Annals of Coloproctology

Case Reports

Metastasis

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report: Sungchul Lee, Euitae Kim, Dong-Guk Park; Ann Coloproctol. 2024;40(Suppl 1):S18-S22. Published online November 21, 2022; DOI: https://doi.org/10.3393/ac.2022.00339.0048

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A 61-year-old man presented with abdominal distension without any symptoms. On colonoscopy and computed tomography findings, it was clinically diagnosed as peritoneal metastasis of sigmoid colon cancer, and diagnostic laparoscopy was performed. Only the peritoneum was partially resected, and the pathology was signet ring cell carcinoma with predominantly local mucinous carcinoma component. However, the patient complained of persistent symptoms and, despite the progress of chemotherapy, the peritoneal dissemination worsened, and additional cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) was performed. Mixed adenoneuroendocrine carcinomas (MANECs) were reported in the appendix with perforated visceral peritoneum. After additional chemotherapy, the patient was discharged. Patients with advanced MANEC with peritoneal spreading may benefit from aggressive treatment by cytoreduction surgery with HIPEC, followed by intravenous chemotherapy.

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Mixed neuroendocrine non-neuroendocrine neoplasms in gastroenteropancreatic tract
Sebastián Díaz-López, Jerónimo Jiménez-Castro, Carlos Enrique Robles-Barraza, Carlos Ayala-de Miguel, Manuel Chaves-Conde
World Journal of Gastrointestinal Oncology.2024; 16(4): 1166. CrossRef

Urinary Bladder Injury During Colonoscopy Without Colon Perforation: Jung Wook Suh, Jun Won Min, Hwan Namgung, Dong-Guk Park; Ann Coloproctol. 2017;33(3):112-114. Published online June 30, 2017; DOI: https://doi.org/10.3393/ac.2017.33.3.112

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We report a case of urinary bladder perforation during colonoscopy. A 67-year-old female, who had undergone a transabdominal hysterectomy for uterine myomas 15 years ago, visited the emergency department with complaint of abdominal pain after a screening colonoscopy. Laparoscopic examination revealed severe adhesion between the sigmoid colon and the urinary bladder. The urinary bladder wall was weakened, and several perforation sites were found. The surgery was converted to a laparotomy. After a thorough examination, we performed primary repair for the perforation sites, followed by an omentopexy.

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Trauma to the solid abdominal organs: The missed dark box of colonoscopy
Mohamed H Emara, Usama Mazid, Yasmine A Elshaer, Mahmoud A Elkerdawy, Dilaver Farooq Malik, Aya M Mahros
World Journal of Gastroenterology.2024; 30(7): 624. CrossRef
Mesenteric laceration of the sigmoid colon after colonoscopy: A rare complication
Min Wu, Yonghua Lin, Zhichao Chen, Jianfeng Wei
Asian Journal of Surgery.2023; 46(11): 5391. CrossRef
Massive retroperitoneal hematoma following colonoscopy
Reo Ohtsuka, Hodaka Amano, Kei Niida, Takeaki Yoshino, Michiyo Owari, Ryotaro Takano, Yuichi Akama, Yohei Watanabe, Toshiyasu Iwao
Medicine.2018; 97(31): e11723. CrossRef

Editorial

Is Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy a Safe and Effective Procedure for Treating Patients With a Peritoneal Surface Malignancy?: Dong-Guk Park; Ann Coloproctol. 2017;33(1):3-4. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.3

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Albumin Leakage Level during Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Associated with Major Complications
Hyun-Chang Kim, Dong Woo Han, Eun Jung Park, Yeon Hwa Hong, Young Song
Cancers.2024; 16(16): 2874. CrossRef
Analgesic effects of combined transversus abdominis plane block and intramuscular electrical stimulation in patients undergoing cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy: a randomized controlled trial
Hyun-Chang Kim, Jinyoung Park, Jinyoung Oh, Minjae Kim, Eun Jung Park, Seung Hyuk Baik, Young Song
International Journal of Surgery.2023; 109(5): 1199. CrossRef

Case Report

Peritoneal Metastatic Goblet-Cell Carcinoid Tumor Treated With Cytoreductive Surgery and Intraperitoneal Chemotherapy: Sang Il Youn, Hwan Namgung, Jeong Seok Yun, Yun Jun Park, Dong-Guk Park; Ann Coloproctol. 2015;31(2):74-78. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.74

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We report a case of a goblet-cell carcinoid tumor of the appendix which metastasized to the peritoneum and was treated by using cytoreductive surgery (CRS) with intraperitoneal chemotherapy. A 47-year-old male presented with chronic constipation and was diagnosed as having a rectal adenocarcinoma with a signet-ring-cell component under colonoscopy. Computed tomography suggested peritoneal metastases with diffuse nodular parietal peritoneal thickening of the entire abdomen and focal invasion of the upper rectum by a seeding mass. CRS with intraperitoneal chemotherapy was done under the diagnosis of a rectal adenocarcinoma with peritoneal metastases. The pathologic diagnosis was a goblet-cell carcinoid tumor of the appendix with peritoneal metastasis. The histological discrepancy between a peritoneal metastatic mass and a rectal mass was due to the mixed histological pattern of a goblet-cell carcinoid tumor. A metastatic mass may not share identical immunohistochemical characteristics from its origin. This histologic discrepancy necessitates caution in diagnosing a distant metastasis of a goblet-cell carcinoid tumor.

Citations

Citations to this article as recorded by

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report
Sungchul Lee, Euitae Kim, Dong-Guk Park
Annals of Coloproctology.2024; 40(Suppl 1): S18. CrossRef
Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum—A Case Report and Brief Review of the Literature
Alexandra Dinu, Mariana Aşchie, Gabriela Isabela Bălţătescu, Manuela Enciu, Ionuţ Burlacu
Reports.2024; 8(1): 1. CrossRef
Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall
Faten Limaiem, Sahir Omrani, Mohamed Hajri
Clinical Case Reports.2023;[Epub] CrossRef
Mixed Neuroendocrine Non-neuroendocrine Neoplasm of Anorectum with Goblet Cell Morphology
Sandhya Biswal, Anirban Kundu, Ankit Sahoo, Prakash Kumar Sasmal, Biswajit Sahoo, Suvradeep Mitra
Journal of Gastrointestinal Cancer.2021; 52(3): 1093. CrossRef
Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
Santosh Shenoy
World Journal of Gastrointestinal Surgery.2016; 8(10): 660. CrossRef

Original Articles

Clinical Trial on the Incidence of Wound Infection and Patient Satisfaction After Stoma Closure: Comparison of Two Skin Closure Techniques: Sang Il Yoon, Sun Mi Bae, Hwan Namgung, Dong Guk Park; Ann Coloproctol. 2015;31(1):29-33. Published online February 28, 2015; DOI: https://doi.org/10.3393/ac.2015.31.1.29

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Abstract PDF

Purpose

Surgical site infection (SSI) is one of the most common complications that can occur after stoma closure. Reports have described differences in the incidence of wound infection depending on the skin closure technique, but there is no consensus on the ideal closure technique for a stoma wound. The aim of this study was to compare the incidence of SSI and the patient satisfaction between a circumferential purse-string approximation (CPA) and a primary linear closure (PC) of a stoma wound.

Methods

This prospective nonrandomized trial enrolled 48 patients who underwent a stoma closure from February 2010 to October 2013. Patients were divided into two groups according to the stoma closing technique: the CPA group (n = 34) and the PC group (n = 14). The incidences of SSI for the two groups were compared, and the patients' satisfaction with the stoma closure was determined by using a questionnaire.

Results

SSI occurred in 3 of 48 patients (6.3%) and was more frequent in the PC group than in the CPA group (3/14 [21.4%] vs. 0/34 [0%], P = 0.021). Time to complete healing after stoma closure in the CPA group was 32 days (range, 14-61 days). Patients in the CPA group were more satisfied with the resulting wound scar (P = 0.043).

Conclusion

After stoma closure, CPA was associated with a significantly lower incidence of wound infection and greater patient satisfaction compared to PC. However, with the CPA technique, the time to heal is longer than it is with PC.

Citations

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First Experience with the NPseal®: A Novel Mechanically Powered Negative Pressure Dressing Applied to Colorectal Surgery Wounds
Johnny Wang, Brian Williams, Jordan R. Wlodarczyk, Abhinav Gupta, Debora Kim, Kyle G. Cologne, Sarah E. Koller, Christine Hsieh, Marjun P. Duldulao, Joongho Shin
Surgical Innovation.2025; 32(2): 127. CrossRef
Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal
Brian Williams, Aubrey Swinford, Jordan Martucci, Johnny Wang, Jordan R. Wlodarczyk, Abhinav Gupta, Kyle G. Cologne, Sarah E. Koller, Christine Hsieh, Marjun P. Duldulao, Joongho Shin
Surgery Open Science.2025; 23: 69. CrossRef
Comparison of Negative Pressure Wound Therapy Systems and Conventional Non-Pressure Dressings on Surgical Site Infection Rate After Stoma Reversal: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Elissavet Anestiadou, Stavros Stamiris, Orestis Ioannidis, Savvas Symeonidis, Stefanos Bitsianis, Konstantinos Bougioukas, Thomas Karagiannis, Efstathios Kotidis, Manousos-Georgios Pramateftakis, Ioannis Mantzoros, Angeliki Cheva, Georgios Geropoulos, Chr
Journal of Clinical Medicine.2025; 14(5): 1654. CrossRef
Clinical Benefits of Reducing Dead Space Using a Closed Suction Drain and Subcutaneous Large-bite Buried Suture Technique to Prevent Superficial Surgical-site Infections Following Primary Closure of a Diverting Stoma
Yusuke Ohara, Yohei Owada, Jaejeong Kim, Shoko Moue, Yoshimasa Akashi, Koichi Ogawa, Kazuhiro Takahashi, Osamu Shimomura, Kinji Furuya, Shinji Hashimoto, Tsuyoshi Enomoto, Tatsuya Oda
Journal of the Anus, Rectum and Colon.2024; 8(2): 70. CrossRef
Comparison of purse-string technique vs linear suture for skin closure after ileostomy reversal. A randomized controlled trial
Filippo Carannante, Gianluca Costa, Valentina Miacci, Gianfranco Bianco, Gianluca Masciana, Sara Lauricella, Marco Caricato, Gabriella Teresa Capolupo
Langenbeck's Archives of Surgery.2024;[Epub] CrossRef
Purse-string versus linear closure of the skin wound following stoma reversal: A meta-analysis with RCT and systematic review
Jinlong Luo, Dan Liu, Junmei Wu, Huaiwu Jiang, Jin Chen, Hua Yang, Lie Yang
Medicine.2024; 103(35): e39477. CrossRef
Gunsight suture with subcutaneous vacuum drainage during enterostomy decreased the surgical site infection rate in obese rectal cancer patients: A retrospective study
Lei Zhang, Zhi-Qiang Xiao, Chang-Ling San, Tong-Lin Miao
Journal of Nutritional Oncology.2023; 8(3): 151. CrossRef
Effectiveness of negative pressure wound therapy with instillation and dwelling after stoma closure: a retrospective and propensity score matching analysis
Yoshinori Yane, Jin-ichi Hida, Yasutaka Chiba, Yusuke Makutani, Hokuto Ushijima, Yasumasa Yoshioka, Masayoshi Iwamoto, Toshiaki Wada, Koji Daito, Tadao Tokoro, Kazuki Ueda, Junichiro Kawamura
Scientific Reports.2022;[Epub] CrossRef
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Ostomy Surgery
Bradley R. Davis, Michael A. Valente, Joel E. Goldberg, Amy L. Lightner, Daniel L. Feingold, Ian M. Paquette
Diseases of the Colon & Rectum.2022; 65(10): 1173. CrossRef
The technique for less infectious and earlier healing of stoma closure wound: negative pressure wound therapy with instillation and dwelling followed by primary closure
Yoshinori Yane, Jin-ichi Hida, Yusuke Makutani, Hokuto Ushijima, Yasumasa Yoshioka, Masayoshi Iwamoto, Toshiaki Wada, Koji Daito, Tadao Tokoro, Kazuki Ueda, Junichiro Kawamura
BMC Surgery.2021;[Epub] CrossRef
Symptoms and Care Satisfaction in Patients Who Underwent Coronary Artery Bypass Graft Surgery
Tuğçe BOZKURT
Clinical and Experimental Health Sciences.2021; 11(3): 481. CrossRef
Evidence-based adoption of purse-string skin closure for stoma wounds
Nilotpal Behuria, Jayant Kumar Banerjee, Sita Ram Ghosh, Shrirang Vasant Kulkarni, Ramanathan Saranga Bharathi
Medical Journal Armed Forces India.2020; 76(2): 185. CrossRef
Gunsight Procedure Versus the Purse-String Procedure for Closing Wounds After Stoma Reversal: A Multicenter Prospective Randomized Trial
Jia Gang Han, Hong Wei Yao, Jian Ping Zhou, Hong Zhang, Gui Ying Wang, Zhan Long Shen, Jian Feng Gong, Zhen Jun Wang
Diseases of the Colon & Rectum.2020; 63(10): 1411. CrossRef
Purse-string approximation vs. primary closure with a drain for stoma reversal surgery: results of a randomized clinical trial
Kunihiko Amamo, Hideyuki Ishida, Kensuke Kumamoto, Norimichi Okada, Satoshi Hatano, Noriyasu Chika, Yusuke Tajima, Tomonori Ohsawa, Masaru Yokoyama, Keiichiro Ishibashi, Erito Mochiki
Surgery Today.2019; 49(3): 231. CrossRef
Purse-string vs. linear skin closure at loop ileostomy reversal: a systematic review and meta-analysis
M. Gachabayov, H. Lee, A. Chudner, A. Dyatlov, N. Zhang, R. Bergamaschi
Techniques in Coloproctology.2019; 23(3): 207. CrossRef
Incisional hernia following closure of loop ileostomy: The main predictor is the patient, not the surgeon
A.J. Brook, S.D. Mansfield, I.R. Daniels, N.J. Smart
The Surgeon.2018; 16(1): 20. CrossRef
Purse-string skin closure versus linear skin closure techniques in stoma closure: a comprehensive meta-analysis with trial sequential analysis of randomised trials
Shahab Hajibandeh, Shahin Hajibandeh, Andrew Kennedy-Dalby, Sheik Rehman, Reza Arsalani Zadeh
International Journal of Colorectal Disease.2018; 33(10): 1319. CrossRef
Effect of a Purse-String Approximation Following Stoma Takedown on Wound Infection and Satisfaction
In Ja Park
Annals of Coloproctology.2015; 31(1): 7. CrossRef

Bezoar-induced Small Bowel Obstruction: Se Heon Oh, Hwan Namgung, Mi Hyun Park, Dong-Guk Park; J Korean Soc Coloproctol. 2012;28(2):89-93. Published online April 30, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.2.89

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Abstract PDF

Purpose

The aim of this study was to observe the clinical features of a bezoar-induced small bowel obstruction and to investigate the role of abdominal computed tomography (CT) in establishing the diagnosis.

Methods

We retrospectively reviewed 20 cases of bezoar-induced small bowel obstruction in our hospital from 1996 to 2010.

Results

Thirteen patients (65%) had a history of abdominal surgery. Nine patients (45%) were diagnosed with a bezoar before surgery, seven patients were diagnosed by using abdominal CT, and two patients were diagnosed with a small bowel series. Abdominal CT was performed in 15 patients, and the diagnostic accuracy was 47% (7/15). Surgery revealed ten bezoars in the jejunum and 11 in the ileum. Two patients had bezoars found concurrently in the stomach. Spontaneous removal took place in two patients. An enterotomy and bezoar extraction was performed in 15 patients. Fragmentation and milking, a small bowel resection, and a Meckel's diverticulectomy were performed in one patient each. Early operative treatment was possible (P = 0.036) once the bezoar had been diagnosed by using abdominal CT. There tended to be fewer postoperative complications in patients who were diagnosed with a bezoar by using abdominal CT, but the result was not statistically significant (P = 0.712).

Conclusion

A preoperative diagnosis of bezoar-induced small bowel obstruction by using clinical features was difficult. Increased use of abdominal CT led to a more accurate diagnosis and to earlier surgery for bezoar-induced small bowel obstructions, thereby reducing the rate of complications.

Citations

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Small intestinal obstruction caused by the gastric bezoars in elderly diabetic patients: A case report
Yifan Huang, Jie Meng, Shuo Zhang
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Small bowel obstruction due to a meat bolus bezoar: the second case report in literature
Ammar Albostani, Fadi Kfelati, Wafaa Alsaadi, Rufaida Ahmad Faraman, Aasem Farman
Annals of Medicine & Surgery.2024; 86(2): 1139. CrossRef
Endoscopic lithotripsy combined with drug lithotripsy vs. drug lithotripsy for the treatment of phytobezoars: analysis of 165 cases
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Surgical Endoscopy.2024; 38(5): 2788. CrossRef
A Rare Case of Gastric Phytobezoar (Diospyrobezoar) in a Healthy Adult
Ahmed M Odeh, Ahmed A Alkhalifa, Mohammed A AlHajji, Alwayah J Alahmed, Jawad H Alsalman, Abdulrahman M AlMulhem, Mohammed S AlGhadeer, Ezzeddin Kurdi, Fatima S Albader, Abdulmohsen Alsuwaigh, Mohammad A Khan
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Evaluation of the location, number and diameter of bezoars in patients with a history of previous gastrointestinal surgery
Ali Muhtaroğlu, Merve Yiğit, Hakan Demir, Uğur Dülger, Muhammed Doğangün, İbrahim Furkan Küçük, Fatih Altintoprak
European Journal of Trauma and Emergency Surgery.2023; 49(4): 1783. CrossRef
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Canadian Journal of Emergency Medicine.2023; 25(3): 244. CrossRef
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Christoforos S. Kosmidis, Chrysi Maria Mystakidou, Nikolaos Varsamis, Charilaos Koulouris, Christina Sevva, Konstantina Papadopoulou, Christina Michael, Nikolaos Iason Katsios, Vasiliki Theodorou, Petrina Miltiadous, Konstantinos Papadopoulos, Konstantino
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Small Bowel Obstruction by a Phytobezoar in a Patient With Previous Antrectomy and Billroth II Reconstruction
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Khat induced bezoar; a rare cause of small bowel obstruction:a case report
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Impending perforation near ileocecal junction due to phytobezoar impaction and intraluminal polyp: a case report
Mehwish Mooghal, Asrar Ahmad, Adnan Safi, Wajiha Khan, Naveed Ahmad
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When eating makes you sick – Gastric stump obstruction caused by a phytobezoar. A case report and literature review
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Phytobezoar: A train can hide another
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From Blocking Shots to Blocking GI Transit, This Professional Basketball Player Does It All: A Case Report on Small Bowel Obstruction
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Intestinal Obstruction Secondary to Multiple Gastrointestinal phytobezoars, A Rare presentation
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Bezoar as a cause of jejunal afferent loop mass after pylorus preserving pancreaticoduodedectomy: A case report
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A rare giant gastric trichobezoar in a young female patient: Case report and review of the literature
Dimitra G. Delimpaltadaki, Ioannis G. Gkionis, Mathaios E. Flamourakis, Andreas F. Strehle, Emmanouil N. Bachlitzanakis, Michail I. Giakoumakis, Manousos S. Christodoulakis, Konstantinos G. Spiridakis
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Clinics in diagnostic imaging (198)
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Small Bowel Obstruction Caused by Aloe vera Bezoars: A Case Report
In Taik Hong, Jae Myung Cha, Hye Jin Ki, Min Seob Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeoun, Sung Il Choi
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Intestinal obstruction due to phytobezoars: An update
Enis Dikicier
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Pei-Yuan Wang
World Journal of Gastroenterology.2015; 21(33): 9774. CrossRef
Imaging differentiation of phytobezoar and small-bowel faeces: CT characteristics with quantitative analysis in patients with small- bowel obstruction
Ya-Cheng Chen, Chang-Hsien Liu, Hsian-He Hsu, Chih-Yung Yu, Hong-Hau Wang, Hsiu-Lung Fan, Ran-Chou Chen, Wei-Chou Chang
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Kyung Hoon Lee, Hyun Young Han, Hee Jin Kim, Hee Kyung Kim, Moon Soo Lee
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Bulbus psododivertikülde mide çıkış obstrüksiyonuna neden olan ve gastroskopi ile mideye alınması sonrası ileus gelişen bezoar: olgu sunumu ve literatürün gözden geçirilmesi (duodenal bezoar)
Ahmet UYANIKOĞLU, Haşim NAR, Ahmet ŞEKER, Ferzan AYDIN, Yusuf YÜCEL, Necati YENİCE
Endoskopi Gastrointestinal.2015; 23(2): 58. CrossRef
Two cases of small bowel obstruction secondary to a swallowed potato
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Phytobezoar: an unexpected cause of bowel obstruction in a pregnant woman with a history of Roux-en-Y gastric bypass
Faustine Deront Bourdin, Antonio Iannelli, Jerôme Delotte
Surgery for Obesity and Related Diseases.2014; 10(6): e49. CrossRef
Bezoar: An unusual cause of intestinal obstruction
K. Stratakis, A. Tsepelaki, E. Karallas, K. Koutsopoulos
Hellenic Journal of Surgery.2014; 86(1): 29. CrossRef
Intussusception caused by dried apricot: A case report
Yana Puckett, Jon Nathan, Sharmila Dissanaike
International Journal of Surgery Case Reports.2014; 5(12): 1254. CrossRef
Acute small bowel obstruction in a girl, caused by a jejunal bezoar composed of textile fibers
S. Zwaveling, D.C. van der Zee
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Complications of Bezoar in Children: What Is New?
Kam Lun Ellis Hon, Jean Cheng, Chung Mo Chow, Hon Ming Cheung, Kam Lau Cheung, Yuk Him Tam, Alexander K. C. Leung
Case Reports in Pediatrics.2013; 2013: 1. CrossRef

Editorial

Are Mutations of the EGFR Gene Promising Predictive Markers for Anti-EGFR mAbs in Colorectal Carcinomas?: Dong-Guk Park; J Korean Soc Coloproctol. 2011;27(3):103-104. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.103

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Original Articles

Effects of DCA on Cell Cycle Proteins in Colonocytes: Yun-Hyung Ha, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):254-259. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.254

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Abstract PDF

Purpose

Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous studies have been based on studies on colon cancer cell lines, the effect of DCA on normal colonocytes is unknown.

Methods

Normal colonocytes and Caco-2 and HCT116 cells were treated with 20 µM and 250 µM of DCA, and the effect of different concentrations of DCA was measured based on the expression of cell-cycle-related proteins by using Western blots.

Results

The expressions of CDK2 and cyclin D1 for different concentrations of DCA in normal colonocytes and colon cancer cells were similar, but the expressions of cyclin E and A were significantly different. In HCT116 colon cancer cells, the expression of cyclin E increased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin E was not changed or decreased. In HCT116 colon cancer cells, the expression of cyclin A was not changed or decreased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin A was increased at a DCA concentration of 20 µM.

Conclusion

The effect of DCA on stimulating cell proliferation suggests that DNA synthesis is stimulated by an increased expression of cyclin E in colon cancer cells. Our results suggest that a low dose of DCA induces cellular proliferation through increased expression of cyclin A and that a high dose of DCA induces decreased expression of cyclin E and CDK2 in normal colonocytes.

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Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells: Won Jun Sohn, Jung Won Lee, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):246-253. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.246

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Abstract PDF

Purpose

Oxaliplatin is a third-generation platinum compound, and it has no nephrotoxicity and has reduced bone marrow toxicity. Cancer cells that are resistant to cisplatin are sensitive to oxaliplatin. Oxaliplatin is used widely for the treatment of colon cancers. Recently, oxaliplatin was reported to inhibit the expression of survivin, which protects cell apoptosis. However, there are no reports on the expressions of survivin variants and the changes in intracellular localization of survivin in cancer cells. We studied the expression of survivin caused by oxaliplatin in HCT116 colon cancer cells, and we observed the localization of survivin in the mitotic phase.

Methods

We treated the HCT116 colon cancer cells with 2.0 µM of oxaliplatin, and we studied the expressions of survivin protein, and survivin mRNA variants, as well as the changes in intracellular localization, by using the Western blot method, RT-PCR, immunocytochemistry, and flowcytometry.

Results

Oxaliplatin inhibits the expression of the survivin protein and survivin mRNA in HCT116 colon cancer cells. The expression of the survivin-2B variants, which have no antiapoptotic activity but control cell mitosis by localization on a microtubule, is reduced continuously 2 days after treatment with oxaliplatin. In immunocytochemistry, expression of survivin in the cytoplasm is reduced and especially is not expressed in microtubules and contractile rings.

Conclusion

One of the mechanisms of oxaliplatin is to inhibit the expression of and to change the localization of survivin. Based on these results, we suggest that changes in the expression of survivin variants and in their localization are two effects of oxaliplatin.

Citations

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Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial
M Verstraete, A Debucquoy, J Dekervel, J van Pelt, C Verslype, E Devos, G Chiritescu, K Dumon, A D'Hoore, O Gevaert, X Sagaert, E Van Cutsem, K Haustermans
British Journal of Cancer.2015; 112(8): 1314. CrossRef
Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
Dong-Guk Park
Annals of Surgical Treatment and Research.2014; 86(2): 68. CrossRef

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