Annals of Coloproctology

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Review

Translation/basic research

Extracellular vesicles in colorectal cancer: Young Il Kim, Chungyeop Lee, Hakho Lee, In Ja Park; Ann Coloproctol. 2025;41(5):379-392. Published online October 16, 2025; DOI: https://doi.org/10.3393/ac.2025.00745.0106

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Abstract PDF: Colorectal cancer (CRC) remains a major global health issue, with challenges including early detection and recurrence monitoring. While colonoscopy and fecal-based tests are standard screening tools, their limitations have driven interest in less invasive alternatives. Extracellular vesicles (EVs) present in patient liquid biopsy samples have emerged as potential biomarkers and therapeutic tools in CRC. EVs carry molecular cargo, including nucleic acids and proteins, that reflect the status of their cells of origin and can be readily accessed through minimally invasive liquid biopsy. This review outlines the role of EVs in the initiation and progression of CRC, summarizes recent advances in EV isolation techniques, and highlights candidate EV-derived biomarkers for diagnosis, prognosis, and treatment monitoring. By providing an updated synthesis of current research, this review aims to inform future studies and support clinical translation of EV-based approaches in CRC.

Original Article

Benign GI diease

Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis: Tae Gyeong Lee, Soomin Nam, Hyung Soon Lee, Jin Ho Lee, Young Ki Hong, Jung Gu Kang; Ann Coloproctol. 2020;36(1):30-34. Published online February 29, 2020; DOI: https://doi.org/10.3393/ac.2019.06.25

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8 Citations

Abstract PDF

Purpose
To compare the surgical outcomes of peritoneal irrigation versus suction alone during laparoscopic appendectomy and to identify the risk factors of surgical site infection in patients with uncomplicated acute appendicitis.
Methods
Data from patients with uncomplicated acute appendicitis between January 2014 and March 2016 were reviewed. We compared the irrigation and suction alone groups with regard to the following parameters: postoperative complication incidence rate, length of hospital stay, operation time, time to flatus, time to diet commencement, and duration of postoperative antibiotic.
Results
A total of 578 patients underwent laparoscopic appendectomy for uncomplicated acute appendicitis. Twenty-five patients were excluded from the analysis because of need for drain insertion, loss to follow-up, simultaneous surgery for another indication, presence of an appendix tumor, or pregnancy. A total of 207 patients (37.4%) had undergone irrigation, and 346 patients (62.6%) received suction alone during laparoscopic appendectomy. The preoperative fever rate was significantly higher in the irrigation group than in the suction alone group. Operative time was also significantly longer in the irrigation group than in the suction alone group (53.8 ± 18.5 minutes vs. 57.8 ± 21.4 minutes, P = 0.027). The postoperative complication rate was higher in the irrigation group than in the suction alone group (4.5% vs. 12.6%, P = 0.001). Multiple logistic regression analysis showed that irrigation and preoperative fever were risk factors for surgical site infection after laparoscopic appendectomy for uncomplicated acute appendicitis.
Conclusion
There is no advantage to irrigating the peritoneal cavity over suction alone during laparoscopic appendectomy for uncomplicated acute appendicitis. Irrigation may actually prolong the operative time and therefore be detrimental.

Citations

Citations to this article as recorded by

Wound Irrigation Prior to Closure During Routine Upper-Extremity Surgery: Is There a Difference in Wound Complications?
Marco Foreman, Isabella Amador, Arman Tabarestani, Kevin A. Hao, Jonathan Benjamin, Jed Casauay, Oluwaferanmi Dada, Persis Desai, Aaron Jennings, Adrienne Orriols, Reed Popp, Supreeya A. Saengchote, Anton Khlopas, Keegan Hones, Richard Hutchison, Jongmin
HAND.2025;[Epub] CrossRef
Establishment and validation of a nomogram for predicting postoperative intestinal adhesion in children with acute appendicitis
Dezhao Liu, Yuchi Wang, Liyun Sun, Lijia Pan, Junkui Wang, Ying Lu, Zhao Cui, Jingying Li, Hui Geng
BMC Pediatrics.2024;[Epub] CrossRef
Management of appendicitis: appendicectomy, antibiotic therapy, or both?
Elroy P. Weledji, Anutebeh V. Zisuh, Eleanore Ngounou
Annals of Medicine & Surgery.2023; 85(4): 897. CrossRef
Wound Irrigation Using Wet Gauze May Reduce Surgical Site Infection Following Laparoscopic Appendectomy
Abdullah Al-Sawat, Ji Yeon Mun, Sung Hoon Yoon, Chul Seung Lee
Frontiers in Surgery.2022;[Epub] CrossRef
To Reduce the Incidence of Postoperative Intraabdominal Abscess, the Application of Nonoperative Management Should be Circumspect Considering Patient Factors and the Nature of Acute Appendicitis
You Jin Lee, Kwang Hyun Yoon
Journal of Acute Care Surgery.2022; 12(3): 111. CrossRef
Effect and safety of peritoneal lavage for appendectomy: A meta-analysis
Yi-Ting Yen, El-Wui Loh, Ka-Wai Tam
The Surgeon.2021; 19(6): e430. CrossRef
A Novel Suction-and-Irrigation Laparoscopic Surgical Instrument: Internal Design and Preclinical Performance Evaluation
Sang Wook Yi
Journal of Medical Devices.2021;[Epub] CrossRef
Aspiration versus peritoneal lavage in appendicitis: a meta-analysis
Gloria Burini, Maria Chiara Cianci, Marco Coccetta, Alessandro Spizzirri, Salomone Di Saverio, Riccardo Coletta, Paolo Sapienza, Andrea Mingoli, Roberto Cirocchi, Antonino Morabito
World Journal of Emergency Surgery.2021;[Epub] CrossRef

Case Reports

Abdominal Sarcoidosis Mimicking Peritoneal Carcinomatosis: Won Seok Roh, Seungho Lee, Ji Hyun Park, Jeonghyun Kang; Ann Coloproctol. 2018;34(2):101-105. Published online April 30, 2018; DOI: https://doi.org/10.3393/ac.2018.01.29

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4 Web of Science
6 Citations

Abstract PDF

We present a patient diagnosed with skin sarcoidosis, breast cancer, pulmonary tuberculosis, and peritoneal sarcoidosis with a past history of colorectal cancer. During stage work up for breast cancer, suspicious lesions on peritoneum were observed in imaging studies. Considering our patient’s history and imaging findings, we initially suspected peritoneal carcinomatosis. However, the peritoneal lesion was diagnosed as sarcoidosis in laparoscopic biopsy. This case demonstrates that abdominal sarcoidosis might be considered as a differential diagnosis when there is a lesion suspected of being peritoneal carcinomatosis with nontypical clinical presentations.

Citations

Citations to this article as recorded by

Unexpected finding of encapsulating peritoneal sclerosis: mind the cocoon
Eva van Boven, Robert R J Coebergh van den Braak, Jan van Laar, Michiel G H Betjes
BMJ Case Reports.2025; 18(1): e264334. CrossRef
Spontaneous Remission of Peritoneal Sarcoidosis Diagnosed as a Result of Appendicitis
Chisa SHIBATA, Shunsuke NAKAMURA, Harutaka INOUE, Naoki TERATANI, Shuhei YAMASHITA, Kazuya SHINMURA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2024; 85(5): 687. CrossRef
Spontaneous remission of peritoneal sarcoidosis
Yosuke Kamiya, Keigo Koda, Mikio Toyoshima, Hitoshi Sumida, Naoko Funai, Takafumi Suda
The Japanese Journal of Sarcoidosis and Other Granulomatous Disorders.2023; 43(1_2): 112. CrossRef
Rectal cancer combined with abdominal tuberculosis: A case report
Pei-Gen Liu, Xiang-Fan Chen, Pan-Feng Feng
World Journal of Clinical Cases.2022; 10(31): 11523. CrossRef
Hypercalcemia and Acute Renal Failure Indicating Peritoneal Sarcoidosis
Claude Bachmeyer, Nicolas Belaube, Valeria Loi, Dominique Wendum, Mathieu Gauthé, Jean Philippe Haymann
The American Journal of Medicine.2021; 134(12): e571. CrossRef
Non-neoplastic conditions mimicking peritoneal carcinomatosis at CT imaging
Mohab M Elmohr, Khaled M Elsayes, Perry J Pickhardt
The British Journal of Radiology.2020;[Epub] CrossRef

High-Grade Mixed Adenoneuroendocrine Carcinoma in the Cecum: A Case Report: Sang Ho Shin, Sae Hee Kim, Sung Hee Jung, Ji Woong Jang, Min Seok Kang, Sang Il Kim, Ji Hye Kim, Jun Ho Lee; Ann Coloproctol. 2017;33(1):39-42. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.39

5,807 View
67 Download
13 Web of Science
9 Citations

Abstract PDF

Gastrointestinal neoplasms with an exocrine and a neuroendocrine component are rare. Such neoplasms are called “mixed adenoneuroendocrine carcinomas” (MANECs) according to the most recent World Health Organization classification of gastrointestinal tract neoplasms. MANECs have no specific findings that distinguish them from pure adenocarcinomas. In addition, the optimal management strategy of MANECs is largely unknown. We describe the case of a 32-year-old man with dizziness and abdominal bloating. A cecal mass was suspected based on an image study done at a local clinic. We evaluated the cecal mass by using colonoscopy, contrast enhanced computed tomography of the abdomen, positron emission tomography-computed tomography, and laboratory studies. The patient underwent a right hemicolectomy and adjuvant chemotherapy. The final histopathological diagnosis was a high-grade MANEC of the ascending colon, tumor stage T3N2M0.

Citations

Citations to this article as recorded by

Mixed neuroendocrine-non-neuroendocrine neoplasm of the colon treated with laparoscopic resection and adjuvant chemotherapy: a case report
Yuya Tanaka, Masayuki Takagi, Toshihiro Nakayama, Shuhei Kawada, Reika Matsushita, Tsunehisa Matsushita, Takahiro Ozaki, Shimpei Takagi, Sota Komai, Yasuhiro Sumi
Clinical Journal of Gastroenterology.2025; 18(2): 314. CrossRef
Colonic Mixed Neuroendocrine Nonneuroendocrine Neoplasm: Two Case Reports with Brief Review of Literature
Sanjay Sharma, Manoj Sharma, Neha Sethi, Abha Mathur, Maneesh K Vijay, Shweta Bansal, Shikha Goyal, Ankur Puniya
Journal of Mahatma Gandhi University of Medical Sciences and Technology.2024; 9(1): 53. CrossRef
Mixed adenoneuroendocrine carcinoma of the caecum presenting as extensive ileocolonic intussusception
Alessandro Iacomino, Ugo Grossi, Stefano Doratiotto, Alberto Brun Peressut, Patrizia Pelizzo, Giacomo Zanus
ANZ Journal of Surgery.2021;[Epub] CrossRef
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis
Ugo Grossi, Alessandro Bonis, Emma V. Carrington, Enrico Mazzobel, Giulio Aniello Santoro, Laura Cattaneo, Giovanni Centonze, Gaetano Gallo, Andrea Kazemi Nava, Maurizio Romano, Gian Luca Di Tanna, Giacomo Zanus
European Journal of Surgical Oncology.2021; 47(11): 2893. CrossRef
Neoadjuvant and Adjuvant Chemotherapeutic Strategy of Colorectal Mixed Adeno-Neuroendocrine Carcinomas
Anita Michael, Debashis K Nath
Cureus.2021;[Epub] CrossRef
Oncologic outcome of mixed adenoneuroendocrine carcinoma (MANEC): A single center case series
Audrius Dulskas, Algirdas Pilvelis
European Journal of Surgical Oncology.2020; 46(1): 105. CrossRef
Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review
Rani Kanthan, Suresh Tharmaradinam, Tehmina Asif, Shahid Ahmed, Selliah C Kanthan
World Journal of Gastroenterology.2020; 26(32): 5181. CrossRef
Colorectal neuroendocrine carcinoma: A case report and review of the literature
Tomoaki Yoshida, Kenya Kamimura, Kazunori Hosaka, Koji Doumori, Hiromitsu Oka, Akito Sato, Yasuo Fukuhara, Shoji Watanabe, Tomomi Sato, Akira Yoshikawa, Takashi Tomidokoro, Shuji Terai
World Journal of Clinical Cases.2019; 7(14): 1865. CrossRef
Management of MANEC of the colon and rectum: A comprehensive review of the literature
Anna Paspala, Nikolaos Machairas, Anastasia Prodromidou, Eleftherios Spartalis, Argyrios Ioannidis, Ioannis Kostakis, Dimetrios Papaconstantinou, Nikolaos Nikiteas
Molecular and Clinical Oncology.2018;[Epub] CrossRef

Original Articles

Multivariate Analysis of the Survival Rate for Treatment Modalities in Incurable Stage IV Colorectal Cancer: Sung Kang Kim, Chang Ho Lee, Min Ro Lee, Jong Hun Kim; J Korean Soc Coloproctol. 2012;28(1):35-41. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.35

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14 Citations

Abstract PDF

Purpose

The aim of this study was to compare survival in patients that underwent palliative resection treatment versus non-resection for incurable colorectal cancer (ICRC).

Methods

The case records of 201 patients with ICRC between January 2000 and December 2009 were reviewed. Demographics, American Society of Anesthesiologists (ASA) score, carcinoembryonic antigen (CEA) level, the location of the colon cancer, histology, metastasis, treatment options and median survival were analyzed retrospectively. We divided the patients into four groups according to the treatment modalities: resection alone, resection with post-operative chemotherapy, non-resection treatment by chemotherapy alone, and stent or bypass. Median survival times were compared according to each treatment option, and the survival rates were analyzed.

Results

105 patients underwent palliative resection whereas 96 were treated with non-resection modalities. A palliative resection was performed in 44 cases for resection alone and in 61 cases for resection with post-operative chemotherapy. In patients treated with non-resection of the primary tumor, chemotherapy alone was done in 65 cases and stent or bypass in 31 cases. Multivariate analysis showed a median survival of 14 months in patients with palliative resections with post-operative chemotherapy, which was significantly higher than those for chemotherapy alone (8 months), primary tumor resection alone (5 months), and stent or bypass (5 months). Gender, age, ASA score, CEA level, the location of colon cancer, histology and the presence of multiple metastases were not independent factors in association with the median survival rate.

Conclusion

In the treatment of ICRC, palliative resection followed by post-operative chemotherapy shows the most favorable median survival compared to other treatment options.

Citations

Citations to this article as recorded by

Incidence and determinants of mortality among patients with colorectal cancer in oncology centers of Amhara region, Ethiopia, 2024: multicenter retrospective follow up study
Getachew Tesfaw Walle, Tegene Atamenta Kitaw, Seteamlak Adane
BMC Cancer.2025;[Epub] CrossRef
Biopsy sampling during self-expandable metallic stent placement in acute malignant colorectal obstruction: a narrative review
Sigrid Skov Bennedsgaard, Lene Hjerrild Iversen
World Journal of Surgical Oncology.2021;[Epub] CrossRef
National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis
Antonio V. Sterpetti, Umberto Costi, Giuseppe D'Ermo
Surgical Oncology.2020; 33: 11. CrossRef
Primary Tumor Resection in Patients with Incurable Localized or Metastatic Colorectal Cancer: A Systematic Review and Meta‐analysis
Constantinos Simillis, Eliana Kalakouti, Thalia Afxentiou, Christos Kontovounisios, Jason J. Smith, David Cunningham, Michel Adamina, Paris P. Tekkis
World Journal of Surgery.2019; 43(7): 1829. CrossRef
Long-Chain Noncoding RNAPVT1Gene Polymorphisms Are Associated with the Risk and Prognosis of Colorectal Cancer in the Han Chinese Population
Lei Zhang, Jiehong Mao
Genetic Testing and Molecular Biomarkers.2019; 23(10): 728. CrossRef
Meta-analysis of outcomes following resection of the primary tumour in patients presenting with metastatic colorectal cancer
U Nitsche, C Stöß, L Stecher, D Wilhelm, H Friess, G O Ceyhan
Journal of British Surgery.2018; 105(7): 784. CrossRef
A systematic analysis highlighting deficiencies in reported outcomes for patients with stage IV colorectal cancer undergoing palliative resection of the primary tumour
Deena P. Harji, Abigail Vallance, Jenny Selgimann, Simon Bach, Faheez Mohamed, Julia Brown, Nicola Fearnhead
European Journal of Surgical Oncology.2018; 44(10): 1469. CrossRef
Meta-analysis of oncologic effect of primary tumor resection in patients with unresectable stage IV colorectal cancer in the era of modern systemic chemotherapy
Gi Won Ha, Jong Hun Kim, Min Ro Lee
Annals of Surgical Treatment and Research.2018; 95(2): 64. CrossRef
Prognostic Implications of Primary Tumor Resection in Stage IVB Colorectal Cancer in Elderly Patients
Heui-June Ahn, Ho-Suk Oh, Yongchel Ahn, Sang Jin Lee, Hyun Joong Kim, Moon Ho Kim, Dae-Woon Eom, Jae Young Kwak, Myoung Sik Han, Jae Seok Song
Annals of Coloproctology.2014; 30(4): 175. CrossRef
A Meta-Analysis to Determine the Effect of Primary Tumor Resection for Stage IV Colorectal Cancer with Unresectable Metastases on Patient Survival
Cillian Clancy, John P. Burke, Mitchel Barry, Matthew F. Kalady, J. Calvin Coffey
Annals of Surgical Oncology.2014; 21(12): 3900. CrossRef
Palliative laparoscopic bowel resection in stage IV colorectal cancer patients with unresectable metastasis
Kwan Mo Yang, Seok-Byung Lim, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Chang Sik Yu, Jin Cheon Kim
Korean Journal of Clinical Oncology.2013; 9(2): 134. CrossRef
Recent Advances in the Management of Stage IV Colon Cancer
Rani Kanthan, Jenna-Lynn Senger, Shahid Ahmed, Selliah Kanthan
Journal of Cancer Therapy.2012; 03(06): 1104. CrossRef
Kolonstents als «Bridge to Surgery»
Karl E. Grund, Annette Zipfel
Visceral Medicine.2012; 28(6): 412. CrossRef
Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles
Hemant K. Tiwari, Jill Barnholtz-Sloan, Nathan Wineinger, Miguel A. Padilla, Laura K. Vaughan, David B. Allison
Human Heredity.2008; 66(2): 67. CrossRef

Delorme's Procedure for Complete Rectal Prolapse: Does It Still Have It's Own Role?: Sooho Lee, Bong-Hyeon Kye, Hyung-Jin Kim, Hyeon-Min Cho, Jun-Gi Kim; J Korean Soc Coloproctol. 2012;28(1):13-18. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.13

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8 Citations

Abstract PDF

Purpose

Although there are more than a hundred techniques, including the transabdominal and the perineal approaches, for the repair of the rectal prolapsed, none of them is perfect. The best repair should be chosen not only to correct the prolapse but also to restore defecatory function and to improve fecal incontinence throughout the patient's lifetime. The aim of this retrospective review is to evaluate clinical outcomes of the Delorme's procedure for the management of the complete rectal prolapse.

Methods

A total of 19 patients (13 females and 6 males) with complete rectal prolapses were treated by using the Delorme's procedure in St. Vincent's Hospital, The Catholic University of Korea, from February 1997 to February 2007. Postoperative anal incontinence was evaluated using the Cleveland Clinic Incontinence Score.

Results

All 19 patients had incontinence to liquid stool, solid stool, and/or flatus preoperatively. Three (15.8%) patients reported recurrence of the rectal prolapse (at 6, 18, 29 months, respectively, after the operation). Information on postoperative incontinence was available for 16 of the 19 patients. Twelve of the 16 patients (75%) reported improved continence (5 [31.3%] were improved and 7 [43.7%] completely recovered from incontinence) while 4 patients had unchanged incontinence symptoms. One (6.3%) patient who did not have constipation preoperatively developed constipation after the operation.

Conclusion

The Delorme's procedure is associated with a marked improvement in anal continence, relatively low recurrence rates, and low incidence of postoperative constipation. This allows us to conclude that this procedure still has its own role in selected patients.

Citations

Citations to this article as recorded by

Transanal rectopexy for external rectal prolapse
Shantikumar Dhondiram Chivate, Meghana Vinay Chougule, Rahul Shantikumar Chivate, Palak Harshuk Thakrar
Annals of Coloproctology.2022; 38(6): 415. CrossRef
Epidemiological trends in surgery for rectal prolapse in England 2001–2012: an adult hospital population‐based study
Y. El‐Dhuwaib, A. Pandyan, C. H. Knowles
Colorectal Disease.2020; 22(10): 1359. CrossRef
Surgical Treatment of Rectal Prolapse in the Laparoscopic Era; A Review of the Literature
Akira Tsunoda
Journal of the Anus, Rectum and Colon.2020; 4(3): 89. CrossRef
Laparoscopic ventral mesh rectopexy vs Delorme's operation in management of complete rectal prolapse: a prospective randomized study
S. H. Emile, H. Elbanna, M. Youssef, W. Thabet, W. Omar, A. Elshobaky, T. M. Abd El‐Hamed, M. Farid
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Perineal resectional procedures for the treatment of complete rectal prolapse: A systematic review of the literature
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Delorme’s Procedure for Complete Rectal Prolapse: A Study of Recurrence Patterns in the Long Term
Carlos Placer, Jose M. Enriquez-Navascués, Ander Timoteo, Garazi Elorza, Nerea Borda, Lander Gallego, Yolanda Saralegui
Surgery Research and Practice.2015; 2015: 1. CrossRef
Surgical treatments for rectal prolapse: how does a perineal approach compare in the laparoscopic era?
Monica T. Young, Mehraneh D. Jafari, Michael J. Phelan, Michael J. Stamos, Steven Mills, Alessio Pigazzi, Joseph C. Carmichael
Surgical Endoscopy.2015; 29(3): 607. CrossRef
Simultaneous Delorme's procedure and inter-sphinteric prosthetic implant for the treatment of rectal prolapse and faecal incontinence: Preliminary experience and literature review
Emanuel Cavazzoni, Emanuele Rosati, Valentina Zavagno, Luigina Graziosi, Annibale Donini
International Journal of Surgery.2015; 14: 45. CrossRef

Case Report

Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report: Yo Na Kim, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Dong Geun Lee, Ho Lee, Min Ro Lee, Kyung Ryoul Kim; J Korean Soc Coloproctol. 2011;27(3):157-161. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.157

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9 Citations

Abstract PDF

Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 × 5.1 cm ulcerative fungating lesion, and the other was a 2.8 × 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.

Citations

Citations to this article as recorded by

Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas
Inayat GILL, Christienne SHAMS, Elisa QUIROZ, Subhashree M. KRISHNAN, Susanna GAIKAZIAN
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2021;[Epub] CrossRef
Large cell neuroendocrine carcinoma of the colon with brain metastasis: A case report
Ali Allouch, Mohamad K. Moussa, Ali Dirany, Zahraa Barek, Mohammad Makke, Nizar Bitar
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A case of colorectal large cell neuroendocrine carcinoma accompanied by disseminated peritoneal leiomyomatosis
Kunihiko Suga, Hiroomi Ogawa, Makoto Sohda, Chika Katayama, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Takuya Shiraishi, Ryuji Katoh, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki
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Colorectal neuroendocrine carcinoma: A case report and review of the literature
Tomoaki Yoshida, Kenya Kamimura, Kazunori Hosaka, Koji Doumori, Hiromitsu Oka, Akito Sato, Yasuo Fukuhara, Shoji Watanabe, Tomomi Sato, Akira Yoshikawa, Takashi Tomidokoro, Shuji Terai
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International Journal of Surgery Oncology.2019; 4(6): e79. CrossRef
Large Cell Neuroendocrine Carcinoma of the Rectum with Long Recurrence-free Survival after Radical Surgery and Adjuvant Chemotherapy
Kukiko SAKIHAMA, Kinuko NAGAYOSHI, Hayato FUJITA, Shuntaro NAGAI, Yoshinao ODA, Masafumi NAKAMURA
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Synchronous Small Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Colon: A Link for Common Stem Cell Origin?
Seth Lipka, Jorge Hurtado-Cordovi, Boris Avezbakiyev, Lester Freedman, Toshimasa Clark, Kaleem Rizvon, Paul Mustacchia
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Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon
Donggeum Shin, Youngsook Park, Soojung Gong, Seonghwan Kim, Yunju Jo, Sangbong Ahn, Joonkil Han, Eunkyung Kim
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Synchronous Occurrence of Advanced Neuroendocrine Carcinoma and Tubular Adenocarcinoma of the Rectum
Yoshifumi Nakayama, Takayuki Torigoe, Noritaka Minagawa, Toshihito Uehara, Koji Yamaguchi
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