Annals of Coloproctology

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ERAS

Predicting venous thromboembolism and determining appropriate prophylaxis in elderly patients undergoing colorectal cancer surgery with Enhanced Recovery After Surgery (ERAS) using the adjusted Caprini score: Young Sun Choi, Hyung Jin Cho, Chul Seung Lee, Dong Geun Lee, Choon Sik Chung, Gwan Cheol Lee, Dong Woo Kang, Jeong Sub Kim, Tae Gyu Kim; Ann Coloproctol. 2025;41(4):279-286. Published online August 26, 2025; DOI: https://doi.org/10.3393/ac.2024.00857.0122

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Abstract PDF Supplementary Material: Purpose
Age and postoperative complications are known risk factors for venous thromboembolism (VTE). Minimally invasive surgery and Enhanced Recovery After Surgery (ERAS) protocol has been implemented to reduce these risks. The purpose of this study was to assess the short- and long-term effects of a VTE prophylaxis program using the Caprini score in elderly patients undergoing minimally invasive colorectal cancer surgery with the ERAS protocol.
Methods
This retrospective cross-sectional study included 1,043 colorectal cancer patients requiring surgery from January 2017 to December 2019, divided into a control group (≤75 years) and an elderly group (>75 years), with 827 and 216 patients, respectively. The primary outcome was the incidence of VTE; secondary outcome was the incidence of postoperative complications, particularly bleeding.
Results
The incidence of VTE was 1.5% in the control group and 3.7% in the elderly group (P=0.061). Five patients (0.5%) experienced symptomatic VTE, and the Caprini score for all VTE patients was ≤8 points; thus, only mechanical prophylaxis was used. In the multivariable logistic regression, the Caprini score (P=0.024) and cancer stage (P=0.004) were selected. The odds ratios (95% confidence interval) of the Caprini score and TNM staging were 1.758 (1.078–2.867) and 6.152 (2.045–26.510), respectively.
Conclusion
When the ERAS protocol was used for patients with colorectal cancer as perioperative care, the VTE risk was lower than that estimated by the Caprini score. Given that age is a recognized risk factor for major bleeding, criteria for the use of anticoagulation to prevent VTE, particularly in elderly patients, should be carefully evaluated, considering both the bleeding risks and the potential benefits of pharmacologic prophylaxis. Trial registration: Clinical Research Information Service (CRIS; cris.nih.go.kr) identifier: KCT0007804

Anorectal benign disease

A comparative study on efficacy and safety of modified partial stapled hemorrhoidopexy versus conventional hemorrhoidectomy: a prospective randomized controlled trial: Tae Gyu Kim, Chul Seung Lee, Dong Geun Lee, Choon Sik Chung, Seung Han Kim, Sang Hwa Yu, Jeong Eun Lee, Gwan Cheol Lee, Dong Woo Kang, Jeong Sub Kim, Gyu Young Jeong; Ann Coloproctol. 2025;41(2):145-153. Published online April 28, 2025; DOI: https://doi.org/10.3393/ac.2024.00535.0076

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Abstract PDF Supplementary Material: Purpose
The long-term outcomes and efficacy of partial stapled hemorrhoidopexy (PSH) compared with those of conventional hemorrhoidectomy (CH) are not fully understood. This study aimed to introduce a modified PSH (mPSH) and compare its clinical efficacy and safety with those of CH.
Methods
A prospective randomized controlled trial was conducted. This study was performed at a single hospital and involved 6 colorectal surgeons. In total, 110 patients were enrolled between July 2019 and September 2020. Patients were randomly assigned to undergo either mPSH group (n=55) or CH group (n=55). The primary outcome was to compare postoperative average pain and postoperative peak pain using visual analog scale score between the 2 groups.
Results
The required duration of analgesia was shorter in the mPSH group than in the CH group, although the difference was not statistically significant (P=0.096). However, the laxative requirement duration (P<0.010), return to work (P<0.010), satisfaction score (P<0.010), and Vaizey score (P=0.014) were significantly better in the mPSH group. The average and peak postoperative pain scores were significantly lower in the mPSH group during the 15 days after surgery (P<0.001). The overall complication rate in both groups was 9.1%, with no significant difference between the groups (P=0.867).
Conclusion
The mPSH group demonstrated better improvement in symptoms, lower pain scores, and greater patient early satisfaction after surgery than the CH group. Therefore, this surgical technique appears to be a safe and effective alternative for CH.

Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer: Han Jo Kim, Moo-Jun Baek, Dong Hyun Kang, Sang-Cheol Lee, Sang Byung Bae, Kyu Taek Lee, Namsu Lee, Hyungjoo Kim, Dongjun Jeong, Tae Sung Ahn, Moon Soo Lee, Dae Sik Hong, Jong-Ho Won; Ann Coloproctol. 2018;34(2):88-93. Published online April 30, 2018; DOI: https://doi.org/10.3393/ac.2017.10.10

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5 Web of Science
4 Citations

Abstract PDF

Purpose
Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods
A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results
Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion
Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.

Citations

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Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression
Ricella Souza da Silva, Eduardo M. Queiroga, Cynthia de Toledo Osório, Karin S. Cunha, Fabiana P. Neves, Julieth P. Andrade, Eliane P. Dias
Pathobiology.2024; 91(2): 99. CrossRef
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
Giuseppe Floresta, Vincenzo Abbate
Medicinal Research Reviews.2022; 42(4): 1588. CrossRef
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
World Journal of Gastroenterology.2022; 28(26): 3177. CrossRef
The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
Seyed Mostafa Parizadeh, Reza Jafarzadeh‐Esfehani, Danial Fazilat‐Panah, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Majid Khazaei, Seyed Mohammad Reza Parizadeh, Majid Ghayour‐Mobarhan, Gordon A. Ferns, Amir Avan
IUBMB Life.2019; 71(7): 802. CrossRef

Distribution of the Colonoscopic Adenoma Detection Rate According to Age: Is Recommending Colonoscopy Screening for Koreans Over the Age of 50 Safe?: Taeseok Bae, Yunhyung Ha, Changkyun Kim, Jihyun Lee, Kwangil Ha, Sanghyun Shin, Youngcheol Lee, Yoonsik Kang; Ann Coloproctol. 2015;31(2):46-51. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.46

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13 Web of Science
15 Citations

Abstract PDF

Purpose

This study was conducted to determine the distributions of the polyp detection rate (PDR) and the adenoma detection rate (ADR) according to age by analyzing the polypectomy results.

Methods

A total of 10,098 patients who underwent a colonoscopy in 2013 were included in this study. Chi-square and logistic regression statistical analyses were performed using SPSS ver. 19.

Results

The mean age of the patients was 52.7 years old (median, 54 ± 12.52 years; range, 14 to 92 years). A total of 6,459 adenomatous polyps (61.7%) from a total of 10,462 polyps were eliminated. The PDR was 50.9% (5,136/10,098), and the. ADR was 35.4% (3,579/10,098). The male-to-female ratio was 51.3%:48.7%, with a male-to-female ADR ratio of 42.8% : 27.7% (P < 0.001). In the age distribution, the values of the ADR were 0% for patients in their 10's, 6.3% for those in their 20's, 14.0% for those in their 30's, 28.7% for those in their 40's, 38.4% for those in their 50's, 46.2% for those in their 60's, 55.8% for those in their 70's, 56.1% for those in their 80's, and 33.3% for those in their 90's. In males, the values of the ADR were 0%, 9.1%, 17.1%, 37.8%, 48.2%, 53.6%, 61.7%, 59.1%, and 33.3% for the same age distribution, and a steep increase was found between patients in their 30's and patients in their 40's. Significant (P < 0.001) factors influencing the ADR included sex, previous colonoscopy experience, polypectomy method, and age of more than 40 years.

Conclusion

In considering the adenoma carcinoma sequence, 28.7% of people, especially 37.8% of males in their 40's showed adenomatous polyps. Whether an earlier first-time colonoscopy will have better results in preventing colorectal cancer should be investigated and discussed.

Citations

Citations to this article as recorded by

Adenoma Detection Rate in Average-Risk Population: An Observational Consecutive Retrospective Study
Xiaoyan He, Xiangyin Lv, Binbin Zhang, Xiaoxuan Ying, Chiyu Hu, Xiaoying Zhou, Jianwen Hu
Cancer Control.2023;[Epub] CrossRef
Adenoma Detection Rates in 45–49-Year-Old Persons Undergoing Screening Colonoscopy: Analysis From the GIQuIC Registry
Mohammad Bilal, Jennifer Holub, David Greenwald, Mark B. Pochapin, Douglas K. Rex, Aasma Shaukat
American Journal of Gastroenterology.2022; 117(5): 806. CrossRef
Adenoma Detection Rate in Colonoscopic Screening with Ketamine-based Sedation: A Prospective Observational Study
Mirza KOVACEVIC, Nermina RIZVANOVIC, Adisa SABANOVIC ADILOVIC, Nedim BARUCIJA, Anida ABAZOVIC
Medeniyet Medical Journal.2022; 37(1): 79. CrossRef
Gastrointestinal Disease in Patients with Common Variable Immunodeficiency: A Retrospective Observational Study
Rishad Khan, Mohamad Habbal, Michael A Scaffidi, Abbas A Bukhari, Amir Rumman, Sarah Al Ghamdi, Stephen D Betschel, Samir C Grover
Journal of the Canadian Association of Gastroenterology.2020; 3(4): 162. CrossRef
Global patterns and trends in colorectal cancer incidence in young adults
Rebecca L Siegel, Lindsey A Torre, Isabelle Soerjomataram, Richard B Hayes, Freddie Bray, Thomas K Weber, Ahmedin Jemal
Gut.2019; 68(12): 2179. CrossRef
Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population
Suk-young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
Annals of Surgical Treatment and Research.2018; 94(1): 36. CrossRef
An Adjusted Level of Adenoma Detection Rate is Necessary for Adults Below 50 Years Old
Jin Young Yoon, Jae Myung Cha, Jeong Eun Shin, Kyeong Ok Kim, Hyo-Joon Yang, Hyun Gun Kim, Young-Seok Cho, Sun-Jin Boo, Jun Lee, Yunho Jung, Hyun Jung Lee, Hoon Sup Koo, Young-Eun Joo
Journal of Clinical Gastroenterology.2018; 52(8): 703. CrossRef
Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients
Mohammed Hussein Kamareddine, Youssef Ghosn, Karam Karam, Anwar Andrew Nader, Ahmad El-Mahmoud, Naseem Bou-Ayash, Mansour El-Khoury, Said Farhat
BMJ Open Gastroenterology.2018; 5(1): e000253. CrossRef
LINE-1 is preferentially hypomethylated within adenomatous polyps in the presence of synchronous colorectal cancer
Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari, Joshua Melson
Clinical Epigenetics.2017;[Epub] CrossRef
Risks of colorectal advanced neoplasia in young adults versus those of screening colonoscopy in patients aged 50 to 54 years
Kyeong Ok Kim, Hyo‐Joon Yang, Jae Myung Cha, Jeong Eun Shin, Hyun Gun Kim, Young‐Seok Cho, Sun‐Jin Boo, Jun Lee, Yunho Jung, Hyun Jung Lee, Kyu Chan Huh, Young‐Eun Joo, Jongha Park, Chang Mo Moon
Journal of Gastroenterology and Hepatology.2017; 32(11): 1825. CrossRef
Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?
Martin Floer, Tobias Meister
Digestion.2016; 93(3): 202. CrossRef
Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy
Bin-Bin Xu, Xiao-Liang Zhao, Gui-Ping Xu
World Journal of Gastroenterology.2016; 22(24): 5609. CrossRef
Role of Colonoscopy in Patients with Hematochezia
Young Wook Kim, Hwang Choi, Gi Jun Kim, Seung Jee Ryu, Sung Min Park, Joon Sung Kim, Jeong-Seon Ji, Byung-Wook Kim, Bo-in Lee, Myung-Gyu Choi
The Korean Journal of Gastroenterology.2016; 67(2): 87. CrossRef
High prevalence of advanced colorectal neoplasia in the Thai population: a prospective screening colonoscopy of 1,404 cases
Bunchorn Siripongpreeda, Chulabhorn Mahidol, Navara Dusitanond, Tassanee Sriprayoon, Bunlung Muyphuag, Thaniya Sricharunrat, Narongchai Teerayatanakul, Watanya Chaiwong, Wipra Worasawate, Prassanee Sattayarungsee, Juthamas Sangthongdee, Jirapa Prarom, Gai
BMC Gastroenterology.2016;[Epub] CrossRef
Adenoma Detection Rate in Patients Younger Than 50 Years of Age: Relationship of the Adenoma Detection Rate to Interval Cancer
In Ja Park
Annals of Coloproctology.2015; 31(2): 41. CrossRef

Postoperative Pain Relief Using Wound Infiltration With 0.5% Bupivacaine in Single-Incision Laparoscopic Surgery for an Appendectomy: So Ra Ahn, Dong Baek Kang, Cheol Lee, Won Cheol Park, Jeong Kyun Lee; Ann Coloproctol. 2013;29(6):238-242. Published online December 31, 2013; DOI: https://doi.org/10.3393/ac.2013.29.6.238

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63 Download
10 Citations

Abstract PDF

Purpose

Recently, single-incision laparoscopic surgery (SILS) has been popular for minimally invasive surgery and cosmetic improvement. However, some papers have reported that SILS for an appendectomy (SILS-A) has had the more postoperative complaints of pain. We investigated postoperative pain relief using wound infiltration with 0.5% bupivacaine in SILS-A and compared the result with that for conventional SILS-A.

Methods

Between July 2010 and September 2012, 75 patients who underwent SILS-A were enrolled in this study. The patients were randomly assigned to two groups: conventional SILS-A group (C-SILS-A) or wound infiltrated with 0.5% bupivacaine in SILS-A group (W-SILS-A). Forty-five patients were in the C-SILS-A, and 30 patients were in the W-SILS-A. Patients with perforated appendicitis were excluded. The clinical outcomes were compared between the groups by using the verbal numerical rating scale (VNRS).

Results

Clinical outcomes were similar in both study groups except for the pain score. The W-SILS-A group showed significantly lower numbers of additional pain killers and lower VNRS scores 1, 6, and 12 hours after surgery than the C-SILS-A group.

Conclusion

W-SILS-A is a technically simple and effective method of reducing early postoperative pain. It may be applicable in SILS-A for pain control system.

Citations

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Transversus abdominis plane block for laparoscopic cholecystectomy in short-term acute care hospital
V.V. Bedin, V.Yu. Vengerov, O.V. Makarov, N.I. Koroleva, K.A. Loginov, V.L. Polianskii, F.G. Pilyus
Pirogov Russian Journal of Surgery.2024; (12): 13. CrossRef
Clinical Outcomes of Single-incision Laparoscopic Appendectomy Versus Conventional Laparoscopic Appendectomy in Adult Acute Appendicitis
SHINTARO KOHAMA, KUNIHIKO NAGAKARI, MASAKAZU OHUCHI, KAZUHIRO TAKEHARA, KUMPEI HONJO, SHUN ISHIYAMA, KIICHI SUGIMOTO, SHINICHI OKA, JIRO YOSHIMOTO, MASAKI FUKUNAGA, YOICHI ISHIZAKI, KAZUHIRO SAKAMOTO
Juntendo Medical Journal.2024; 70(6): 436. CrossRef
Updates on Wound Infiltration Use for Postoperative Pain Management: A Narrative Review
Dusica M. Stamenkovic, Mihailo Bezmarevic, Suzana Bojic, Dragana Unic-Stojanovic, Dejan Stojkovic, Damjan Z. Slavkovic, Vladimir Bancevic, Nebojsa Maric, Menelaos Karanikolas
Journal of Clinical Medicine.2021; 10(20): 4659. CrossRef
Determination of the efficacy of ultrasound-guided bilateral transversus abdominis plane (US-TAP) block in laparoscopic total extraperitoneal (TEP) repair of unilateral hernia surgeries: A randomized controlled trial
Vijayalakshmi Sivapurapu, SriVengadesh Gopal, Ashley Solomon
Journal of Anaesthesiology Clinical Pharmacology.2021; 37(3): 475. CrossRef
Effect of bupivacaine on postoperative pain and analgesics use after single-incision laparoscopic appendectomy: double-blind randomized study
Heon-Kyun Ha, Kyung-Goo Lee, Kang Kook Choi, Wan Sung Kim, Hyung Rae Cho
Annals of Surgical Treatment and Research.2020; 98(2): 96. CrossRef
Unilateral transversus abdominis plane block and port-site infiltration
Emine Arık, T. Akkaya, S. Ozciftci, A. Alptekin, Ş. Balas
Der Anaesthesist.2020; 69(4): 270. CrossRef
Effect of Local Anesthesia on the Postoperative Pain After Laparoscopic Appendectomy
Samir Čustovic, Haris Pandža, Samir Delibegovic
Journal of Laparoendoscopic & Advanced Surgical Techniques.2019; 29(1): 65. CrossRef
Diagnosis and management of acute appendicitis. EAES consensus development conference 2015
Ramon R. Gorter, Hasan H. Eker, Marguerite A. W. Gorter-Stam, Gabor S. A. Abis, Amish Acharya, Marjolein Ankersmit, Stavros A. Antoniou, Simone Arolfo, Benjamin Babic, Luigi Boni, Marlieke Bruntink, Dieuwertje A. van Dam, Barbara Defoort, Charlotte L. Dei
Surgical Endoscopy.2016; 30(11): 4668. CrossRef
Is transverse abdominis plane block effective following local anesthetic infiltration in laparoscopic totally extraperitoneal hernia repair?
Mun Gyu Kim, Soon Im Kim, Si Young Ok, Sang Ho Kim, Se-Jin Lee, Sun Young Park, Jae-Hwa Yoo, Ana Cho, Kyung Yul Hur, Myung Jin Kim
Korean Journal of Anesthesiology.2014; 67(6): 398. CrossRef
Preemptive Analgesia in Single-Incision Laparoscopic Surgery
Eui Gon Youk
Annals of Coloproctology.2013; 29(6): 221. CrossRef

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