior resection syndrome in patients with rectal cancer: An evidence-based summary
    Meirong Hong, Wei Yu, Yating Gao, Bei Pei, Ji Chen, Yan Lou
    Asia-Pacific Journal of Oncology Nursing.2025; 12: 100620.     CrossRef
  • Diagnosis and Treatment of Low Anterior Resection Syndrome
    Masaaki Miyo, Emi Akizuki, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Ichiro Takemasa
    Journal of the Anus, Rectum and Colon.2025; 9(1): 1.     CrossRef
  • Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-
    Julie Croft, Emily Farrow, Alexandra Harriet Coxon-Meggy, Katie Gordon, Neil Corrigan, Hannah Mather, Deborah D Stocken, Megan Dale, Huey Yi Chong, Judith White, Laura Knight, Alun Meggy, Christina Lloydwin, Betty Tan, Ashley Douglas, Ralph Powell, Julie
    BMJ Open.2025; 15(2): e092612.     CrossRef
  • Optimal interventions for low anterior resection syndrome: Bayesian network meta-analysis of randomized controlled trials
    M. Yu, Y. Liu, N. Li, J. Xu, H. Zhang, F. Li, H. Chen, B. Li
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Evaluation of pelvic floor rehabilitation in the prevention of low anterior resection syndrome: Study protocol of the CONTICARE trial
    Alexandra Poinas, Noémie Périard, Solène Schirr‐Bonnans, Jean‐Benoit Hardouin, Valery‐Pierre Riche, Odile Cormerais, Michel Guérineau, Guy Valancogne, Antoine Hamy, Mehdi Ouaissi, Yannick Tourreau, Jeremie H Lefevre, Abdelli Amar, Emeric Abet, Jean‐Michel
    Colorectal Disease.2025;[Epub]     CrossRef
  • Treatment options for postoperative faecal incontinence after colorectal surgery
    Conor Thomas Hamilton, Oonagh McCloy
    British Journal of Community Nursing.2025; 30(Sup4a): S12.     CrossRef
  • Progress in diagnosis and treatment of postoperative low anterior resection syndrome
    Wan-Jing Diao, Yi Ji, Jie-Ge Huo
    World Chinese Journal of Digestology.2025; 33(6): 448.     CrossRef
  • Challenges in evaluating pelvic floor physiotherapy based strategies in low anterior resection syndrome: a systematic review and qualitative analysis
    Lauren J. Lambrineas, Henry G. Brock, Hwa Ian Ong, Santha Tisseverasinghe, Emma Carrington, Alexander Heriot, Adele Burgess, David Proud, Helen Mohan
    Colorectal Disease.2024; 26(2): 258.     CrossRef
  • The Effect of a Temporary Stoma on Long-term Functional Outcomes Following Surgery for Rectal Cancer
    Sanne J. Verkuijl, Jara E. Jonker, Edgar J.B. Furnée, Wendy Kelder, Christiaan Hoff, Daniel A. Hess, Fennie Wit, Ronald J. Zijlstra, Monika Trzpis, Paul M.A. Broens
    Diseases of the Colon & Rectum.2024; 67(2): 291.     CrossRef
  • The effectiveness of physiotherapy interventions on fecal incontinence and quality of life following colorectal surgery: a systematic review and meta-analysis of randomized controlled trials
    Ming Yan Pun, Pak Ho Leung, Tsz Ching Chan, Chunn Pang, Kin Hei Chan, Priya Kannan
    Supportive Care in Cancer.2024;[Epub]     CrossRef
  • Treatment of anterior resection syndrome: A systematic review and network meta-analysis
    Lu Zhou, Zhengyang Zhang, Ling Wang
    European Journal of Surgical Oncology.2024; 50(6): 108336.     CrossRef
  • Pelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome
    Nathan A. Coppersmith, Kurt S. Schultz, Andrew C. Esposito, Kimberly Reinhart, Emily Ray, Ira L. Leeds, Haddon J. Pantel, Vikram B. Reddy, Walter E. Longo, Anne K. Mongiu
    Surgical Oncology Insight.2024; 1(4): 100097.     CrossRef
  • Application of pelvic floor rehabilitation in patients with colorectal cancer: a scoping review
    Lu Zhou, Changkun Zhong, Yuanyuan Su, Zhengyang Zhang, Ling Wang
    Techniques in Coloproctology.2024;[Epub]     CrossRef
  • Guideline for the assessment and management of gastrointestinal symptoms following colorectal surgery—A UEG/ESCP/EAES/ESPCG/ESPEN/ESNM/ESSO collaboration. Part I—Sequelae to oncological diseases
    Anke H. C. Gielen
    United European Gastroenterology Journal.2024; 12(10): 1489.     CrossRef
  • Transanal Irrigation in Patients with Low Anterior Resection Syndrome After Rectal-Sphincter-Preserving Surgery for Oncological and Non-Oncological Disease: A Systematic Review
    Andrea Morini, Massimiliano Fabozzi, Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Alfredo Annicchiarico, Candida Bonelli, Maurizio Zizzo
    Surgical Techniques Development.2024; 13(4): 409.     CrossRef
  • Management of treatment‐related sequelae following colorectal cancer
    Susanne Haas, Anette Højer Mikkelsen, Camilla Jensenius Skovhus Kronborg, Birthe T. Oggesen, Pia F. Møller, Janne Fassov, Nina Abild Frederiksen, Marianne Krogsgaard, Charlotte Graugaard‐Jensen, Lise Ventzel, Peter Christensen, Katrine Jøssing Emmertsen
    Colorectal Disease.2023; 25(3): 458.     CrossRef
  • The Effectiveness of a Self-management Program of Bowel Dysfunction in Patients With Mid and Low Rectal Cancer After Sphincter-Preserving Surgery
    Cong Li, Zhao-Yu Li, Qian Lu, Yu-Jie Zhou, Xue-Ying Qin, Ai-Wen Wu, Dong Pang
    Cancer Nursing.2023; 46(1): 67.     CrossRef
  • A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery
    Emil H.A. Pieniowski, Charlotta M. Bergström, Caroline A.M. Nordenvall, Karin S. Westberg, Asif M. Johar, Susanne F. Tumlin Ekelund, Kristina R. Larsson, Klas J. Pekkari, Gabriella C. Jansson Palmer, Pernilla Lagergren, Mirna Abraham-Nordling
    Annals of Surgery.2023; 277(1): 30.     CrossRef
  • Effectiveness of Pelvic Floor Muscle Training for Patients Following Low Anterior Resection
    Young Man Kim, Eui Geum Oh
    Journal of Wound, Ostomy & Continence Nursing.2023; 50(2): 142.     CrossRef
  • Low anterior resection syndrome
    Seung‐Bum Ryoo
    Annals of Gastroenterological Surgery.2023; 7(5): 719.     CrossRef
  • Low anterior resection syndrome
    Matthew C. Hernandez, Paul Wong, Kurt Melstrom
    Journal of Surgical Oncology.2023; 127(8): 1271.     CrossRef
  • Incidencia y manejo fisioterápico del síndrome de resección anterior bajo
    M.J. Escribano Martínez, J.D. Turiño-Luque
    Fisioterapia.2023; 45(6): 326.     CrossRef
  • Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment
    Ruijia Zhang, Wenqin Luo, Yulin Qiu, Fan Chen, Dakui Luo, Yufei Yang, Weijing He, Qingguo Li, Xinxiang Li
    Cancers.2023; 15(20): 5011.     CrossRef
  • Acupuncture for Rectal Cancer Patients with Low Anterior Resection Syndrome: A Mixed Method Pilot Study Protocol
    Ming Yang, Honglin Jiang, Lin Xu, Qiaoli Zhang, Xun Li, Liu Han, Yudong Bao, Lu Yang, Mi Zhang, Lihua Zheng, Ningyuan Liu, Jianping Liu, Jinchang Huang
    Perspectives on Integrative Medicine.2023; 2(3): 195.     CrossRef
  • Low Anterior Resection Syndrome: Predisposing Factors and Treatment
    Richard Garfinkle, Marylise Boutros
    Surgical Oncology.2022; 43: 101691.     CrossRef
  • A national survey of oncology physiotherapy services for cancer survivors in Australia
    Daniel A. Shipton, Amy M. Dennett, Alesha M. Sayner, Clarice Y. Tang
    Asia-Pacific Journal of Clinical Oncology.2022;[Epub]     CrossRef
  • Patienten mit Uro- und Kolostoma in der Rehabilitation
    Jürgen Körber, Wilfried Hoffmann
    Der Onkologe.2022; 28(3): 203.     CrossRef
  • Colorectal nursing and low anterior resection syndrome
    Ellie Bradshaw
    British Journal of Nursing.2022; 31(4): 194.     CrossRef
  • Patienten mit Uro- und Kolostoma in der Rehabilitation
    Jürgen Körber, Wilfried Hoffmann
    best practice onkologie.2022; 17(6): 274.     CrossRef
  • Pelvic Floor Rehabilitation After Rectal Cancer Surgery
    J. A. G. van der Heijden, A. J. Kalkdijk-Dijkstra, J. P. E. N. Pierie, H. L. van Westreenen, P. M. A. Broens, B. R. Klarenbeek
    Annals of Surgery.2022; 276(1): 38.     CrossRef
  • Efficacy of Tibial Nerve Stimulation on Fecal Incontinence in Patients With Low Anterior Resection Syndrome Following Surgery for Colorectal Cancer
    Aigul Tazhikova, Abay Makishev, Aizhan Bekisheva, Mariya Dmitriyeva, Medet Toleubayev, Alina Sabitova
    Annals of Rehabilitation Medicine.2022; 46(3): 142.     CrossRef
  • The Role of Pelvic Floor Muscle Training on Low Anterior Resection Syndrome
    Anne Asnong, André D’Hoore, Marijke Van Kampen, Albert Wolthuis, Yves Van Molhem, Bart Van Geluwe, Nele Devoogdt, An De Groef, Ipek Guler Caamano Fajardo, Inge Geraerts
    Annals of Surgery.2022; 276(5): 761.     CrossRef
  • Low anterior resection syndrome: An unavoidable price to pay to preserve the rectum?
    Franco Marinello, Gianluca Pellino, Eloy Espín-Basany
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Optimising functional outcomes in rectal cancer surgery
    Fabio Nocera, Fiorenzo Angehrn, Markus von Flüe, Daniel C. Steinemann
    Langenbeck's Archives of Surgery.2021; 406(2): 233.     CrossRef
  • Biofeedback for Pelvic Floor Disorders
    Melissa Hite, Thomas Curran
    Clinics in Colon and Rectal Surgery.2021; 34(01): 056.     CrossRef
  • Efficacy of pelvic floor rehabilitation for bowel dysfunction after anterior resection for colorectal cancer: a systematic review
    K. Y. C. Chan, M. Suen, S. Coulson, Janette L. Vardy
    Supportive Care in Cancer.2021; 29(4): 1795.     CrossRef
  • Management guidelines for low anterior resection syndrome – the MANUEL project
    Peter Christensen, Coen IM Baeten, Eloy Espín‐Basany, Jacopo Martellucci, Karen P Nugent, Frank Zerbib, Gianluca Pellino, Harald Rosen
    Colorectal Disease.2021; 23(2): 461.     CrossRef
  • Randomised controlled trial to assess efficacy of pelvic floor muscle training on bowel symptoms after low anterior resection for rectal cancer: study protocol
    Anne Asnong, André D"Hoore, Marijke Van Kampen, Nele Devoogdt, An De Groef, Kim Sterckx, Hilde Lemkens, Albert Wolthuis, Yves Van Molhem, Bart Van Geluwe, Lynn Debrun, Inge Geraerts
    BMJ Open.2021; 11(1): e041797.     CrossRef
  • Nurse‐led standardized intervention for low anterior resection syndrome. A population‐based pilot study
    Peter Dalsgaard, Katrine Jøssing Emmertsen, Mira Mekhael, Søren Laurberg, Peter Christensen
    Colorectal Disease.2021; 23(2): 434.     CrossRef
  • Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis
    I. Vogel, N. Reeves, P. J. Tanis, W. A. Bemelman, J. Torkington, R. Hompes, J. A. Cornish
    Techniques in Coloproctology.2021; 25(7): 751.     CrossRef
  • Financial and occupational impact of low anterior resection syndrome in rectal cancer survivors
    Richard Garfinkle, Aurelie Ky, Aashiyan Singh, Nancy Morin, Gabriela Ghitulescu, Julio Faria, Carol‐Ann Vasilevsky, Marylise Boutros
    Colorectal Disease.2021; 23(7): 1777.     CrossRef
  • Anterior resection syndrome: a randomized clinical trial of a 5-HT3 receptor antagonist (ramosetron) in male patients with rectal cancer
    S -B Ryoo, J W Park, D W Lee, M A Lee, Y -H Kwon, M J Kim, S H Moon, S -Y Jeong, K J Park
    British Journal of Surgery.2021; 108(6): 644.     CrossRef
  • A study on the clinical application of greater omental pedicle flap transplantation to correct anterior resection syndrome in patients with low rectal cancer
    Haiquan Qin, Linghou Meng, Zigao Huang, Jiankun Liao, Yan Feng, Shanshan Luo, Hao Lai, Weizhong Tang, Xianwei Mo
    Regenerative Therapy.2021; 18: 146.     CrossRef
  • Low Anterior Resection Syndrome: A Questionnaire Survey for Colorectal Surgeons in Tokyo and the Surrounding Districts
    Hiroyoshi Matsuoka, Masamichi Yasuno, Keiichi Takahashi, Kimihiko Funahashi, Yoshihisa Saida, Michio Itabashi, Keiji Matsuda, Shouichi Fujii, Shinpei Ogawa, Takeshi Yamada, Ken Etoh, Tadahiko Masaki
    Nippon Daicho Komonbyo Gakkai Zasshi.2021; 74(7): 430.     CrossRef
  • A randomized clinical trial to assess the effectiveness of pre- and post-surgical pelvic floor physiotherapy for bowel symptoms, pelvic floor function, and quality of life of patients with rectal cancer: CARRET protocol
    Cinara Sacomori, Luz Alejandra Lorca, Mónica Martinez-Mardones, Roberto Ignacio Salas-Ocaranza, Guillermo Patricio Reyes-Reyes, Marta Natalia Pizarro-Hinojosa, Jorge Plasser-Troncoso
    Trials.2021;[Epub]     CrossRef
  • A novel bowel rehabilitation programme after total mesorectal excision for rectal cancer: the BOREAL pilot study
    Deena Harji, Benjamin Fernandez, Lara Boissieras, Arthur Berger, Maylis Capdepont, Frank Zerbib, Eric Rullier, Quentin Denost
    Colorectal Disease.2021; 23(10): 2619.     CrossRef
  • Low anterior resection syndrome: can it be prevented?
    Alfredo Annicchiarico, Jacopo Martellucci, Stefano Solari, Maximilian Scheiterle, Carlo Bergamini, Paolo Prosperi
    International Journal of Colorectal Disease.2021; 36(12): 2535.     CrossRef
  • LARS: A review of therapeutic options and their efficacy
    Kheng-Seong Ng, Marc A Gladman
    Seminars in Colon and Rectal Surgery.2021; 32(4): 100849.     CrossRef
  • Effect of Biofeedback Therapy during Temporary Stoma Period in Rectal Cancer Patients: A Prospective Randomized Trial
    Hyeon-Min Cho, Hyungjin Kim, RiNa Yoo, Gun Kim, Bong-Hyeon Kye
    Journal of Clinical Medicine.2021; 10(21): 5172.     CrossRef
  • Functional outcomes after sphincter-preserving surgeries for low-lying rectal cancer: A review
    Eun Jung Park, Seung Hyuk Baik
    Precision and Future Medicine.2021; 5(4): 164.     CrossRef
  • Fecal Incontinence Diagnosed by the Rome IV Criteria in the United States, Canada, and the United Kingdom
    William E. Whitehead, Magnus Simren, Jan Busby-Whitehead, Steve Heymen, Miranda A.L. van Tilburg, Ami D. Sperber, Olafur S. Palsson
    Clinical Gastroenterology and Hepatology.2020; 18(2): 385.     CrossRef
  • Pelvic floor rehabilitation to improve functional outcome and quality of life after surgery for rectal cancer: study protocol for a randomized controlled trial (FORCE trial)
    A.J. Kalkdijk-Dijkstra, J.A.G. van der Heijden, H.L. van Westreenen, P.M.A. Broens, M. Trzpis, J.P.E.N. Pierie, B.R. Klarenbeek
    Trials.2020;[Epub]     CrossRef
  • ‘French LARS score’: validation of the French version of the low anterior resection syndrome (LARS) score for measuring bowel dysfunction after sphincter-preserving surgery among rectal cancer patients: a study protocol
    Yassine Eid, Véronique Bouvier, Olivier Dejardin, Benjamin Menahem, Fabien Chaillot, Yannick Chene, Jean Jacques Dutheil, Therese Juul, Rémy Morello, Arnaud Alves
    BMJ Open.2020; 10(3): e034251.     CrossRef
  • Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow‐up within the QoLiRECT study
    S. Sandberg, D. Asplund, T. Bisgaard, D. Bock, E. González, L. Karlsson, P. Matthiessen, B. Ohlsson, J. Park, J. Rosenberg, S. Skullman, M. Sörensson, E. Angenete
    Colorectal Disease.2020; 22(10): 1367.     CrossRef
  • Five-year single center experience of sacral neuromodulation for isolated fecal incontinence or fecal incontinence combined with low anterior resection syndrome
    C. De Meyere, F. Nuytens, I. Parmentier, M. D’Hondt
    Techniques in Coloproctology.2020; 24(9): 947.     CrossRef
  • Low Anterior Resection Syndrome
    Theresa H. Nguyen, Reena V. Chokshi
    Current Gastroenterology Reports.2020;[Epub]     CrossRef
  • Nachsorge und Behandlung funktioneller Störungen nach operativer Therapie des Rektumkarzinoms
    C. Holmer
    Der Onkologe.2020; 26(12): 1154.     CrossRef
  • Changes to gastrointestinal function after surgery for colorectal cancer
    David Lam, Oliver Jones
    Best Practice & Research Clinical Gastroenterology.2020; 48-49: 101705.     CrossRef
  • Randomized Pilot Trial of Percutaneous Posterior Tibial Nerve Stimulation Versus Medical Therapy for the Treatment of Low Anterior Resection Syndrome: One-Year Follow-up
    Dajana Cuicchi, Francesca Di Fabio, Alessandra Guido, Fabiola Lorena Rojas Llimpe, Alessio G. Morganti, Andrea Ardizzoni, Maurizio Coscia, Gilberto Poggioli
    Diseases of the Colon & Rectum.2020; 63(12): 1602.     CrossRef
  • Comment améliorer la fonction anorectale après proctectomie ?
    E. Duchalais, G. Meurette
    Côlon & Rectum.2019; 13(1): 5.     CrossRef
  • Survivorship Guidance for Patients with Colorectal Cancer
    Jillian Simard, Suneel Kamath, Sheetal Kircher
    Current Treatment Options in Oncology.2019;[Epub]     CrossRef
  • Etiology and management of low anterior resection syndrome based on the normal defecation mechanism
    Keiji Koda, Masato Yamazaki, Kiyohiko Shuto, Chihiro Kosugi, Mikito Mori, Kazuo Narushima, Isamu Hosokawa, Hiroaki Shimizu
    Surgery Today.2019; 49(10): 803.     CrossRef
  • Health-Related Quality of Life in Older Adults with Colorectal Cancer
    Evan Lapinsky, Lillian C. Man, Amy R. MacKenzie
    Current Oncology Reports.2019;[Epub]     CrossRef
  • Implementation of a Postoperative Screening and Treatment Guidance for the Low Anterior Resection Syndrome: Preliminary Results
    Joost A.G. van der Heijden, Maarten van Heinsbergen, Gwendolyn Thomas, Freeke Caers, Gerrit D. Slooter, Adriana J.G. Maaskant-Braat
    Diseases of the Colon & Rectum.2019; 62(9): 1033.     CrossRef
  • Postoperative Bowel Function After Anal Sphincter-Preserving Rectal Cancer Surgery: Risks Factors, Diagnostic Modalities, and Management
    Chris George Cura Pales, Sanghyun An, Jan Paolo Cruz, Kwangmin Kim, Youngwan Kim
    Annals of Coloproctology.2019; 35(4): 160.     CrossRef
  • Efficacy of biofeedback therapy for objective improvement of pelvic function in low anterior resection syndrome
    Kyung Ha Lee, Jin Soo Kim, Ji Yeon Kim
    Annals of Surgical Treatment and Research.2019; 97(4): 194.     CrossRef
  • Expert Commentary on Low Anterior Resection Syndrome
    Larissa K.F. Temple
    Diseases of the Colon & Rectum.2019; 62(12): 1423.     CrossRef
  • Low Anterior Resection Syndrome
    Nicholas P. McKenna
    Diseases of the Colon & Rectum.2019; 62(12): 1420.     CrossRef
  • Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer
    Mark Lawler, Deborah Alsina, Richard A Adams, Annie S Anderson, Gina Brown, Nicola S Fearnhead, Stephen W Fenwick, Stephen P Halloran, Daniel Hochhauser, Mark A Hull, Viktor H Koelzer, Angus G K McNair, Kevin J Monahan, Inke Näthke, Christine Norton, Marc
    Gut.2018; 67(1): 179.     CrossRef
  • Developing advanced clinical practice skills in gastrointestinal consequences of cancer treatment
    Caroline Gee, Jervoise Andreyev, Ann Muls
    Gastrointestinal Nursing.2018; 16(2): 27.     CrossRef
  • Treatment possibilities for low anterior resection syndrome: a review of the literature
    Audrius Dulskas, Edgaras Smolskas, Inga Kildusiene, Narimantas E. Samalavicius
    International Journal of Colorectal Disease.2018; 33(3): 251.     CrossRef
  • Developing advanced clinical practice skills in gastrointestinal consequences of cancer treatment
    Caroline Gee, Jervoise Andreyev, Ann Muls
    British Journal of Nursing.2018; 27(5): 237.     CrossRef
  • Antegrade Enema After Total Mesorectal Excision for Rectal Cancer: The Last Chance to Avoid Definitive Colostomy for Refractory Low Anterior Resection Syndrome and Fecal Incontinence
    Romain Didailler, Quentin Denost, Paula Loughlin, Edouard Chabrun, Julie Ricard, Flor Picard, Frank Zerbib, Eric Rullier
    Diseases of the Colon & Rectum.2018; 61(6): 667.     CrossRef
  • Adult Inflammatory Bowel Disease, Physical Rehabilitation, and Structured Exercise
    Jessica Elia, Sunanda Kane
    Inflammatory Bowel Diseases.2018; 24(12): 2543.     CrossRef
  • Role of transanal irrigation in the treatment of anterior resection syndrome
    J. Martellucci, A. Sturiale, C. Bergamini, L. Boni, F. Cianchi, A. Coratti, A. Valeri
    Techniques in Coloproctology.2018; 22(7): 519.     CrossRef
  • Le syndrome de résection antérieure du rectum. Quels messages délivrer aux praticiens et aux patients en 2018 ?
    T. Sarcher, B. Dupont, A. Alves, B. Menahem
    Journal de Chirurgie Viscérale.2018; 155(5): 390.     CrossRef
  • Anterior resection syndrome: What should we tell practitioners and patients in 2018?
    T. Sarcher, B. Dupont, A. Alves, B. Menahem
    Journal of Visceral Surgery.2018; 155(5): 383.     CrossRef
  • Transanal irrigation in lower anterior resection syndrome (LARS): a case study
    Amanda Eccles
    Gastrointestinal Nursing.2018; 16(8): 24.     CrossRef
  • Comparison of Pelvic Autonomic Nerve Function Recovery Between the Group only with Surgery and Group with Additional Acupuncture and Electrotherapy for Treatment in Patients with Rectal Cancer after Anus-Preserving Operation
    Jiaying Zhao, Yuankun Cai, Huipeng Wang, Yan Zhou, Yanbin Zhang, Wenjie Chen, Chenxia Shen, Tao Ye
    Acupuncture & Electro-Therapeutics Research.2018; 43(2): 103.     CrossRef
  • Physiotherapy and Anterior Resection Syndrome (PARiS) trial: feasibility study protocol
    Anna Powell-Chandler, Buddug Rees, Carole Broad, Jared Torkington, Claire O’Neill, Julie A Cornish
    BMJ Open.2018; 8(6): e021855.     CrossRef
  • Functional outcome following rectal surgery—predisposing factors for low anterior resection syndrome
    Daniel Ll Hughes, Julie Cornish, Chris Morris
    International Journal of Colorectal Disease.2017; 32(5): 691.     CrossRef
  • Successful Restoration of Fecal Continence Using Sacral Nerve Stimulation Following Chemoradiation and Transanal Excision of an Anal Melanoma With Partial Internal Anal Sphincter Resection: A Case Report
    Tyler Cameron Tolopka, Craig A. Messick
    Neuromodulation: Technology at the Neural Interface.2017; 20(8): 783.     CrossRef
  • A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005‐2017)
    Nicole L. Stout, Jennifer Baima, Anne K. Swisher, Kerri M. Winters‐Stone, Judith Welsh
    PM&R.2017;[Epub]     CrossRef
  • Aspectos fisiopatológicos da síndrome pós-ressecção anterior do reto para o tratamento de câncer retal
    Kelly Cristine de Lacerda Rodrigues Buzatti, Andy Petroianu
    Revista do Colégio Brasileiro de Cirurgiões.2017; 44(4): 397.     CrossRef
  • Management of surgical challenges in actively treated cancer patients
    David A. Santos, Adnan Alseidi, Vickie R. Shannon, Craig Messick, Guobin Song, Celia Robinson Ledet, Hun Lee, An Ngo-Huang, George J. Francis, Arash Asher
    Current Problems in Surgery.2017; 54(12): 612.     CrossRef
  • Short‐term outcome of percutaneous tibial nerve stimulation for low anterior resection syndrome: results of a pilot study
    D. F. Altomare, A. Picciariello, C. Ferrara, R. Digennaro, Y. Ribas, M. De Fazio
    Colorectal Disease.2017; 19(9): 851.     CrossRef
  • Pelvic floor muscle exercise for fecal incontinence quality of life after coloanal anastomosis
    Shu‐Ling Hung, Yu‐Hua Lin, Hsing‐Yu Yang, Chia‐Chan Kao, Hong‐Yu Tung, Li‐Hsiang Wei
    Journal of Clinical Nursing.2016; 25(17-18): 2658.     CrossRef
  • The Effect of Biofeedback Therapy on Anorectal Function After the Reversal of Temporary Stoma When Administered During the Temporary Stoma Period in Rectal Cancer Patients With Sphincter-Saving Surgery
    Bong-Hyeon Kye, Hyung-Jin Kim, Gun Kim, Ri Na Yoo, Hyeon-Min Cho
    Medicine.2016; 95(18): e3611.     CrossRef
  • Toward a National Initiative in Cancer Rehabilitation: Recommendations From a Subject Matter Expert Group
    Nicole L. Stout, Julie K. Silver, Vishwa S. Raj, Julia Rowland, Lynn Gerber, Andrea Cheville, Kirsten K. Ness, Mary Radomski, Ralph Nitkin, Michael D. Stubblefield, G. Stephen Morris, Ana Acevedo, Zavera Brandon, Brent Braveman, Schuyler Cunningham, Laura
    Archives of Physical Medicine and Rehabilitation.2016; 97(11): 2006.     CrossRef
  • Lengthening of left colon after rectal resection: What all is adequate? A prospective cohort study
    Shruthi H.S. Reddy, Vikas Gupta, Thakur D. Yadav, Gurpreet Singh, Daisy Sahni
    International Journal of Surgery.2016; 31: 27.     CrossRef
  • Low anterior resection syndrome: a survey of the members of the American Society of Colon and Rectal Surgeons (ASCRS), the Spanish Association of Surgeons (AEC), and the Spanish Society of Coloproctology (AECP)
    Luis Miguel Jimenez-Gomez, Eloy Espin-Basany, Marc Marti-Gallostra, Jose Luis Sanchez-Garcia, Francesc Vallribera-Valls, Manuel Armengol-Carrasco
    International Journal of Colorectal Disease.2016; 31(4): 813.     CrossRef
  • Effects of pelvic floor muscle exercise on faecal incontinence in rectal cancer patients after stoma closure
    Y.-H. Lin, H.-Y. Yang, S.-L. Hung, H.-P. Chen, K.-W. Liu, T.-B. Chen, S.-C. Chi
    European Journal of Cancer Care.2016; 25(3): 449.     CrossRef
  • Conversations for providers caring for patients with rectal cancer: Comparison of long‐term patient‐centered outcomes for patients with low rectal cancer facing ostomy or sphincter‐sparing surgery
    Lisa J. Herrinton, Andrea Altschuler, Carmit K. McMullen, Joanna E. Bulkley, Mark C. Hornbrook, Virginia Sun, Christopher S. Wendel, Marcia Grant, Carol M. Baldwin, Wendy Demark‐Wahnefried, Larissa K. F. Temple, Robert S. Krouse
    CA: A Cancer Journal for Clinicians.2016; 66(5): 387.     CrossRef
  • Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist
    Stacy Tessler Lindau, Emily M. Abramsohn, Shirley R. Baron, Judith Florendo, Hope K. Haefner, Anuja Jhingran, Vanessa Kennedy, Mukta K. Krane, David M. Kushner, Jennifer McComb, Diane F. Merritt, Julie E. Park, Amy Siston, Margaret Straub, Lauren Streiche
    CA: A Cancer Journal for Clinicians.2016; 66(3): 241.     CrossRef
  • Quality of Life After a Low Anterior Resection for Rectal Cancer in Elderly Patients
    Verena N.N. Kornmann, Marieke S. Walma, Marnix A.J. de Roos, Djamila Boerma, Henderik L. van Westreenen
    Annals of Coloproctology.2016; 32(1): 27.     CrossRef
  • Biofeedback Therapy After Sphincter-Preservation Surgery for the Treatment of Rectal Cancer
    Ik Yong Kim
    Annals of Coloproctology.2015; 31(4): 119.     CrossRef
  • Role of electromyography and functional electrical stimulation in the treatment of anorectal diseases
    Katarzyna Borycka-Kiciak, Karolina Wawiernia, Jan Namysł, Krystyna Garstka-Namysł, Wiesław Tarnowski
    Polish Journal of Surgery.2015;[Epub]     CrossRef
  • Biofeedback Therapy Before Ileostomy Closure in Patients Undergoing Sphincter-Saving Surgery for Rectal Cancer: A Pilot Study
    Jeong-Ki Kim, Byeong Geon Jeon, Yoon Suk Song, Mi Sun Seo, Yoon-Hye Kwon, JI Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
    Annals of Coloproctology.2015; 31(4): 138.     CrossRef
  • Pregnancy and Postpartum Bowel Changes: Constipation and Fecal Incontinence
    Grace Hewon Shin, Erin Lucinda Toto, Ron Schey
    American Journal of Gastroenterology.2015; 110(4): 521.     CrossRef
  • A systematic review of sacral nerve stimulation for low anterior resection syndrome
    L. Ramage, S. Qiu, C. Kontovounisios, P. Tekkis, S. Rasheed, E. Tan
    Colorectal Disease.2015; 17(9): 762.     CrossRef
  • Spätpostoperative Komplikationen und Folgezustände nach Rektumresektion
    J. Reibetanz, M. Kim, C.-T. Germer, N. Schlegel
    Der Chirurg.2015; 86(4): 326.     CrossRef
Optimal Total Mesorectal Excision for Rectal Cancer: the Role of Robotic Surgery from an Expert's View
Nam-Kyu Kim, Jeonghyun Kang
J Korean Soc Coloproctol. 2010;26(6):377-387.   Published online December 31, 2010
DOI: https://doi.org/10.3393/jksc.2010.26.6.377
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AbstractAbstract PDF

Total mesorectal excision (TME) has gained worldwide acceptance as a standard surgical technique in the treatment of rectal cancer. Ever since laparoscopic surgery was first applied to TME for rectal cancer, with increasing penetration rates, especially in Asia, an unstable camera platform, the limited mobility of straight laparoscopic instruments, the two-dimensional imaging, and a poor ergonomic position for surgeons have been regarded as limitations. Robotic technology was developed in an attempt to reduce the limitations of laparoscopic surgery. The robotic system has many advantages, including a more ergonomic position, stable camera platform and stereoscopic view, as well as elimination of tremor and subsequent improved dexterity. Current comparison data between robotic and laparoscopic rectal cancer surgery show similar intraoperative results and morbidity, postoperative recovery, and short-term oncologic outcomes. Potential benefits of a robotic system include reduction of surgeon's fatigue during surgery, improved performance and safety for intracorporeal suture, reduction of postoperative complications, sharper and more meticulous dissection, and completion of autonomic nerve preservation techniques. However, the higher cost for a robotic system still remains an obstacle to wide application, and many socioeconomic issues remain to be solved in the future. In addition, we need more concrete evidence regarding the merits for both patients and surgeons, as well as the merits compared to conventional laparoscopic techniques. Therefore, we need large-scale prospective randomized clinical trials to prove the potential benefits of robot TME for the treatment of rectal cancer.

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  • The urinary and sexual outcomes of robot-assisted versus laparoscopic rectal cancer surgery: a systematic review and meta-analysis
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    Surgery Today.2024; 54(5): 397.     CrossRef
  • Deep neuromuscular block attenuates intra‐abdominal pressure and inflammation and improves post‐operative cognition in prostate cancer patients following robotic‐assisted radical prostatectomy
    Guangjun Hu, Weidong Shao, Zhuo Chen, Bixi Li, Bo Xu
    The International Journal of Medical Robotics and Computer Assisted Surgery.2024;[Epub]     CrossRef
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    Mitsuru Ishizuka, Norisuke Shibuya, Hiroyuki Hachiya, Yusuke Nishi, Takahiro Kono, Masashi Takayanagi, Tetsutaro Nemoto, Keisuke Ihara, Takayuki Shiraki, Takatsugu Matsumoto, Shozo Mori, Takatoshi Nakamura, Taku Aoki, Tsunekazu Mizushima
    European Journal of Surgical Oncology.2024; 50(10): 108538.     CrossRef
  • Learning curve of robotic rectal surgery using risk-adjusted cumulative summation: a 5-year institutional experience
    Hiroshi Oshio, Tsuneo Konta, Yukiko Oshima, Gen Yunome, Shinji Okazaki, Ichiro Kawamura, Yuya Ashitomi, Masaaki Kawai, Hiroaki Musha, Fuyuhiko Motoi
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Risk factors for and longitudinal course of male sexual dysfunction after robotic rectal cancer surgery
    Marie Hanaoka, Hiroyasu Kagawa, Akio Shiomi, Hitoshi Hino, Shoichi Manabe, Yusuke Yamaoka, Yusuke Kinugasa
    Colorectal Disease.2023; 25(5): 932.     CrossRef
  • Comparing minimally invasive surgical and open approaches to pelvic exenteration for locally advanced or recurrent pelvic malignancies - Systematic review and meta-analysis
    Odhrán K. Ryan, Katie L. Doogan, Éanna J. Ryan, Mark Donnelly, Ian S. Reynolds, Ben Creavin, Matthew G. Davey, Michael E. Kelly, Rory Kennelly, Ann Hanly, Seán T. Martin, Des C. Winter
    European Journal of Surgical Oncology.2023; 49(8): 1362.     CrossRef
  • Current Status of Robotic Gastrointestinal Surgery
    Keisuke Minamimura, Keisuke Hara, Satoshi Matsumoto, Tomohiko Yasuda, Hiroki Arai, Daisuke Kakinuma, Yukio Ohshiro, Youichi Kawano, Masanori Watanabe, Hideyuki Suzuki, Hiroshi Yoshida
    Journal of Nippon Medical School.2023; 90(4): 308.     CrossRef
  • Potential urinary function benefits of initial robotic surgery for rectal cancer in the introductory phase
    Hiroshi Oshio, Yukiko Oshima, Gen Yunome, Mitsuyasu Yano, Shinji Okazaki, Yuya Ashitomi, Hiroaki Musha, Yukinori Kamio, Fuyuhiko Motoi
    Journal of Robotic Surgery.2022; 16(1): 159.     CrossRef
  • Colorectal cancer surgery: by Cambridge Medical Robotics Versius Surgical Robot System—a single-institution study. Our experience
    Shailesh P. Puntambekar, K. N. Rajesh, Arjun Goel, Mangesh Hivre, Suyog Bharambe, Mihir Chitale, Mangesh Panse
    Journal of Robotic Surgery.2022; 16(3): 587.     CrossRef
  • Surgical approach for rectal cancer: A network meta-analysis comparing open, laparoscopic, robotic and transanal TME approaches
    Odhrán K. Ryan, Éanna J. Ryan, Ben Creavin, Emanuele Rausa, Michael E. Kelly, Fausto Petrelli, Gianluca Bonitta, Rory Kennelly, Ann Hanly, Seán T. Martin, Des C. Winter
    European Journal of Surgical Oncology.2021; 47(2): 285.     CrossRef
  • Predictive and Diagnostic Biomarkers of Anastomotic Leakage: A Precision Medicine Approach for Colorectal Cancer Patients
    Mark Gray, Jamie R. K. Marland, Alan F. Murray, David J. Argyle, Mark A. Potter
    Journal of Personalized Medicine.2021; 11(6): 471.     CrossRef
  • Transanal total mesorectal excision and transabdominal robotic surgery for rectal cancer: A retrospective study
    Hiroshi Oshio, Yukiko Oshima, Gen Yunome, Shinji Okazaki, Ichiro Kawamura, Yuya Ashitomi, Hiroaki Musha, Masaaki Kawai, Fuyuhiko Motoi
    Annals of Medicine and Surgery.2021; 70: 102902.     CrossRef
  • Comparison of the quality of total mesorectal excision after robotic and laparoscopic surgery for rectal cancer: a multicenter, propensity score-matched study
    Keehyun Park, Sohyun Kim, Hye Won Lee, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong
    Korean Journal of Clinical Oncology.2021; 17(2): 82.     CrossRef
  • Robotic Surgery for Rectal Cancer: Operative Technique and Review of the Literature
    Hidetoshi Katsuno, Tsunekazu Hanai, Koji Masumori, Yoshikazu Koide, Keigo Ashida, Hiroshi Matsuoka, Yosuke Tajima, Tomoyoshi Endo, Masahiro Mizuno, Yeongcheol Cheong, Kotaro Maeda, Ichiro Uyama
    Journal of the Anus, Rectum and Colon.2020; 4(1): 14.     CrossRef
  • Robotics Total Mesorectal Excision Up To the Minute
    Homoud Alawfi, Ho Seung Kim, Seung Yoon Yang, Nam Kyu Kim
    Indian Journal of Surgical Oncology.2020; 11(4): 552.     CrossRef
  • Robotic-Assisted Laparoscopic Surgery for Rectal Cancer (RALS): A Review of the Literature
    Emil T. Filipov, Tsvetomir M. Ivanov
    Journal of Biomedical and Clinical Research.2020; 13(2): 100.     CrossRef
  • Robotic versus laparoscopic sphincter‐preserving total mesorectal excision: A propensity case‐matched analysis
    Pavan Sugoor, Kamlesh Verma, Aditi Chaturvedi, Sadhana Kannan, Ashwin Desouza, Vikas Ostwal, Reena Engineer, Avanish Saklani
    The International Journal of Medical Robotics and Computer Assisted Surgery.2019;[Epub]     CrossRef
  • Robotic vs laparoscopic rectal tumour surgery: a cohort study
    D. Asklid, R. Gerjy, F. Hjern, K. Pekkari, U. O. Gustafsson
    Colorectal Disease.2019; 21(2): 191.     CrossRef
  • Robotic versus conventional laparoscopic surgery for rectal cancer: systematic review and meta-analysis
    Xi-Yu Sun, Lai Xu, Jun-Yang Lu, Guan-Nan Zhang
    Minimally Invasive Therapy & Allied Technologies.2019; 28(3): 135.     CrossRef
  • Robotic Surgery for Rectal Cancer and Cost-Effectiveness
    Youngbae Jeon, Eun Jung Park, Seung Hyuk Baik
    The Journal of Minimally Invasive Surgery.2019; 22(4): 139.     CrossRef
  • The short-term outcomes of robotic sphincter-preserving surgery for rectal cancer: comparison with open and laparoscopic surgery using a propensity score analysis
    Soichiro Ishihara, Tomomichi Kiyomatsu, Kazushige Kawai, Toshiaki Tanaka, Keisuke Hata, Shinsuke Kazama, Eiji Sunami, Hiroaki Nozawa, Toshiaki Watanabe
    International Journal of Colorectal Disease.2018; 33(8): 1047.     CrossRef
  • The impact of robotic surgery on quality of life, urinary and sexual function following total mesorectal excision for rectal cancer: a propensity score‐matched analysis with laparoscopic surgery
    H. J. Kim, G.‐S. Choi, J. S. Park, S. Y. Park, C. S. Yang, H. J. Lee
    Colorectal Disease.2018;[Epub]     CrossRef
  • Laparoscopic vs Robotic Surgery in Colorectal Cases
    Shalmali Alva
    World Journal of Laparoscopic Surgery with DVD.2018; 11(1): 43.     CrossRef
  • Outcomes of robotic versus laparoscopic surgery for mid and low rectal cancer after neoadjuvant chemoradiation therapy and the effect of learning curve
    Yu-Min Huang, Yan Jiun Huang, Po-Li Wei
    Medicine.2017; 96(40): e8171.     CrossRef
  • Use of the new da Vinci Xi® during robotic rectal resection for cancer: a pilot matched-case comparison with the da Vinci Si®
    Luca Morelli, Simone Guadagni, Gregorio Di Franco, Matteo Palmeri, Giovanni Caprili, Cristiano D'Isidoro, Luigi Cobuccio, Emanuele Marciano, Giulio Di Candio, Franco Mosca
    The International Journal of Medical Robotics and Computer Assisted Surgery.2017; 13(1): e1728.     CrossRef
  • Long-term oncological outcomes of robotic versus laparoscopic total mesorectal excision of mid–low rectal cancer following neoadjuvant chemoradiation therapy
    Dae Ro Lim, Sung Uk Bae, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
    Surgical Endoscopy.2017; 31(4): 1728.     CrossRef
  • Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis
    Yanlai Sun, Huirong Xu, Zengjun Li, Jianjun Han, Wentao Song, Junwei Wang, Zhongfa Xu
    World Journal of Surgical Oncology.2016;[Epub]     CrossRef
  • Totally robotic rectal resection: an experience of the first 100 consecutive cases
    J. Ahmed, M. Nasir, K. Flashman, J. Khan, A. Parvaiz
    International Journal of Colorectal Disease.2016; 31(4): 869.     CrossRef
  • Open, Laparoscopic, and Robotic Surgery for Rectal Cancer: Medium-Term Comparative Outcomes from a Multicenter Study
    Carlo Corbellini, Roberto Biffi, Fabrizio Luca, Antonio Chiappa, Stefano Costa, Emilio Bertani, Stefano Bona, Davide Lombardi, Darina Tamayo, Edoardo Botteri, Bruno Andreoni
    Tumori Journal.2016; 102(4): 414.     CrossRef
  • Outcomes in 132 patients following laparoscopic total mesorectal excision (TME) for rectal cancer with greater than 5-year follow-up
    John H. Marks, Renee Huang, Dominique McKeever, Morgan Greenfield
    Surgical Endoscopy.2016; 30(1): 307.     CrossRef
  • Effects of robotic rectal surgery on sexual and urinary functions in male patients
    Shinji Ozeki, Kotaro Maeda, Tsunekazu Hanai, Koji Masumori, Hidetoshi Katsuno, Hiroshi Takahashi
    Surgery Today.2016; 46(4): 491.     CrossRef
  • Robotic Surgery for Colon and Rectal Cancer
    Eun Jung Park, Seung Hyuk Baik
    Current Oncology Reports.2016;[Epub]     CrossRef
  • A population-based study comparing laparoscopic and robotic outcomes in colorectal surgery
    Michael S. Tam, Christodoulos Kaoutzanis, Andrew J. Mullard, Scott E. Regenbogen, Michael G. Franz, Samantha Hendren, Greta Krapohl, James F. Vandewarker, Richard M. Lampman, Robert K. Cleary
    Surgical Endoscopy.2016; 30(2): 455.     CrossRef
  • Robotic Versus Laparoscopic Surgery for Rectal Cancer after Preoperative Chemoradiotherapy: Case-Matched Study of Short-Term Outcomes
    Yong Sok Kim, Min Jung Kim, Sung Chan Park, Dae Kyung Sohn, Dae Yong Kim, Hee Jin Chang, Byung-Ho Nam, Jae Hwan Oh
    Cancer Research and Treatment.2016; 48(1): 225.     CrossRef
  • A Pooled Analysis of Robotic Versus Laparoscopic Surgery for Total Mesorectal Excision for Rectal Cancer
    Yue Wang, Guo-Hua Zhao, Helen Yang, Jie Lin
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2016; 26(3): 259.     CrossRef
  • Robotics in Colorectal Surgery
    Allison Weaver, Scott Steele
    F1000Research.2016; 5: 2373.     CrossRef
  • Recent advances in robotic surgery for rectal cancer
    Soichiro Ishihara, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Junichiro Tanaka, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama, Toshiaki Watanabe
    International Journal of Clinical Oncology.2015; 20(4): 633.     CrossRef
  • Robotic Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer: a Meta-analysis of Eight Studies
    Binghong Xiong, Li Ma, Wei Huang, Qikang Zhao, Yong Cheng, Jingshan Liu
    Journal of Gastrointestinal Surgery.2015; 19(3): 516.     CrossRef
  • Simultaneous development of laparoscopy and robotics provides acceptable perioperative outcomes and shows robotics to have a faster learning curve and to be overall faster in rectal cancer surgery: analysis of novice MIS surgeon learning curves
    George Melich, Young Ki Hong, Jieun Kim, Hyuk Hur, Seung Hyuk Baik, Nam Kyu Kim, A. Sender Liberman, Byung Soh Min
    Surgical Endoscopy.2015; 29(3): 558.     CrossRef
  • Robotic rectal surgery
    Ahmet Rencuzogullari, Emre Gorgun
    Journal of Surgical Oncology.2015; 112(3): 326.     CrossRef
  • The Role of Robotic Surgery for Rectal Cancer: Overcoming Technical Challenges in Laparoscopic Surgery by Advanced Techniques
    Seungwan Park, Nam Kyu Kim
    Journal of Korean Medical Science.2015; 30(7): 837.     CrossRef
  • SAGES TAVAC safety and effectiveness analysis: da Vinci® Surgical System (Intuitive Surgical, Sunnyvale, CA)
    Shawn Tsuda, Dmitry Oleynikov, Jon Gould, Dan Azagury, Bryan Sandler, Matthew Hutter, Sharona Ross, Eric Haas, Fred Brody, Richard Satava
    Surgical Endoscopy.2015; 29(10): 2873.     CrossRef
  • Robotic and laparoscopic pelvic lymph node dissection for rectal cancer: short-term outcomes of 21 consecutive series
    Sung Uk Bae, Avanish P. Saklani, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
    Annals of Surgical Treatment and Research.2014; 86(2): 76.     CrossRef
  • Comparative effectiveness of laparoscopic versus robot-assisted colorectal resection
    Deborah S. Keller, Anthony J. Senagore, Justin K. Lawrence, Brad J. Champagne, Conor P. Delaney
    Surgical Endoscopy.2014; 28(1): 212.     CrossRef
  • Robotic versus laparoscopic total mesorectal excision for rectal cancer: a meta-analysis
    Binghong Xiong, Li Ma, CaiQuan Zhang, Yong Cheng
    Journal of Surgical Research.2014; 188(2): 404.     CrossRef
  • Robotic assisted minimally invasive pelvic exenteration in advanced rectal cancer: review and case report
    P. R. Nanayakkara, S. A. Ahmed, D. Oudit, S. T. O’Dwyer, C. R. Selvasekar
    Journal of Robotic Surgery.2014; 8(2): 173.     CrossRef
  • Robotic colorectal surgery: summary of the current evidence
    E. H. Aly
    International Journal of Colorectal Disease.2014; 29(1): 1.     CrossRef
  • Quality of total mesorectal excision and depth of circumferential resection margin in rectal cancer: a matched comparison of the first 20 robotic cases
    M. Barnajian, D. Pettet, E. Kazi, C. Foppa, R. Bergamaschi
    Colorectal Disease.2014; 16(8): 603.     CrossRef
  • Robotic surgery for rectal cancer: Current immediate clinical and oncological outcomes
    Sergio Eduardo Alonso Araujo
    World Journal of Gastroenterology.2014; 20(39): 14359.     CrossRef
  • Laparoscopic versus Robotic-assisted Rectal Surgery: A Comparison of Postoperative Outcomes
    Monica T. Young, Gopal Menon, Timothy F. Feldmann, Steven Mills, Joseph Carmichael, Michael J. Stamos, Alessio Pigazzi
    The American Surgeon™.2014; 80(10): 1059.     CrossRef
  • Laparoscopic Surgery for Rectal Cancer
    Suguru Hasegawa, Koya Hida, Kenji Kawada, Yoshiharu Sakai
    Nippon Daicho Komonbyo Gakkai Zasshi.2013; 66(10): 971.     CrossRef
  • The current status of robotic oncologic surgery
    Hua‐yin Yu, David F. Friedlander, Sunil Patel, Jim C. Hu
    CA: A Cancer Journal for Clinicians.2013; 63(1): 45.     CrossRef
  • Mechanical Bowel Preparation and Prophylactic Antibiotic Administration in Colorectal Surgery: A Survey of the Current Status in Korea
    Byung Mo Kang, Kil Yeon Lee, Sun Jin Park, Suk-Hwan Lee
    Annals of Coloproctology.2013; 29(4): 160.     CrossRef
  • Impact of Robotic Surgery on Sexual and Urinary Functions After Fully Robotic Nerve-Sparing Total Mesorectal Excision for Rectal Cancer
    Fabrizio Luca, Manuela Valvo, Tiago Leal Ghezzi, Massimiliano Zuccaro, Sabina Cenciarelli, Cristina Trovato, Angelica Sonzogni, Roberto Biffi
    Annals of Surgery.2013; 257(4): 672.     CrossRef
  • Unique Complications of Robotic Colorectal Surgery
    Sonia Ramamoorthy, Vincent Obias
    Surgical Clinics of North America.2013; 93(1): 273.     CrossRef
  • Robot-assisted low anterior resection in fifty-three consecutive patients: an Indian experience
    R. D. Kenawadekar, R. Z. Dhange, A. Pandit, M. S. Bandawar, S. Joshi, G. Agarwal, A. P. Jagtap, S. Puntambekar
    Journal of Robotic Surgery.2013; 7(4): 311.     CrossRef
  • Does Robotic Rectal Cancer Surgery Offer Improved Early Postoperative Outcomes?
    Rosaria Scarpinata, Emad H. Aly
    Diseases of the Colon & Rectum.2013; 56(2): 253.     CrossRef
  • Initial experience of robotic intersphincteric resection for rectal cancer
    Soo Yun Moon, Min-Su Park, Sun Jin Park, Kil Yeon Lee
    Korean Journal of Clinical Oncology.2013; 9(1): 42.     CrossRef
  • Current Status and Future Perspectives of Robotic Surgery for Colorectal Cancer
    Hidetoshi Katsuno, Koutarou Maeda, Tsunekaze Hanai, Harunobu Sato, Koji Masumori, Yoshikazu Koide, Hiroshi Matsuoka, Miho Shiota, Tomoyoshi Endo, Shinji Matsuoka, Kohei Hatta, Masahiro Mizuno, Kunihiro Tohyama
    Nippon Daicho Komonbyo Gakkai Zasshi.2013; 66(10): 982.     CrossRef
  • Artificial interfaces (“AI”) in surgery: Historic development, current status and program implementation in the public health sector
    Donagh A. Healy, Shane P. Murphy, John P. Burke, John C. Coffey
    Surgical Oncology.2013; 22(2): 77.     CrossRef
  • Robotic Use in Colorectal Disease: A Critical Analysis
    Marco Ettore Allaix, Alessandro Fichera
    Seminars in Colon and Rectal Surgery.2013; 24(1): 14.     CrossRef
  • Oncologic Outcomes of a Laparoscopic Right Hemicolectomy for Colon Cancer: Results of a 3-Year Follow-up
    Jung Hoon Cho, Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
    Journal of the Korean Society of Coloproctology.2012; 28(1): 42.     CrossRef
  • Current status of robotic rectal cancer surgery
    Jeonghyun Kang, Kang Young Lee
    Colorectal Cancer.2012; 1(6): 525.     CrossRef
  • Robotic resection compared with laparoscopic rectal resection for cancer: systematic review and meta‐analysis of short‐term outcome
    S. Trastulli, E. Farinella, R. Cirocchi, D. Cavaliere, N. Avenia, F. Sciannameo, N. Gullà, G. Noya, C. Boselli
    Colorectal Disease.2012;[Epub]     CrossRef
  • Robotic versus Laparoscopic Proctectomy for Rectal Cancer: A Meta-analysis
    Sameer Memon, Alexander G. Heriot, Declan G. Murphy, Mathias Bressel, A. Craig Lynch
    Annals of Surgical Oncology.2012; 19(7): 2095.     CrossRef
  • Robotic Colorectal Surgery: A Systematic Review
    Sami AlAsari, Byung Soh Min
    ISRN Surgery.2012; 2012: 1.     CrossRef
  • Risk Factor Analysis of Postoperative Complications After Robotic Rectal Cancer Surgery
    Jeonghyun Kang, Byung Soh Min, Yoon Ah Park, Hyuk Hur, Seung Hyuk Baik, Nam Kyu Kim, Seung Kook Sohn, Kang Young Lee
    World Journal of Surgery.2011; 35(11): 2555.     CrossRef
Original Articles
Incidence and Risk Factors of Parastomal Hernia
Yeun Ju Sohn, Sun Mi Moon, Ui Sup Shin, Sun Hee Jee
J Korean Soc Coloproctol. 2012;28(5):241-246.   Published online October 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.5.241
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AbstractAbstract PDF
Purpose

Among the various stoma complications, the parastomal hernia (PSH) is the most common. Prevention of PSH is very important to improve the quality of life and to prevent further serious complications. The aim of this study was to analyze the incidence and the risk factors of PSH.

Methods

From January 2002 and October 2008, we retrospectively reviewed 165 patients who underwent an end colostomy. As a routine oncologic follow-up, abdomino-pelvic computed tomography was used to examine the occurrence of the PSH. The associations of age, sex, body mass index (BMI), history of steroid use and comorbidities to the development of the PSH were analyzed. The median duration of the follow-up was 36 months (0 to 99 months).

Results

During follow-up, 50 patients developed a PSH and the 5-year cumulative incidence rate of a PSH, obtained by using the Kaplan-Meier method, was 37.8%. In the multivariate COX analysis, female gender (hazard ratio [HR], 3.29; 95% confidence interval [CI], 1.77 to 6.11; P < 0.0001), age over 60 years (HR, 2.37; 95% CI, 1.26 to 4.46; P = 0.01), BMI more than 25 kg/m2 (HR, 1.8; 95% CI, 1.02 to 3.16; P = 0.04), and hypertension (HR, 2.08; 95% CI, 1.14 to 3.81; P = 0.02) were all independent risk factors for the development of a PSH.

Conclusion

The 5-year incidence rate of a PSH was 37.8%. The significant risk factors of a PSH were as follows: female gender, age over 60 years, BMI more than 25 kg/m2, and hypertension. Using a prophylactic mesh during colostomy formation might be advisable when the patients have these factors.

Citations

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  • Long-term outcomes after open parastomal hernia repair at a high-volume center
    Alexis M. Holland, William R. Lorenz, Brittany S. Mead, Gregory T. Scarola, Vedra A. Augenstein, B. Todd Heniford, Monica E. Polcz
    Surgical Endoscopy.2025; 39(1): 639.     CrossRef
  • Outcomes after surgical repair of primary parastomal hernia
    Nulvin Djebbara-Bozo, Nellie B. Zinther, Anette Søgaard, Hans Friis-Andersen
    Hernia.2025;[Epub]     CrossRef
  • Rectus abdominis muscle atrophy, prophylactic mesh, and stoma placement: retrospective findings from a prospective multicenter trial
    Staffan Täckström, Eva Angenete, Rode Grönkvist, Eva Haglind, Peter Kälebo, Adiela Correa Marinez, Jacob Rosenberg, Maziar Nikberg
    Hernia.2025;[Epub]     CrossRef
  • Sandwich parastomal hernia repair, a prospective observational study
    T. B. Johnsen, T. Stornes, B. Ystgaard, T. E. Bernstein
    Hernia.2025;[Epub]     CrossRef
  • Development and validation of a nomogram prediction model for the risk of parastomal hernia
    Huasheng Liu, Weiqin Wang, Chen Qin, Hongxia Wang, Wei Qi, Yanhua Wei, Longbo Zheng, Jilin Hu
    Intelligent Medicine.2024; 4(2): 128.     CrossRef
  • Modified Approach for Extraperitoneal Colostomy Creation in Laparoscopic Abdominoperineal Resection
    Xiang Zhang, Xin Li, Zhiqiang Cheng, Kexin Wang, Yong Dai, Yanlei Wang
    Diseases of the Colon & Rectum.2024; 67(2): 333.     CrossRef
  • The clinical applications of D-type parastomal hernia repair surgery
    Y. Y. Fu, Y. Ma, C. K. Zhang, L. H. Sun, D. Tang, W. Wang, D. R. Wang
    Hernia.2024; 28(2): 427.     CrossRef
  • Comparison of the 3-D mesh and Sugarbaker repair for parastomal hernia: a single center experience in China
    Hekai Shi, Shaochun Li, Yiming Lin, Dongchao Yang, Wenpei Dong, Zhicheng Song, Heng Song, Yan Gu
    Updates in Surgery.2024; 76(5): 1991.     CrossRef
  • Evaluating EHS parastomal hernia classification for surgical planning: a retrospective analysis of 160 consecutive cases in a single center
    Marek Szczepkowski, Mateusz Zamkowski, Suwała Alicja, Witkowski Piotr, Maciej Śmietański
    Hernia.2024; 28(5): 1915.     CrossRef
  • Lap-re-Do Keyhole versus Lap-re-Do Sugarbaker techniques in large parastomal hernia repair: a retrospective cohort study
    Xiaojian Fu, Minglei Li, Rong Hua, Qiyuan Yao
    Hernia.2024; 28(5): 1945.     CrossRef
  • Risk factors for parastomal hernia after abdominoperineal resection of rectal cancer
    Lele Zhu, Shun Li, Feitong Wang
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study
    Dieter Hahnloser
    Colorectal Disease.2024; 26(10): 1794.     CrossRef
  • A giant parastomal hernia in a high risk patient: preparation to make surgery worthwhile
    Seda Gunes, Ali Bohlok, Antoine El Asmar, Thibaut Engels, Marie Magdelaine Lefort, Eleonora Farinella, Issam El Nakadi
    Acta Chirurgica Belgica.2023; 123(3): 309.     CrossRef
  • Sugarbaker Versus Keyhole Repair for Parastomal Hernia: a Systematic Review and Meta-analysis of Comparative Studies
    Andrew M. Fleming, Alisa L. Phillips, Justin A. Drake, Megan G. Gross, Danny Yakoub, Justin Monroe, Nathan M. Hinkle, David Shibata, Elizabeth H. Wood
    Journal of Gastrointestinal Surgery.2023; 27(3): 573.     CrossRef
  • Contemporary Outcomes of Elective Parastomal Hernia Repair in Older Adults
    Ryan Howard, Farizah Rob, Jyothi Thumma, Anne Ehlers, Sean O’Neill, Justin B. Dimick, Dana A. Telem
    JAMA Surgery.2023; 158(4): 394.     CrossRef
  • The Risk Factors for Parastomal Hernia Development: A 8-year Retrospective Study in Colorectal Surgery
    Tayfun BİŞGİN, Cahide AYİK, Deniz CENAN, Berke MANOĞLU, Dilek ÖZDEN, Selman SÖKMEN
    Journal of Basic and Clinical Health Sciences.2023; 7(2): 773.     CrossRef
  • 67/w mit Vorwölbung um das Stoma
    F. Köhler, Michael Meir
    Die Chirurgie.2023; 94(S1): 35.     CrossRef
  • Effect of Obesity Classification on Complications after Sigmoidostomy for Low-Grade Rectal Cancer: A Retrospective Cohort Study
    慧 王
    Advances in Clinical Medicine.2023; 13(07): 11825.     CrossRef
  • Risk Factors for the Development of Parastomal Hernia: A Narrative Review
    Teodora Elena Manole, Ion Daniel, Bolocan Alexandra, Păduraru N. Dan, Octavian Andronic
    Saudi Journal of Medicine & Medical Sciences.2023; 11(3): 187.     CrossRef
  • Prophylactic retromuscular mesh placement for parastomal hernia prevention: a retrospective cohort study of permanent colostomies and ileostomies
    Jonathan Frigault, Simon Lemieux, Dominic Breton, Philippe Bouchard, Alexandre Bouchard, Roger C. Grégoire, François Letarte, Gilles Bouchard, Vincent Boun, Katia Massé, Sébastien Drolet
    Hernia.2022; 26(2): 495.     CrossRef
  • Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the “fighting over the fascia” theory concerning the incision and stoma hole
    Noriaki Ohara, Kay Uehara, Atsushi Ogura, Masanori Sando, Toshisada Aiba, Yuki Murata, Takashi Mizuno, Kokuryo Toshio, Yukihiro Yokoyama, Satoko Ishigaki, Yuanying Li, Hiroshi Yatsuya, Tomoki Ebata
    Surgery Today.2022; 52(6): 953.     CrossRef
  • Risk factors for the development of a parastomal hernia in patients with enterostomy: a systematic review and meta-analysis
    Niu Niu, Shizheng Du, Dongliang Yang, Liuliu Zhang, Bainv Wu, Xiaoxu Zhi, Jun Li, Dejing Xu, Yinan Zhang, Aifeng Meng
    International Journal of Colorectal Disease.2022; 37(3): 507.     CrossRef
  • An Analysis of the Risk Factors for the Development of Parastomal Hernia: A Single Institutional Experience
    Faiza H Soomro, Sufyan Azam, Sritharan Ganeshmoorthy, Peter Waterland
    Cureus.2022;[Epub]     CrossRef
  • Is absorbable mesh useful in preventing parastomal hernia after emergency surgery? The PARTHENOPE study
    F. Pizza, D. D’Antonio, F. S. Lucido, P. Del Rio, C. Dell’Isola, L. Brusciano, S. Tolone, L. Docimo, C. Gambardella
    Hernia.2022; 26(2): 507.     CrossRef
  • Comparison of the extraperitoneal and transperitoneal routes for permanent colostomy: a meta-analysis with RCTs and systematic review
    Jinlong Luo, Dujanand Singh, Faqiang Zhang, Xinting Yang, Xiaoying Zha, Huaiwu Jiang, Lie Yang, Hua Yang
    World Journal of Surgical Oncology.2022;[Epub]     CrossRef
  • Bariatric Surgery in Patients with Existing Ostomy: A Preliminary Feasibility Study
    Ray Portela, Ahmet Vahibe, Joseph N. Badaoui, Omer U.I. Hassan, Travis J. Mckenzie, Todd A. Kellogg, Omar M. Ghanem
    Bariatric Surgical Practice and Patient Care.2022; 17(2): 127.     CrossRef
  • Use of prophylactic stoma mesh is a risk factor for developing rectus abdominis muscle atrophy
    S. Täckström, A. Chabok, K. Smedh, M. Nikberg
    Hernia.2022; 26(2): 517.     CrossRef
  • Incidence and risk factors for parastomal hernia with a permanent colostomy
    Lei Liu, Longbo Zheng, Maoshen Zhang, Jilin Hu, Yun Lu, Dongsheng Wang
    Journal of Surgical Oncology.2022; 126(3): 535.     CrossRef
  • Obesity Stratification Predicts Short-Term Complications After Parastomal Hernia Repair
    Mustafa Tamim Alam Khan, Ronit Patnaik, Lee Hausman-Cohen, Olivia Panchal, Mackenzie Ewart, Rehana Sultana Lovely, Aashish Rajesh
    Journal of Surgical Research.2022; 280: 27.     CrossRef
  • Stoma-Related Complications: A Single-Center Experience and Literature Review
    Zalán Benedek, Loránd Kocsis, Orsolya Bauer, Nicolae Suciu, Sorin Sorlea, Călin Crăciun, Rareș Georgescu, Marius Florin Coroș
    Journal of Interdisciplinary Medicine.2022; 7(2): 31.     CrossRef
  • Permanent end-colostomy parastomal hernia prevention using a novel three-dimensional mesh
    Camillo Leonardo Bertoglio, Marianna Maspero, Lorenzo Morini, Andrea Zironda, Bruno Domenico Alampi, Michele Mazzola, Carmelo Magistro, Pietro Carnevali, Giovanni Ferrari
    Hernia.2021; 25(3): 655.     CrossRef
  • Risk Factors for Parastomal Hernia Associated with Covering Stoma in Rectal Surgery
    Kazuhiro Ishimaru, Yasutaka Shuno, Hiroaki Nozawa, Kazushige Kawai, Koji Murono, Soichiro Ishihara
    Indian Journal of Surgery.2021; 83(S3): 749.     CrossRef
  • The role of radiological classification of parastomal hernia as a predictor of the need for surgical hernia repair: a retrospective cohort study
    Jonathan Frigault, Simon Lemieux, Dominic Breton, Gilles Bouchard, Sébastien Drolet
    Langenbeck's Archives of Surgery.2021; 406(5): 1643.     CrossRef
  • Short-term outcomes of laparoscopic Sugarbaker repair of parastomal hernia
    Hữu Thịnh Nguyễn, Ngọc Trường Vinh Nguyễn
    Vietnam Journal of Endolaparoscopic Surgery.2021;[Epub]     CrossRef
  • Use of prophylactic mesh during initial stoma creation to prevent parastomal herniation: a systematic review and meta‐analysis of randomised controlled trials
    Syed Mohiuddin, William Hollingworth, Niroshini Rajaretnam, Barnaby C. Reeves, Neil J. Smart
    Colorectal Disease.2021; 23(11): 2821.     CrossRef
  • A semi‐Markov model comparing the lifetime cost‐effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer
    Syed Mohiuddin, Barnaby C. Reeves, Neil J. Smart, William Hollingworth
    Colorectal Disease.2021; 23(11): 2967.     CrossRef
  • Abdominal Oblique Internal and External Muscles Gap Colostomy for Lower Incidence of Parastomal Hernia and Higher Quality of Life: A Retrospective Cohort Study
    Yongjian Huang, Hengkai Chen, Qiajun Zheng, Xiaohan Lin, Guangwei Zhu, Jinzhou Wang, Changli Huang, Jianxin Ye
    World Journal of Surgery.2021; 45(12): 3623.     CrossRef
  • Patient-Related Factors Associated With Stoma and Peristomal Complications Following Fecal Ostomy Surgery
    Piotr Zelga, Piotr Kluska, Marta Zelga, Joanna Piasecka-Zelga, Adam Dziki
    Journal of Wound, Ostomy & Continence Nursing.2021; 48(5): 415.     CrossRef
  • Comparison of different modalities for the diagnosis of parastomal hernia: a systematic review
    Gijs H. J. de Smet, Daniël P. V. Lambrichts, Sjoerd van den Hoek, Leonard F. Kroese, Stefan Buettner, Anand G. Menon, Gert-Jan Kleinrensink, Johan F. Lange
    International Journal of Colorectal Disease.2020; 35(2): 199.     CrossRef
  • Stoma-Related Complications Following Ostomy Surgery in 3 Acute Care Hospitals
    Robert Pearson, Stephen R. Knight, James C. K. Ng, Isabell Robertson, Clare McKenzie, Angus M. Macdonald
    Journal of Wound, Ostomy & Continence Nursing.2020; 47(1): 32.     CrossRef
  • Stomach in a parastomal hernia: a rare complication of stomas
    Onyekachi Ezekiel Ekowo, Ammar Al Midani, Yasser Abdulaal, Mohamed Boshnaq
    BMJ Case Reports.2020; 13(8): e234325.     CrossRef
  • Parastomal Hernia Following Abdominoperineal Resection
    Alimohammad Bananzadeh, Ibrahim Jaweek, Mohammad Rezazadehkermani, Leila Ghahramani, Faranak Bahrami, Seyed Vahid Hosseini, Ahmad Izadpanah, Seyed Mohammad Kazem Tadayon
    Journal of Coloproctology.2020; 40(04): 311.     CrossRef
  • Radiological progression of end colostomy trephine diameter and area
    K. K. Ho, T. Economou, N. J. Smart, I. R. Daniels
    BJS Open.2019; 3(1): 112.     CrossRef
  • Colostomy on CT and fluoroscopy: What the radiologist needs to know
    Shari Friedman, Zina J. Ricci, Marjorie W. Stein, Ellen L. Wolf, Tulay Ekinci, Fernanda S. Mazzariol, Mariya Kobi
    Clinical Imaging.2019; 56: 17.     CrossRef
  • Parastomal hernias causing symptoms or requiring surgical repair after colorectal cancer surgery—a national population-based cohort study
    Mathilda Tivenius, Pia Näsvall, Gabriel Sandblom
    International Journal of Colorectal Disease.2019; 34(7): 1267.     CrossRef
  • Prevention of parastomal hernia after abdominoperineal excision with a prophylactic three‐dimensional funnel mesh
    J. López‐Borao, Z. Madrazo‐González, E. Kreisler, S. Biondo
    Colorectal Disease.2019; 21(11): 1326.     CrossRef
  • Parastomal Hernia Repair Outcomes: A Nine-Year Experience
    You Wei Lin, Patrick Keller, Daniel L. Davenport, Margaret A. Plymale, Crystal F. Totten, John Scott Roth
    The American Surgeon™.2019; 85(7): 738.     CrossRef
  • European Hernia Society guidelines on prevention and treatment of parastomal hernias
    S. A. Antoniou, F. Agresta, J. M. Garcia Alamino, D. Berger, F. Berrevoet, H.-T. Brandsma, K. Bury, J. Conze, D. Cuccurullo, U. A. Dietz, R. H. Fortelny, C. Frei-Lanter, B. Hansson, F. Helgstrand, A. Hotouras, A. Jänes, L. F. Kroese, J. R. Lambrecht, I. K
    Hernia.2018; 22(1): 183.     CrossRef
  • Incidence and risk factors for parastomal bulging in patients with ileostomy or colostomy: a register‐based study using data from the Danish Stoma Database Capital Region
    R. M. Andersen, T. W. Klausen, A. K. Danielsen, A. Vinther, I. Gögenur, T. Thomsen
    Colorectal Disease.2018; 20(4): 331.     CrossRef
  • Relationship between stoma creation route for end colostomy and parastomal hernia development after laparoscopic surgery
    Hitoshi Hino, Tomohiro Yamaguchi, Yusuke Kinugasa, Akio Shiomi, Hiroyasu Kagawa, Yushi Yamakawa, Masakatsu Numata, Akinobu Furutani, Takuya Suzuki, Kakeru Torii
    Surgical Endoscopy.2017; 31(4): 1966.     CrossRef
  • Prophylactic mesh to prevent parastomal hernia after end colostomy: a meta-analysis and trial sequential analysis
    M. López-Cano, H.-T. Brandsma, K. Bury, B. Hansson, I. Kyle-Leinhase, J. G. Alamino, F. Muysoms
    Hernia.2017; 21(2): 177.     CrossRef
  • Laparoscopic prosthetic parastomal and perineal hernia repair after abdominoperineal resection
    G. Dapri, L. Gerard, L. Cardinali, D. Repullo, I. Surdeanu, S. H. Sondji, G.-B. Cadière, S. Saussez
    Techniques in Coloproctology.2017; 21(1): 73.     CrossRef
  • Predictors of quality-of-life after ileal pouch-anal anastomosis in patients with ulcerative colitis
    Sherif Abolfotouh, Tero Rautio, Kai Klintrup, Ilona Helavirta, Jyrki Mäkelä
    Scandinavian Journal of Gastroenterology.2017; 52(10): 1078.     CrossRef
  • An Evaluation of Parastomal Hernia Repair Using the Americas Hernia Society Quality Collaborative
    Sarah S. Fox, Randy Janczyk, Jeremy A. Warren, Alfredo M. Carbonell, Benjamin K. Poulose, Michael J. Rosen, William W. Hope
    The American Surgeon™.2017; 83(8): 881.     CrossRef
  • Parastomal hernias after radical cystectomy and ileal conduit diversion
    Timothy F. Donahue, Bernard H. Bochner
    Investigative and Clinical Urology.2016; 57(4): 240.     CrossRef
  • Parastomal Hernia Containing Stomach
    Sebastian Barber-Millet, Salvador Pous, Vicente Navarro, Jose Iserte, Eduardo García-Granero
    International Surgery.2014; 99(4): 404.     CrossRef
  • Paracolostomy Hernia Repair: Who and When?
    Zachary A. Gregg, Haisar E. Dao, Steven Schechter, Nishit Shah
    Journal of the American College of Surgeons.2014; 218(6): 1105.     CrossRef
  • Risk factors for parastomal hernia in Japanese patients with permanent colostomy
    Kimihiko Funahashi, Takayuki Suzuki, Yasuo Nagashima, Satoshi Matsuda, Junichi Koike, Hiroyuki Shiokawa, Mitsunori Ushigome, Kenichiro Arai, Tomoaki Kaneko, Akiharu Kurihara, Hironori Kaneko
    Surgery Today.2014; 44(8): 1465.     CrossRef
Risk Factors for Anastomotic Leakage after Laparoscopic Rectal Resection
Dong Hyun Choi, Jae Kwan Hwang, Yong Tak Ko, Han Jeong Jang, Hyeon Keun Shin, Young Chan Lee, Cheong Ho Lim, Seung Kyu Jeong, Hyung Kyu Yang
J Korean Soc Coloproctol. 2010;26(4):265-273.   Published online August 31, 2010
DOI: https://doi.org/10.3393/jksc.2010.26.4.265
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AbstractAbstract PDF
Purpose

The anastomotic leakage rate after rectal resection has been reported to be approximately 2.5-21 percent, but most results were associated with open surgery. The aim of this study was to identify risk factors and their relationship to the experience of the surgeon for anastomotic leakage after laparoscopic rectal resection.

Methods

Between March 2003 and December 2008, 156 patients underwent a laparoscopic rectal resection without a diverting ileostomy. The patients' characteristics, the details of treatment, the intraoperative results, and the postoperative results were recorded prospectively. Univariate and multivariate analyses were applied to identify risk factors for anastomotic leakage.

Results

The majority of operations were performed for malignant disease (n = 150; 96.2%), and 96 patients (61.5%) were males. Conversion to open surgery occurred in 1 case (0.6%). The anastomotic leak rate was 10.3% (16/156), and there were no mortalities. In the univariate analysis, tumor location, anastomotic level, intraoperative events, and operation time were associated with increased anastomotic leakage rate. In the multivariate analysis, anastomotic level (odds ratio [OR], 6.855; 95% confidence interval [CI], 1.271 to 36.964) and operation time (OR, 8.115; 95% CI, 1.982 to 33.222) were significantly associated with anastomotic leakage.

Conclusion

The important risk factors for anastomotic leakage after laparoscopic rectal resection without a diverting ileostomy were low anastomosis and long operation time. An additional procedure, such as diverting stoma, may reduce the anastomotic leakage if it is selectively applied in cases with these risk factors.

Citations

Citations to this article as recorded by  
  • Risk Factors for Anastomotic Leakage: A Comprehensive Single-Center Analysis of Colorectal Anastomoses for Ovarian and Gastrointestinal Cancers
    Francesco Santullo, Virginia Vargiu, Andrea Rosati, Barbara Costantini, Valerio Gallotta, Claudio Lodoli, Carlo Abatini, Miriam Attalla El Halabieh, Valentina Ghirardi, Federica Ferracci, Lorena Quagliozzi, Angelica Naldini, Fabio Pacelli, Giovanni Scambi
    Annals of Surgical Oncology.2025; 32(4): 2620.     CrossRef
  • Risk factors for anastomotic leakage in rectal cancer surgery reflecting current practices
    Tatsunosuke Harada, Masakatsu Numata, Yosuke Atsumi, Toshiyuki Fukuda, Shota Izukawa, Yusuke Suwa, Jun Watanabe, Tsutomu Sato, Aya Saito
    Surgery Today.2025;[Epub]     CrossRef
  • Anastomotic Leak Following Colorectal Surgery
    Olivia Ziegler, Audrey S. Kulaylat
    Clinics in Colon and Rectal Surgery.2025;[Epub]     CrossRef
  • Laparoscopic versus open ileostomy closure: a systematic review and meta-analysis of postoperative outcomes
    Xiao-Qiang Zhang, Run-xi Tang, Dong-Hao Pan, Chao-Fu Zhang, Ming-Yang Xia, Lei-Yuan Shuai, Hua Tang, Guang-Yan Ji
    International Journal of Colorectal Disease.2025;[Epub]     CrossRef
  • Colonic Anastomotic Leakage: Current State of the Problem and Prospects for Early Diagnosis
    M. A. Chernykh, A. M. Belousov, K. G. Shostka
    Innovative Medicine of Kuban.2024; (3): 131.     CrossRef
  • Vorhersagbarkeit von Anastomoseninsuffizienzen in der Viszeralchirurgie
    Jin-On Jung, Georg Dieplinger, Christiane Bruns
    Die Chirurgie.2024; 95(11): 901.     CrossRef
  • Anastomotic Leak Rate and Prolonged Postoperative Paralytic Ileus in Patients Undergoing Laparoscopic Surgery for Colo-Rectal Cancer After Placement of No-Coil Endoanal Tube
    Michele Ammendola, Giorgio Ammerata, Francesco Filice, Rosalinda Filippo, Michele Ruggiero, Roberto Romano, Riccardo Memeo, Patrick Pessaux, Giuseppe Navarra, Severino Montemurro, Giuseppe Currò
    Surgical Innovation.2023; 30(1): 20.     CrossRef
  • Potential short-term outcome advantage of low vs. high ligation of inferior mesenteric artery for sigmoid and rectal cancer: propensity score matching analysis
    Chia-Chen Hsu, Yu-Jen Hsu, Yih-Jong Chern, Bor-Kang Jong, Chun-Kai Liao, Pao-Shiu Hsieh, Wen-Sy Tsai, Jeng-Fu You
    BMC Surgery.2023;[Epub]     CrossRef
  • Predictive Factors for Anastomotic Leakage Following Colorectal Cancer Surgery: Where Are We and Where Are We Going?
    Christos Tsalikidis, Athanasia Mitsala, Vasileios I. Mentonis, Konstantinos Romanidis, George Pappas-Gogos, Alexandra K. Tsaroucha, Michail Pitiakoudis
    Current Oncology.2023; 30(3): 3111.     CrossRef
  • Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery
    Valeria Tonini, Manuel Zanni
    World Journal of Gastrointestinal Surgery.2023; 15(5): 745.     CrossRef
  • Efficacy and Safety of Transanal Drainage Tube for Prevention of Anastomotic Leakage after Surgery for Rectal Cancer
    Tatsunosuke Harada, Yasuhiro Ishiyama, Yume Minagawa, Shingo Ito, Masataka Oneyama, Kazuhiro Narita
    Nihon Daicho Komonbyo Gakkai Zasshi.2023; 76(6): 420.     CrossRef
  • Preservation of the left colic artery in modified laparoscopic anterior rectal resections without auxiliary abdominal incisions for transanal specimen retrieval
    Yulin Liu, Peng Yu, Han Li, Lijian Xia, Xiangmin Li, Meijuan Zhang, Zhonghui Cui, Jingbo Chen
    BMC Surgery.2022;[Epub]     CrossRef
  • The Role of Indocyanine Near-Infrared Fluorescence in Colorectal Surgery
    Francesco Maione, Michele Manigrasso, Alessia Chini, Sara Vertaldi, Pietro Anoldo, Anna D’Amore, Alessandra Marello, Carmen Sorrentino, Grazia Cantore, Rosa Maione, Nicola Gennarelli, Salvatore D’Angelo, Nicola D’Alesio, Giuseppe De Simone, Giuseppe Servi
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Risk factors for colorectal anastomotic leakage and preventive measures: a retrospective cohort study
    M. S. Lebedko, S. S. Gordeev, E. V. Alieva, M. D. Sivolob, Z. Z. Mamedli, S. G. Gaydarov, V. Yu. Kosyrev
    Pelvic Surgery and Oncology.2022; 12(2): 17.     CrossRef
  • Intracorporeal reinforcement with barbed suture is associated with low anastomotic leakage rates after laparoscopic low anterior resection for rectal cancer: a retrospective study
    Haiping Lin, Minhao Yu, Guangyao Ye, Shaolan Qin, Hongsheng Fang, Ran Jing, Tingyue Gong, Yang Luo, Ming Zhong
    BMC Surgery.2022;[Epub]     CrossRef
  • Factors Contributing to Anastomotic Leakage Following Colorectal Surgery: Why, When, and Who Leaks?
    Shravani Sripathi, Mashal I Khan, Naomi Patel, Roja T Meda, Surya P Nuguru, Sriker Rachakonda
    Cureus.2022;[Epub]     CrossRef
  • Anastomotic Leak in Ovarian Cancer Cytoreduction Surgery: A Systematic Review and Meta-Analysis
    Massimiliano Fornasiero, Georgios Geropoulos, Konstantinos S. Kechagias, Kyriakos Psarras, Konstantinos Katsikas Triantafyllidis, Panagiotis Giannos, Georgios Koimtzis, Nikoletta A. Petrou, James Lucocq, Christos Kontovounisios, Dimitrios Giannis
    Cancers.2022; 14(21): 5464.     CrossRef
  • Association between circular stapler size and anastomotic leakage after laparoscopic low anterior resection for rectal cancer
    Yugang Jiang, Hongyuan Chen, Meng Kong, Dong Sun, Hongguang Sheng
    Journal of Cancer Research and Therapeutics.2022; 18(7): 1931.     CrossRef
  • Preliminary surgical outcomes of laparoscopic right hemicolectomy with transrectal specimen extraction: a propensity score matching study of 120 cases (with video)
    Mingguang Zhang, Zheng Liu, Peng Sun, Xiyue Hu, Haitao Zhou, Zheng Jiang, Jianqiang Tang, Qian Liu, Xishan Wang
    Gastroenterology Report.2022;[Epub]     CrossRef
  • Anastomotic Leak in Colorectal Surgery: Predictive Factors and Survival
    Swetha Prabhakaran, Sowmya Prabhakaran, Wei Mou Lim, Glen Guerra, Alexander G. Heriot, Joseph C. Kong
    Polish Journal of Surgery.2022; 95(5): 56.     CrossRef
  • Anastomotic Leakage After Laparoscopic Colectomy: Who Will Require Emergency Fecal Diversion?
    Alban Zarzavadjian Le Bian, Nicolas Tabchouri, Christine Denet, Théophile Guilbaud, Anaïs Laforest, Christophe Tresallet, Jean-Marc Ferraz, Brice Gayet, David Fuks
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(9): 1040.     CrossRef
  • Postoperative morbidity and mortality after anterior resection with preventive diverting loop ileostomy versus loop colostomy for rectal cancer: A updated systematic review and meta-analysis
    Rui Du, Jiajie Zhou, Guifan Tong, Yue Chang, Dongliang Li, Feng Wang, Xu Ding, Qi Zhang, Wei Wang, Liuhua Wang, Daorong Wang
    European Journal of Surgical Oncology.2021; 47(7): 1514.     CrossRef
  • Risk factors of symptomatic anastomotic leakage and its impacts on a long-term survival after laparoscopic low anterior resection for rectal cancer: a retrospective single-center study
    Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
    World Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • A Novel Nomogram for Prediction of Early Postoperative Complications of Total Gastrectomy for Gastric Cancer
    Jiawen Zhang, Linhua Jiang, Xinguo Zhu
    Cancer Management and Research.2021; Volume 13: 7579.     CrossRef
  • A Retrospective Study of Risk Factors for Symptomatic Anastomotic Leakage after Laparoscopic Anterior Resection of the Rectal Cancer without a Diverting Stoma
    Zhi-Jie Wang, Qian Liu
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Impact of the number of stapler firings on anastomotic leakage in laparoscopic rectal surgery: a systematic review and meta-analysis
    Z. Balciscueta, N. Uribe, L. Caubet, M. López, I. Torrijo, J. Tabet, M. C. Martín
    Techniques in Coloproctology.2020; 24(9): 919.     CrossRef
  • Computed tomography based cross-sectional anatomy of the pelvis predicts surgical outcome after rectal cancer surgery
    Gyoung Tae Noh, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee
    Annals of Surgical Treatment and Research.2020; 99(2): 90.     CrossRef
  • Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
    Marius Kryzauskas, Augustinas Bausys, Austeja Elzbieta Degutyte, Vilius Abeciunas, Eligijus Poskus, Rimantas Bausys, Audrius Dulskas, Kestutis Strupas, Tomas Poskus
    World Journal of Surgical Oncology.2020;[Epub]     CrossRef
  • Analysis of risk factors for anastomotic leakage after lower rectal Cancer resection, including drain type: a retrospective single-center study
    Tetsushi Kinugasa, Sachiko Nagasu, Kenta Murotani, Tomoaki Mizobe, Takafumi Ochi, Taro Isobe, Fumihiko Fujita, Yoshito Akagi
    BMC Gastroenterology.2020;[Epub]     CrossRef
  • Prediction model for anastomotic leakage after laparoscopic rectal cancer resection
    Enesh Shiwakoti, Jianning Song, Jun Li, Shanshan Wu, Zhongtao Zhang
    Journal of International Medical Research.2020;[Epub]     CrossRef
  • Drainage smell and peritonitis are efficient indicators of anastomotic leakage after laparoscopic rectal cancer resection
    Enesh Shiwakoti, Jianning Song, Jun Li, Shanshan Wu, Zhongtao Zhang
    Journal of International Medical Research.2020;[Epub]     CrossRef
  • Laparoscopic loop ileostomy reversal with intracorporeal anastomosis is associated with shorter length of stay without increased direct cost
    Sarath Sujatha-Bhaskar, Matthew Whealon, Colette S. Inaba, Christina Y. Koh, Mehraneh D. Jafari, Steven Mills, Alessio Pigazzi, Michael J. Stamos, Joseph C. Carmichael
    Surgical Endoscopy.2019; 33(2): 644.     CrossRef
  • Risk and early predictive factors of anastomotic leakage in laparoscopic low anterior resection for rectal cancer
    Masahiro Fukada, Nobuhisa Matsuhashi, Takao Takahashi, Hisashi Imai, Yoshihiro Tanaka, Kazuya Yamaguchi, Kazuhiro Yoshida
    World Journal of Surgical Oncology.2019;[Epub]     CrossRef
  • Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision
    Chi Zhou, Xian-rui Wu, Xuan-hui Liu, Yu-feng Chen, Jia Ke, Xiao-wen He, Xiao-sheng He, Tuo Hu, Yi-feng Zou, Xiao-bin Zheng, Hua-shan Liu, Jian-cong Hu, Xiao-jian Wu, Jian-ping Wang, Ping Lan
    Gastroenterology Report.2018; 6(2): 137.     CrossRef
  • Predictive factors for anastomotic leakage after laparoscopic colorectal surgery
    Antonio Sciuto, Giovanni Merola, Giovanni D De Palma, Maurizio Sodo, Felice Pirozzi, Umberto M Bracale, Umberto Bracale
    World Journal of Gastroenterology.2018; 24(21): 2247.     CrossRef
  • Predictive Factors for Small Intestinal and Colonic Anastomotic Leak: a Multivariate Analysis
    Ahmad Sakr, Sameh Hany Emile, Emad Abdallah, Waleed Thabet, Wael Khafagy
    Indian Journal of Surgery.2017; 79(6): 555.     CrossRef
  • Smoking and tumor obstruction are risk factors for anastomotic leakage after laparoscopic anterior resection during rectal cancer treatment
    Hiroyuki Matsuzaki, Soichiro Ishihara, Kazushige Kawai, Koji Murono, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Toshiaki Watanabe
    Journal of the Anus, Rectum and Colon.2017; 1(1): 7.     CrossRef
  • De Prefectos a Mandatarios de la Nación. La violencia en la política peruana (1829-1836)
    Víctor Peralta Ruiz
    Revista de Indias.2016; 76(266): 173.     CrossRef
  • New technique of compression anastomosis in colorectal surgery – first results in 25 patients in Macedonia
    Svetozar Antovic, Aleksandar Mitevski, Aleksandar Karagozov, Biljana Kuzmanovska, Nikola Jankulovski
    PRILOZI.2016;[Epub]     CrossRef
  • Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis
    Kenji Kawada, Yoshiharu Sakai
    World Journal of Gastroenterology.2016; 22(25): 5718.     CrossRef
  • Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis
    Hui Qu, Yao Liu, Dong-song Bi
    Surgical Endoscopy.2015; 29(12): 3608.     CrossRef
  • Safe anastomosis in laparoscopic and robotic low anterior resection for rectal cancer: A narrative review and outcomes study from an expert tertiary center
    S. AL Asari, M.S. Cho, N.K. Kim
    European Journal of Surgical Oncology (EJSO).2015; 41(2): 175.     CrossRef
  • Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: a systematic review and meta‐analysis
    H.‐C. Pommergaard, B. Gessler, J. Burcharth, E. Angenete, E. Haglind, J. Rosenberg
    Colorectal Disease.2014; 16(9): 662.     CrossRef
  • Incidence and Mortality of Anastomotic Dehiscence Requiring Reoperation After Rectal Carcinoma Resection
    Zhi-jie Cong, Liang-hao Hu, Jun-jie Xing, Zheng-qian Bian, Chuan-gang Fu, En-da Yu, Zhao-shen Li, Ming Zhong
    International Surgery.2014; 99(2): 112.     CrossRef
  • Anastomotic leakage as an outcome measure for quality of colorectal cancer surgery
    H S Snijders, D Henneman, N L van Leersum, M ten Berge, M Fiocco, T M Karsten, K Havenga, T Wiggers, J W Dekker, R A E M Tollenaar, M W J M Wouters
    BMJ Quality & Safety.2013; 22(9): 759.     CrossRef
  • Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery
    D Roos, L M Dijksman, J G Tijssen, D J Gouma, M F Gerhards, H M Oudemans-van Straaten
    British Journal of Surgery.2013; 100(12): 1579.     CrossRef
  • Systematic Review of Anastomotic Leakage Rate According to an International Grading System Following Anterior Resection for Rectal Cancer
    Zhi-Jie Cong, Liang-Hao Hu, Zheng-Qian Bian, Guang-Yao Ye, Min-Hao Yu, Yun-He Gao, Zhao-Shen Li, En-Da Yu, Ming Zhong, Georgina L Hold
    PLoS ONE.2013; 8(9): e75519.     CrossRef
  • A systematic review of outcome reporting in colorectal cancer surgery
    R. N. Whistance, R. O. Forsythe, A. G. K. McNair, S. T. Brookes, K. N. L. Avery, A. M. Pullyblank, P. A. Sylvester, D. G. Jayne, J. E. Jones, J. Brown, M. G. Coleman, S. J. Dutton, R. Hackett, R. Huxtable, R. H. Kennedy, D. Morton, A. Oliver, A. Russell,
    Colorectal Disease.2013;[Epub]     CrossRef
  • Compression anastomosis ring device in colorectal anastomosis: a review of 1,180 patients
    Hossein Masoomi, Ruihong Luo, Steven Mills, Joseph C. Carmichael, Anthony J. Senagore, Michael J. Stamos
    The American Journal of Surgery.2013; 205(4): 447.     CrossRef
  • Spontaneous Healing of a Rectovaginal Fistula Developing after Laparoscopic Segmental Bowel Resection for Intestinal Deep Infiltrating Endometriosis
    William Kondo, Reitan Ribeiro, Carlos Henrique Trippia, Monica Tessmann Zomer
    Case Reports in Obstetrics and Gynecology.2013; 2013: 1.     CrossRef
  • A Novel Rodent Model Modifying Perioperative Temperature and Humidity during Bowel Surgery and Mimicking Laparoscopic Conditions
    Torben Glatz, Gabriel Seifert, Philipp A. Holzner, S. Chikhladze, Birte Kulemann, Olivia Sick, Jens Höppner, Ulrich Theodor Hopt, Goran Marjanovic
    Surgical Science.2012; 03(07): 353.     CrossRef
  • Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery
    D Roos, L M Dijksman, H M Oudemans-van Straaten, L T de Wit, D J Gouma, M F Gerhards
    British Journal of Surgery.2011; 98(10): 1365.     CrossRef
  • Ghost Ileostomy with or without abdominal parietal split
    Michele Cerroni, Roberto Cirocchi, Umberto Morelli, Stefano Trastulli, Jacopo Desiderio, Mario Mezzacapo, Chiara Listorti, Luigi Esperti, Diego Milani, Nicola Avenia, Nino Gullà, Giuseppe Noya, Carlo Boselli
    World Journal of Surgical Oncology.2011;[Epub]     CrossRef
Cancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer
Nari Shin, Gyung Mo Son, Dong-Hoon Shin, Myeong-Sook Kwon, Byung-Soo Park, Hyun-Sung Kim, Dongryeol Ryu, Chi-Dug Kang
Ann Coloproctol. 2019;35(1):36-46.   Published online February 28, 2019
DOI: https://doi.org/10.3393/ac.2018.09.10
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AbstractAbstract PDF
Purpose
We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC).
Methods
Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Overall survival and systemic recurrence were analyzed. A network analysis was performed between CAF maturation, desmoplastic reaction, and cancer invasiveness.
Results
The proportions of mature CAFs in the intratumoral stroma and the invasive front were 57.6% and 60.3%, respectively. Epidermal growth factor receptor (EGFR) overexpression was significantly higher in the mature CAFs in the invasive front as compared to immature CAFs. Lymphatic invasion increased as the number of mature fibroblasts in the intratumoral stroma increased. Tumor budding was observed in almost half of both mature and immature stroma samples and occurred more frequently in infiltrating tumors. On network analysis, well-connected islands were identified that was associated with EGFR overexpression, CAF maturation, and infiltrating tumor growth patterns leading to tumor budding.
Conclusion
The maturity of CAFs and desmoplastic reactions were associated with cancer invasion. However, the cytomorphologic characteristics of CAFs were insufficient as an independent prognostic factor for patients with CRC.

Citations

Citations to this article as recorded by  
  • Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment
    Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohammad Rahmati, Mostafa Golshekan, Mahmoud Abedinzade, Elham Ahmadi, Singh Neha, Masoud Najafi
    Current Topics in Medicinal Chemistry.2025; 25(3): 243.     CrossRef
  • Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence
    Atehkeng Zinkeng, F. Lloyd Taylor, Samuel H. Cheong, Heyu Song, Juanita L. Merchant
    Cellular and Molecular Gastroenterology and Hepatology.2025; 19(2): 101425.     CrossRef
  • Prognostic impact of tumor‑associated stroma in triple-negative breast cancer
    Akinari Kakumoto, Tsengelmaa Jamiyan, Ai Koyanagi, Hajime Kuroda, Rin Yamaguchi, Hitoshi Tsuda, Akira Hirano, Shunichi Shiozawa
    Breast Cancer.2025; 32(2): 347.     CrossRef
  • Unravelling the difference of immune microenvironment characteristics between esophageal basaloid squamous cell carcinoma and conventional esophageal squamous cell carcinoma
    Dongxian Jiang, Yuhao Xiao, Zixiang Yu, Minying Deng, Qi Song, Jie Huang, Jieakesu Su, Chen Xu, Yingyong Hou
    Human Pathology.2025; 155: 105716.     CrossRef
  • Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier
    Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto
    Therapeutic Advances in Medical Oncology.2025;[Epub]     CrossRef
  • High-performance CT features supporting accurate pre-operative tumor staging in colon cancer
    Jianhua Yuan, Cangzheng Jin, Jianrong Si, Baobao Liu, Xiaohan Si, Jianzhi Chen
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Crosstalk between cancer‑associated fibroblasts and inflammation in tumor microenvironment: A novel perspective in cancer therapy (Review)
    Xinyan Liu, Chaofeng Wang, Huijuan Mao, Jianzi Wei
    Oncology Reports.2025; 54(2): 1.     CrossRef
  • Intratumoral Fibrotic Features are Associated with Lymph Node Metastasis and Recurrence in Patients with Advanced Colon Cancer
    Ayako Mine, Maiko Tabuchi, Yasuhiko Nakao, Nazigul Zhumagazhiyeva, Takahiro Motoyama, Keiichi Hashiguchi, Eri Yoshioka, Kanan Matsushima, Junya Shiota, Taro Akashi, Moto Kitayama, Hiroko Inomata, Kayoko Matsushima, Naoyuki Yamaguchi, Takashi Nonaka, Kazuh
    Modern Pathology.2025; : 100828.     CrossRef
  • The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
    Yang Lyu, Fuda Xie, Bonan Chen, Wing Sum Shin, Wei Chen, Yulong He, Kam Tong Leung, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
    Oncogene.2024; 43(2): 77.     CrossRef
  • Prognostic significance of tumor budding in patients with pancreatic invasive ductal carcinoma who received neoadjuvant therapy
    Emi Ibuki, Kyuichi Kadota, Nachino Kimura, Ryou Ishikawa, Minoru Oshima, Keiichi Okano, Reiji Haba
    Heliyon.2024; 10(1): e23928.     CrossRef
  • The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal Carcinomas
    Larissa Maria Henrich, Kristina Greimelmaier, Michael Wessolly, Nick Alexander Klopp, Elena Mairinger, Yvonne Krause, Sophia Berger, Jeremias Wohlschlaeger, Hans-Ulrich Schildhaus, Hideo Andreas Baba, Fabian Dominik Mairinger, Sabrina Borchert
    Genes.2024; 15(2): 209.     CrossRef
  • Exosomes—Promising Carriers for Regulatory Therapy in Oncology
    Teresa Maria Jóźwicka, Patrycja Maria Erdmańska, Agnieszka Stachowicz-Karpińska, Magdalena Olkiewicz, Wojciech Jóźwicki
    Cancers.2024; 16(5): 923.     CrossRef
  • Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients
    Masayuki Komura, Chengbo Wang, Sunao Ito, Shunsuke Kato, Akane Ueki, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
    International Journal of Molecular Sciences.2024; 25(5): 2537.     CrossRef
  • Biophysical perspectives to understanding cancer-associated fibroblasts
    Somayadineshraj Devarasou, Minwoo Kang, Jennifer H. Shin
    APL Bioengineering.2024;[Epub]     CrossRef
  • Diagnostic and prognostic significance of keloid-like collagen remodeling patterns in the extracellular matrix of colorectal cancer
    Nauryzbay M. Imanbayev, Yerbolat M. Iztleuov, Yevgeniy K. Kamyshanskiy, Aigul V. Zhumasheva
    Pathology and Oncology Research.2024;[Epub]     CrossRef
  • Correlation analysis of interstitial maturity and prognosis of colorectal cancer: Meta-analysis
    Zhen-Jun Liu, Xu-Wen Zhang, Qi-Qi Liu, Shao-Zhao Wang
    World Journal of Gastrointestinal Oncology.2024; 16(6): 2816.     CrossRef
  • Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma‐related markers
    Sunao Ito, Akira Koshino, Chengbo Wang, Takahiro Otani, Masayuki Komura, Akane Ueki, Shunsuke Kato, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
    The Journal of Pathology: Clinical Research.2024;[Epub]     CrossRef
  • Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions
    Yaquan Sun, Wei Jiang, Xiang Liao, Dongqing Wang
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Improving tumor microenvironment assessment in chip systems through next-generation technology integration
    Daniela Gaebler, Stephanie J. Hachey, Christopher C. W. Hughes
    Frontiers in Bioengineering and Biotechnology.2024;[Epub]     CrossRef
  • Prognostic Significance of Tumour Budding and Desmoplastic Reaction in Intestinal-Type Gastric Adenocarcinoma
    Cherry Pun, Shelly Luu, Carol Swallow, Richard Kirsch, James R. Conner
    International Journal of Surgical Pathology.2023; 31(6): 957.     CrossRef
  • Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion
    Zirong Chen, Yan Fang, Weihong Jiang
    Cancers.2023; 15(5): 1360.     CrossRef
  • Microphysiological systems to study colorectal cancer: state-of-the-art
    Pedro Ramos, Mariana R Carvalho, Wei Chen, Le-Ping Yan, Chang-Hua Zhang, Yu-long He, Rui L Reis, Joaquim M Oliveira
    Biofabrication.2023; 15(3): 032001.     CrossRef
  • Antibody-Loaded Nanoplatforms for Colorectal Cancer Diagnosis and Treatment: An Update
    Rania Djermane, Celia Nieto, Milena A. Vega, Eva M. Martín del Valle
    Pharmaceutics.2023; 15(5): 1514.     CrossRef
  • Prognostic evaluation of cancer associated fibrosis and tumor budding in colorectal cancer
    Adil Aziz Khan, Shaivy Malik, Sherrin Jacob, Durre Aden, Sana Ahuja, Sufian Zaheer, Sunil Ranga
    Pathology - Research and Practice.2023; 248: 154587.     CrossRef
  • Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers
    Betul Unal, Mennan Yigitcan Celik, Elif Ocak Gedik, Cumhur Ibrahim Bassorgun, Gulsum Ozlem Elpek
    World Journal of Hepatology.2023; 15(6): 775.     CrossRef
  • Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
    Eric Jou
    Exploration of Targeted Anti-tumor Therapy.2023; : 474.     CrossRef
  • A Vaccine against Cancer: Can There Be a Possible Strategy to Face the Challenge? Possible Targets and Paradoxical Effects
    Roberto Zefferino, Massimo Conese
    Vaccines.2023; 11(11): 1701.     CrossRef
  • Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy
    ELYN AMIELA SALLEH, YEONG YEH LEE, ANDEE DZULKARNAEN ZAKARIA, NUR ASYILLA CHE JALIL, MARAHAINI MUSA
    BIOCELL.2023; 47(10): 2233.     CrossRef
  • Mechanobiology of Colorectal Cancer
    Maria Manuela Brás, Susana R. Sousa, Fátima Carneiro, Manfred Radmacher, Pedro L. Granja
    Cancers.2022; 14(8): 1945.     CrossRef
  • Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer
    Phimmada Hatthakarnkul, Jean A. Quinn, Aula Ammar, Gerard Lynch, Hester Van Wyk, Donald C. McMillan, Chanitra Thuwajit, Joanne Edwards
    Clinical Science.2022; 136(8): 521.     CrossRef
  • Construction and Verification of a Fibroblast-Related Prognostic Signature Model for Colon Cancer
    Zhe Zhao, Wenqi Li, LiMeng Zhu, Bei Xu, Yudong Jiang, Nan Ma, LiQun Liu, Jie Qiu, Min Zhang
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Intratumoral Budding in Pretreatment Biopsies, among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma
    Kwangil Yim, Won Mo Jang, Uiju Cho, Der Sheng Sun, Yosep Chong, Kyung Jin Seo
    Medicina.2022; 58(7): 926.     CrossRef
  • Evaluation of histopathological response to neoadjuvant therapy in rectal cancer using slide‐free, stain‐free multimodal multiphoton microscopy
    Yancheng Cui, Qinghua Zhong, Dawei Sun, Yan Chen, Zhe Jiang, Xiaodong Yang, Zhanlong Shen, Yunhua Sun, Mujun Yin, Bin Liang, Xin Zhu, Xuefeng Guo, Yingjiang Ye
    Journal of Biophotonics.2022;[Epub]     CrossRef
  • Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis
    Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Engineering chimeric antigen receptor T cells for solid tumour therapy
    Longwei Liu, Yunjia Qu, Leonardo Cheng, Chi Woo Yoon, Peixiang He, Abdula Monther, Tianze Guo, Sarah Chittle, Yingxiao Wang
    Clinical and Translational Medicine.2022;[Epub]     CrossRef
  • FSP-1 expression in cancer cells is relevant to long-term oncological outcomes in nonmetastatic colorectal cancer
    Sun Bin Im, Jae Min Cho, Han Byul Kim, Dong-Hoon Shin, Myeong Sook Kwon, In Young Lee, Gyung Mo Son
    Korean Journal of Clinical Oncology.2022; 18(2): 66.     CrossRef
  • Immunohistochemical expression of FAP and PCNA in neoplastic epithelial colonic lesions
    Aya S. Ali, Duaa S. Helal, Dareen A. Mohamed, Fersan A. Sallam
    Tanta Medical Journal.2022; 50(3): 236.     CrossRef
  • Stromal categorization in early oral tongue cancer
    Alhadi Almangush, Ibrahim O. Bello, Ilkka Heikkinen, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Antti A. Mäkitie, Tuula Salo, Ilmo Leivo
    Virchows Archiv.2021; 478(5): 925.     CrossRef
  • Transvaginal Strain Elastosonography in the Differential Diagnosis of Rectal Endometriosis: Some Potentials and Limits
    Marco Scioscia, Antonio Simone Laganà, Giuseppe Caringella, Stefano Guerriero
    Diagnostics.2021; 11(1): 99.     CrossRef
  • Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
    Fanglong Wu, Jin Yang, Junjiang Liu, Ye Wang, Jingtian Mu, Qingxiang Zeng, Shuzhi Deng, Hongmei Zhou
    Signal Transduction and Targeted Therapy.2021;[Epub]     CrossRef
  • CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion
    Gurcan Gunaydin
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • High-Resolution Diffusion-Weighted Imaging for Evaluation of Extramural Tumor Invasion in Primary Rectal Cancer
    Eun Joo Park, Seung Ho Kim, Sung Jae Jo, Kyung Han Nam, Yun-jung Lim, Hyun Kyung Jung
    Journal of Computer Assisted Tomography.2021; 45(4): 522.     CrossRef
  • Cancer-associated fibroblasts are associated with poor prognosis in solid type of lung adenocarcinoma in a machine learning analysis
    Kyueng-Whan Min, Dong-Hoon Kim, Yung-Kyun Noh, Byoung Kwan Son, Mi Jung Kwon, Ji-Yong Moon
    Scientific Reports.2021;[Epub]     CrossRef
  • The Versatile Roles of Cancer-Associated Fibroblasts in Colorectal Cancer and Therapeutic Implications
    Longfei Deng, Nianfen Jiang, Jun Zeng, Yi Wang, Hongjuan Cui
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis
    Raghav Chandra, John D. Karalis, Charles Liu, Gilbert Z. Murimwa, Josiah Voth Park, Christopher A. Heid, Scott I. Reznik, Emina Huang, John D. Minna, Rolf A. Brekken
    Cancers.2021; 13(24): 6206.     CrossRef
  • Potential Pitfalls in Diagnostic Digital Image Analysis: Experience with Ki-67 and PHH3 in Gastrointestinal Neuroendocrine Tumors
    Sean M Hacking, Sujata Sajjan, Lili Lee, Yonah Ziemba, Mallorie Angert, Yihe Yang, Cao Jin, Hector Chavarria, Nidhi Kataria, Swachi Jain, Mansoor Nasim
    Pathology - Research and Practice.2020; 216(3): 152753.     CrossRef
  • Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer
    Cuong Cao Le, Amar Bennasroune, Benoit Langlois, Stéphanie Salesse, Camille Boulagnon-Rombi, Hamid Morjani, Stéphane Dedieu, Aline Appert-Collin
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Immature Stroma and Prognostic Profiling in Colorectal Carcinoma: Development and Validation of Novel Classification Systems
    Sean Hacking, Kingsley Ebare, Mallorie Angert, Lili Lee, Taisia Vitkovski, Rebecca Thomas, Hector Chavarria, Cao Jin, Mansoor Nasim
    Pathology - Research and Practice.2020; 216(7): 152970.     CrossRef
  • Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis
    Ana C. Martins Cavaco, Sara Dâmaso, Sandra Casimiro, Luís Costa
    Cancer and Metastasis Reviews.2020; 39(3): 603.     CrossRef
  • Tumor Budding in Colorectal Carcinoma Showing a Paradoxical Mitotic Index (Via PHH3) With Possible Association to the Tumor Stromal Microenvironment
    Sean Hacking, Sujata Sajjan, Mallorie Angert, Kingsley Ebare, Cao Jin, Hector Chavarria, Nidhi Kataria, Lei Zhang, Margaret Cho, Rebecca Thomas, Lili Lee, Mansoor Nasim
    Applied Immunohistochemistry & Molecular Morphology.2020; 28(8): 627.     CrossRef
  • Whole slide imaging and colorectal carcinoma: A validation study for tumor budding and stromal differentiation
    Sean Hacking, Rafae Nasim, Lili Lee, Taisia Vitkovski, Rebecca Thomas, Emily Shaffer, Mansoor Nasim
    Pathology - Research and Practice.2020; 216(11): 153233.     CrossRef
  • Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer
    Ting Xu, Yinjie Zhang, Jing Zhang, Changsong Qi, Dan Liu, Zhenghang Wang, Yanyan Li, Congcong Ji, Jian Li, Xuan Lin, Ting Hou, Hao Liu, Lu Zhang, Han Han-Zhang, Lin Shen, Xicheng Wang
    Frontiers in Oncology.2020;[Epub]     CrossRef
Reviews
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer
Surgical Treatment of Low-Lying Rectal Cancer: Updates
Cristopher Varela, Nam Kyu Kim
Ann Coloproctol. 2021;37(6):395-424.   Published online December 22, 2021
DOI: https://doi.org/10.3393/ac.2021.00927.0132
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AbstractAbstract PDF
Despite innovative advancements, distally located rectal cancer remains a critical disease of challenging management. The crucial location of the tumor predisposes it to a circumferential resection margin (CRM) that tends to involve the anal sphincter complex and surrounding organs, with a high incidence of delayed anastomotic complications and the risk of the pelvic sidewall or rarely inguinal lymph node metastases. In this regard, colorectal surgeons should be aware of other issues beyond total mesorectal excision (TME) performance. For decades, the concept of extralevator abdominoperineal resection to avoid compromised CRM has been introduced. However, the complexity of deep pelvic dissection with poor visualization in low-lying rectal cancer has led to transanal TME. In contrast, neoadjuvant chemoradiotherapy (NCRT) has allowed for the execution of more sphincter-saving procedures without oncologic compromise. Significant tumor regression after NCRT and complete pathologic response also permit applying the watch-and-wait protocol in some cases, now with more solid evidence. This review article will introduce the current surgical treatment options, their indication and technical details, and recent oncologic and functional outcomes. Lastly, the novel characteristics of distal rectal cancer, such as pelvic sidewall and inguinal lymph node metastases, will be discussed along with its tailored and individualized treatment approach.

Citations

Citations to this article as recorded by  
  • Oncologic impact of technical difficulties during the early experience with laparoscopic surgery for colorectal cancer: long-term follow-up results of a prospective cohort study
    Hong-min Ahn, Tae Gyun Lee, Hye-Rim Shin, Jeehye Lee, In Jun Yang, Jung Wook Suh, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang
    Current Problems in Surgery.2025; 63: 101694.     CrossRef
  • Comparative efficacy analysis of laparoscopic-assisted transanal total mesorectal excision vs laparoscopic transanal mesorectal excision for low-lying rectal cancer
    Feng Lu, Shu-Guang Tan, Juan Zuo, Hai-Hua Jiang, Jian-Hua Wang, Yu-Ping Jiang
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery
    Jia-Rui Liu, Jin Zhang, Xiang-Long Duan
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Clinical using of innovative biodegradable stent with extension sleeve in Ta_tme for low rectal cancer with high risk of anastomotic leakage
    Rongrong Hao, Wensheng Wang, Yuanhang Ma, Jianghong Chen, Yunbo Li, Yang Yang, Dan Ma, Zhicao Zhang
    Scientific Reports.2025;[Epub]     CrossRef
  • Robotic-assisted colorectal surgery in colorectal cancer management: a narrative review of clinical efficacy and multidisciplinary integration
    Engeng Chen, Li Chen, Wei Zhang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Radiomic Features of Mesorectal Fat as Indicators of Response in Rectal Cancer Patients Undergoing Neoadjuvant Therapy
    Francesca Treballi, Ginevra Danti, Sofia Boccioli, Sebastiano Paolucci, Simone Busoni, Linda Calistri, Vittorio Miele
    Tomography.2025; 11(4): 44.     CrossRef
  • Unlocking the in vivo therapeutic potential of radiation-activated photodynamic therapy for locally advanced rectal cancer with lymph node involvement
    Rui Sang, Sheri Nixdorf, Tzongtyng Hung, Carl Power, Fei Deng, Thuy Anh Bui, Alexander Engel, Ewa M. Goldys, Wei Deng
    eBioMedicine.2025; 116: 105724.     CrossRef
  • MRI Monitoring of Locally Advanced Rectal Cancer in Watch and Wait Patients
    Jian Zhao, Kanghua Huang, Akao Zhu, Jinghan Zhu, Yimin Fang, Xiaofeng Zhou, Hao Jiang, Li Shen, Haiyan Chen
    Clinical Colorectal Cancer.2025;[Epub]     CrossRef
  • Real‐World Long‐Term Outcomes of Operated and Non‐Operated Rectal Cancer in the Elderly: A 14‐Year Retrospective Multicentre Study
    Harun Demir, Gül Kanyılmaz, İbrahim Babalıoğlu, Bedriye Doğan, Meryem Aktan, Berrin Benli Yavuz, Ayşe Sümeyye Safi
    Journal of Medical Imaging and Radiation Oncology.2025;[Epub]     CrossRef
  • Sagittal FOCUS-MUSE Diffusion-weighted Imaging MRI Improves the Accuracy of Rectal Cancer Location: A Prospective Observational Study
    Jingjing Liu, Wei Sun, Shujie Zhang, Gengyun Miao, Lamei Deng, Mengsu Zeng, Liheng Liu
    Academic Radiology.2025;[Epub]     CrossRef
  • Personalized Treatment Modalities for Rectal Cancer: Advances in Neoadjuvant Treatment
    Nussara Pakvisal, Leontios Pappas, Bennett A. Caughey, Rocco Ricciardi, Aparna Parikh
    Journal of Clinical Medicine.2025; 14(13): 4411.     CrossRef
  • Elderly Rectal Cancer: An Updated Review
    Chih-Kai Huang, Chi-Hsiu Shih, Yung-Shuo Kao
    Current Oncology Reports.2024; 26(2): 181.     CrossRef
  • Sex Disparities in Rectal Cancer Surgery: An In-Depth Analysis of Surgical Approaches and Outcomes
    Chungyeop Lee, In Ja Park
    The World Journal of Men's Health.2024; 42(2): 304.     CrossRef
  • Robotic-Assisted versus Laparoscopic Surgery for Rectal Cancer: An Analysis of Clinical and Financial Outcomes from a Tertiary Referral Center
    Jasper Max Gebhardt, Neno Werner, Andrea Stroux, Frank Förster, Ioannis Pozios, Claudia Seifarth, Christian Schineis, Benjamin Weixler, Katharina Beyer, Johannes Christian Lauscher
    Journal of Clinical Medicine.2024; 13(6): 1795.     CrossRef
  • Study of surgical feasibility and outcome of laparoscopic surgery in malignant rectal tumors
    Islam Abdelkhalek, Galal AbuElnagah, Tarek Elfayoumi, Ahmed shoukry Hafez, Mohamed Asal
    Alexandria Journal of Medicine.2024; 60(1): 113.     CrossRef
  • Postoperative Imaging Findings of Colorectal Surgery: A Pictorial Essay
    Inkeon Yeo, Myung-Won Yoo, Seong Jin Park, Sung Kyoung Moon
    Journal of the Korean Society of Radiology.2024; 85(4): 727.     CrossRef
  • Complications Rate and Related Factors After Laparoscopic Sphincter-Preserving Total Mesorectal Excision for Low Rectal Cancer: A Single-Center Study in Vietnam
    Ly Huu Phu, Ho Tat Bang, Ung Van Viet, Hoang Danh Tan, Nguyen Trung Tin
    Cureus.2024;[Epub]     CrossRef
  • Tailoring rectal cancer surgery: Surgical approaches and anatomical insights during deep pelvic dissection for optimal outcomes in low‐lying rectal cancer
    Youn Young Park, Nam Kyu Kim
    Annals of Gastroenterological Surgery.2024; 8(5): 761.     CrossRef
  • Personalized Decisional Algorithms for Soft Tissue Defect Reconstruction after Abdominoperineal Resection for Low-Lying Rectal Cancers
    Dan Cristian Moraru, Mihaela Pertea, Stefana Luca, Valentin Bejan, Andrian Panuta, Raluca Tatar, Dan Mircea Enescu, Dragos Viorel Scripcariu, Viorel Scripcariu
    Current Oncology.2024; 31(6): 3253.     CrossRef
  • Comparative analysis of organ preservation attempt and radical surgery in clinical T2N0 mid to low rectal cancer
    Hyeung-min Park, Jaram Lee, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
    International Journal of Colorectal Disease.2024;[Epub]     CrossRef
  • Essential knowledge and technical tips for total mesorectal excision and related procedures for rectal cancer
    Min Soo Cho, Hyeon Woo Bae, Nam Kyu Kim
    Annals of Coloproctology.2024; 40(4): 384.     CrossRef
  • The role of robotic-assisted surgery in the management of rectal cancer: a systematic review and meta-analysis
    Chenxiong Zhang, Hao Tan, Han Xu, Jiaming Ding
    International Journal of Surgery.2024; 110(10): 6282.     CrossRef
  • Endoscopic submucosal dissection for superficial ultra-low rectal tumors: outcomes and predictive factors for procedure difficulty
    Yinxin Wu
    American Journal of Cancer Research.2024; 14(12): 5784.     CrossRef
  • Pathologic Implications of Magnetic Resonance Imaging-detected Extramural Venous Invasion of Rectal Cancer
    Hyun Gu Lee, Chan Wook Kim, Jong Keon Jang, Seong Ho Park, Young Il Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Clinical Colorectal Cancer.2023; 22(1): 129.     CrossRef
  • Customized Denonvilliers’ Fascia Excision: An Advanced Total Mesorectal Excision Technique for Anteriorly Located Rectal Cancer
    Sung Uk Bae, Cristopher Varela, Manar Nassr, Nam Kyu Kim
    Diseases of the Colon & Rectum.2023; 66(6): e304.     CrossRef
  • Organ preservation for early rectal cancer using preoperative chemoradiotherapy
    Gyung Mo Son
    Annals of Coloproctology.2023; 39(3): 191.     CrossRef
  • The Safe Values of Quantitative Perfusion Parameters of ICG Angiography Based on Tissue Oxygenation of Hyperspectral Imaging for Laparoscopic Colorectal Surgery: A Prospective Observational Study
    Gyung Son, Armaan Nazir, Mi Yun, In Lee, Sun Im, Jae Kwak, Sang-Ho Park, Kwang-Ryul Baek, Ines Gockel
    Biomedicines.2023; 11(7): 2029.     CrossRef
  • International Society of University Colon and Rectal Surgeons survey of surgeons’ preference on rectal cancer treatment
    Audrius Dulskas, Philip F. Caushaj, Domas Grigoravicius, Liu Zheng, Richard Fortunato, Joseph W. Nunoo-Mensah, Narimantas E. Samalavicius
    Annals of Coloproctology.2023; 39(4): 307.     CrossRef
  • Clinical Significance of Combining Preoperative and Postoperative Albumin-Bilirubin Score in Colorectal Cancer
    Doyoun Kim, Jae-Hoon Lee, Eun-Suk Cho, Su-Jin Shin, Hye Sun Lee, Hwa-Hee Koh, Kang Young Lee, Jeonghyun Kang
    Cancer Research and Treatment.2023; 55(4): 1261.     CrossRef
  • Do Laparoscopic Approaches Ensure Oncological Safety and Prognosis for Serosa-Exposed Colon Cancer? A Comparative Study against the Open Approach
    Ji-Hyun Seo, In-Ja Park
    Cancers.2023; 15(21): 5211.     CrossRef
  • Low anterior resection syndrome: is it predictable?
    Dong Hyun Kang
    Annals of Coloproctology.2023; 39(5): 373.     CrossRef
  • Beyond the Horizon: Unveiling the Frontiers of Rectal Cancer Research and Treatment
    Reda H Mithany, M Hasaan Shahid, Shenouda Abdallah, Mark Abdelmaseeh, Mina Manasseh, Farid Gerges, Andrew Wanees, Mohamed S Mohamed, Mina W Hakim, Samana Aslam, Nesma Daniel
    Cureus.2023;[Epub]     CrossRef
  • Optimal surgical techniques for curative resection of the rectal cancer
    Hyeon Woo Bae, Nam Kyu Kim
    Formosan Journal of Surgery.2023; 56(6): 171.     CrossRef
  • Unveiling the profound advantages of total neoadjuvant therapy in rectal cancer: a trailblazing exploration
    Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Donghyoun Lee, Chinock Cheong
    Annals of Surgical Treatment and Research.2023; 105(6): 341.     CrossRef
  • Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases: A Focus on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
    Youngbae Jeon, Eun Jung Park
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • How Can We Improve the Tumor Response to Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer?
    Jeonghee Han
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Preventing Anastomotic Leakage, a Devastating Complication of Colorectal Surgery
    Hyun Gu Lee
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Surgical Techniques for Transanal Local Excision for Early Rectal Cancer
    Gyoung Tae Noh
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Influence of the COVID-19 Pandemic on the Treatment Patterns and Outcomes of Colorectal Cancer
    In Ja Park
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Epidemiologie, Diagnostik und Therapie des Rektumkarzinoms
    Maurice Vuattoux, Soleen Stocker-Ghafoor, Hatice Bunea, Christoph Kettelhack, Andreas Wicki, Frank B. Zimmermann
    InFo Hämatologie + Onkologie.2022; 25(3): 44.     CrossRef
  • Current status and role of robotic approach in patients with low-lying rectal cancer
    Hyo Seon Ryu, Jin Kim
    Annals of Surgical Treatment and Research.2022; 103(1): 1.     CrossRef
  • Multidisciplinary treatment strategy for early colon cancer
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Korean Medical Association.2022; 65(9): 558.     CrossRef
  • Direction of diagnosis and treatment improvement in colorectal cancer
    In Ja Park
    Journal of the Korean Medical Association.2022; 65(9): 540.     CrossRef
  • Robotic surgery for colorectal cancer
    Sung Uk Bae
    Journal of the Korean Medical Association.2022; 65(9): 577.     CrossRef
  • Current Status and Future of Robotic Surgery for Colorectal Cancer-An English Version
    Sung Uk Bae
    Journal of the Anus, Rectum and Colon.2022; 6(4): 221.     CrossRef
  • Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 203.     CrossRef
  • Low Anterior Resection Syndrome: Pathophysiology, Risk Factors, and Current Management
    Seung Mi Yeo, Gyung Mo Son
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • Robot-Assisted Colorectal Surgery
    Young Il Kim
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • Update on Diagnosis and Treatment of Colorectal Cancer
    Chan Wook Kim
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • The watch-and-wait strategy versus radical resection for rectal cancer patients with a good response (≤ycT2) after neoadjuvant chemoradiotherapy
    Chungyeop Lee, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Annals of Surgical Treatment and Research.2022; 103(6): 350.     CrossRef
  • It Is a Pleasure to Announce the Issue Titled “Master Class 2021” in Annals of Coloproctology
    In Ja Park
    Annals of Coloproctology.2021; 37(6): 349.     CrossRef
Clinical Implications of Lymph Node Metastasis in Colorectal Cancer: Current Status and Future Perspectives
Hye Jin Kim, Gyu–Seog Choi
Ann Coloproctol. 2019;35(3):109-117.   Published online June 30, 2019
DOI: https://doi.org/10.3393/ac.2019.06.12
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AbstractAbstract PDF
Lymph node metastasis is regarded as an indubitable prognostic factor for predicting disease recurrence and survival in patients with colorectal cancer. Lymph node status based on examination of a resected specimen is a key element of the current staging system and is also a crucial factor to determine use of adjuvant chemotherapy after surgical resection. However, the current tumor-node-metastasis (TNM) staging system only incorporates the number of metastatic lymph nodes in the N category. Numerous attempts have been made to supplement this simplified N staging including lymph node ratio, distribution of metastatic lymph nodes, tumor deposits, or extracapsular invasion. In addition, several attempts have been made to identify more specific prognostic factors in resected colorectal specimens than lymph node status. In this review, we will discuss controversies in lymph node staging and factors that may influence survival beyond lymph node status.

Citations

Citations to this article as recorded by  
  • Role of Adjuvant Chemotherapy After Surgical Resection of Paraaortic Lymph Node Metastasis from Colorectal Cancer—A Multicenter Retrospective Study
    Hiroaki Nozawa, Sono Ito, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Shinichi Yamauchi, Yusuke Kinugasa, Yoichi Ajioka, Soichiro Ishihara
    Annals of Surgical Oncology.2025; 32(4): 2282.     CrossRef
  • Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors
    Qi Dang, Linhao Zhang, Huipeng Ma, Xiaoshan Sun, Anguo Ren, Jiuyang Chen, Xiaohua Huang, Boyu Zhang, Wen Sun
    Biomaterials.2025; 316: 123020.     CrossRef
  • Lymph node yield does not affect the cancer-specific survival of patients with T1 colorectal cancer: a population-based retrospective study of the U.S. database and a Chinese registry
    Jiyun Li, Ruoxi Tian, Fei Huang, Pu Cheng, Fuqiang Zhao, Zhixun Zhao, Qian Liu, Zhaoxu Zheng
    International Journal of Colorectal Disease.2025;[Epub]     CrossRef
  • Long‐Term Outcomes of Sigmoid, Rectosigmoid, and Rectal Cancers: A Matched Analysis
    Cigdem Benlice, Atilla Halil Elhan, Emre Gorgun, Mehmet Ayhan Kuzu
    World Journal of Surgery.2025; 49(4): 819.     CrossRef
  • The Value of Spectroscopic CT for Lymph Node Metastasis in Rectal Cancer
    冬冬 穆
    Journal of Clinical Personalized Medicine.2025; 04(01): 501.     CrossRef
  • A novel pN stage prediction model for resectable rectal adenocarcinoma based on preoperative MRI features and multiregional apparent diffusion coefficients
    Hui Luo, Yue-qin Gou, Yue-su Wang, Hui-lin Qin, Hai-ying Zhou, Xiao-ming Zhang, Tian-wu Chen
    European Radiology.2025;[Epub]     CrossRef
  • Indocyanine Green Near-Infrared Fluorescence-Guided Sentinel Lymph Node Biopsy in Colon Cancer
    Vlad Fagarasan, Vasile V. Bintintan, Radu I. Seicean, Giorgiana Fagarasan, David Andras, Emil Botan, Gabriel Samasca, George C. Dindelegan, Calin I. Cainap
    Biomedicines.2025; 13(4): 902.     CrossRef
  • TRAIL‐conjugated liposomes that bind natural killer cells to induce colorectal cancer cell apoptosis
    Joshua D. Greenlee, Zhenjiang Zhang, Tejas Subramanian, Kevin Liu, Michael R. King
    Journal of Biomedical Materials Research Part A.2024; 112(1): 110.     CrossRef
  • Lymph Node Ratio as a Predictor of Survival for Colon Cancer: A Systematic Review and Meta-Analysis
    Simarpreet Ichhpuniani, Tyler McKechnie, Jay Lee, Jeremy Biro, Yung Lee, Lily Park, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu
    The American Surgeon™.2024; 90(4): 840.     CrossRef
  • Acetone compression improves lymph node yield and metastasis detection in colorectal cancer
    Christina Schnoz, Katrin Schmid, Guacimara Ortega Sanchez, Sabina Schacher-Kaufmann, Michel Adamina, Georgios Peros, Dieter Erdin, Peter Karl Bode
    Clinical & Experimental Metastasis.2024; 41(1): 45.     CrossRef
  • Computational methods for metastasis detection in lymph nodes and characterization of the metastasis-free lymph node microarchitecture: A systematic-narrative hybrid review
    Elzbieta Budginaite, Derek R. Magee, Maximilian Kloft, Henry C. Woodruff, Heike I. Grabsch
    Journal of Pathology Informatics.2024; 15: 100367.     CrossRef
  • Sequential Lateral Lymphatic Metastasis Shows Similar Oncologic Outcomes to Upward Spread in Advanced Rectal Cancer After Preoperative Chemoradiotherapy
    Hye Jin Kim, Gyu-Seog Choi, Seung Hyun Cho, Min Kyu Kang, Jun Seok Park, Soo Yeun Park, Byung Woog Kang, Jong Gwang Kim
    Diseases of the Colon & Rectum.2024; 67(3): 359.     CrossRef
  • The Evolving Role of Artificial Intelligence in Gastrointestinal Histopathology: An Update
    D. Chamil Codipilly, Shahriar Faghani, Catherine Hagan, Jason Lewis, Bradley J. Erickson, Prasad G. Iyer
    Clinical Gastroenterology and Hepatology.2024; 22(6): 1170.     CrossRef
  • INFLUENCE OF NEOADJUVANT THERAPY ON THE RATIO OF LYMPH NODES
    Laura CREDIDIO, Carlos Augusto Real MARTINEZ, Daniéla Oliveira MAGRO, Rita Barbosa de CARVALHO, Maria de Lourdes Setsuko AYRIZONO, Cláudio Saddy Rodrigues COY
    Arquivos de Gastroenterologia.2024;[Epub]     CrossRef
  • National screening for colorectal cancer is associated with stage shift to earlier diagnosis
    Mina Sarofim, Amir Ashrafizadeh, Anthony J. Gill, Keshani de Silva, Justin Evans, Stephen Clarke, Nick Pavlakis, Ian Norton, Alexander Engel
    ANZ Journal of Surgery.2024; 94(7-8): 1279.     CrossRef
  • Competing‐risks model for predicting the prognosis of patients with regressive melanoma based on the SEER database
    Chaodi Huang, Liying Huang, Jianguo Huang, Xinkai Zheng, Congjun Jiang, Kong Ching Tom, U. Tim Wu, WenHsien Ethan Huang, Yunfei Gao, Fangmin Situ, Hai Yu, Liehua Deng, Jun Lyu
    Malignancy Spectrum.2024; 1(2): 123.     CrossRef
  • The Relationship between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma
    Zdenko Bilić, Mario Zovak, Goran Glavčić, Dubravka Mužina, Amir Ibukić, Andro Košec, Davor Tomas, Alma Demirović
    Journal of Clinical Medicine.2024; 13(9): 2583.     CrossRef
  • Standardizing data collection in adjuvant colon cancer trials: A consensus project from the IDEA and ACCENT international consortia and national experts
    Julien Taieb, Debora Basile, Jenny Seligmann, Guillem Argiles, Thierry André, Claire Gallois, Richard M. Goldberg, Greg Yothers, Alberto Sobrero, Jeffrey A. Meyerhardt, John Souglakos, Roberto Labianca, Tim Iveson, David N. Church, Dirk Arnold, Jeanne Tie
    European Journal of Cancer.2024; 206: 114118.     CrossRef
  • GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis
    Feng Cao, Yang-Yan Chen, Hong-Cheng Wang
    World Journal of Gastrointestinal Surgery.2024; 16(5): 1328.     CrossRef
  • Application of radiomics for preoperative prediction of lymph node metastasis in colorectal cancer: a systematic review and meta-analysis
    Elahe Abbaspour, Sahand Karimzadhagh, Abbas Monsef, Farahnaz Joukar, Fariborz Mansour-Ghanaei, Soheil Hassanipour
    International Journal of Surgery.2024; 110(6): 3795.     CrossRef
  • A pathologist–AI collaboration framework for enhancing diagnostic accuracies and efficiencies
    Zhi Huang, Eric Yang, Jeanne Shen, Dita Gratzinger, Frederick Eyerer, Brooke Liang, Jeffrey Nirschl, David Bingham, Alex M. Dussaq, Christian Kunder, Rebecca Rojansky, Aubre Gilbert, Alexandra L. Chang-Graham, Brooke E. Howitt, Ying Liu, Emily E. Ryan, Tr
    Nature Biomedical Engineering.2024; 9(4): 455.     CrossRef
  • OPTIMIZATION OF THE DIAGNOSIS OF LYMPH NODE METASTASIS IN PATIENTS WITH COLORECTAL CANCER USING RADIOLOGICAL IMAGING METHODS
    S.V. Maliborska, V.V. Holotiuk
    Art of Medicine.2024; : 63.     CrossRef
  • Low muscle mass-to-fat ratio is an independent factor that predicts worse overall survival and complications in patients with colon cancer: a retrospective single-center cohort study
    Jiabao Tang, Jingwen Xu, Xiaohua Li, Chun Cao
    Annals of Surgical Treatment and Research.2024; 107(2): 68.     CrossRef
  • Biomarkers of lymph node metastasis in colorectal cancer: update
    Xiao Zhu, Shui-quan Lin, Jun Xie, Li-hui Wang, Li-juan Zhang, Ling-ling Xu, Jian-guang Xu, Yang-bo Lv
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • SURGICAL TREATMENT OF RECTAL CANCER WITH PRESERVATION OF THE LEFT COLIC ARTERY AND ICG NAVIGATION
    S.V. Maliborska
    Art of Medicine.2024; : 86.     CrossRef
  • Assessing the clinical utility of tumor invasion proportion of lymph nodes for enhanced risk stratification in N1 colorectal cancer
    Ru-Jie Chen
    American Journal of Cancer Research.2024; 14(12): 5826.     CrossRef
  • Survival outcomes after synchronous para‐aortic lymph node metastasis in colorectal cancer: A systematic review
    Conor Aylward, Jawed Noori, Jack Tyrrell, Niall O'sullivan, Dara O. Kavanagh, John O. Larkin, Brian J. Mehigan, Paul H. McCormick, Michael E. Kelly
    Journal of Surgical Oncology.2023; 127(4): 645.     CrossRef
  • National assessment of lymph node status indicators & predictors in pediatric head and neck rhabdomyosarcomas in the US
    David J. Fei-Zhang, Asher C. Park, Joseph M. Berry, Rebecca S. Arch, Daniel C. Chelius, Anthony M. Sheyn, Jeffrey C. Rastatter
    International Journal of Pediatric Otorhinolaryngology.2023; 164: 111419.     CrossRef
  • Increased Kremen2 predicts worse prognosis in colon cancer
    Junxian Long, Fengyun Cong, Yousheng Wei, Jungang Liu, Weizhong Tang
    Pathology and Oncology Research.2023;[Epub]     CrossRef
  • Predictors and survival outcomes of having less than 12 harvested lymph nodes in proctectomy for rectal cancer
    Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Rachel Gefen, Peige Zhou, Steven D. Wexner
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions
    Haoran Ji, Chuang Hu, Xuhui Yang, Yuanhao Liu, Guangyu Ji, Shengfang Ge, Xiansong Wang, Mingsong Wang
    Signal Transduction and Targeted Therapy.2023;[Epub]     CrossRef
  • The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review
    Alexander J. Pennings, Brecht A. van der Velden, Maximilian Kloft, Loes F. S. Kooreman, Jos M. P. Kleijnen, Stephanie O. Breukink, Geerard L. Beets, Heike I. Grabsch, Jarno Melenhorst
    Annals of Surgery Open.2023; 4(4): e336.     CrossRef
  • Multicenter study of prognostic factors in paraaortic lymph node dissection for metastatic colorectal cancer
    Jun Woo Bong, Sanghee Kang, Pyoungjae Park
    Annals of Surgical Treatment and Research.2023; 105(5): 271.     CrossRef
  • Long-Term Outcomes of Surgical Resection of Pathologically Confirmed Isolated Para-Aortic Lymph Node Metastases in Colorectal Cancer: A Systematic Review
    Maurizio Zizzo, Maria Pia Federica Dorma, Magda Zanelli, Francesca Sanguedolce, Maria Chiara Bassi, Andrea Palicelli, Stefano Ascani, Alessandro Giunta
    Cancers.2022; 14(3): 661.     CrossRef
  • Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection
    Marcin Zeman, Władysław Skałba, Piotr Szymański, Grzegorz Hadasik, Dmytro Żaworonkow, Dominik A. Walczak, Agnieszka Czarniecka
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
  • An unusual case of right-sided colon cancer with isolated lateral pelvic side wall lymph node metastases
    Rishaan Pawaskar, James Wei Tatt Toh
    Laparoscopic, Endoscopic and Robotic Surgery.2022; 5(3): 121.     CrossRef
  • High-resolution MRI-based radiomics analysis to predict lymph node metastasis and tumor deposits respectively in rectal cancer
    Yan-song Yang, Feng Feng, Yong-juan Qiu, Gui-hua Zheng, Ya-qiong Ge, Yue-tao Wang
    Abdominal Radiology.2021; 46(3): 873.     CrossRef
  • Extricating the Association Between the Prognostic Factors of Colorectal Cancer
    Younis Mohd, Balamuralikrishnan Balasubramanian, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Suresh Kumar Shanmugam, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Sasikala Keshavarao, Vijaya Anand Arumugam
    Journal of Gastrointestinal Cancer.2021; 52(3): 1022.     CrossRef
  • Retrospective survival analysis of stage II–III rectal cancer: tumour regression grade, grading and lymphovascular invasion are the only predictors
    Andrea Morini, Alfredo Annicchiarico, Andrea Romboli, Matteo Ricco', Pellegrino Crafa, Filippo Montali, Paolo Dell'Abate, Renato Costi
    ANZ Journal of Surgery.2021;[Epub]     CrossRef
  • Competitive Risk Analysis of Prognosis in Patients With Cecum Cancer: A Population-Based Study
    Wentao Wu, Jin Yang, Daning Li, Qiao Huang, Fanfan Zhao, Xiaojie Feng, Hong Yan, Jun Lyu
    Cancer Control.2021;[Epub]     CrossRef
  • Increased Expression of VANGL1 is Predictive of Lymph Node Metastasis in Colorectal Cancer: Results from a 20-Gene Expression Signature
    Noshad Peyravian, Stefania Nobili, Zahra Pezeshkian, Meysam Olfatifar, Afshin Moradi, Kaveh Baghaei, Fakhrosadat Anaraki, Kimia Nazari, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Enrico Mini, Ehsan Nazemalhosseini Mojarad
    Journal of Personalized Medicine.2021; 11(2): 126.     CrossRef
  • Management of indeterminate hepatic nodules and evaluation of factors predicting their malignant potential in patients with colorectal cancer
    Mizelle D’Silva, Jai Young Cho, Ho-Seong Han, Taupyk Yerlan, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Moonhwan Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Optimal Postoperative Surveillance Strategies for Colorectal Cancer: A Retrospective Observational Study
    Min-Young Park, In-Ja Park, Hyo-Seon Ryu, Jay Jung, Min-Sung Kim, Seok-Byung Lim, Chang-Sik Yu, Jin-Cheon Kim
    Cancers.2021; 13(14): 3502.     CrossRef
  • Outcomes of Level of Ligation of Inferior Mesenteric Artery in Colorectal Cancer: a Systematic Review and Meta-Analysis
    Pavan Kumar Jonnada, Monish Karunakaran, Dayakar Rao
    Future Oncology.2021; 17(27): 3645.     CrossRef
  • Gastrointestinal cancer classification and prognostication from histology using deep learning: Systematic review
    Sara Kuntz, Eva Krieghoff-Henning, Jakob N. Kather, Tanja Jutzi, Julia Höhn, Lennard Kiehl, Achim Hekler, Elizabeth Alwers, Christof von Kalle, Stefan Fröhling, Jochen S. Utikal, Hermann Brenner, Michael Hoffmeister, Titus J. Brinker
    European Journal of Cancer.2021; 155: 200.     CrossRef
  • One-Step Nucleic Acid Amplification (OSNA) of Sentinel Lymph Node in Early-Stage Endometrial Cancer: Spanish Multicenter Study (ENDO-OSNA)
    María Diestro, Alberto Berjón, Ignacio Zapardiel, Laura Yébenes, Irune Ruiz, Arantza Lekuona, Marta Rezola, Ibon Jaunarena, Jaime Siegrist, Margarita Sánchez-Pastor, María Cuadra, Amaia Sagasta, Isabel Guerra, Luis Lete, Fernando Roldán, Carlo Marta, Marí
    Cancers.2021; 13(17): 4465.     CrossRef
  • Deep learning can predict lymph node status directly from histology in colorectal cancer
    Lennard Kiehl, Sara Kuntz, Julia Höhn, Tanja Jutzi, Eva Krieghoff-Henning, Jakob N. Kather, Tim Holland-Letz, Annette Kopp-Schneider, Jenny Chang-Claude, Alexander Brobeil, Christof von Kalle, Stefan Fröhling, Elizabeth Alwers, Hermann Brenner, Michael Ho
    European Journal of Cancer.2021; 157: 464.     CrossRef
  • Pathological Features and Prognostication in Colorectal Cancer
    Kabytto Chen, Geoffrey Collins, Henry Wang, James Wei Tatt Toh
    Current Oncology.2021; 28(6): 5356.     CrossRef
  • Distant Metastasis in Colorectal Cancer Patients—Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review
    Stanislav Filip, Veronika Vymetalkova, Jiri Petera, Ludmila Vodickova, Ondrej Kubecek, Stanislav John, Filip Cecka, Marketa Krupova, Monika Manethova, Klara Cervena, Pavel Vodicka
    International Journal of Molecular Sciences.2020; 21(15): 5255.     CrossRef
  • Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging
    Victor M. Baart, Marion M. Deken, Mark W. Bordo, Shadhvi S. Bhairosingh, Daniela C. F. Salvatori, Hoon Hyun, Maged Henary, Hak Soo Choi, Cornelis F. M. Sier, Peter J. K. Kuppen, Anton G. T. Terwisscha van Scheltinga, Taryn L. March, Adrianus R. P. M. Vale
    Frontiers in Oncology.2020;[Epub]     CrossRef
Original Articles
Single-center Experience of 24 Cases of Tailgut Cyst
Ahmad Sakr, Ho Seung Kim, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2019;35(5):268-274.   Published online October 31, 2019
DOI: https://doi.org/10.3393/ac.2018.12.18
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AbstractAbstract PDF
Purpose
Tailgut cysts are rare congenital or developmental lesions that arise from vestiges of the embryological hindgut. They are usually present in the presacral space. We report our single-center experience with managing tailgut cysts.
Methods
We conducted a retrospective analysis of 24 patients with tailgut cyst treated surgically at the Colorectal Surgery Department of Severance Hospital, Yonsei University, Seoul, South Korea, between 2007–2018.
Results
This study included 24 patients (18 females) with a median age of 51.5 years (range, 21–68 years). Ten cases were symptomatic and 14 were asymptomatic. Cysts were retrorectal in 21 patients. Cysts were below the coccyx level in 16 patients, opposite the coccyx in 6, and above the coccyx in 2. Cysts were supralevator in 5 patients, had a supra- and infralevator extension in 18 patients, and were infralevator in 1. Ten patients were managed using an anterior laparoscopic approach, 11 using a posterior approach, and 3 using a combined approach. Mean cyst size was 5.5 ± 2.7 cm. Postoperative complications were Clavien-Dindo (CD) classification grade II in 9 patients (37.5%) and CD grade III in 1 (4.2%). The posterior approach group showed the highest rate of complications (P = 0.021). Patients managed using a combined approach showed a larger cyst size (P < 0.001), longer operation times (P < 0.001), and a greater likelihood of tumor level above the coccyx (P = 0.002) compared to other approaches. The tumors of 2 male patients were malignant: 1 was a neuroendocrine tumor treated with radiotherapy, while the other was a closely followed adenocarcinoma. Median follow-up was 12 months (range, 1–66 months) with no recurrence.
Conclusion
Tailgut cysts are uncommon but can cause perineal or pelvic pain. Complete surgical excision via an appropriate approach according to tumor size, location, and correlation with adjacent pelvic floor muscles is the key treatment.

Citations

Citations to this article as recorded by  
  • Risk factors for rectal perforation during presacral cyst removal: a comparison between transabdominal, perineal, and combined surgical approaches
    P. Tsarkov, S. Barkhatov, D. Shlyk, L. Safyanov, V. Balaban, M. He
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Tailgut Cyst—Gynecologist’s Pitfall: Literature Review and Case Report
    Andrei Mihai Malutan, Viorela-Elena Suciu, Florin Laurentiu Ignat, Doru Diculescu, Razvan Ciortea, Emil-Claudiu Boțan, Carmen Elena Bucuri, Maria Patricia Roman, Ionel Nati, Cristina Ormindean, Dan Mihu
    Diagnostics.2025; 15(1): 108.     CrossRef
  • Laparoscopic Excision of a Tailgut Cyst With Refractory Pain: A Case Report
    Masato Kitazawa, Seishu Karasawa, Satoshi Nakamura, Yuta Yamamoto, Yuji Soejima
    Cureus.2025;[Epub]     CrossRef
  • Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass
    Faraz Khalid, Haris Naveed, Masab Ali, Muhammad Saad Ansari, Muhammad Sajjad Shafiq, Muhammad Husnain Ahmad
    Annals of Medicine & Surgery.2025; 87(1): 421.     CrossRef
  • Transanal-transrektale endoskopische Resektion einer Schwanzdarmzyste
    Hussein Abdallah, Stefan Heinrich, Matthias Birth
    coloproctology.2025; 47(3): 220.     CrossRef
  • Partial Resection of a Tailgut Cyst Attached to the Rectum via a Transcoccygeal Approach: A Case Report With a Favorable Outcome
    Eitaro Okumura, Motoo Kubota, Ouji Momosaki, Ryo Hashimoto, Kotaro Kohara
    Cureus.2025;[Epub]     CrossRef
  • Recurrent presacral tailgut cyst with mucinous adenocarcinoma and metastasis
    Iyad Al Jada, Majd Oweidat, Mohammad Khaleel, Omar Harb, Ursula Abu Nahla, Rahaf Bleibel, Mai Arafeh, Ammar W.M. Hassouneh
    Radiology Case Reports.2025; 20(8): 4022.     CrossRef
  • Trans‐abdominal single‐incision robotic surgery with the da Vinci SP® surgical system for 8 cases of retrorectal tumour
    Ho Seung Kim, Bo‐Young Oh, Soon Sup Chung, Ryung‐Ah Lee, Gyoung Tae Noh
    The International Journal of Medical Robotics and Computer Assisted Surgery.2024;[Epub]     CrossRef
  • Three Cases of Anal Cystic Lesions in Our Hospital
    Kaori Tanaka, Toshiharu Mori, Hideki Yamada, Hideki Mori
    Nihon Daicho Komonbyo Gakkai Zasshi.2024; 77(4): 199.     CrossRef
  • Diagnosis and treatment of retrorectal cystic hamartoma: clinical case
    S. A. Zvezda, D. G. Dimitriadi, P. I. Tamrazov, A. V. Simonov, E. M. Frank, N. M. Fedorov, L. N. Komarova
    Surgery and Oncology.2024; 14(1): 72.     CrossRef
  • Presacral Tailgut Cyst
    Shriya Haval, Divyansh Dwivedi, Prabhat Nichkaode
    Annals of African Medicine.2024; 23(2): 237.     CrossRef
  • A neuroendocrine tumor arising in a tailgut cyst: Case report and literature review
    Wei Guo, Ming Deng, Qiongrong Chen
    International Journal of Surgery Case Reports.2024; 120: 109912.     CrossRef
  • Tailgut Cyst in a Child: A Case Report and Review of Literature
    Ramendra Shukla, Jay Divyesh Patel, Sudhir B. Chandna, Urvish Parikh
    African Journal of Paediatric Surgery.2024; 21(3): 184.     CrossRef
  • Two Cases of Symptomatic Tailgut Cysts
    Jan Wojciechowski, Tomasz Skołozdrzy, Piotr Wojtasik, Maciej Romanowski
    Journal of Clinical Medicine.2024; 13(17): 5136.     CrossRef
  • The management of retrorectal tumors – a single-center analysis of 21 cases and overview of the literature
    K. Fechner, B. Bittorf, M. Langheinrich, K. Weber, M. Brunner, R. Grützmann, K. E. Matzel
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Kraske-Zugang für Tumoren im kaudalen retrorektalen Raum
    Rosita Sortino, Sebastian Christen, Daniel Steinemann, Ida Füglistaler
    coloproctology.2024; 46(6): 413.     CrossRef
  • Laparoscopic approach in the surgical treatment of large retrorectal tumors: a short-term experience at a single tertiary center case series in Korea
    Jun Seong Chung, Han Deok Kwak, Jae Kyun Ju
    Journal of Minimally Invasive Surgery.2024; 27(4): 221.     CrossRef
  • Open surgical treatment for giant presacral tailgut cyst – a case report
    Q Liu, P Guo, C Li, G Yu, J Jiao
    South African Journal of Surgery.2024; 62(4): 358.     CrossRef
  • Cystic lesions of the retrorectal space
    Ian S Brown, Anna Sokolova, Christophe Rosty, Rondell P Graham
    Histopathology.2023; 82(2): 232.     CrossRef
  • Tailgut cyst mimicking second anal opening in an infant
    Jay Lodhia, Mujaheed Suleman, Doreen Msemakweli, Joshua Tadayo, Patrick Amsi, David Msuya
    Journal of Pediatric Surgery Case Reports.2023; 89: 102550.     CrossRef
  • Surgery of presacral cysts: case series analysis and literature review
    K. V. Stegnii, Zh. A. Rakhmonov, R. A. Goncharuk, M. A. Krekoten, E. R. Dvoinikova, E. V. Morova, M. О. Dmitriev
    Pacific Medical Journal.2023; (2): 15.     CrossRef
  • Surgical treatment of retrorectal tumors: a plea for a laparoscopic approach
    Clara Galán, M. Pilar Hernández, M. Carmen Martínez, Anna Sánchez, Jesús Bollo, Eduardo Mª Targarona
    Surgical Endoscopy.2023; 37(12): 9080.     CrossRef
  • Robotic approach to remove four tailgut cyst cases in Brazil: a case series
    Bruno Mirandola Bulisani, Luiz Guilherme Lisboa Gomes, Milena Arruda de Oliveira Leite, Ricardo Moreno, Murilo Rocha Rodrigues, Felipe Martin Bianco Rossi, Renato Barretto Ferreira da Silva, Luiz Carlos Benjamin do Carmo, Jaques Waisberg
    einstein (São Paulo).2023;[Epub]     CrossRef
  • Tumor neuroendocrino asociado con quiste intestinal: presentación de un caso
    Lismary Ruiz Cabezas, Alicia Moreno Ontalba, Mario Díaz Delgado, Esther María Cidoncha Pérez, Alejandro Rubio Fernández, María Victoria González Ibáñez
    Revista Española de Patología.2022; 55(4): 278.     CrossRef
  • Risk of malignancy and outcomes of surgically resected presacral tailgut cysts: A current review of the Mayo Clinic experience
    Sacha P. Broccard, Dorin T. Colibaseanu, Kevin T. Behm, Nitin Mishra, Peter Davis, Kristi L. Maimone, Kellie L. Mathis, Luca Stocchi, Eric J. Dozois, Amit Merchea
    Colorectal Disease.2022; 24(4): 422.     CrossRef
  • Squamous cell carcinoma in a retrorectal cystic hamartoma
    Quintáns Ana Teijo, Valadés José Ignacio Martín , del Río Cristina Garrán , Rojo Irene López , Casado Oscar Alonso
    Journal of Radiology and Oncology.2022; 6(1): 001.     CrossRef
  • Retrorectal Tailgut Cyst: A Case Report
    Neel Shah, Peter Edelstein
    Cureus.2022;[Epub]     CrossRef
  • A Case of Tailgut Cyst Treated with Laparoscopic Transabdominal and Transsacral Surgery
    Naoki Kawahara, Yoshiyuki Suzuki, Yu Sakai, Shinji Maeshima, Takehiro Shimada
    Nippon Daicho Komonbyo Gakkai Zasshi.2022; 75(4): 170.     CrossRef
  • Promoting Laparoscopic Anterior Approach for a Very Low Presacral Primary Neuroendocrine Tumor Arising in a Tailgut Cyst
    Maria Michela Di Nuzzo, Carlo De Werra, Mirella Pace, Raduan Ahmed Franca, Maria D’Armiento, Umberto Bracale, Ruggero Lionetti, Michele D’Ambra, Armando Calogero
    Healthcare.2022; 10(5): 805.     CrossRef
  • A Case of Dermoid Cyst in the Ischiorectal Fossa Resected by the Transperineal Approach
    Susumu Daibo, Hirokazu Suwa, Seiya Sato, Koki Goto, Yusuke Suwa, Jun Watanabe
    Nippon Daicho Komonbyo Gakkai Zasshi.2022; 75(5): 237.     CrossRef
  • Perianal Tailgut Cyst: An Unusual Presentation
    Rabia Arshad, Noor Khalid, Mubashir Rafique, Ruqia Mushtaq, Fakhar Munir Sial
    Cureus.2022;[Epub]     CrossRef
  • Squamous cell carcinoma arising in a tailgut cyst: role of radiotherapy
    Diego Aldave, Ana Teijo, Claudia Abril, Laura Cerezo
    BMJ Case Reports.2022; 15(9): e247985.     CrossRef
  • Hamartoma quístico retrorrectal (tailgut cyst): reporte de un caso y revisión de la literatura
    Juan Dario Puerta Diaz, Rodrigo Castaño Llano, Alfredo Enrique Martelo Román, Juan Esteban Puerta Botero
    Revista colombiana de Gastroenterología.2022; 37(3): 316.     CrossRef
  • Diagnostic, Therapeutic and Evolutionary Problems of Retro-Rectal Tumors (About 3 Cases)
    Hajri Amal, Ahmed Elmi Abdirahim, Rachid Boufettal, Erguibi Driss, Saad Rifki El Jai, Farid Chehab
    European Journal of Medical and Health Sciences.2022; 4(5): 13.     CrossRef
  • Epidemiology, diagnostic approach and therapeutic management of tailgut cysts: A systematic review
    Aikaterini Mastoraki, Ilias Giannakodimos, Karmia Panagiotou, Maximos Frountzas, Dimosthenis Chrysikos, Stylianos Kykalos, Georgios E. Theodoropoulos, Dimitrios Schizas
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Re: Malignant transformation of tailgut cysts is significantly higher than previously reported: Systematic review of cases in the literature
    Tamara Glyn, Peter Sagar, Frank Frizelle
    Colorectal Disease.2021; 23(11): 3027.     CrossRef
  • Multicenter Analysis of Presacral Neuroendocrine Neoplasms—Clinicopathological Characterization and Treatment Outcomes of a Rare Disease
    Sami Matrood, Leonidas Apostolidis, Jörg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kröcher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Surgical Management of Retrorectal Tumors
    Mathilde Aubert, Diane Mege, Yann Parc, Eric Rullier, Eddy Cotte, Guillaume Meurette, Philippe Zerbib, Bertrand Trilling, Bernard Lelong, Charles Sabbagh, Zaher Lakkis, Mehdi Ouaissi, Gil Lebreton, Philippe Rouanet, Gilles Manceau, Jean-Jacques Tuech, Gui
    Annals of Surgery.2021; 274(5): 766.     CrossRef
  • Isolated lumbar intradural tailgut cyst: A case report and review of the literature
    Antonio Colamaria, Matteo Sacco, Giovanni Parbonetti, Maria Blagia, Francesco Carbone, Matteo de Notaris
    Heliyon.2021; 7(10): e08223.     CrossRef
  • Prerectal tailgut cyst presenting with constipation and pseudo-rectal prolapse. A rare case presentation
    Allan Ngulube, Blessing Zambuko, Crispin O.M. Ntoto, Simbarashe Gift Mungazi, Derek Matsika
    Human Pathology Reports.2021; 26: 300557.     CrossRef
  • Anal Canal Duplication in an Adult Female—Case Report and Pathology Guiding
    Tudor Mateescu, Cristi Tarta, Paul Stanciu, Alis Dema, Fulger Lazar
    Medicina.2021; 57(11): 1205.     CrossRef
  • “The Innate Tail”: An Unusual Cause of Rectal Bleeding in an Adult Male
    Sujit Padmanabhan Nair, Sanjay Chandnani, Prasanta Debnath, Pravin M. Rathi, Parmeshwar Junare, Vinay Zanwar, Sangeeta Kini
    GE - Portuguese Journal of Gastroenterology.2021; 28(5): 349.     CrossRef
  • Robotic approach to large tailgut cyst with malignant transformation: A case report
    Alessandra Marano, Maria Carmela Giuffrida, Chiara Peluso, Valentina Testa, Paolo Bosio, Felice Borghi
    International Journal of Surgery Case Reports.2020; 77: S57.     CrossRef
  • Laparoscopic resection of a neuroendocrine tumor that almost fully replaced tailgut cysts: a case report
    Keita Kodera, Seiichiro Eto, Nei Fukasawa, Wataru Kai, Tomo Matsumoto, Tsuyoshi Hirabayashi, Hidejiro Kawahara, Nobuo Omura
    Surgical Case Reports.2020;[Epub]     CrossRef
  • Retrorectal tumors: Case report and review of literature
    Giorgio La Greca, Giovanni Trombatore, Guido Basile, Pietro Conti
    International Journal of Surgery Case Reports.2020; 77: 726.     CrossRef
  • A Tailgut Cyst in the Ischiorectal Fossa—A Case Report—
    Ryo INADA, Eri KURODA, Ayako WATANABE, Toshiaki TOSHIMA, Kazuhide OZAKI, Yuichi SHIBUYA, Manabu MATSUMOTO, Jun IWATA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2020; 81(9): 1866.     CrossRef
  • Tailgut Cyst, Report of 24 Cases Single Center Experience
    Han Deok Kwak, Chang Hyun Kim
    Annals of Coloproctology.2019; 35(5): 227.     CrossRef
Rectourethral Fistula: Systemic Review of and Experiences With Various Surgical Treatment Methods
Ji Hye Choi, Byeong Geon Jeon, Sang-Gi Choi, Eon Chul Han, Heon-Kyun Ha, Heung-Kwon Oh, Eun Kyung Choe, Sang Hui Moon, Seung-Bum Ryoo, Kyu Joo Park
Ann Coloproctol. 2014;30(1):35-41.   Published online February 28, 2014
DOI: https://doi.org/10.3393/ac.2014.30.1.35
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AbstractAbstract PDF
Purpose

A rectourethral fistula (RUF) is an uncommon complication resulting from surgery, radiation or trauma. Although various surgical procedures for the treatment of an RUF have been described, none has gained acceptance as the procedure of choice. The aim of this study was to review our experience with surgical management of RUF.

Methods

The outcomes of 6 male patients (mean age, 51 years) with an RUF who were operated on by a single surgeon between May 2005 and July 2012 were assessed.

Results

The causes of the RUF were iatrogenic in four cases (two after radiation therapy for rectal cancer, one after brachytherapy for prostate cancer, and one after surgery for a bladder stone) and traumatic in two cases. Fecal diversion was the initial treatment in five patients. In one patient, fecal diversion was performed simultaneously with definitive repair. Four patients underwent staged repair after a mean of 12 months. Rectal advancement flaps were done for simple, small fistula (n = 2), and flap interpositions (gracilis muscle flap, n = 2; omental flap, n = 1) were done for complex or recurrent fistulae. Urinary strictures and incontinence were observed in patients after gracilis muscle flap interposition, but they were resolved with simple treatments. The mean follow-up period was 28 months, and closure of the fistula was achieved in all five patients (100%) who underwent definitive repairs. The fistula persisted in one patient who refused further definitive surgery after receiving only a fecal diversion.

Conclusion

Depending on the severity and the recurrence status of RUF, a relatively simple rectal advancement flap repair or a more complex gracilis muscle or omental flap interposition can be used to achieve closure of the fistula.

Citations

Citations to this article as recorded by  
  • The Uroplastic Approach to Complex Rectourethral Fistula Repair: Indications, Technique, Results
    Erin Brush, J. Andres Hernandez, Ann Marie Flusché, Nicholas C. Oleck, Hani I. Naga, Victoria Wickenheisser, Joshua P. Hayden, Christopher R. Mantyh, Andrew C. Peterson, Detlev Erdmann
    Plastic and Reconstructive Surgery - Global Open.2025; 13(4): e6662.     CrossRef
  • Complex case of granulomatosis with polyangiitis involving the urethra and prostate causing outflow obstruction and ano-urethral fistula
    Mustafa Rashid, Adam Cox
    Journal of Clinical Urology.2024; 17(1): 89.     CrossRef
  • A rare case of fatal rectal perforation and sepsis following traumatic urinary catheterization
    Darshan Sitharthan, Paul Sved
    Urology Case Reports.2024; 54: 102706.     CrossRef
  • Gracilis muscle interposition for complex perineal fistulas: A systematic review and meta‐analysis of the literature
    Zoe Garoufalia, Rachel Gefen, Sameh Hany Emile, Emanuela Silva‐Alvarenga, Nir Horesh, Michael R. Freund, Steven D. Wexner
    Colorectal Disease.2023; 25(4): 549.     CrossRef
  • Outcomes of gracilis muscle interposition for rectourethral fistulas caused by treatment of prostate cancer
    S. H. Emile, N. Horesh, V. Strassmann, Z. Garoufalia, R. Gefen, P. Zhou, E. Ray-Offor, G. Dasilva, S. D. Wexner
    Techniques in Coloproctology.2023; 27(10): 937.     CrossRef
  • Case report on a rare complication after transanal total mesorectal excision (TaTME) for rectal malignancy vesicorectal fistula
    Sapphire Melody Ho, Kishore Rajaguru, Jing Yu Ng, Choon Sheong Seow
    International Journal of Surgery Case Reports.2023; 105: 108009.     CrossRef
  • Laparoscopic repair of acquired rectourethral fistula by vesical peritoneal flap
    Christian Mouawad, Elie El Helou, Houssam Dahboul, Rhea Akel, Bilal Chamaa, Rany Aoun, Serge Kassar, Michael Osseis, Roger Noun, Ghassan Chakhtoura
    Asian Journal of Endoscopic Surgery.2023; 16(4): 814.     CrossRef
  • Pelvic Extirpative Surgery for the “End-Stage Irradiated Bladder”
    Nikolas Moring, Seamus Barrett, Andrew C. Peterson, Brian M. Inouye
    Cancers.2023; 15(17): 4238.     CrossRef
  • Radiation-induced recto-urinary fistula: A dreaded complication with devastating consequences
    Kyeong Ri Yu, Lucas Keller-Biehl, Leon Smith-Harrison, Sarah Z. Hazell, William R. Timmerman, Jeannie F. Rivers, Thomas A. Miller
    Surgery in Practice and Science.2023; 15: 100216.     CrossRef
  • Gracilis muscle flap combined with a laparoscopic transabdominal approach is effective in the treatment of post-prostatectomy rectourethral fistula: A case report
    Tomohiro Takeda, Tatsuya Shonaka, Chikayoshi Tani, Toshihiko Hayashi, Hidehiro Kakizaki, Yasuo Sumi
    International Journal of Surgery Case Reports.2022; 92: 106856.     CrossRef
  • Effectiveness of York-Mason Procedure for a Refractory Rectourethral Fistula that Relapsed after Repair by a Perineal Approach:A Case Report
    Masatsugu Kojima, Toru Miyake, Tomoyuki Ueki, Tomoharu Shimizu, Masaji Tani
    Nippon Daicho Komonbyo Gakkai Zasshi.2022; 75(6): 297.     CrossRef
  • Robotic-Assisted Lower Genitourinary Tract Reconstruction
    Alex J. Xu, Kirtishri Mishra, Yeonsoo S. Lee, Lee Cheng Zhao
    Urologic Clinics of North America.2022; 49(3): 507.     CrossRef
  • Rectal Perforation During Pelvic Surgery
    Bernardo Rocco, Gaia Giorgia, Assumma Simone, Calcagnile Tommaso, Sangalli Mattia, Terzoni Stefano, Eissa Ahmed, Bozzini Giorgio, Bernardino De Concilio, Antonio Celia, Micali Salvatore, Maria Chiara Sighinolfi
    European Urology Open Science.2022; 44: 54.     CrossRef
  • Preventing Rectourethral Fistula Recurrence With Gracilis Flap
    Keon Min Park, Yenny Y. Rosli, Allen Simms, Rachel Lentz, Deepak R. Bharadia, Benjamin Breyer, William Y. Hoffman
    Annals of Plastic Surgery.2022; 88(4): S316.     CrossRef
  • Validating the Martini Staging System for Rectourethral Fistula: A Meta-Analysis of Postoperative Outcomes
    Kirtishri Mishra, Amr Mahran, Bissan Abboud, Laura Bukavina, Ahmed Elshafei, Al Ray, Austin Fernstrum, Rayan Abboud, Mohammed Elgammal, Lee C. Zhao, Shubham Gupta
    Urology.2021; 147: 299.     CrossRef
  • Rectourethral Fistula Repair With Endorectal Advancement Flap and Implantation of Biologic Mesh
    Tae David Kim, Gerald Gantt, Kunal Kochar, Slawomir Marecik, John J. Park
    Diseases of the Colon & Rectum.2021; 64(1): e1.     CrossRef
  • Clinical outcome and quality of life after gracilis muscle transposition for fistula closure over a 10-year period
    M. Grott, A. Rickert, S. Hetjens, P. Kienle
    International Journal of Colorectal Disease.2021; 36(3): 569.     CrossRef
  • Urorectal fistula repair using different approaches: operative results and quality of life issues
    Javier C. Angulo, Ignacio Arance, Yannick Apesteguy, João Felicio, Natália Martins, Francisco E. Martins
    International braz j urol.2021; 47(2): 399.     CrossRef
  • Robotic transanal rectourethral fistula repair—a video vignette
    Thomas Surya Suhardja, Belinda Errington, Amirala Khalessi, Kim‐Chi Phan‐Thien
    Colorectal Disease.2021; 23(5): 1275.     CrossRef
  • Tratamiento de las fístulas uretrorrectales tras prostatectomía radical mediante la interposición de material biológico vía perineal
    J.U. Juan Escudero, F. Villalba Ferrer, M. Ramos de Campos, M. Fabuel Deltoro, M.J. García Coret, F. Sánchez Ballester, I. Povo Martín, Y. Pallas Costa, P. Pardo Duarte, J. García Ibañez, A. Monzó Cataluña, K. Rechi Sierra, C. Juliá Romero, E. López Alcin
    Actas Urológicas Españolas.2021; 45(5): 398.     CrossRef
  • Treatment for rectourethral fistulas after radical prostatectomy with biological material interposition through a perineal access
    J.U. Juan Escudero, F. Villaba Ferrer, M. Ramos de Campos, M. Fabuel Deltoro, M.J. Garcia Coret, F. Sanchez Ballester, I. Povo Martín, Y. Pallas Costa, P. Pardo Duarte, J. García Ibañez, A. Monzó Cataluña, K. Rechi Sierra, C. Juliá Romero, E. Lopez Alcina
    Actas Urológicas Españolas (English Edition).2021; 45(5): 398.     CrossRef
  • A Curious Case of Rectal Ejaculation
    Frank L Ventura, Christopher M Nguyen, Alexander Dang, Michelle Baliss, Lindsay K Sonstein
    Cureus.2021;[Epub]     CrossRef
  • Adverse Features of Rectourethral Fistula Requiring Extirpative Surgery and Permanent Dual Diversion: Our Experience and Recommendations
    Francisco E. Martins, João Felicio, Tiago Ribeiro Oliveira, Natália Martins, Vítor Oliveira, Artur Palmas
    Journal of Clinical Medicine.2021; 10(17): 4014.     CrossRef
  • Fistelchirurgie
    C. M. Rosenbaum, M. W. Vetterlein, M. Fisch
    Der Urologe.2020; 59(4): 489.     CrossRef
  • Conservative treatment of rectovesical fistula after leakage following laparoscopic radical resection of rectal cancer
    Shunli Yan, Huimin Sun, Zhaohui Li, Shuaifeng Liu, Baowei Han
    Journal of International Medical Research.2020;[Epub]     CrossRef
  • A rare case of tubercular recto-prostatic urethral fistula with tuberculous orchitis
    Niramya Pathak, Mohan Keshavamurthy, Karthik Rao, Shakir Tabrez, Mohan Balaiah Ashwathaiya, Premakumar Krishnappa
    Urology Case Reports.2020; 33: 101355.     CrossRef
  • Minimally invasive perineal redo surgery for rectovesical and rectovaginal fistulae: A case series
    A.A.J. Grüter, S.E. Van Oostendorp, L.J.H. Smits, M. Kusters, M. Özer, J.A. Nieuwenhuijzen, J.B. Tuynman
    International Journal of Surgery Case Reports.2020; 77: 733.     CrossRef
  • Iatrogenic bowel injury (early vs delayed)
    Elyse Leevan, Joseph C. Carmichael
    Seminars in Colon and Rectal Surgery.2019; 30(3): 100688.     CrossRef
  • Management of acquired rectourethral fistulas in adults
    Shulian Chen, Rang Gao, Hong Li, Kunjie Wang
    Asian Journal of Urology.2018; 5(3): 149.     CrossRef
  • The Place of Transanal Endoscopic Surgery in the Treatment of Rectourethral Fistula
    Xavier Serra-Aracil, Meritxell Labró-Ciurans, Laura Mora-López, Jesús Muñoz-Rodríguez, Raúl Martos-Calvo, Joan Prats-López, Salvador Navarro-Soto
    Urology.2018; 111: 139.     CrossRef
  • A Case of Rectourethal Fistula Caused by a Urethral Foreign Body
    Nobuyuki OKAMOTO, Norimitsu SHIMADA, Raita YANO, Yusuke WATADANI, Hiroki OHGE, Taijiro SUEDA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(8): 1900.     CrossRef
  • Diagnosis and Treatments for Vesico-Enteric Fistulas: a 2017 Current Review
    Justin W. Fincher, Ehab Eltahawy
    Current Bladder Dysfunction Reports.2017; 12(3): 212.     CrossRef
  • Management of radiation-induced rectovesical fistula in a woman using ileum
    Qiqi Mao, Jindan Luo, Jiajie Fang, Hai Jiang
    Medicine.2017; 96(46): e8553.     CrossRef
  • Treatment Efficacy of Different Surgical Procedures for Postoperative Residual Rectourethral Fistula Following Anoplasty
    Tingchong Zhang, Wei Chen, Wenbo Pang, Chunhui Peng, Yajun Chen, Jinzhe Zhang
    International Surgery.2017; 102(11-12): 560.     CrossRef
  • Rectourethral fistula reconstruction in elderly patients
    Nirmish Singla, Allen F. Morey
    Current Opinion in Urology.2016; 26(2): 171.     CrossRef
  • Rectourethral fistula: A challenging management problem
    Michael Stamatakos, K. Ntzeros, G. Christis, F. Anyfanti, S. Sotirianakos
    Hellenic Journal of Surgery.2016; 88(4): 257.     CrossRef
  • Diagnosis and Surgical Management of Uroenteric Fistula
    Harcharan S. Gill
    Surgical Clinics of North America.2016; 96(3): 583.     CrossRef
  • Minimally invasive treatment of rectovesical fistula: A case report
    Alba Manuel Vázquez, Francisco Javier Jiménez Miramón, José Luis Ramos Rodríguez, José María Jover Navalón
    Revista Española de Enfermedades Digestivas.2016;[Epub]     CrossRef
  • Abordaje perineal de fístulas rectouretrales tras prostatectomía radical laparoscópica
    J. Guimerà-García, E. Pieras-Ayala, J.P. Burgués-Gasion, M. Ozonas-Moragues, V. Tubau-Vidaña, P. Piza-Reus
    Actas Urológicas Españolas.2016; 40(2): 119.     CrossRef
  • Unusual Case of Urethrorectal Fistula in Adolescence in a Patient with a History of Congenital Anorectal Malformation
    Constantinos Nastos, Ira Sotirova, Athanasios Papatsoris, Andreas Skolarikos, Ioannis Papaconstantinou, Athanasios Dellis
    Journal of Endourology Case Reports.2016; 2(1): 24.     CrossRef
  • Perineal approach for rectourethral fistulae after radical laparoscopic prostatectomy
    J. Guimerà García, E. Pieras Ayala, J.P. Burgués Gasion, M. Ozonas Moragues, V. Tubau Vidaña, P. Piza Reus
    Actas Urológicas Españolas (English Edition).2016; 40(2): 119.     CrossRef
  • Testicular Interposition Flap for Repair of Perineal Urinary Fistulae: A Novel Surgical Technique
    Valary T. Raup, Jairam R. Eswara, Stephen D. Marshall, Steven B. Brandes
    Case Reports in Urology.2015; 2015: 1.     CrossRef
  • Fístulas recto-uretrales adquiridas: etiopatogenia, diagnóstico y opciones terapéuticas
    Carlos Cerdán Santacruz, Javier Cerdán Miguel
    Cirugía Española.2015; 93(3): 137.     CrossRef
  • A review of rectal toxicity following permanent low dose-rate prostate brachytherapy and the potential value of biodegradable rectal spacers
    M E Schutzer, P F Orio, M C Biagioli, D A Asher, H Lomas, D Moghanaki
    Prostate Cancer and Prostatic Diseases.2015; 18(2): 96.     CrossRef
  • Acquired Recto-Uretral Fistulas: Etiopathogenesis, Diagnosis and Therapeutic Options
    Carlos Cerdán Santacruz, Javier Cerdán Miguel
    Cirugía Española (English Edition).2015; 93(3): 137.     CrossRef
  • Surgical Treatment of Rectourinary Fistulas: Review of the Literature
    Alessandro Crestani, Fabrizio Dal Mora
    Urologia Journal.2015; 82(1): 30.     CrossRef
  • Individualized Treatment for a Rectourethral Fistula: Rare Complications
    In Ja Park
    Annals of Coloproctology.2014; 30(1): 7.     CrossRef
Bezoar-induced Small Bowel Obstruction
Se Heon Oh, Hwan Namgung, Mi Hyun Park, Dong-Guk Park
J Korean Soc Coloproctol. 2012;28(2):89-93.   Published online April 30, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.2.89
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AbstractAbstract PDF
Purpose

The aim of this study was to observe the clinical features of a bezoar-induced small bowel obstruction and to investigate the role of abdominal computed tomography (CT) in establishing the diagnosis.

Methods

We retrospectively reviewed 20 cases of bezoar-induced small bowel obstruction in our hospital from 1996 to 2010.

Results

Thirteen patients (65%) had a history of abdominal surgery. Nine patients (45%) were diagnosed with a bezoar before surgery, seven patients were diagnosed by using abdominal CT, and two patients were diagnosed with a small bowel series. Abdominal CT was performed in 15 patients, and the diagnostic accuracy was 47% (7/15). Surgery revealed ten bezoars in the jejunum and 11 in the ileum. Two patients had bezoars found concurrently in the stomach. Spontaneous removal took place in two patients. An enterotomy and bezoar extraction was performed in 15 patients. Fragmentation and milking, a small bowel resection, and a Meckel's diverticulectomy were performed in one patient each. Early operative treatment was possible (P = 0.036) once the bezoar had been diagnosed by using abdominal CT. There tended to be fewer postoperative complications in patients who were diagnosed with a bezoar by using abdominal CT, but the result was not statistically significant (P = 0.712).

Conclusion

A preoperative diagnosis of bezoar-induced small bowel obstruction by using clinical features was difficult. Increased use of abdominal CT led to a more accurate diagnosis and to earlier surgery for bezoar-induced small bowel obstructions, thereby reducing the rate of complications.

Citations

Citations to this article as recorded by  
  • Small intestinal obstruction caused by the gastric bezoars in elderly diabetic patients: A case report
    Yifan Huang, Jie Meng, Shuo Zhang
    International Journal of Surgery Case Reports.2025; 127: 110761.     CrossRef
  • Small bowel obstruction caused by dehydrated apple ingestion: the challenges of preoperative radiological diagnosis and surgical management
    Rama Hala Gamal Mikhail, Siobhan McKay, Mark Goodwin, Osamu Yoshino
    BMJ Case Reports.2024; 17(2): e256710.     CrossRef
  • Small bowel obstruction due to a meat bolus bezoar: the second case report in literature
    Ammar Albostani, Fadi Kfelati, Wafaa Alsaadi, Rufaida Ahmad Faraman, Aasem Farman
    Annals of Medicine & Surgery.2024; 86(2): 1139.     CrossRef
  • Endoscopic lithotripsy combined with drug lithotripsy vs. drug lithotripsy for the treatment of phytobezoars: analysis of 165 cases
    Xiao Zheng, Bin Qiu, Xiao-wei Jin, Lin-na Liu, Peng Wang, Hai-jing Yu, Juan Zhang, Wen-jing Geng, Rui Wang, Hua Liu
    Surgical Endoscopy.2024; 38(5): 2788.     CrossRef
  • A Rare Case of Gastric Phytobezoar (Diospyrobezoar) in a Healthy Adult
    Ahmed M Odeh, Ahmed A Alkhalifa, Mohammed A AlHajji, Alwayah J Alahmed, Jawad H Alsalman, Abdulrahman M AlMulhem, Mohammed S AlGhadeer, Ezzeddin Kurdi, Fatima S Albader, Abdulmohsen Alsuwaigh, Mohammad A Khan
    Cureus.2024;[Epub]     CrossRef
  • Evaluation of the location, number and diameter of bezoars in patients with a history of previous gastrointestinal surgery
    Ali Muhtaroğlu, Merve Yiğit, Hakan Demir, Uğur Dülger, Muhammed Doğangün, İbrahim Furkan Küçük, Fatih Altintoprak
    European Journal of Trauma and Emergency Surgery.2023; 49(4): 1783.     CrossRef
  • Diagnosis of a rare pediatric case of small-bowel obstruction secondary to a phytobezoar in a Meckel’s diverticulum aided by point-of-care ultrasound
    Anastasia Zello, David Kirschner
    Canadian Journal of Emergency Medicine.2023; 25(3): 244.     CrossRef
  • Phytobezoar-Induced Mechanical Ileus and Incipient Intussusception: A Case Report
    Christoforos S. Kosmidis, Chrysi Maria Mystakidou, Nikolaos Varsamis, Charilaos Koulouris, Christina Sevva, Konstantina Papadopoulou, Christina Michael, Nikolaos Iason Katsios, Vasiliki Theodorou, Petrina Miltiadous, Konstantinos Papadopoulos, Konstantino
    Medicina.2023; 59(7): 1227.     CrossRef
  • Small Bowel Obstruction by a Phytobezoar in a Patient With Previous Antrectomy and Billroth II Reconstruction
    Alberto Abreu da Silva, Jéssica Ricardo, Andreia Ferreira, Diogo Sousa, José Augusto Martins
    Cureus.2023;[Epub]     CrossRef
  • Intestinal bezoar aggravated by hypomotility of ischemic small intestine: A case report
    Ting‐Hsuan Chiang, Hsing‐Jung Yeh, Chun‐Chao Chang, Kuan‐Chieh Fang
    Advances in Digestive Medicine.2022; 9(1): 52.     CrossRef
  • Khat induced bezoar; a rare cause of small bowel obstruction:a case report
    Badhaasaa Beyene, Burka Mohammadsani, Minewor Abdlhadi, Kedest Getachew, Hatae Ahmedin
    International Journal of Surgery Case Reports.2022; 91: 106811.     CrossRef
  • Impending perforation near ileocecal junction due to phytobezoar impaction and intraluminal polyp: a case report
    Mehwish Mooghal, Asrar Ahmad, Adnan Safi, Wajiha Khan, Naveed Ahmad
    Journal of Medical Case Reports.2022;[Epub]     CrossRef
  • Inflammation and Obstruction of the Small Intestine Due to Phytobezoar: a Case Report
    Van Trung Hoang, The Huan Hoang, Ngoc Trinh Thi Pham, Vichit Chansomphou, Duc Thanh Hoang
    SN Comprehensive Clinical Medicine.2022;[Epub]     CrossRef
  • Small bowel obstruction secondary to a plastic bezoar
    Sarah Li-Ling Goh, Christopher Steen, Enoch Wong, Monique Scott
    BMJ Case Reports.2022; 15(11): e251438.     CrossRef
  • Small Bowel Obstruction Caused by an Aggressive Weight Loss Diet in a Patient With No Predisposing Factors
    Samara C Hassranah, Aryaa Ramnarine, Sangeeta Parbhu, Vijay Naraynsingh
    Cureus.2022;[Epub]     CrossRef
  • Hematological manifestations of trichobezoar in a child
    S.O. Nykytyuk, R.V. Bodnarchuk, O.R. Boyarchuk, S.S. Levenets, M.V. Dolynna
    CHILD`S HEALTH.2022; 16(6): 435.     CrossRef
  • Clinical characteristics and indications for surgery for bezoar-induced small bowel obstruction
    Shuai Wang, Xiaohui Yang, Yixiong Zheng, Yulian Wu
    Journal of International Medical Research.2021;[Epub]     CrossRef
  • When eating makes you sick – Gastric stump obstruction caused by a phytobezoar. A case report and literature review
    Mariana Claro, Daniel Costa Santos, Alberto Abreu Silva, Cláudia Deus, João Grilo, Diogo Sousa, José Augusto Martins
    International Journal of Surgery Case Reports.2021; 79: 263.     CrossRef
  • Phytobezoar: A train can hide another
    Atef Mejri, Emna Trigui
    International Journal of Surgery Case Reports.2021; 81: 105814.     CrossRef
  • From Blocking Shots to Blocking GI Transit, This Professional Basketball Player Does It All: A Case Report on Small Bowel Obstruction
    Emily L. DeMaio, Richard C. Jarvis, Jessica A. Cohen, Courtney N. Gleason, Aristomenis K. Exadaktylos
    Case Reports in Medicine.2021; 2021: 1.     CrossRef
  • Intestinal Obstruction Secondary to Multiple Gastrointestinal phytobezoars, A Rare presentation
    Abdullah G. Alsahwan, Ameen M. Almarhoon, Jihad AlSafwani, Hanan Alsahwan, Neamat Alturki
    International Journal of Surgery Case Reports.2021; 83: 106004.     CrossRef
  • Bezoar as a cause of jejunal afferent loop mass after pylorus preserving pancreaticoduodedectomy: A case report
    Woo Yong Lee
    International Journal of Surgery Case Reports.2021; 85: 106177.     CrossRef
  • A rare giant gastric trichobezoar in a young female patient: Case report and review of the literature
    Dimitra G. Delimpaltadaki, Ioannis G. Gkionis, Mathaios E. Flamourakis, Andreas F. Strehle, Emmanouil N. Bachlitzanakis, Michail I. Giakoumakis, Manousos S. Christodoulakis, Konstantinos G. Spiridakis
    Clinical Case Reports.2021;[Epub]     CrossRef
  • A case series of intestinal obstruction secondary to shiitake mushroom intake during Chinese New Year
    Gaik Huey Ng, Li Ying Teoh, Mei Sze Teh, Suniza Jamaris, Mee Hoong See
    Journal of Surgical Case Reports.2020;[Epub]     CrossRef
  • Clinical Case of a Patient with Small Bowel Obstruction and Multiple Diospirobesoaras of the Gastrointestinal Tract
    A. S. Harutyunyan, V. D. Levitsky, V. V. Kiselev, P. A. Yartsev, A. V. Vodyasov, N. V. Shavrina
    Russian Sklifosovsky Journal "Emergency Medical Care".2020; 9(2): 281.     CrossRef
  • Adhesive small bowel obstruction – an update
    Jia Wei Valerie Tong, Pravin Lingam, Vishalkumar Girishchandra Shelat
    Acute Medicine & Surgery.2020;[Epub]     CrossRef
  • Intestinal obstruction by a phytobezoar in a patient with a history of gastroplasty
    Luiz de Abreu Junior, Gustavo Garcia Marques, Ingredy Tavares da Silva, Flávia Munhos Granja, Marcelo Zindel Salem
    Radiologia Brasileira.2019; 52(2): 133.     CrossRef
  • Parsnip phytobezoar causing small bowel obstruction
    Denise I. Garcia, William Taylor Head, Aaron P. Lesher
    Journal of Pediatric Surgery Case Reports.2019; 47: 101227.     CrossRef
  • Clinics in diagnostic imaging (198)
    YQA Soon, HM Low, CWT Huey, GKL Wansaicheong
    Singapore Medical Journal.2019; 60(8): 397.     CrossRef
  • When a cure becomes the pathology: mechanical bowel obstruction due to herbal pharmacobezoar. A case report with review of literature
    Saurabh Gandhi, Eham Arora, Ajay Bhandarwar, Arun Patil, Amol Wagh, Shubham Gupta
    Clinical Journal of Gastroenterology.2018; 11(5): 396.     CrossRef
  • An unusual cause of small bowel obstruction due to an ingested mango seed: a case report
    A. R. Fernando, R. Bulathsinghela, D. N. Samarasekera
    BMC Research Notes.2017;[Epub]     CrossRef
  • Small Bowel Obstruction Caused by Aloe vera Bezoars: A Case Report
    In Taik Hong, Jae Myung Cha, Hye Jin Ki, Min Seob Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeoun, Sung Il Choi
    The Korean Journal of Gastroenterology.2017; 69(5): 312.     CrossRef
  • Small bowel obstruction attributable to phytobezoar
    Nasrin Razavianzadeh, Behzad Foroutan, Farhad Honarvar, Mohammad Forozeshfard
    Oxford Medical Case Reports.2016; 2016(12): omw092.     CrossRef
  • Intestinal obstruction due to phytobezoars: An update
    Enis Dikicier
    World Journal of Clinical Cases.2015; 3(8): 721.     CrossRef
  • Bezoar-induced small bowel obstruction: Clinical characteristics and diagnostic value of multi-slice spiral computed tomography
    Pei-Yuan Wang
    World Journal of Gastroenterology.2015; 21(33): 9774.     CrossRef
  • Imaging differentiation of phytobezoar and small-bowel faeces: CT characteristics with quantitative analysis in patients with small- bowel obstruction
    Ya-Cheng Chen, Chang-Hsien Liu, Hsian-He Hsu, Chih-Yung Yu, Hong-Hau Wang, Hsiu-Lung Fan, Ran-Chou Chen, Wei-Chou Chang
    European Radiology.2015; 25(4): 922.     CrossRef
  • Ultrasonographic differentiation of bezoar from feces in small bowel obstruction
    Kyung Hoon Lee, Hyun Young Han, Hee Jin Kim, Hee Kyung Kim, Moon Soo Lee
    Ultrasonography.2015; 34(3): 211.     CrossRef
  • Bulbus psododivertikülde mide çıkış obstrüksiyonuna neden olan ve gastroskopi ile mideye alınması sonrası ileus gelişen bezoar: olgu sunumu ve literatürün gözden geçirilmesi (duodenal bezoar)
    Ahmet UYANIKOĞLU, Haşim NAR, Ahmet ŞEKER, Ferzan AYDIN, Yusuf YÜCEL, Necati YENİCE
    Endoskopi Gastrointestinal.2015; 23(2): 58.     CrossRef
  • Two cases of small bowel obstruction secondary to a swallowed potato
    E Castren, A Hakeem, N S Mahmood, K Aryal
    BMJ Case Reports.2015; 2015: bcr2015213744.     CrossRef
  • Phytobezoar: an unexpected cause of bowel obstruction in a pregnant woman with a history of Roux-en-Y gastric bypass
    Faustine Deront Bourdin, Antonio Iannelli, Jerôme Delotte
    Surgery for Obesity and Related Diseases.2014; 10(6): e49.     CrossRef
  • Bezoar: An unusual cause of intestinal obstruction
    K. Stratakis, A. Tsepelaki, E. Karallas, K. Koutsopoulos
    Hellenic Journal of Surgery.2014; 86(1): 29.     CrossRef
  • Intussusception caused by dried apricot: A case report
    Yana Puckett, Jon Nathan, Sharmila Dissanaike
    International Journal of Surgery Case Reports.2014; 5(12): 1254.     CrossRef
  • Acute small bowel obstruction in a girl, caused by a jejunal bezoar composed of textile fibers
    S. Zwaveling, D.C. van der Zee
    Journal of Pediatric Surgery Case Reports.2013; 1(8): 192.     CrossRef
  • Complications of Bezoar in Children: What Is New?
    Kam Lun Ellis Hon, Jean Cheng, Chung Mo Chow, Hon Ming Cheung, Kam Lau Cheung, Yuk Him Tam, Alexander K. C. Leung
    Case Reports in Pediatrics.2013; 2013: 1.     CrossRef
Reviews
Malignant disease, Rectal cancer,Colorectal cancer,Biomarker & risk factor
Multifunctional Indocyanine Green Applications for Fluorescence-Guided Laparoscopic Colorectal Surgery
Gyung Mo Son, Hong-min Ahn, In Young Lee, Gi Won Ha
Ann Coloproctol. 2021;37(3):133-140.   Published online June 9, 2021
DOI: https://doi.org/10.3393/ac.2021.05.07
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AbstractAbstract PDF
Indocyanine green (ICG) could be applied for multiple functions such as fluorescent tumor localization, fluorescence lymph node mapping (FLNM), and intraoperative angiography in colorectal cancer surgery. With the near-infrared (NIR) systems, colonoscopic ICG tattooing can be used to define the early colorectal cancer that cannot be easily distinguished through the serosal surface. The lymphatic pathways can be visualized under the NIR system when ICG is injected through the submucosal or subserosal layer around the tumor. Intraoperative ICG angiography can be applied to find a favorable perfusion segment before the colon transection. Although all fluorescence functions are considered essential steps in image-guided surgery, it is difficult to perform multifunctional ICG applications in a single surgical procedure at once because complex protocols could interfere with each other. Therefore, we review the multifunctional ICG applications for fluorescent tumor localization, FLNM, and ICG angiography. We also discuss the optimal protocol for fluorescence-guided colorectal surgery.

Citations

Citations to this article as recorded by  
  • Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment
    Yu-Hsiang Lee, Cheng-You Huang
    International Journal of Nanomedicine.2025; Volume 20: 327.     CrossRef
  • Comparison of a submucosal and subserosal approach in ICG-guided laparoscopic lymphadenectomy in gastric cancer patients: long-term outcomes of a phase 3 randomized clinical trial
    Qing Zhong, Zhi-Xin Shang-Guan, Zhi-Yu Liu, Dong Wu, Ze-Ning Huang, Hua-Gen Wang, Jun-Yun Chen, Jin-Xun Wu, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang
    International Journal of Surgery.2025; 111(3): 2558.     CrossRef
  • Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study
    Oscar MacCormac, Conor C. Horgan, Dale Waterhouse, Philip Noonan, Mirek Janatka, Richard Miles, Jaco Jacobs, Cameron Dockerill, Théo Trotouin, Alexis Schizas, Barbara Seeliger, Sebastien Ourselin, Michael Ebner, Tom Vercauteren, Jonathan Shapey
    Frontiers in Medical Technology.2025;[Epub]     CrossRef
  • Factors Affecting the Efficiency of Near-Infrared Indocyanine Green (NIR/ICG) in Lymphatic Mapping for Colorectal Cancer: A Systematic Review
    Irina Shevchenko, Dragos Serban, Ana Maria Dascalu, Laura Tribus, Catalin Alius, Bogdan Mihai Cristea, Andra Iulia Suceveanu, Daniel Voiculescu, Dan Dumitrescu, Florin Bobirca, Adrian Paul Suceveanu, Dragos Eugen Georgescu, Crenguta Sorina Serboiu
    Cureus.2024;[Epub]     CrossRef
  • Developments in the Use of Indocyanine Green (ICG) Fluorescence in Colorectal Surgery
    Shayan Khalafi, Cristina Botero Fonnegra, Ana Reyes, Vanessa W. Hui
    Journal of Clinical Medicine.2024; 13(14): 4003.     CrossRef
  • Clearly fluorescent delineating ER+ breast tumor incisal edge and identifying tiny metastatic tumor foci at high resolution
    Changle Li, Changyu Zhang, Wenkai Liu, Jia Liu, Wanying Ma, Chengyuan Lv, Zhuoran Xia, Yingchao Chen, Hua Gu, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
    Journal of Materials Chemistry B.2024; 12(29): 7135.     CrossRef
  • Carcinomembrane-Camouflaged Perfluorochemical Dual-Layer Nanopolymersomes Bearing Indocyanine Green and Camptothecin Effectuate Targeting Photochemotherapy of Cancer
    Yu-Hsiang Lee, Cai-Sin Chen
    ACS Biomaterials Science & Engineering.2024; 10(10): 6332.     CrossRef
  • Effect of Fluorescence Lymph Node Mapping on Improving Diagnostic Values of CT D3 Lymph Node Staging for Right-Sided Colon Cancer
    Gyung Mo Son, Tae Un Kim, Mi Sook Yun, ChangYeop Kim, In Young Lee, Su Bum Park, Dong-Hoon Shin, Gi Won Ha
    Cancers.2024; 16(20): 3496.     CrossRef
  • Optimal Indocyanine Green Dosage for Repetitive Angiography for Laparoscopic Colorectal Surgery
    Gyung Mo Son, Sang-Ho Park, Nam Su Kim, Mi Sook Yun, In Young Lee, Myeong-Sook Kwon, Tae Kyun Kim, Eun Hwa Lee, Eun Jung Hwang, Kwang-Ryul Baek
    Medicina.2024; 60(12): 1966.     CrossRef
  • The Colorectal Anastomosis: A Timeless Challenge
    Alexander A. Gaidarski III, Marco Ferrara
    Clinics in Colon and Rectal Surgery.2023; 36(01): 011.     CrossRef
  • Lymphatic flow mapping during colon cancer surgery using indocyanine green fluorescence imaging
    Kazuki Ueda, Hokuto Ushijima, Junichiro Kawamura
    Minimally Invasive Therapy & Allied Technologies.2023; 32(5): 233.     CrossRef
  • Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review
    Michael G. Fadel, Mosab Ahmed, Gianluca Pellino, Shahnawaz Rasheed, Paris Tekkis, David Nicol, Christos Kontovounisios, Erik Mayer
    Cancers.2023; 15(2): 455.     CrossRef
  • Engineered indocyanine green and PD-L1 inhibitors co-loaded perfluorochemical double-layered nanodroplets offer effective photoimmunotherapy against colorectal cancer
    Yu-Hsiang Lee, Uyen Nu Thu Pham
    Chemical Engineering Journal.2023; 460: 141819.     CrossRef
  • The primary application of indocyanine green fluorescence imaging in surgical oncology
    Zhang-Yi Dai, Cheng Shen, Xing-Qi Mi, Qiang Pu
    Frontiers in Surgery.2023;[Epub]     CrossRef
  • Lymphatic Mapping in Colon Cancer Depending on Injection Time and Tracing Agent: A Systematic Review and Meta-Analysis of Prospective Designed Studies
    Katharina Lucas, Nathaniel Melling, Anastasios D. Giannou, Matthias Reeh, Oliver Mann, Thilo Hackert, Jakob R. Izbicki, Daniel Perez, Julia K. Grass
    Cancers.2023; 15(12): 3196.     CrossRef
  • The Safe Values of Quantitative Perfusion Parameters of ICG Angiography Based on Tissue Oxygenation of Hyperspectral Imaging for Laparoscopic Colorectal Surgery: A Prospective Observational Study
    Gyung Son, Armaan Nazir, Mi Yun, In Lee, Sun Im, Jae Kwak, Sang-Ho Park, Kwang-Ryul Baek, Ines Gockel
    Biomedicines.2023; 11(7): 2029.     CrossRef
  • Intraoperative fluorescence mapping of lymph nodes in colon cancer
    Yu.A. Streltsov, M.A. Danilov, K.V. Shishin, A.V. Leontiev, A.B. Baychorov, V.V. Tsvirkun
    Endoscopic Surgery.2023; 29(4): 5.     CrossRef
  • Indocyanine green dye and its application in gastrointestinal surgery: The future is bright green
    Zavier Yongxuan Lim, Swetha Mohan, Sunder Balasubramaniam, Saleem Ahmed, Caroline Ching Hsia Siew, Vishal G Shelat
    World Journal of Gastrointestinal Surgery.2023; 15(9): 1841.     CrossRef
  • Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study
    Gyung Mo Son, Mi Sook Yun, In Young Lee, Sun Bin Im, Kyung Hee Kim, Su Bum Park, Tae Un Kim, Dong-Hoon Shin, Armaan M. Nazir, Gi Won Ha
    Cancers.2023; 15(20): 4927.     CrossRef
  • Fluorescence-guided colorectal surgery: applications, clinical results, and protocols
    Jin-Min Jung, In Ja Park, Eun Jung Park, Gyung Mo Son
    Annals of Surgical Treatment and Research.2023; 105(5): 252.     CrossRef
  • Advancements and challenges in minimally invasive surgery training among general-surgery residents in Thailand
    Gyung Mo Son
    Journal of Minimally Invasive Surgery.2023; 26(4): 178.     CrossRef
  • Preventing Anastomotic Leakage, a Devastating Complication of Colorectal Surgery
    Hyun Gu Lee
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • How Can We Improve the Tumor Response to Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer?
    Jeonghee Han
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Descenso en el valor de pulsioximetría tras administración intravenosa de verde de indocianina. Un artefacto no recogido en ficha técnica
    P. Rama-Maceiras, D. Ferrera Castro, E. Turrado Blanco, S. Albiñana Pérez
    Revista Española de Anestesiología y Reanimación.2022; 69(9): 608.     CrossRef
  • Safety considerations in laparoscopic surgery: A narrative review
    Brij Madhok, Kushan Nanayakkara, Kamal Mahawar
    World Journal of Gastrointestinal Endoscopy.2022; 14(1): 1.     CrossRef
  • Clinical Implication of Lateral Pelvic Lymph Node Metastasis in Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy
    In Ja Park
    The Ewha Medical Journal.2022; 45(1): 3.     CrossRef
  • Near-infrared fluorescence imaging guided surgery in colorectal surgery
    Sung Uk Bae
    World Journal of Gastroenterology.2022; 28(12): 1284.     CrossRef
  • Variant Sudeck’s Point Confirmed Using Indocyanine Green (ICG) Angiography
    Gyung Mo Son, In Young Lee, Shin Hoo Park
    Annals of Robotic and Innovative Surgery.2022; 3(1): 30.     CrossRef
  • Double-layered hand-sewn anastomosis: a valuable resource for the colorectal surgeon
    Cristopher Varela, Manar Nassr, Azharuddin Razak, Nam Kyu Kim
    Annals of Coloproctology.2022; 38(3): 271.     CrossRef
  • Current status and role of robotic approach in patients with low-lying rectal cancer
    Hyo Seon Ryu, Jin Kim
    Annals of Surgical Treatment and Research.2022; 103(1): 1.     CrossRef
  • Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets
    P. S. Russell, R. Velivolu, V. E. Maldonado Zimbrón, J. Hong, I. Kavianinia, A. J. R. Hickey, J. A. Windsor, A. R. J. Phillips
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Ileal long-segment ischemia after the unintended ligation of variant ileal branch during laparoscopic right hemicolectomy
    Gyung Mo Son, Tae Un Kim, Dong-Hoon Shin, Joo-Young Na, In Young Lee, Shin Hoo Park
    Journal of Minimally Invasive Surgery.2022; 25(3): 116.     CrossRef
  • Decrease in pulse oximetry value after intravenous administration of indocyanine green. An artifact not included in the data sheet
    P. Rama-Maceiras, D. Ferrera Castro, E. Turrado Blanco, S. Albiñana Pérez
    Revista Española de Anestesiología y Reanimación (English Edition).2022; 69(9): 608.     CrossRef
  • Direction of diagnosis and treatment improvement in colorectal cancer
    In Ja Park
    Journal of the Korean Medical Association.2022; 65(9): 540.     CrossRef
  • In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications
    Ahmed Refaat, May Lin Yap, Geoffrey Pietersz, Aidan Patrick Garing Walsh, Johannes Zeller, Blanca del Rosal, Xiaowei Wang, Karlheinz Peter
    Journal of Nanobiotechnology.2022;[Epub]     CrossRef
  • Multidisciplinary treatment strategy for early colon cancer
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Korean Medical Association.2022; 65(9): 558.     CrossRef
  • Robotic surgery for colorectal cancer
    Sung Uk Bae
    Journal of the Korean Medical Association.2022; 65(9): 577.     CrossRef
  • Intraoperative Indocyanine Green Imaging for the Evaluation of Blood Perfusion Area in Cancer of the Splenic Flexure With an Occluded Inferior Mesenteric Artery: A Report of Two Cases
    Ryo Takahashi, Nobuji Kouno, Takumi Furuya, Takahisa Fujikawa
    Cureus.2022;[Epub]     CrossRef
  • Current Status and Future of Robotic Surgery for Colorectal Cancer-An English Version
    Sung Uk Bae
    Journal of the Anus, Rectum and Colon.2022; 6(4): 221.     CrossRef
  • Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 203.     CrossRef
  • Lymph Node Cluster Dissection After Carbon Nanoparticles Injection Enhances the Retrieval Number in Colorectal Cancer
    Lu Liu, Xi Li, Yulin Hu, Jingyue Sun, Jielin Chen, Desheng Xiao, Wei Wu, Bin Xie
    Journal of Biomedical Nanotechnology.2022; 18(7): 1885.     CrossRef
  • Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
    Francesco Mainini, Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Marta Truffi, Fabio Corsi, Serena Mazzucchelli
    Pharmaceutics.2021; 13(12): 2000.     CrossRef
  • Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?
    Gyung Mo Son, In Young Lee, Yoon Suk Lee, Bong-Hyeon Kye, Hyeon-Min Cho, Je-Ho Jang, Chang-Nam Kim, Kil Yeon Lee, Suk-Hwan Lee, Jun-Gi Kim
    Annals of Coloproctology.2021; 37(6): 434.     CrossRef
Synthetic Versus Biological Mesh-Related Erosion After Laparoscopic Ventral Mesh Rectopexy: A Systematic Review
Andrea Balla, Silvia Quaresima, Sebastian Smolarek, Mostafa Shalaby, Giulia Missori, Pierpaolo Sileri
Ann Coloproctol. 2017;33(2):46-51.   Published online April 28, 2017
DOI: https://doi.org/10.3393/ac.2017.33.2.46
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AbstractAbstract PDF
Purpose

This review reports the incidence of mesh-related erosion after ventral mesh rectopexy to determine whether any difference exists in the erosion rate between synthetic and biological mesh.

Methods

A systematic search of the MEDLINE and the Ovid databases was conducted to identify suitable articles published between 2004 and 2015. The search strategy capture terms were laparoscopic ventral mesh rectopexy, laparoscopic anterior rectopexy, robotic ventral rectopexy, and robotic anterior rectopexy.

Results

Eight studies (3,956 patients) were included in this review. Of those patients, 3,517 patients underwent laparoscopic ventral rectopexy (LVR) using synthetic mesh and 439 using biological mesh. Sixty-six erosions were observed with synthetic mesh (26 rectal, 32 vaginal, 8 recto-vaginal fistulae) and one (perineal erosion) with biological mesh. The synthetic and the biological mesh-related erosion rates were 1.87% and 0.22%, respectively. The time between rectopexy and diagnosis of mesh erosion ranged from 1.7 to 124 months. No mesh-related mortalities were reported.

Conclusion

The incidence of mesh-related erosion after LVR is low and is more common after the placement of synthetic mesh. The use of biological mesh for LVR seems to be a safer option; however, large, multicenter, randomized, control trials with long follow-ups are required if a definitive answer is to be obtained.

Citations

Citations to this article as recorded by  
  • Feasibility and safety of biologic OviTex mesh in ventral mesh rectopexy: a prospective pilot study
    M. A. Boom, E. M. van der Schans, N. A. T. Wijffels, P. M. Verheijen, E. C. J. Consten
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Outcomes of laparoscopic ventral mesh rectopexy versus trans-vaginal repair in management of anterior rectocele, a randomized controlled trial
    A. Sanad, A. Sakr, H. Elfeki, W. Omar, W. Thabet, E. Fouda, E. Abdallah, S. A. Elbaz
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Treatment Outcomes of Laparoscopic Suture Rectopexy for Rectal Prolapse
    Takamichi Kudo, Taichi Yabuno, Natsuki Hoshino, Shunya Yamamoto, Yasuko Okutsu, Minoru Honma, Yasuhiro Shimizu
    Nihon Daicho Komonbyo Gakkai Zasshi.2025; 78(6): 262.     CrossRef
  • Ventral mesh rectopexy for recurrent rectal prolapse after Altemeier perineal proctosigmoidectomy: feasibility and outcomes
    Lukas Schabl, Tracy Hull, Kamil Erozkan, Ali Alipouriani, Kristen A. Ban, Scott R. Steele, Anna R. Spivak
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Treatment of complete rectal prolapse using the TEO® platform (transanal endoscopic operation) – a video vignette
    Antonio D'Urso, Alfonso Lapergola, Jacques Marescaux, Didier Mutter, Xavier Serra‐Aracil
    Colorectal Disease.2024; 26(4): 820.     CrossRef
  • Now is the time to establish a registry for mesh rectopexy
    Yui Kaneko, Corina Behrenbruch, James Keck
    ANZ Journal of Surgery.2024; 94(7-8): 1209.     CrossRef
  • Mesh-associated complications in minimally invasive ventral mesh rectopexy: a systematic review
    Gabriel Fridolin Hess, Fabio Nocera, Stephanie Taha-Mehlitz, Sebastian Christen, Marco von Strauss Und Torney, Daniel C. Steinemann
    Surgical Endoscopy.2024; 38(12): 7073.     CrossRef
  • Anatomic and functional results of ventral biological mesh rectopexy for posterior pelvic floor disorders
    F. Rogier-Mouzelas, F. Drissi, J. Podevin, E. Duchalais, G. Meurette
    Journal of Visceral Surgery.2023; 160(3): 188.     CrossRef
  • Building a Multidisciplinary Pelvic Floor Clinic: Why Bother?
    Alison Hainsworth, Linda Ferrari, Sachin Malde, Lucia Berry
    Seminars in Colon and Rectal Surgery.2023; 34(1): 100933.     CrossRef
  • Management of full thickness rectal prolapse
    Charlotte M. Rajasingh, Brooke H. Gurland
    Seminars in Colon and Rectal Surgery.2023; 34(1): 100938.     CrossRef
  • Résultats anatomiques et fonctionnels de la rectopexie ventrale avec renfort par bio-prothèse pour trouble de la statique rectale
    F. Rogier-Mouzelas, F. Drissi, J. Podevin, E. Duchalais, G. Meurette
    Journal de Chirurgie Viscérale.2023; 160(3): 203.     CrossRef
  • Evaluation of the Safety and Efficacy of Modified Laparoscopic Suture Rectopexy for Rectal Prolapse
    Rina Takahashi, Tetsuo Yamana, Risa Nishio, Kazuhiro Sakamoto, Shuko Nojiri, Kiichi Sugimoto
    Journal of the Anus, Rectum and Colon.2023; 7(2): 102.     CrossRef
  • Comparing the Outcomes and Complication Rates of Biologic vs Synthetic Meshes in Implant-Based Breast Reconstruction
    Nathan Makarewicz, David Perrault, Ayushi Sharma, Mohammed Shaheen, Jessica Kim, Christian Calderon, Brian Sweeney, Rahim Nazerali
    Annals of Plastic Surgery.2023; 90(5): 516.     CrossRef
  • Current diagnostic tools and treatment modalities for rectal prolapse
    Mustafa Oruc, Timucin Erol
    World Journal of Clinical Cases.2023; 11(16): 3680.     CrossRef
  • Moving from Laparoscopic Synthetic Mesh to Robotic Biological Mesh for Ventral Rectopexy: Results from a Case Series
    Farouk Drissi, Fabien Rogier-Mouzelas, Sebastian Fernandez Arias, Juliette Podevin, Guillaume Meurette
    Journal of Clinical Medicine.2023; 12(17): 5751.     CrossRef
  • Robotic mesh rectopexy for rectal prolapse: The Geneva technique—A video vignette
    Jeremy Meyer, Emilie Liot, Vaihere Delaune, Alexandre Balaphas, Bruno Roche, Guillaume Meurette, Frédéric Ris
    Colorectal Disease.2023; 25(12): 2469.     CrossRef
  • The international variability of surgery for rectal prolapse
    Jesse K Kelley, Edward R Hagen, Brooke Gurland, Andrew RL Stevenson, James W Ogilvie
    BMJ Surgery, Interventions, & Health Technologies.2023; 5(1): e000198.     CrossRef
  • Trends in the surgical management of rectal prolapse: An Asian experience
    Yvonne Ying‐Ru Ng, Emile John Kwong Wei Tan, Cherylin Wan Pei Fu
    Asian Journal of Endoscopic Surgery.2022; 15(1): 110.     CrossRef
  • Mesh-related complications and recurrence after ventral mesh rectopexy with synthetic versus biologic mesh: a systematic review and meta-analysis
    E. M. van der Schans, M. A. Boom, M. El Moumni, P. M. Verheijen, I. A. M. J. Broeders, E. C. J. Consten
    Techniques in Coloproctology.2022; 26(2): 85.     CrossRef
  • Case series of mesh migration after rectopexy surgery for rectal prolapse
    Omar Marghich, Benjamin Benichou, Efoé-Ga Yawod Olivier Amouzou, Alexandre Maubert, Jean Hubert Etienne, Emmanuel Benizri, Mohamed Amine Rahili
    Journal of Surgical Case Reports.2022;[Epub]     CrossRef
  • Mesh erosion into the rectum after laparoscopic posterior rectopexy: A case report
    Shun Yamanaka, Tsuyoshi Enomoto, Shoko Moue, Yohei Owada, Yusuke Ohara, Tatsuya Oda
    International Journal of Surgery Case Reports.2022; 95: 107136.     CrossRef
  • Patients’ Perception of Long-term Outcome After Laparoscopic Ventral Mesh Rectopexy; Single Tertiary Center Experience
    Sandeep Singh, Keshara Ratnatunga, Roel Bolckmans, Naeem Iqbal, Oliver Jones, Ian Lindsey, Kim Gorissen, Chris Cunningham
    Annals of Surgery.2022; 276(5): e459.     CrossRef
  • Laparoscopic posterior rectopexy for complete rectal prolapse
    Senthil Kumar Ganapathi, Rajapandian Subbiah, Sathiyamoorthy Rudramurthy, Harish Kakkilaya, Parthasarathi Ramakrishnan, Palanivelu Chinnusamy
    Journal of Minimal Access Surgery.2022; 18(2): 295.     CrossRef
  • Polyvinylidene Fluoride Mesh Use in Laparoscopic Ventral Mesh Rectopexy in Patients with Obstructive Defecation Syndrome for the First Time
    Mahdi Alemrajabi, Behnam Darabi, Behrouz Banivaheb, Nima Hemmati, Sepideh Jahanian, Mohammad Moradi
    Journal of Investigative Surgery.2021; 34(10): 1083.     CrossRef
  • Ventral Rectopexy
    Kenneth C. Loh, Konstantin Umanskiy
    Clinics in Colon and Rectal Surgery.2021; 34(01): 062.     CrossRef
  • Thulium laser to endoscopically manage a rectal erosion and intraluminal mesh migration after ventral rectopexy
    Lorenzo Dioscoridi, Francesco Pugliese, Camillo Leonardo Bertoglio, Massimiliano Mutignani
    BMJ Case Reports.2021; 14(1): e235807.     CrossRef
  • Operationstechniken aus viszeralchirurgischer Sicht
    Mia Kim
    coloproctology.2021; 43(5): 314.     CrossRef
  • Suture rectopexy versus ventral mesh rectopexy for complete full-thickness rectal prolapse and intussusception: systematic review and meta-analysis
    H S Lobb, C C Kearsey, S Ahmed, R Rajaganeshan
    BJS Open.2021;[Epub]     CrossRef
  • Evaluation of a Novel Absorbable Mesh in a Porcine Model of Abdominal Wall Repair
    Alexei S. Mlodinow, Ketan Yerneni, Michelle E. Hasse, Todd Cruikshank, Markian J. Kuzycz, Marco F. Ellis
    Plastic and Reconstructive Surgery - Global Open.2021; 9(5): e3529.     CrossRef
  • Approaching Combined Rectal and Vaginal Prolapse
    Shannon Wallace, Brooke Gurland
    Clinics in Colon and Rectal Surgery.2021; 34(05): 302.     CrossRef
  • Troubles de la statique rectale de l’adulte. Syndrome du prolapsus rectal
    G. Lebreton, B. Menahem, A. Alves
    EMC - Gastro-entérologie.2021; 38(2): 1.     CrossRef
  • What happens to the biological prosthesis implanted during laparoscopic ventral mesh rectopexy? – a video vignette
    A. Di Leo, J. Andreuccetti
    Colorectal Disease.2020; 22(11): 1754.     CrossRef
  • Minimally invasive organ‐preserving approaches in the management of mesh erosion after laparoscopic ventral mesh rectopexy
    K. Ratnatunga, S. Singh, R. Bolckmans, S. Goodbrand, K. Gorissen, O. Jones, I. Lindsey, C. Cunningham
    Colorectal Disease.2020; 22(11): 1642.     CrossRef
  • Position statement by the Pelvic Floor Society on behalf of the Association of Coloproctology of Great Britain and Ireland on the use of mesh in ventral mesh rectopexy
    M. A. Mercer‐Jones, S. R. Brown, C. H. Knowles, A. B. Williams
    Colorectal Disease.2020; 22(10): 1429.     CrossRef
  • Outcome of laparoscopic ventral mesh rectopexy for full-thickness external rectal prolapse: a systematic review, meta-analysis, and meta-regression analysis of the predictors for recurrence
    Sameh Hany Emile, Hossam Elfeki, Mostafa Shalaby, Ahmad Sakr, Pierpaolo Sileri, Steven D. Wexner
    Surgical Endoscopy.2019; 33(8): 2444.     CrossRef
  • Ventral rectopexy with biological mesh for recurrent disorders of the posterior pelvic organ compartment
    M. Brunner, H. Roth, K. Günther, R. Grützmann, Klaus E. Matzel
    International Journal of Colorectal Disease.2019; 34(10): 1763.     CrossRef
  • Ventral rectopexy with biological mesh: short-term functional results
    M. Brunner, H. Roth, K. Günther, R. Grützmann, K. E. Matzel
    International Journal of Colorectal Disease.2018; 33(4): 449.     CrossRef
  • Short‐ and long‐term clinical and patient‐reported outcomes following laparoscopic ventral mesh rectopexy using biological mesh for pelvic organ prolapse: a prospective cohort study of 224 consecutive patients
    R. McLean, M. Kipling, E. Musgrave, M. Mercer‐Jones
    Colorectal Disease.2018; 20(5): 424.     CrossRef
  • Chirurgische Therapie des Rektumprolapses
    J. Hardt, P. Kienle
    coloproctology.2018; 40(3): 187.     CrossRef
  • Chirurgische Therapie beim Rektumprolaps
    A. J. Kroesen
    coloproctology.2018; 40(3): 181.     CrossRef
  • A Delorme operation for full‐thickness complete rectal prolapse – a video vignette
    W. Omar, H. Elfeki, M. A. Abdel‐Razik, M. Shalaby
    Colorectal Disease.2018; 20(12): 1156.     CrossRef
  • Consensus Statement of the Italian Society of Colorectal Surgery (SICCR): management and treatment of complete rectal prolapse
    G. Gallo, J. Martellucci, G. Pellino, R. Ghiselli, A. Infantino, F. Pucciani, M. Trompetto
    Techniques in Coloproctology.2018; 22(12): 919.     CrossRef
  • Erosion after laparoscopic ventral mesh rectopexy with a biological mesh
    M. Shalaby, A. Matarangolo, I. Capuano, G. Petrella, P. Sileri
    Techniques in Coloproctology.2017; 21(12): 985.     CrossRef
Original Article
Comparison of Short-term Surgical Outcomes between a Robotic Colectomy and a Laparoscopic Colectomy during Early Experience
Jin Yong Shin
J Korean Soc Coloproctol. 2012;28(1):19-26.   Published online February 29, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.1.19
  • 5,570 View
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AbstractAbstract PDF
Purpose

Although robotic surgery was invented to overcome the technical limitations of laparoscopic surgery, the role of a robotic (procto)colectomy (RC) for the treatment of colorectal cancer compared to that of a laparoscopic (procto)colectomy (LC) was not well defined during the initial adoption periods of both procedures. This study aimed to evaluate the efficacy and the safety of a RC for the treatment of colorectal cancer by comparing the authors' initial experiences with both a RC and a LC.

Methods

The first 30 patients treated by using a RC for colorectal cancer from July 2010 to March 2011 were compared with the first 30 patients treated by using a LC for colorectal cancer from December 2006 to June 2007 by the same surgeon. Perioperative variables and short-term outcomes were analyzed. In addition, the 30 RC and the 30 LC cases involved were divided into rectal cancer (n = 17 and n = 12, respectively), left-sided colon cancer (n = 7 and n = 12, respectively) and right-sided colon cancer (n = 6 and n = 6, respectively) for subgroup analyses.

Results

The mean operating times for RC and LC were significantly different at 371.8 and 275.5 minutes, respectively, but other perioperative parameters (rates of open conversion, numbers of retrieved lymph node, estimated blood losses, times to first flatus, maximal pain scores before discharge and postoperative hospital stays) were not significantly different in the two groups. Subgroup analyses showed that the mean operative times for a robotic proctectomy and a laparoscopic proctectomy were 396.5 and 298.8 minutes, respectively (P < 0.000). Postoperative complications occurred in five patients in the RC group and in six patients in the LC group (P = 0.739).

Conclusion

Although the short-term outcomes of a RC during its initial use were better than those of a LC (with the exception of operating time), differences were not found to be significantly different. On the other hand, the longer operation time of a robotic proctectomy compared to that of a laparoscopic proctectomy during the early period may be problematic.

Citations

Citations to this article as recorded by  
  • Comparison of Operative Time Between Robotic and Laparoscopic Low Anterior Resection for Rectal Cancer:A Systematic Review and Meta-Analysis
    Zhen Chen, Hua Yu, Huaping Wu, Pingxi Wang, Fanwei Zeng
    Surgical Innovation.2023; 30(3): 390.     CrossRef
  • Comparison of robotic right colectomy and laparoscopic right colectomy: a systematic review and meta-analysis
    Jianchun Zheng, Shuai Zhao, Wei Chen, Ming Zhang, Jianxiang Wu
    Techniques in Coloproctology.2023; 27(7): 521.     CrossRef
  • Robotic versus laparoscopic left colectomy: a systematic review and meta-analysis
    Leonardo Solaini, Antonio Bocchino, Andrea Avanzolini, Domenico Annunziata, Davide Cavaliere, Giorgio Ercolani
    International Journal of Colorectal Disease.2022; 37(7): 1497.     CrossRef
  • The Senhance Surgical System in Colorectal Surgery: A Systematic Review
    Tyler McKechnie, Jigish Khamar, Ryan Daniel, Yung Lee, Lily Park, Aristithes G. Doumouras, Dennis Hong, Mohit Bhandari, Cagla Eskicioglu
    Journal of Robotic Surgery.2022; 17(2): 325.     CrossRef
  • Comparison of Robotic and Laparoscopic Colectomies Using the 2019 ACS NSQIP Database
    Sara S. Soliman, Joseph Flanagan, Yun Hsiang Wang, Patricia B. Stopper, Rolando H. Rolandelli, Zoltan H. Nemeth
    Southern Medical Journal.2022; 115(12): 887.     CrossRef
  • Laparoscopic versus robotic right colectomy with extra-corporeal or intra-corporeal anastomosis: a systematic review and meta-analysis
    Pietro Genova, Gianni Pantuso, Calogero Cipolla, Mario Adelfio Latteri, Solafah Abdalla, Jean-Christophe Paquet, Francesco Brunetti, Nicola de’Angelis, Salomone Di Saverio
    Langenbeck's Archives of Surgery.2021; 406(5): 1317.     CrossRef
  • Urological and sexual function after robotic and laparoscopic surgery for rectal cancer: A systematic review, meta‐analysis and meta‐regression
    Ian Jun Yan Wee, Li‐Jen Kuo, James Chi‐Yong Ngu
    The International Journal of Medical Robotics and Computer Assisted Surgery.2021; 17(1): 1.     CrossRef
  • Comparison of clinical efficacy of robotic right colectomy and laparoscopic right colectomy for right colon tumor
    Quan Li Zhu, Xin Xu, Zhi Jian Pan
    Medicine.2021; 100(33): e27002.     CrossRef
  • Safety with Innovation in Colon and Rectal Robotic Surgery
    Deborah S. Keller, Christina N. Jenkins
    Clinics in Colon and Rectal Surgery.2021; 34(05): 273.     CrossRef
  • Robotic and robotic-assisted vs laparoscopic rectal cancer surgery: A meta-analysis of short-term and long-term results
    Guojun Tong, Guiyang Zhang, Zhaozheng Zheng
    Asian Journal of Surgery.2021;[Epub]     CrossRef
  • Robotic versus laparoscopic colorectal surgery in elderly patients in terms of recovery time: a monocentric experience
    Giuseppe Palomba, Vincenza Paola Dinuzzi, Marianna Capuano, Pietro Anoldo, Marco Milone, Giovanni Domenico De Palma, Giovanni Aprea
    Journal of Robotic Surgery.2021; 16(4): 981.     CrossRef
  • Robotic surgery for colorectal disease: review of current port placement and future perspectives
    Jong Lyul Lee, Hassan A. Alsaleem, Jin Cheon Kim
    Annals of Surgical Treatment and Research.2020; 98(1): 31.     CrossRef
  • The “Micro Hand S” Robot-Assisted Versus Conventional Laparoscopic Right Colectomy: Short-Term Outcomes at a Single Center
    Yijia Zeng, Guohui Wang, Yong Liu, Zheng Li, Bo Yi, Shaihong Zhu
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2020; 30(4): 363.     CrossRef
  • Robotic right colonic resection. Is the robotic third arm a game-changer?
    Alberto Mangano, Federico Gheza, Roberto Bustos, Mario Masrur, Francesco Bianco, Eduardo Fernandes, Valentina Valle, Pier C. Giulianotti
    Minerva Chirurgica.2020;[Epub]     CrossRef
  • Robotic Right Colectomy for Colon Cancer; Two Case Reports
    Ryosuke Fukuyo, Hironobu Baba, Takatoshi Matsuyama, Akifumi Kikuchi, Shinichi Yamauchi, Ayumi Takaoka, Yuriko Matsumiya, Yudai Yamamoto, Masanori Tokunaga, Yusuke Kinugasa
    The Japanese Journal of Gastroenterological Surgery.2020; 53(2): 164.     CrossRef
  • Impact of ASA-score, age and learning curve on early outcome in the initiation phase of an oncological robotic colorectal program
    Hülya Sarikaya, Tahar Benhidjeb, Sergiu I. Iosivan, Theodoros Kolokotronis, Christine Förster, Stephan Eckert, Ludwig Wilkens, Alaa Nasser, Sebastian Rehberg, Martin Krüger, Jan Schulte am Esch
    Scientific Reports.2020;[Epub]     CrossRef
  • Robotic or laparoscopic surgery for rectal cancer - which is the best answer? a comprehensive review of non-oncological outcomes and learning curve
    Sandra L. Kavalukas, Amandeep Ghuman, Stephen P. Sharp, Steven D. Wexner
    Mini-invasive Surgery.2020;[Epub]     CrossRef
  • Right hemicolectomy: a network meta-analysis comparing open, laparoscopic-assisted, total laparoscopic, and robotic approach
    Emanuele Rausa, Michael Eamon Kelly, Emanuele Asti, Alberto Aiolfi, Gianluca Bonitta, Luigi Bonavina
    Surgical Endoscopy.2019; 33(4): 1020.     CrossRef
  • Long-term oncologic after robotic versus laparoscopic right colectomy: a prospective randomized study
    Jun Seok Park, Hyun Kang, Soo Yeun Park, Hye Jin Kim, In Teak Woo, In-Kyu Park, Gyu-Seog Choi
    Surgical Endoscopy.2019; 33(9): 2975.     CrossRef
  • Robotic Versus Conventional Laparoscopic Surgery for Colorectal Cancer: A Systematic Review and Meta‐Analysis with Trial Sequential Analysis
    Ka Ting Ng, Azlan Kok Vui Tsia, Vanessa Yu Ling Chong
    World Journal of Surgery.2019; 43(4): 1146.     CrossRef
  • A standardized suprapubic bottom-to-up approach in robotic right colectomy: technical and oncological advances for complete mesocolic excision (CME)
    Jan Schulte am Esch, Sergio-I. Iosivan, Fabian Steinfurth, Ammar Mahdi, Christine Förster, Ludwig Wilkens, Alaa Nasser, Hülya Sarikaya, Tahar Benhidjeb, Martin Krüger
    BMC Surgery.2019;[Epub]     CrossRef
  • Robotic versus laparoscopic right colectomy: an updated systematic review and meta-analysis
    Leonardo Solaini, Francesca Bazzocchi, Davide Cavaliere, Andrea Avanzolini, Alessandro Cucchetti, Giorgio Ercolani
    Surgical Endoscopy.2018; 32(3): 1104.     CrossRef
  • Short-Term Outcomes with Robotic Right Colectomy
    Scott R. Kelley, Emilie Duchalais, David W. Larson
    The American Surgeon™.2018; 84(11): 1768.     CrossRef
  • Robot-Assisted Colectomy for Left-Sided Colon Cancer: Comparison of Reduced-Port and Conventional Multi-Port Robotic Surgery
    Sung Uk Bae, Woon Kyung Jeong, Seong Kyu Baek
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2017; 27(4): 398.     CrossRef
  • Colorectal surgery in elderly patients: our experience with DaVinci Xi® System
    A. Oldani, P. Bellora, M. Monni, B. Amato, S. Gentilli
    Aging Clinical and Experimental Research.2017; 29(S1): 91.     CrossRef
  • Robot-assisted versus laparoscopic-assisted surgery for colorectal cancer: a meta-analysis
    Xuan Zhang, ZhengQiang Wei, MengJun Bie, XuDong Peng, Cheng Chen
    Surgical Endoscopy.2016; 30(12): 5601.     CrossRef
  • Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis
    Yanlai Sun, Huirong Xu, Zengjun Li, Jianjun Han, Wentao Song, Junwei Wang, Zhongfa Xu
    World Journal of Surgical Oncology.2016;[Epub]     CrossRef
  • Comparison of perioperative and short-term outcomes between robotic and conventional laparoscopic surgery for colonic cancer: a systematic review and meta-analysis
    Sungwon Lim, Jin Hee Kim, Se-Jin Baek, Seon-Hahn Kim, Seon Heui Lee
    Annals of Surgical Treatment and Research.2016; 90(6): 328.     CrossRef
  • Laparoscopic and robot-assisted laparoscopic digestive surgery: Present and future directions
    Juan C Rodríguez-Sanjuán
    World Journal of Gastroenterology.2016; 22(6): 1975.     CrossRef
  • Effect of BMI on Short-Term Outcomes with Robotic-Assisted Laparoscopic Surgery: a Case-Matched Study
    Deborah S. Keller, Nisreen Madhoun, Juan Ramon Flores-Gonzalez, Sergio Ibarra, Reena Tahilramani, Eric M. Haas
    Journal of Gastrointestinal Surgery.2016; 20(3): 488.     CrossRef
  • Robotic single docking total colectomy for ulcerative colitis: First experience with a novel technique
    Franco Roviello, Riccardo Piagnerelli, Francesco Ferrara, Maximilian Scheiterle, Lorenzo De Franco, Daniele Marrelli
    International Journal of Surgery.2015; 21: 63.     CrossRef
  • Is robot-assisted laparoscopic right colectomy more effective than the conventional laparoscopic procedure? A meta-analysis of short-term outcomes
    Fabio Rondelli, Ruben Balzarotti, Fabio Villa, Adriano Guerra, Nicola Avenia, Enrico Mariani, Walter Bugiantella
    International Journal of Surgery.2015; 18: 75.     CrossRef
  • Robotic colonic resection
    Emmanouil P. Pappou, Martin R. Weiser
    Journal of Surgical Oncology.2015; 112(3): 315.     CrossRef
  • European association of endoscopic surgeons (EAES) consensus statement on the use of robotics in general surgery
    Amir Szold, Roberto Bergamaschi, Ivo Broeders, Jenny Dankelman, Antonello Forgione, Thomas Langø, Andreas Melzer, Yoav Mintz, Salvador Morales-Conde, Michael Rhodes, Richard Satava, Chung-Ngai Tang, Ramon Vilallonga
    Surgical Endoscopy.2015; 29(2): 253.     CrossRef
  • Robotic versus conventional laparoscopic surgery for rectal cancer: systematic review and meta-analysis
    Seon Heui Lee, Sungwon Lim, Jin Hee Kim, Kil Yeon Lee
    Annals of Surgical Treatment and Research.2015; 89(4): 190.     CrossRef
  • Robot-assisted single-incision total colectomy: a case report
    Yen-Yi Juo, Vincent Obias
    The International Journal of Medical Robotics and Computer Assisted Surgery.2015; 11(1): 104.     CrossRef
  • Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables
    Alberto Zarak, Alvaro Castillo, Kandace Kichler, Lucy de la Cruz, Leonardo Tamariz, Srinivas Kaza
    Surgical Endoscopy.2015; 29(6): 1341.     CrossRef
  • Outcomes of Robotic-Assisted Colorectal Surgery Compared with Laparoscopic and Open Surgery: a Systematic Review
    Chang Woo Kim, Chang Hee Kim, Seung Hyuk Baik
    Journal of Gastrointestinal Surgery.2014; 18(4): 816.     CrossRef
  • Robotic Surgery for Colorectal Cancer
    Ioannis G. Papanikolaou
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2014; 24(6): 478.     CrossRef
  • Robotic versus laparoscopic right colectomy: a meta-analysis
    Huirong Xu, Jianning Li, Yanlai Sun, Zengjun Li, Yanan Zhen, Bin Wang, Zhongfa Xu
    World Journal of Surgical Oncology.2014; 12(1): 274.     CrossRef
  • Outcomes and Costs Associated With Robotic Colectomy in the Minimally Invasive Era
    Joshua A. Tyler, Justin P. Fox, Mayur M. Desai, W. Brian Perry, Sean C. Glasgow
    Diseases of the Colon & Rectum.2013; 56(4): 458.     CrossRef
  • Robotic Colonic Surgery
    Andrew Kai-Yip Fung, Emad H. Aly
    Diseases of the Colon & Rectum.2013; 56(6): 786.     CrossRef
  • Lap Colectomy and Robotics for Colon Cancer
    Eduardo Parra-Davila, Sonia Ramamoorthy
    Surgical Oncology Clinics of North America.2013; 22(1): 143.     CrossRef
Review
Malignant disease, Rectal cancer ,Functional outcomes,Colorectal cancer,Minimally invasive surgery
Robotic Intersphincteric Resection for Low Rectal Cancer: Technical Controversies and a Systematic Review on the Perioperative, Oncological, and Functional Outcomes
Guglielmo Niccolò Piozzi, Seon Hahn Kim
Ann Coloproctol. 2021;37(6):351-367.   Published online November 17, 2021
DOI: https://doi.org/10.3393/ac.2021.00836.0119
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AbstractAbstract PDF
Intersphincteric resection (ISR) is the ultimate anus-sparing technique for low rectal cancer and is considered an oncologically safe alternative to abdominoperineal resection. The application of the robotic approach to ISR (RISR) has been described by few specialized surgical teams with several differences regarding approach and technique. This review aims to discuss the technical aspects of RISR by evaluating point by point each surgical controversy. Moreover, a systematic review was performed to report the perioperative, oncological, and functional outcomes of RISR. Postoperative morbidities after RISR are acceptable. RISR allows adequate surgical margins and adequate oncological outcomes. RISR may result in severe bowel and genitourinary dysfunction affecting the quality of life in a portion of patients.

Citations

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  • Rectal Eversion as an Anus-sparing Technique in Laparoscopic Low Anterior Resection With Double Stapling Anastomosis: Long-term Functional Results
    Servet Karagul, Serdar Senol, Oktay Karakose, Huseyin Eken, Cuneyt Kayaalp
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2025;[Epub]     CrossRef
  • Robotic surgery versus laparoscopic surgery for rectal cancer: a comparative study on surgical safety and functional outcomes
    Li TengTeng, Fu HaiXiao, Fu Wei, Zhang Xuan
    ANZ Journal of Surgery.2025; 95(1-2): 156.     CrossRef
  • The Review of Modified Intersphincteric Resection in the Treatment of Ultra-Low Rectal Cancer
    Danni Li, Xi Xiong, Pan Diao, Jitao Hu, Wenbo Niu, Guiying Wang, Baokun Li
    Current Treatment Options in Oncology.2025; 26(2): 84.     CrossRef
  • Long-term functional and prognostic outcomes of robotic intersphincteric resection for treating low rectal cancer: a single-center retrospective study
    Yang Bo, Wang Yigao, Zheng Mingye, Jian Zhao, Yongxiang Li
    International Journal of Colorectal Disease.2025;[Epub]     CrossRef
  • Comparison of laparoscopic versus robot-assisted sugery for rectal cancer after neo-adjuvant therapy: a large volume single center experience
    Heyuan Zhu, Jingyu Zou, Hongfeng Pan, Ying Huang, Pan Chi
    BMC Surgery.2025;[Epub]     CrossRef
  • Robotic Anterior Resection for Rectosigmoid Colon Cancer Using Single-Port Access
    Sung Uk Bae, Woon Kyung Jeong, Seong Kyu Baek
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    Journal of Robotic Surgery.2023; 17(6): 2911.     CrossRef
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