Annals of Coloproctology

Original Articles

Clinical Significance of Preoperative Virtual Colonoscopy for Evaluation of the Proximal Colon in Patient With Obstructive Colorectal Cancer: Jae-Hyuk Heo, Chun-Geun Ryu, Eun-Joo Jung, Jin-Hee Paik, Dae-Yong Hwang; Ann Coloproctol. 2017;33(4):130-133. Published online August 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.4.130

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Purpose

Virtual colonoscopy is the most recently developed tool for detecting colorectal cancers and polyps, but its effectiveness is limited. In our study, we compared the result of preoperative virtual colonoscopy to result of preoperative and postoperative colonoscopy. We evaluated also the accuracy of preoperative virtual colonoscopy in patients who had obstructive colorectal cancer that did not allow passage of a colonoscope.

Methods

A total of 164 patients who had undergone preoperative virtual colonoscopy and curative surgery after the diagnosis of a colorectal adenocarcinoma between November 2008 and August 2013 were pooled. We compared the result of conventional colonoscopy with that of virtual colonoscopy in the nonobstructive group and the results of preoperative virtual colonoscopy with that of postoperative colonoscopy performed at 6 months after surgery in the obstructive group.

Results

Of the 164 patients, 108 were male and 56 were female patients. The mean age was 62.7 years. The average sensitivity, specificity, and accuracy of virtual colonoscopy for all patients were 31.0%, 67.2%, and 43.8%, respectively. In the nonobstructive group, the average sensitivity, specificity, and accuracy were 36.6%, 66.2%, and 48.0%, respectively, whereas in the obstructive group, they were 2%, 72.4%, and 25.4%. Synchronous cancer was detected via virtual colonoscopy in 4 of the 164 patients.

Conclusion

Virtual colonoscopy may not be an effective method for the detection of proximal colon polyps, but it can be helpful in determining the therapeutic plan when its results are correlated with the results of other studies.

Citations

Citations to this article as recorded by

Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
Hyo Seon Ryu, Hyun Jung Kim, Woong Bae Ji, Byung Chang Kim, Ji Hun Kim, Sung Kyung Moon, Sung Il Kang, Han Deok Kwak, Eun Sun Kim, Chang Hyun Kim, Tae Hyung Kim, Gyoung Tae Noh, Byung-Soo Park, Hyeung-Min Park, Jeong Mo Bae, Jung Hoon Bae, Ni Eun Seo, Cha
Annals of Coloproctology.2024; 40(2): 89. CrossRef
Application of Virtual Endoscopy in Microvascular Decompression of Trigeminal Neuralgia
Wenbin Wei, Zhiyang Liu, Weijie Zhang, Yiwen Wang, Minjie Chen
Journal of Craniofacial Surgery.2021; 32(5): 1696. CrossRef
Performance of CT Colonography in Diagnosis of Synchronous Colonic Lesions in Patients With Occlusive Colorectal Cancer
Nicola Flor, Andrea Pisani Ceretti, Carmelo Luigiano, Pietro Brambillasca, Anna Paola Savoldi, Clemente Verrusio, Daris Ferrari
American Journal of Roentgenology.2020; 214(2): 348. CrossRef
Synchronous colorectal cancer using CT colonography vs. other means: a systematic review and meta-analysis
Nicola Flor, Edoardo Zanchetta, Giovanni Di Leo, Miriam Mezzanzanica, Massimiliano Greco, Gianpaolo Carrafiello, Francesco Sardanelli
Abdominal Radiology.2018; 43(12): 3241. CrossRef
Correlation between microsatellite instability and RAS gene mutation and stage Ⅲ colorectal cancer
Wenbo Niu, Guiying Wang, Jun Feng, Zheng Li, Chenhui Li, Baoen Shan
Oncology Letters.2018;[Epub] CrossRef

Detection of Polyps After Resection of Colorectal Cancer: Jin-Hee Paik, Eun-Joo Jung, Chun-Geun Ryu, Dae-Yong Hwang; Ann Coloproctol. 2015;31(5):182-186. Published online October 31, 2015; DOI: https://doi.org/10.3393/ac.2015.31.5.182

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Abstract PDF

Purpose

Because colonoscopy after colorectal cancer surgery is important for detecting synchronous or metachronous colorectal neoplasms, we designed this study to investigate, by using postoperative colonoscopy, the miss rate for and the location of polyps remaining after colorectal cancer surgery.

Methods

In a prospectively-collected patient database, 264 patients were shown to have undergone a colorectal cancer resection between May 2012 and June 2013. Of these, 116 who had received a complete colonoscopy preoperatively and postoperatively were included in this study.

Results

Of these 116 patients, 68 were males and 48 were females; their mean age was 63 years. The mean time after surgery at which postoperative colonoscopy was performed was 7.1 months (range, 3-15 months). On postoperative colonoscopy, a total of 125 polyps were detected. Of these, there were no cancerous lesions; 46 (36.8%) were neoplastic polyps, and 79 (63.2%) were nonneoplastic polyps. Fifty-nine polyps (47.2%) and 15 polyps (12%) were located in the proximal and the distal parts of the anastomosis, respectively. The miss rates for the total numbers of polyps and of neoplastic polyps remaining after surgery were 37.4% and 24.2%, respectively. The incidence of neoplastic polyps increased during postoperative colonoscopy as it had during preoperative colonoscopy (r = 0.164, P = 0.048).

Conclusion

Colonoscopic surveillance after colorectal cancer resection results in the detection of pathologic polyps in one-fourth of the cases. During postoperative colonoscopy, careful examination of the proximal colon is necessary. Patients in whom multiple neoplastic polyps had been detected during preoperative colonoscopy require careful and thorough follow-up.

Citations

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Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system
Harris Bernstein, Carol Bernstein
Experimental Biology and Medicine.2023; 248(1): 79. CrossRef
Current status of water-assisted colonoscopy
Jun-Quan Shen
World Chinese Journal of Digestology.2020; 28(22): 1162. CrossRef
Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence
Jihye Park, Jae Hyun Kim, Yehyun Park, Soo Jung Park, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y. Jeon, Tae Il Kim, John Green
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A Study of Metachronous Colorectal Neoplasms after Colorectal Cancer Resection Detected by Surveillance Colonoscopy
Seiji Kimura, Masanori Tanaka, Shinsaku Fukuda
Nippon Daicho Komonbyo Gakkai Zasshi.2017; 70(3): 149. CrossRef
Kolon polipleri sayı ve büyüklüğü malignite göstergesi olabilir mi?
Abdurahman ŞAHİN, Nurettin TUNÇ, Salih KILIÇ, Gökhan ARTAŞ, Ulvi DEMİREL, Orhan K. POYRAZOĞLU, İbrahim H. BAHÇECİOĞLU, Mehmet YALNIZ
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The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer
Jihye Park, Jae Hyun Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y. Jeon, Tae Il Kim
Cancer Prevention Research.2017; 10(8): 478. CrossRef
Frequency of colonic adenomatous polyps in a tertiary hospital in Mumbai
Anjali D. Amarapurkar, Prachi Nichat, Nitin Narawane, Deepak Amarapurkar
Indian Journal of Gastroenterology.2016; 35(4): 299. CrossRef
Surveillance Colonoscopy After a Resection of Colorectal Cancer
Byung Chun Kim
Annals of Coloproctology.2015; 31(5): 170. CrossRef

Letter to the Editor

Reply on "What Is the Role of Surgeons When Implanting a Totally Implantable Venous Access Device to Prevent Immediate Complications?": Eun-Joo Jung, Dae-Yong Hwang; Ann Coloproctol. 2015;31(4):165-166. Published online August 31, 2015; DOI: https://doi.org/10.3393/ac.2015.31.4.165

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Original Articles

Insertion of Totally Implantable Central Venous Access Devices by Surgeons: Hyeonjun An, Chun-Geun Ryu, Eun-Joo Jung, Hyun Jong Kang, Jin Hee Paik, Jung-Hyun Yang, Dae-Yong Hwang; Ann Coloproctol. 2015;31(2):63-67. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.63

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Abstract PDF

Purpose

The aim of this study is to evaluate the results for the insertion of totally implantable central venous access devices (TICVADs) by surgeons.

Methods

Total 397 patients, in whom TICVADs had been inserted for intravenous chemotherapy between September 2008 and June 2014, were pooled. This procedure was performed under local anesthesia in an operation room. The insertion site for the TICVAD was mainly in the right-side subclavian vein. In the case of breast cancer patients, the subclavian vein opposite the surgical site was used for insertion.

Results

The 397 patients included 73 males and 324 females. Primary malignant tumors were mainly colorectal and breast cancer. The mean operation time was 54 minutes (18-276 minutes). Operation-related complications occurred in 33 cases (8.3%). Early complications developed in 15 cases with catheter malposition and puncture failure. Late complications, which developed after 24 hours, included inflammation in 6 cases, skin necrosis in 6 cases, hematoma in 3 cases, port malfunction in 1 case, port migration in 1 case, and intractable pain at the port site in 1 case.

Conclusion

Insertion of a TICVAD under local anesthesia by a surgeon is a relatively safe procedure. Meticulous undermining of the skin and carefully managing the TICVAD could minimize complications.

Citations

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Implantable catheter chambers: a 14-year descriptive study
Anas Erragh, Salma Bellaftouh, Safia Chaabi, Yassine Hafiani, Afak Nsiri, Rachid Alharrar
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Vascular access device type for systemic anti-cancer therapies in cancer patients: A scoping review
C. Duggan, O. Hernon, R. Dunne, V. McInerney, S.R. Walsh, A. Lowery, M. McCarthy, P.J. Carr
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Machine learning risk prediction model for bloodstream infections related to totally implantable venous access ports in patients with cancer
Fan Wang, Yanyi Zhu, Lijuan Wang, Caiying Huang, Ranran Mei, Li-e Deng, Xiulan Yang, Yan Xu, Lingling Zhang, Min Xu
Asia-Pacific Journal of Oncology Nursing.2024; 11(8): 100546. CrossRef
Catheter malposition analysis of totally implantable venous access port in breast cancer patients
Wenbo Liu, Qingzheng Han, Lin Li, Jiangrui Chi, Xinwei Liu, Yuanting Gu
Frontiers in Surgery.2023;[Epub] CrossRef
Portocath insertion technique: retrospective study & step-by-step surgical description without tunneling in a high-complexity service
ANNA MARIA GARCIA CARDOSO, FERNANDA SANTOS WENGROVER, ALINE WÜRZIUS, MARINA PUERARI PIETA, RAFFAELA NASCIMENTO DE CARLI, CARLOS EDUARDO BASTIAN DA-CUNHA, RICARDO BREIGEIRON
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Sağ Atriumdan Sağ Juguler Vene Yolculuk: Nadir Bir Port Kateter Komplikasyonu
Orhan ÜREYEN, Hüseyin FENERCİOĞLU, Demet ALAY, İlhan DURSUN, Enver İLHAN
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Forty years after the first totally implantable venous access device (TIVAD) implant: the pure surgical cut-down technique only avoids immediate complications that can be fatal
Adriana Toro, Elena Schembari, Emanuele Gaspare Fontana, Salomone Di Saverio, Isidoro Di Carlo
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An analysis of the outcomes of totally implantable access port implantation performed by surgical residents
Se-Beom Jeon, Youngbae Jeon, Kyoung-Won Han, Yong-Soon Chun, Jeong-Heum Baek
Korean Journal of Clinical Oncology.2021; 17(1): 15. CrossRef
Totally implantable venous access devices
Swapnil Patel, Preeti Vijayakumaran
Cancer Research, Statistics, and Treatment.2021; 4(3): 536. CrossRef
Long-Term Management of Vascular Access Ports in Nonhuman Primates Used in Preclinical Efficacy and Tolerability Studies
Lucas A. Mutch, Samuel T. Klinker, Jody J. Janecek, Melanie N. Niewinski, Rachael M. Z. Lee, Melanie L. Graham
Journal of Investigative Surgery.2020; 33(6): 493. CrossRef
Validation of a questionnaire of knowledge and attitudes about the subcutaneous venous reservoir in nursing
Roberto Raña-Rocha, Ignacio López-de-Ullibarri, María-Jesús Movilla-Fernández, Carmen Coronado Carvajal
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Comparison of Care Outcomes Between Two Methods of Drug Injection Through Ports and Peripheral Veins in Patients Undergoing Chemotherapy
Seied Hashem Mosavi, Nasrin Elahi, Marziyeh Asadizaker, Ahmad Ahmadzadeh Deilami
Jundishapur Journal of Chronic Disease Care.2020;[Epub] CrossRef
Supraclavicular versus infraclavicular approach in inserting totally implantable central venous access for cancer therapy: A comparative retrospective study
Amine Souadka, Hajar Essangri, Imad Boualaoui, Abdelilah Ghannam, Amine Benkabbou, Laila Amrani, Raouf Mohsine, Mohammed Anass Majbar, Robert Jeenchen Chen
PLOS ONE.2020; 15(11): e0242727. CrossRef
Ultrasound‐guided totally implantable venous access device through the right innominate vein in older patients is safe and reliable
Xingwei Sun, Yu Zhang, Chuanlai Yang, Yubin Zhou, Xuming Bai, Weiwei Zheng, Yong Jin
Geriatrics & Gerontology International.2019; 19(3): 218. CrossRef
An unusual catheter malposition following totally implantable venous access port insertion: The catheter tip located into the right axillary vein
Ahmet Yüksel, Yusuf Velioğlu, Mustafa Enes Demirel, Erhan Renan Uçaroğlu
Journal of Surgery and Medicine.2019;[Epub] CrossRef
Usefulness of Percutaneous Puncture in Insertion of Totally Implantable Venous Access Devices in Pediatric Patients
Jung Sik Choi, Keun-Myoung Park, Sungteak Jung, Kee Chun Hong, Yong Sun Jeon, Soon Gu Cho, Yun-Mee Choe
Vascular Specialist International.2017; 33(3): 108. CrossRef
Reply on "What Is the Role of Surgeons When Implanting a Totally Implantable Venous Access Device to Prevent Immediate Complications?"
Eun-Joo Jung, Dae-Yong Hwang
Annals of Coloproctology.2015; 31(4): 165. CrossRef
Commentary on "Insertion of Totally Implantable Central Venous Access Devices by Surgeons" - What Is the Role of Surgeons When Implanting a Totally Implantable Venous Access Device to Prevent Immediate Complications?
Adriana Toro, Gaetano Bertino, Annalisa Ardiri, Isidoro Di Carlo
Annals of Coloproctology.2015; 31(4): 163. CrossRef

Is Microsatellite Instability Really a Good Prognostic Factor of Colorectal Cancer?: Ui Sup Shin, Sang Sik Cho, Sun Mi Moon, Sun Hoo Park, Sun Hee Jee, Eun-Joo Jung, Dae-Yong Hwang; Ann Coloproctol. 2014;30(1):28-34. Published online February 28, 2014; DOI: https://doi.org/10.3393/ac.2014.30.1.28

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Abstract PDF

Purpose

The aim of this study was to investigate the clinicopathologic features of and the prognosis for colorectal cancers (CRCs) with microsatellite instabilities (MSIs).

Methods

Between 2006 and 2009, genotyping was performed on 245 patients with stage II/III CRCs to establish the MSI status. The clinicopathologic differences and the prognostic value of MSI were analyzed. The median follow-up period was 38 months (range, 7-68 months).

Results

Of the total 245 patients, 20 (8.2%) had MSI-high (H) and 225 (91.8%) had MSI-low (L) or stable (S) CRCs. Adjuvant chemotherapies were performed on 101 stage II (87.8%) and 107 stage III patients (82.3%). Patients with MSI-H CRCs more frequently had a family history of colon cancer (10% vs. 2.7%, P = 0.003), more frequently had a cancer located at the proximal colon (90.0% vs. 19.1%, P < 0.0001), and more often showed a mucinous phenotype or poor differentiation (35.0% vs. 7.1%, P = 0.001). Despite less frequent lymph node metastasis (25% vs. 55.6%, P = 0.01), the number of retrieved lymph nodes was higher (26.3 ± 13.1 vs. 20.7 ± 1.2, P = 0.04) in the MSI-H group. The overall survival and the disease-free survival (DFS) did not differ with respect to MSI status. However, in the stage II subgroup, the DFS for patients with MSI-H CRCs was significantly worse (72.2% vs. 90.7%, P = 0.03). The multivariate analysis performed on this subgroup revealed that MSI-H was an independent poor prognostic factor (adjusted hazard ratio, 4.0; 95% confidence interval, 1.0-15.6, P = 0.046).

Conclusion

MSI-H CRCs had distinct clinicopathologic features, and MSI-H was an independent poor prognostic factor in stage II CRCs. Considering the majority of stage II patients were administrated adjuvant chemotherapy, the efficacy of adjuvant chemotherapy for treating MSI CRCs might be different from that for treating MSI-L/S tumors.

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Reassessing the Prognostic Value of Lymph Node Metastasis in Deficient Mismatch Repair Colorectal Cancer
Zilan Ye, Dakui Luo, Fan Chen, Jiayu Chen, Zezhi Shan, Junyong Weng, Yu Zhang, Qingguo Li, Xinxiang Li
Current Oncology.2025; 32(5): 254. CrossRef
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Ahmad R Mafi, Shima Azimi Oliaei, Ramin Heshmat, Hossein Yahyazadeh, Ali G Motlagh
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Short-term Outcomes of Hand-Assisted Laparoscopic Surgery vs. Open Surgery on Right Colon Cancer: A Case-Controlled Study: Jae-Hoon Sim, Eun-Joo Jung, Chun-Geun Ryu, Jin Hee Paik, Gangmi Kim, Su Ran Kim, Dae-Yong Hwang; Ann Coloproctol. 2013;29(2):72-76. Published online April 30, 2013; DOI: https://doi.org/10.3393/ac.2013.29.2.72

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Abstract PDF

Purpose

This study was designed to evaluate short-term clinical outcomes by comparing hand-assisted laparoscopic surgery with open surgery for right colon cancer.

Methods

Sixteen patients who underwent a hand-assisted laparoscopic right hemicolectomy (HAL-RHC group) and 33 patients who underwent a conventional open right hemicolectomy (open group) during the same period were enrolled in this study with a case-controlled design.

Results

The operation time was 217 minutes in the HAL-RHC group and 213 minutes in the open group (P = 0.389). The numbers of retrieved lymph nodes were similar between the two groups (31 in the HAL-RHC group and 36 in the open group, P = 0.737). Also, there were no significant difference in the incidence of immediate postoperative leukocytosis, the administration of additional pain killers, and the postoperative recovery parameters. First flatus was shown on postoperative days 3.5 in the HAL-RHC group and 3.4 in the open group (P = 0.486). Drinking water and soft diet were started on postoperative days 4.8 and 5.9, respectively, in the HAL-RHC group and similarly 4.6 and 5.6 in the open group (P = 0.402 and P = 0.551). The duration of hospital stay was shorter in the HAL-RHC group than in the open group (10.3 days vs. 13.5 days, P = 0.048). No significant difference in the complication rates was shown between the two groups, and no postoperative mortality was encountered in either group.

Conclusion

The patients with right colon cancer in the HAL-RHC group had similar pathologic and postoperative recovery parameters to those of the patients in the open group. The patients in the HAL-RHC group had shorter hospital stays than those in the open group. Therefore, hand-assisted laparoscopic right hemicolectomy for right-sided colon cancer is feasible.

Citations

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Takayuki Tajima, Masaya Mukai, Daiki Yokoyama, Shigeo Higami, Shuji Uda, Sayuri Hasegawa, Eiji Nomura, Sotaro Sadahiro, Seiei Yasuda, Hiroyasu Makuuchi
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International Journal of Colorectal Disease.2016; 31(7): 1291. CrossRef
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Zhengrong Li, Daojiang Li, Zhigang Jie, Guoyang Zhang, Yi Liu
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TAKAYUKI TAJIMA, MASAYA MUKAI, WATARU NOGUCHI, SHIGEO HIGAMI, SHUUJI UDA, SOUICHIROU YAMAMOTO, SAYURI HASEGAWA, EIJI NOMURA, SOTARO SADAHIRO, SEIEI YASUDA, HIROYASU MAKUUCHI
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Hand-assisted laparoscopic versus laparoscopy-assisted D2 radical gastrectomy: a prospective study
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Comparison of hand-assisted laparoscopic surgery and conventional laparotomy for colorectal cancer: Interim results from a single institution
TAKAYUKI TAJIMA, MASAYA MUKAI, MASASHI YAMAZAKI, SHIGEO HIGAMI, SOUICHIROU YAMAMOTO, SAYURI HASEGAWA, EIJI NOMURA, SOTARO SADAHIRO, SEIEI YASUDA, HIROYASU MAKUUCHI
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Should Hand-Assisted Laparoscopic Surgery Be Placed in the Realm of Minimally Invasive Surgery?
Hungdai Kim
Annals of Coloproctology.2013; 29(2): 42. CrossRef

Feasibility of Hand-Assisted Laparoscopic Surgery as Compared to Open Surgery for Sigmoid Colon Cancer: A Case-Controlled Study: Sang Eun Nam, Eun-Joo Jung, Chun-Geun Ryu, Jin Hee Paik, Dae-Yong Hwang; Ann Coloproctol. 2013;29(1):17-21. Published online February 28, 2013; DOI: https://doi.org/10.3393/ac.2013.29.1.17

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Abstract PDF

Purpose

The aim of this study was to evaluate short-term clinical outcomes by comparing hand-assisted laparoscopic surgery (HALS) with open surgery for sigmoid colon cancer.

Methods

Twenty-six patients who underwent a hand-assisted laparoscopic anterior resection (HAL-AR group) and 52 patients who underwent a conventional open anterior resection during the same period were enrolled (open group) in this study with a case-controlled design.

Results

Pathologic parameters were similar between the two groups. The incidences of immediate postoperative leukocytosis were 38.5% in the HAL-AR group and 69.2% in the open group (P = 0.009). There were no significant differences between the two groups as to leukocyte count, hemoglobin, and hematocrits (P = 0.758, P = 0.383, and P = 0.285, respectively). Of the postoperative recovery indicators, first flatus, sips of water and soft diet started on postoperative days 3, 5, 7 in the HALS group and on days 4, 5, 6 in the open group showed statistical significance (P = 0.021, P = 0.259, and P = 0.174, respectively). Administration of additional pain killers was needed for 1.2 days in the HAL-AR group and 2.4 days in the open group (P = 0.002). No significant differences in the durations of hospital stay and the rates of postoperative complications were noted, and no postoperative mortality was encountered in either group.

Conclusion

The patients with sigmoid colon cancer who underwent a HAL-AR had a lower incidence of postoperative leukocytosis, less administration of pain killers, and faster first flatus than those who underwent open surgery. Clinical outcomes for patients' recovery and pathology status were similar between the two groups. Therefore, a HAL-AR for sigmoid colon cancer is feasible and has the same benefit as minimally invasive surgery.

Citations

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Hand-assisted laparoscopic surgery versus conventional open surgery in intraoperative and postoperative outcomes for colorectal cancer
Xubing Zhang, Qingbin Wu, Chaoyang Gu, Tao Hu, Liang Bi, Ziqiang Wang
Medicine.2017; 96(33): e7794. CrossRef
Hand-Assisted Laparoscopic Surgery: A Versatile Tool for Colorectal Surgeons
Ju Yong Cheong, Christopher J. Young
Annals of Coloproctology.2017; 33(4): 125. CrossRef
Hand-assisted laparoscopic vs open colectomy: an assessment from the American College of Surgeons National Surgical Quality Improvement Program procedure-targeted cohort
Cigdem Benlice, Meagan Costedio, Luca Stocchi, Maher A. Abbas, Emre Gorgun
The American Journal of Surgery.2016; 212(5): 808. CrossRef
Learning curve for hand-assisted laparoscopic D2 radical gastrectomy
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World Journal of Gastroenterology.2015; 21(5): 1606. CrossRef
Hand-assisted laparoscopic versus laparoscopy-assisted D2 radical gastrectomy: a prospective study
JiaQing Gong, YongKuan Cao, YunMing Li, GuoHu Zhang, PeiHong Wang, GuoDe Luo
Surgical Endoscopy.2014; 28(10): 2998. CrossRef

Incidence and Multiplicities of Adenomatous Polyps in TNM Stage I Colorectal Cancer in Korea: Young-Sang Hong, Eun-Joo Jung, Chun-Geun Ryu, Gang-Mi Kim, Su-Ran Kim, Sung-Noh Hong, Dae-Yong Hwang; J Korean Soc Coloproctol. 2012;28(4):213-218. Published online August 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.4.213

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Abstract PDF

Purpose

In recent years, the incidence of early-stage colorectal cancer (CRC) has markedly increased in the population within the Republic of Korea. The aim of this study was to evaluate the clinicopathologic features of adenomatous polyps in TNM stage I CRC patients and in the general population.

Methods

Between March 2003 and September 2009, 168 patients with stage I CRC were enrolled in this study. In addition, the records of 4,315 members of the general population without CRC, as determined by colonoscopy during a health check-up, were reviewed.

Results

Of the 168 patients with stage I CRC, 68 (40.5%) had coexisting colorectal adenomatous polyps and of the 4,315 members of the general population, 1,112 (26.0%) had coexisting adenomatous polyps (P = 0.006). The prevalences of adenomatous polyp multiplicity in early CRC and in the general population were 32% and 15%, respectively (P = 0.023). Patients with coexisting adenomatous polyps had a higher frequency of tubulovillous or villous adenomas than members of the general population with polyps (7.5% vs. 2.0%, P = 0.037). Furthermore, a subgroup analysis showed that the occurrence (44% vs. 34%, P = 0.006) and the multiplicity (32% vs. 15%, P = 0.023) of adenomatous polyps were greater for T2 than T1 cancer.

Conclusion

The prevalence and the multiplicity of adenomatous polyps in TNM stage I CRC is higher than it is in the general population. The findings of this study suggest that depth of invasion of early stage CRC affects the prevalence and the number of adenomatous polyps in the remaining colon and rectum.

Citations

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Risk factors of recurrence in TNM stage I colorectal cancer
Jin-Hee Paik, Chun-Geun Ryu, Dae-Yong Hwang
Annals of Surgical Treatment and Research.2023; 104(5): 281. CrossRef

Effectiveness of Adjuvant Chemotherapy with 5-FU/Leucovorin and Prognosis in Stage II Colon Cancer: Sun Hee Jee, Sun Mi Moon, Ui Sup Shin, Hoe Min Yang, Dae-Yong Hwang; J Korean Soc Coloproctol. 2011;27(6):322-328. Published online December 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.6.322

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17 Citations

Abstract PDF

Purpose

The aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemotherapy in stage II colon cancer in the sparsity of Korean data.

Methods

From 1993 to 2006, 363 curatively resected pathologic stage II colon cancer patients were enrolled. Six cycles of adjuvant chemotherapy was performed: intravenous bolus 5-fluorouracil (5-FU) 500 mg/m² with leucovorin 20 mg/m2 for 2 hours daily for 5 days, followed by a 3-week resting period (n = 308). Fifty-five patients received only curative surgery. A high risk of recurrence was defined as the presence of one or more of the following factors: T4 tumor, lympho-vascular invasion, perineural invasion, perforation, obstruction, retrieved lymph node < 12, and poorly differention. The median follow-up period was 68 months (1 to 205 months).

Results

The five-year overall survival (OS) rate was 90.1%, and the five-year disease-free survival (DFS) rate was 84.7%. Among high-risk patients, the OS and the DFS rates of the treatment group were significantly higher than those of the non-treatment group (OS: 90.6% vs. 69.1%, P < 0.0001; DFS: 85.9% vs. 54.1%, P < 0.0001). Among low-risk patients, the survival results of the treatment group were also significantly superior (OS: 97.7% vs. 88.2%, P < 0.0001; DFS: 93.0% vs. 80.0%, P = 0.001). In the multivariate analysis, adjuvant chemotherapy was a significantly favorable prognostic factor for overall survival (hazard ratio, 0.41; 95% confidence interval, 0.22 to 0.75; P = 0.004).

Conclusion

In our population, adjuvant chemotherapy showed superior survival to curative surgery alone and significantly reduced the risk of death. A nationwide multicenter randomized trial is needed.

Citations

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Alberto Repici, Anna Paola Capra, Ahmed Hasan, Rossella Basilotta, Sarah Adriana Scuderi, Michela Campolo, Irene Paterniti, Emanuela Esposito, Alessio Ardizzone
International Journal of Molecular Sciences.2024; 25(23): 12988. CrossRef
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Chao Zhang, Songcheng Yin, Yuen Tan, Jinyu Huang, Pengliang Wang, Wenbin Hou, Zhe Zhang, Huimian Xu
American Journal of Clinical Oncology.2020; 43(4): 279. CrossRef
Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells
Jiaxun Tian, Jiamei Mo, Lan Xu, Rui Zhang, Yun Qiao, Bin Liu, Lei Jiang, Siyang Ma, Gang Shi
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Yusuke Okuda, Takaya Shimura, Tomonori Yamada, Yoshikazu Hirata, Ryuzo Yamaguchi, Eiji Sakamoto, Hiromi Kataoka
International Journal of Clinical Oncology.2018; 23(6): 1101. CrossRef
Effect of Adjuvant Chemotherapy on Stage II Colon Cancer: Analysis of Korean National Data
Min Ki Kim, Daeyoun David Won, Sun Min Park, Taejung Kim, Sung Ryong Kim, Seong Taek Oh, Seung Kook Sohn, Mi Yeon Kang, In Kyu Lee
Cancer Research and Treatment.2018; 50(4): 1149. CrossRef
Perineural Invasion Is a Strong Prognostic Factor in Colorectal Cancer
Nikki Knijn, Stephanie C. Mogk, Steven Teerenstra, Femke Simmer, Iris D. Nagtegaal
American Journal of Surgical Pathology.2016; 40(1): 103. CrossRef
Prognostic Value of Perineural Invasion in Colorectal Cancer: A Meta-Analysis
Yuchong Yang, Xuanzhang Huang, Jingxu Sun, Peng Gao, Yongxi Song, Xiaowan Chen, Junhua Zhao, Zhenning Wang
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ZHEN HUANG, YE XU, WEI PENG
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Ui Sup Shin, Sang Sik Cho, Sun Mi Moon, Sun Hoo Park, Sun Hee Jee, Eun-Joo Jung, Dae-Yong Hwang
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Sho Sawazaki, Manabu Shiozawa, Teni Godai, Yusuke Katayama, Koji Numata, Akio Higuchi, Yasushi Rino, Munetaka Masuda, Makoto Akaike
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Case Report

Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports: Chun-Geun Ryu, Eun-Joo Jung, Gangmi Kim, Su Ran Kim, Dae-Yong Hwang; J Korean Soc Coloproctol. 2011;27(5):266-269. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.266

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Abstract PDF

Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.

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Thomas S. Zajonz, Michael Sander, Winfried Padberg, Andreas Hecker, Ruediger Hörbelt, Christian Koch, Emmanuel Schneck
Annals of Medicine and Surgery.2018; 27: 26. CrossRef
Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient
Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens, Philippe G. Jorens
BMC Cancer.2017;[Epub] CrossRef
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Mor Moskovitz, Mira Wollner, Nissim Haim
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Pulmonary Fibrosis Secondary to FOLFOX Chemotherapy: A Case Report
Wai Cheong Soon, Kate West, David Gibeon, Elizabeth Frances Bowen
Case Reports in Oncology.2014; 7(3): 662. CrossRef
Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Case Report
Dane Wildner, Frank Boxberger, Axel Wein, Kerstin Wolff, Heinz Albrecht, Gudrun Männlein, Rolf Janka, Kerstin Amann, Jürgen Siebler, Werner Hohenberger, Markus F. Neurath, Richard Strauß
Case Reports in Oncological Medicine.2013; 2013: 1. CrossRef

Original Article

Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer: Geum Youb Noh, Dae-Yong Hwang, Yoon Hee Choi, Yun Yong Lee; J Korean Soc Coloproctol. 2010;26(6):424-428. Published online December 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.6.424

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Abstract PDF

Purpose

Many studies have revealed that diabetes mellitus (DM) increases a person's lifetime risk of colorectal cancer and that DM is associated with a worse outcome of colon cancer, but this association is controversial. In this study, we intended to examine the relationship between DM and the long-term outcomes of colorectal cancer.

Methods

A retrospective analysis was conducted on 657 patients who underwent surgery due to colorectal cancer between 1997 and 2004 at Korea Cancer Center Hospital. The operations were done by a single surgeon. With a median follow-up of 4.7 years, we analyzed differences in recurrence-free survival (RFS) and overall survival (OS) between patients with DM and those without DM.

Results

Of the 657 patients, 374 (57%) were males and 67 (10%) had DM. There was no difference in age at diagnosis, sex and pathologic stage of colorectal cancer according to the presence of DM. There were no difference in the RFS and the OS of colon cancer between the patients with DM and those without DM. At 5 years, the RFS was 71.3% in diabetic patients vs. 70.4% in non-diabetic patients (P = 0.480), and the OS was 68.8% in diabetic patients vs. 75.0% in non-diabetic patients (P = 0.498). There was no difference in the median survival between the groups (9.6 years in the diabetic group vs. 10.6 years in the non-diabetic group; P = 0.495).

Conclusion

In this study, we did not find any relation between the presence of DM and either the recurrence or the survival in cases of colorectal cancer. More studies to elucidate whether the influence of DM is directly related to a higher rate of cancer recurrence or survival are needed.

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Daniel J. Becker, Arjun D. Iyengar, Salman R. Punekar, Dalia Kaakour, Megan Griffin, Joseph Nicholson, Heather T. Gold
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Utsav Gupta, MadhuKumari Upadhyay, Rahul Sharma
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Postoperative serum carcinoembryonic antigen levels cannot predict survival in colorectal cancer patients with type II diabetes
Chih-Sheng Huang, Chin-Yau Chen, Li-Kuo Huang, Wei-Shu Wang, Shung-Haur Yang
Journal of the Chinese Medical Association.2020; 83(10): 911. CrossRef
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Nina J Karlin, Shailja B Amin, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Curtiss B Cook
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Jessica Chubak, Onchee Yu, Rebecca A. Ziebell, Erin J. Aiello Bowles, Andrew T. Sterrett, Monica M. Fujii, Jennifer M. Boggs, Andrea N. Burnett-Hartman, Denise M. Boudreau, Lu Chen, James S. Floyd, Debra P. Ritzwoller, Rebecca A. Hubbard
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Shin Jun Lee, Jae Hyun Kim, Seun Ja Park, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
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Bo Zhu, Xiaomei Wu, Bo Wu, Dan Pei, Lu Zhang, Lixuan Wei, Masaru Katoh
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Case Report

Impaction of a Foreign Body in the Rectum by Improper Use of a (Electronic) Massager: A Case Report: Eun-Joo Jung, Chun-Geun Ryu, Gangmi Kim, Dae-Yong Hwang; J Korean Soc Coloproctol. 2010;26(4):298-301. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.298

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Abstract PDF

A male, 67 years old, visited the emergency room because of a foreign body impacted in his rectum. While he was being treated for grade-II hemorrhoids conservatively, he heard that massage of the peri-anal area could be helpful for preventing hemorrhoids. Thus, while using an electronic massager after placing the head of the machine into a short round bar, the head became separated from the machine, and this was inserted into the anus and impacted. The patient had anal discomfort without abdominal pain. His vital signs were stable, and no abnormal physical findings were found for the abdomen. On digital rectal examination, the rim of the foreign body was palpated about 8 cm from the anal verge. Anal bleeding, abnormal discharge, or foul odor was not found. On a simple abdominal X-ray, a radio-opaque foreign body was observed in the pelvic cavity, and mild leukocytosis was noted on the laboratory test. To avoid injury to the anal sphincter, we tried to remove the foreign body under the spinal anesthesia. After anesthesia had been administered, the foreign body was palpated more distally at 5-6 cm from the anal verge by digital examination, and the foreign body was found to have a hole in its center. This was held using a Kelly clamp, and with digital guiding, was removed through the anus. After removal, an anoscopic examination was performed to determine if mucosal injury had occurred in the rectum or anal canal. The patient was discharged without complication after 24 hours of close observation.

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