Annals of Coloproctology

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Original Article

Colorectal cancer

Comparing the efficacy of combined versus single immune cell adaptive therapy targeting colorectal cancer: Denis Nchang Che, NaHye Lee, Hyo-Jung Lee, Yea-Won Kim, Solongo Battulga, Ha Na Lee, Won-Kook Ham, Hyunah Lee, Mi Young Lee, Dawoon Kim, Haengji Kang, Subin Yun, Jinju Park, Daeyoun David Won, Jong Kyun Lee; Ann Coloproctol. 2024;40(2):121-135. Published online April 22, 2024; DOI: https://doi.org/10.3393/ac.2023.00402.0057

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Abstract PDF Supplementary Material: Purpose
Colorectal cancer (CRC) is the most frequent cancer with limited therapeutic achievements. Recently, adoptive cellular immunotherapy has been developed as an antitumor therapy. However, its efficacy has not been tested in CRC. This study investigated the ability of an immune cell cocktail of dendritic cells (DCs), T cells, and natural killer (NK) cells to overcome immunological hurdles and improve the therapeutic efficacy of cell therapy for CRC.
Methods
CRC lysate-pulsed monocyte-derived DCs (Mo-DCs), CRC antigen-specifically expanded T cells (CTL), and in vitro-expanded NK cells were cultured from patient peripheral blood mononuclear cells (PBMC). The ability of the combined immune cells to kill autologous tumor cells was investigated by co-culturing the combined immune cells with patient-derived tumor cells.
Results
The Mo-DCs produced expressed T cell co-stimulating molecules like CD80, CD86, human leukocyte antigen (HLA)-DR and HLA-ABC, at high levels and were capable of activating naive T cells. The expanded T cells were predominantly CD8 T cells with high levels of CD8 effector memory cells and low levels of regulatory T cells. The NK cells expressed high levels of activating receptors and were capable of killing other cancer cell lines (K562 and HT29). The immune cell cocktail demonstrated a higher ability to kill autologous tumor cells than single types. An in vivo preclinical study confirmed the safety of the combined immune cell adaptive therapy showing no therapy-related death or general toxicity symptoms.
Conclusion
The results suggested that combined immune cell adaptive therapy could overcome the limited efficacy of cell immunotherapy.

Case Report

Giant Peritoneal Loose Body in the Pelvic Cavity: Joung Teak Jang, Haeng Ji Kang, Ji Young Yoon, Seo Gue Yoon; J Korean Soc Coloproctol. 2012;28(2):108-110. Published online April 30, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.2.108

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17 Citations

Abstract PDF

We report a case of a large peritoneal loose body diagnosed on computed tomography. The most common causes of a peritoneal loose body are thought to be torsion and separation of the appendices epiploicae. Peritoneal loose bodies are usually small, 0.5 to 2.5 cm in diameter. However, "giant" peritoneal loose bodies, larger than 4 cm in diameter, are an uncommon disease and present with various symptoms, and are difficult to diagnose preoperatively. Especially, abdominal large peritoneal loose bodies are frequently misdiagnosed as tumorous disease preoperatively. In our case, the loose body appeared as a round pelvic mass with central calcifications and a distinct fat plane separating it from adjacent organs. Preoperatively, we suspected a tumorous lesion from the wall of the upper rectum; however, at laparoscopy, a large peritoneal loose body was detected. An extraction of the giant peritoneal loose body was performed laparoscopically.

Citations

Citations to this article as recorded by

Epiploic appendagitis: An overlooked cause of acute abdominal pain
Yasser El-Sawaf, Salman Alzayani, Nermin K Saeed, Adel S Bediwy, Reem Elbeltagi, Khaldoon Al-Roomi, Mohammed Al-Beltagi
World Journal of Gastroenterology.2025;[Epub] CrossRef
A giant peritoneal loose body: A case report and updated literature review and data synthesis
Guo-Le Nie, Shicheng Chu, Song Geng, Hong Jiang, Hao Zhan
Medicine.2025; 104(50): e45956. CrossRef
Unveiling the rarity: A case report of giant peritoneal loose body
Abdudin Heru Mehammed, Natnael Alemu Bezabih, Muluken Yifru Gebresilassie, Yohanna Aregawi Hailu, Mengistu Yismie Semahegn, Misganaw Yigletie Damtie
Radiology Case Reports.2024; 19(11): 5492. CrossRef
A Case of a Fixed Giant Peritoneal Loose Body outside the Peritoneum and near the Rectovesical Excavation
Kotaro Nanno, Seiichi Shinji, Takeshi Yamada, Akihisa Matsuda, Ryo Ohta, Hiromichi Sonoda, Takuma Iwai, Kohki Takeda, Kazuhide Yonaga, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Hiromasa Komori, Yoshinobu Shioda, Hiroshi Yoshida
Journal of Nippon Medical School.2023; 90(3): 276. CrossRef
Incidental peritoneal loose body in a polytrauma patient: The unnoticed scenario: A case report
Abraham Ariaya, Musse Ahmed, Esubalew Taddese Mindaye
International Journal of Surgery Case Reports.2021; 85: 106158. CrossRef
Peritoneal loose body presenting as a hepatic mass: A case report and review of the literature
Yang Wen, Min-jie Shang, Yan-qing Ma, Song-hua Fang, Yuan Chen
Open Medicine.2021; 16(1): 1356. CrossRef
A rare peritoneal egg: Case report with literature review
Nilu Malpani Dhoot, Shivaraj Afzalpurkar, Usha Goenka, Vinay Mahendra, Enam Murshed Khan, Arpita Sutradhar, Mahesh Goenka
Radiology Case Reports.2020; 15(10): 1895. CrossRef
Exploratory laparoscopy as first choice procedure for the diagnosis of giant peritoneal loose body: a case report
RuiBin Li, ZhiHeng Wan, HaoTian Li
Journal of International Medical Research.2020;[Epub] CrossRef
A giant peritoneal loose body impacted in the pelvic cavity, a rare and interesting finding during laparotomy
Ayad A. Mohammed
International Journal of Surgery: Global Health.2020; 3(6): e24. CrossRef
Giant peritoneal loose body in a patient with end-stage renal disease
Nadejda Cojocari, Leonard David
SAGE Open Medical Case Reports.2018;[Epub] CrossRef
Laparoscopic extraction of a giant peritoneal loose body: Case report and review of literature
Keiso Matsubara, Yuji Takakura, Takashi Urushihara, Takashi Nishisaka, Toshiyuki Itamoto
International Journal of Surgery Case Reports.2017; 39: 188. CrossRef
Two giant peritoneal loose bodies were simultaneously found in one patient: A case report and review of the literature
Qingxing Huang, Aihong Cao, Jun Ma, Zhenhua Wang, Jianhong Dong
International Journal of Surgery Case Reports.2017; 36: 74. CrossRef
Symptomatic giant peritoneal loose body in the pelvic cavity: A case report
Andreas Elsner, Mikolaj Walensi, Maya Fuenfschilling, Robert Rosenberg, Robert Mechera
International Journal of Surgery Case Reports.2016; 21: 32. CrossRef
Giant peritoneal loose body in the pelvic cavity confirmed by laparoscopic exploration: a case report and review of the literature
Hong Zhang, Yun-zhi Ling, Ming-ming Cui, Zhi-xiu Xia, Yong Feng, Chun-sheng Chen
World Journal of Surgical Oncology.2015;[Epub] CrossRef
Autoamputation of a pedunculated, subserosal uterine leiomyoma presenting as a giant peritoneal loose body
Izumi Suganuma, Taisuke Mori, Tokuei Takahara, Hiroko Torii, Masanori Fujishiro, Tomohisa Kihira, Yuko Urabe, Mamoru Urabe, Jo Kitawaki
Archives of Gynecology and Obstetrics.2015; 291(4): 951. CrossRef
Laparoscopic Surgery for a Peritoneal Loose Body 50 mm in Diameter ^|^mdash;A Case Report^|^mdash;
Takashi MIYAKE, Masahiko SUZUKI, Yutaro ASABA, Masahito UJI, Tomohito SATO, Yasunobu MIZUKAMI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(2): 569. CrossRef
A Giant Peritoneal Loose Body
Hyun-Soo Kim, Ji-Youn Sung, Won Seo Park, Youn Wha Kim
Korean Journal of Pathology.2013; 47(4): 378. CrossRef

Original Article

Clinical Study and Review of Articles (Korean) about Retrorectal Developmental Cysts in Adults: Sung Wook Baek, Haeng Ji Kang, Ji Yong Yoon, Do Youn Whang, Duk Hoon Park, Seo Gue Yoon, Hyun Sik Kim, Jong Kyun Lee, Jung Dal Lee, Kwang Yun Kim; J Korean Soc Coloproctol. 2011;27(6):303-314. Published online December 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.6.303

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57 Download
22 Citations

Abstract PDF

Purpose

A retrorectal developmental cyst (tailgut cyst, epidermoid cyst, dermoid cyst, teratoma, and duplication) is very rare disease, and the symptoms are not characteristic so that sometimes this disease is still misdiagnosed as a supralevator abscess or a complex anal fistula. We would like to present a clinical approach to this disease.

Methods

We retrospectively examined the charts of 15 patients who were treated for retrorectal cysts from January 2001 to November 2009.

Results

All 15 patients were female. The average age was 41 years (range, 21 to 60 years). Fourteen patients (93.3%) were symptomatic, and the most common symptom was anal pain or discomfort. Nine patients (60%) had more than one previous operation (range, 1 to 9 times) for a supralevator abscess, an anal fistula, etc. In 12 patients (80%), the diagnosis could be made by using the medical history and physical examination. Thirteen cysts (80%) were excised completely through the posterior approach. The average diameter of the cysts was 4.8 cm (range, 2 to 10 cm). Pathologic diagnoses were 8 tailgut cysts (53.3%), 5 epidermoid cysts (33.3%) and 2 dermoid cysts (13.3%). The average follow-up period was 18.3 months (range, 1 to 64 months).

Conclusion

In our experience, high suspicion and physical examination are the most important diagnostic methods. If a female patient has a history of multiple perianal operations, a retrorectal bulging soft mass, a posterior anal dimple, and no conventional creamy foul odorous pus in drainage, the possibility of a retrorectal developmental cyst must be considered.

Citations

Citations to this article as recorded by

Clinical characteristics of presacral cysts and risk factors for long-term fecal incontinence following laparoscopic resection of lesions
Zi-Yan Wang, Pei-Pei Wang, Kai-Wen Xu, Qian-Yu Wang, Jiao-Lin Zhou, Hui-Zhong Qiu, Chen Lin, Bin Wu
Surgery.2025; 187: 109660. CrossRef
Pararectal Epidermal Inclusion Cyst in a Pediatric Patient
Nour H Moosa, Hadeel Bozieh, Nermin Darawi, Fatima Hajjaj, Noor Awad, Firas Almasaid
Cureus.2024;[Epub] CrossRef
Endoscopic Resection of Tailgut Cyst
Oleksandr Kiosov, Vladyslav Tkachov, Sergii Gulevskyi, Yoshifumi Nakayama
Case Reports in Gastrointestinal Medicine.2024;[Epub] CrossRef
Presacral Keratinous and Dermoid Cyst Masquerading as Meningocele – A Rare Case Report
Lucky Gupta
African Journal of Paediatric Surgery.2024; 21(4): 271. CrossRef
A report of presacral epidermoid cyst in perimenopausal women: An extremely rare site and an unusual cause of chronic constipation
Salem M. Tos, Afnan W.M. Jobran, Anas Alasafrah, Izzeddin Bakri, Fahmi Jubran
International Journal of Surgery Case Reports.2023; 103: 107880. CrossRef
Retrorectal epidermoid mistaken for perirectal swelling: A case report
Mossaab Ghannouchi, Mohamed Ben Khalifa, Olfa Zoukar, Karim Nacef, Amina Chakka, Moez Boudokhan
International Journal of Surgery Case Reports.2022; 95: 107187. CrossRef
Perirectal epidermoid cyst in a patient with sacrococcygeal scoliosis and anal sinus: A case report
Zhou-Xin Ji, Song Yan, Xu-Can Gao, Li-Fen Lin, Qiang Li, Qi Yao, Dong Wang
World Journal of Clinical Cases.2022; 10(30): 11139. CrossRef
Chinese expert consensus on standardized treatment for presacral cysts
Gangcheng Wang, Chengli Miao
Gastroenterology Report.2022;[Epub] CrossRef
Presacral epidermoid cyst in a pediatric patient
Lilly Gu, Cara L. Berkowitz, John D. Stratigis, Lee K. Collins, Maria Mostyka, Nitsana A. Spigland
Journal of Pediatric Surgery Case Reports.2021; 71: 101904. CrossRef
Epidemiology, diagnostic approach and therapeutic management of tailgut cysts: A systematic review
Aikaterini Mastoraki, Ilias Giannakodimos, Karmia Panagiotou, Maximos Frountzas, Dimosthenis Chrysikos, Stylianos Kykalos, Georgios E. Theodoropoulos, Dimitrios Schizas
International Journal of Clinical Practice.2021;[Epub] CrossRef
Successful excision of a retrorectal cyst through trans-sacral approach: A case report
Tlal Matouq Alsofyani, Mohammed Yousef Aldossary, Faisal Fahd AlQahtani, Khalid Sabr, Ameera Balhareth
International Journal of Surgery Case Reports.2020; 71: 307. CrossRef
Anal Gland/Duct Cyst: A Case Report
Guh Jung Seo, Ju Heon Seo, Kyung Jin Cho, Hyung-Suk Cho
Annals of Coloproctology.2020; 36(3): 204. CrossRef
Retrorectal Epidermal Inclusion Cyst: An Incidental Finding During Cesarean Section
Sundus Nasim, Sohail Kumar, Dua Azim, Lajpat Rai, Summaya Saeed
Cureus.2020;[Epub] CrossRef
Combined laparoscopic and perineal approach for the management of recurrent tailgut cyst
Ankur Patel, Pranav Mandovra, Tanveer Majeed, Roy V Patankar
Asian Journal of Endoscopic Surgery.2019; 12(2): 181. CrossRef
Laparoscopic management of epidermoid cyst in an unusual location
Sindhuja Kesavan, Ramakrishnan Parthasarathi, Prakhar Gupta, Chinnusamy Palanivelu
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Ann-Sophie Hufkens, Peter Cools, Paul Leyman
Acta Chirurgica Belgica.2019; 119(2): 110. CrossRef
Malignant transformation of tailgut cysts is significantly higher than previously reported: systematic review of cases in the literature
K. Nicoll, C. Bartrop, S. Walsh, R. Foster, G. Duncan, C. Payne, C. Carden
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Laparoscopic surgical management of a mature presacral teratoma: a case report
Liming Wang, Yasumitsu Hirano, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Shintaro Ishikawa, Takuhisa Okada, Nao Obara, Shigeki Yamaguchi
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Pre-sacral (retrorectal) abnormal tissue and tumours may be described by a new classification – A review article
Mohammad Bukhetan Alharbi
International Journal of Surgery Open.2018; 11: 1. CrossRef
Precoccygeal epidermoid cyst in a child — A unique case report
J.S. Aihole, G. Aruna, J. Deepak, S. Supriya
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A Complicated Case of Pregnancy Involving a Presacral Epidermoid Cyst
Daisuke Shigemi, Seiryu Kamoi, Akihisa Matsuda, Toshiyuki Takeshita
Journal of Nippon Medical School.2017; 84(2): 100. CrossRef
Presacral Noncommunicating Enteric Duplication Cyst
Shabnam Seydafkan, David Shibata, Julian Sanchez, Nam D. Tran, Marino Leon, Domenico Coppola
Cancer Control.2016; 23(2): 170. CrossRef

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