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Case Report
Malignant disease,Colorectal cancer
Synchronous Quadruple Colon Cancer With Two Lesions Previously Obscured by Ischemic Colitis, Plus Bladder Cancer and Thymoma: A Case Report
Byung-Soo Park, Sung Hwan Cho, Su Jin Kim, Tae Un Kim, Dong Il Kim, Gyung Mo Son, Hyun Sung Kim
Ann Coloproctol. 2021;37(Suppl 1):S44-S47.   Published online September 18, 2020
DOI: https://doi.org/10.3393/ac.2020.06.18
  • 3,531 View
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  • 3 Web of Science
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AbstractAbstract PDF
Synchronous quadruple colorectal cancer (CRC) is extremely rare without genetic alterations. We present a case of synchronous quadruple CRC with 2 lesions previously obscured by ischemic colitis. A 73-year-old woman was admitted to our emergency department. An abdominal computed tomography revealed ischemic colitis and irregular wall thickening of the sigmoid colon and sigmoid-descending junction, suspicious of 2 colon cancers. A colonoscopy examination revealed a fungating mass 20 cm from the anal verge, as well as ischemic colitis spanning the mucosa from the sigmoid colon to the transverse colon. The patient underwent laparoscopic Hartmann procedure. Pathologic examination confirmed both lesions as adenocarcinomas with microsatellite stable. Seven months postoperatively, instead of a laparoscopic Hartmann reversal, a laparoscopic total colectomy was performed due to the continued presence of severe ischemic colitis. The pathologic report suggested the presence of 2 distinct invasive adenocarcinomas in the descending colon without genetic alterations such as microsatellite instability.

Citations

Citations to this article as recorded by  
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Original Articles
Cancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer
Nari Shin, Gyung Mo Son, Dong-Hoon Shin, Myeong-Sook Kwon, Byung-Soo Park, Hyun-Sung Kim, Dongryeol Ryu, Chi-Dug Kang
Ann Coloproctol. 2019;35(1):36-46.   Published online February 28, 2019
DOI: https://doi.org/10.3393/ac.2018.09.10
  • 10,562 View
  • 317 Download
  • 52 Web of Science
  • 52 Citations
AbstractAbstract PDF
Purpose
We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC).
Methods
Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Overall survival and systemic recurrence were analyzed. A network analysis was performed between CAF maturation, desmoplastic reaction, and cancer invasiveness.
Results
The proportions of mature CAFs in the intratumoral stroma and the invasive front were 57.6% and 60.3%, respectively. Epidermal growth factor receptor (EGFR) overexpression was significantly higher in the mature CAFs in the invasive front as compared to immature CAFs. Lymphatic invasion increased as the number of mature fibroblasts in the intratumoral stroma increased. Tumor budding was observed in almost half of both mature and immature stroma samples and occurred more frequently in infiltrating tumors. On network analysis, well-connected islands were identified that was associated with EGFR overexpression, CAF maturation, and infiltrating tumor growth patterns leading to tumor budding.
Conclusion
The maturity of CAFs and desmoplastic reactions were associated with cancer invasion. However, the cytomorphologic characteristics of CAFs were insufficient as an independent prognostic factor for patients with CRC.

Citations

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Distribution and Impact of the Visceral Fat Area in Patients With Colorectal Cancer
Hyeon Yu, Yong-Geul Joh, Gyung-Mo Son, Hyun-Sung Kim, Hong-Jae Jo, Hae-Young Kim
Ann Coloproctol. 2016;32(1):20-26.   Published online February 29, 2016
DOI: https://doi.org/10.3393/ac.2016.32.1.20
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AbstractAbstract PDF
Purpose

The purposes of this study were to investigate the distribution of the visceral fat area (VFA) and general obesity and to compare visceral and general obesity as predictors of surgical outcomes of a colorectal cancer resection.

Methods

The prospectively collected data of 102 patients with preoperatively-diagnosed sigmoid colon or rectal cancer who had undergone a curative resection at Pusan National University Yangsan Hospital between April 2011 and September 2012 were reviewed retrospectively. Men with a VFA of >130 cm2 and women with a VFA of >90 cm2 were classified as obese (VFA-O, n = 22), and the remaining patients were classified as nonobese (VFA-NO, n = 80).

Results

No differences in morbidity, mortality, postoperative bowel recovery, and readmission rate after surgery were observed between the 2 groups. However, a significantly higher number of harvested lymph nodes was observed in the VFA-NO group compared with the VFA-O group (19.0 ± 1.0 vs. 13.5 ± 1.2, respectively, P = 0.001).

Conclusion

Visceral obesity has no influence on intraoperative difficulties, postoperative complications, and postoperative recovery in patients with sigmoid colon or rectal cancer.

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Case Report
Adult Intussusception due to Cecal Lymphangioma: A Case Report
Dong Il Kim, Hyung Il Seo, Jae Hun Kim, Hyun Sung Kim, Hong Jae Jo
J Korean Soc Coloproctol. 2011;27(2):99-101.   Published online April 30, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.2.99
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  • 7 Citations
AbstractAbstract PDF

We present a rare case of adult intussusception due to cecal lymphangioma. A 30-year-old female was admitted to our hospital with abdominal pain and a palpatable mass on the right lower quadrant. Preoperative radiologic studies by ultrasound and computed tomography showed ileocolic intussusception with a multiseptated cystic tumor as a leading point on the cecum. An ileocecectomy was performed, and the postoperative course was uneventful. Histopathology showed a cecal lymphangioma. Although endoscopic polypectomy or endoscopic mucosal resection is recommended for pedunculated or semi-pedunculated colonic lymphangiomas less than 2 cm in size, it is proper to treat large or symptomatic colonic lymphangiomas with limited a bowel resection or a tumor resection.

Citations

Citations to this article as recorded by  
  • An Incidental Finding of a Cecal Lymphangioma Managed Conservatively
    Richard Mitchell, Jonathan Reyes, Vennis Lourdusamy, Raghav Bansal
    Cureus.2024;[Epub]     CrossRef
  • A Case of Colonic Intussusception Caused by Cecal Lymphangioma and Requiring Emergency Surgery
    Mitsutoshi Okuda, Takahiro Yoshioka, Ryosuke Tsunemitsu, Hiroaki Inoeu, Ryo Inada
    Cureus.2024;[Epub]     CrossRef
  • Cystic Lymphangioma of Rectum-A Case Report and Review of Literature
    Govindraj S Dessai, Nikhil Kumar Soni, Sharvari Pujari, Ramkrishna Prabhu, Chetan V Kantharia
    The Korean Journal of Gastroenterology.2023; 82(2): 91.     CrossRef
  • Cystic lymphangioma causing intussusception of the right colon: a case report and review of current literature
    Jae Hyun Park, Jesung Park, Ga Yoon Ku, Do Kyoon Moon, Jong Sung Ahn, Hyo Jun Kim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
    Journal of Surgical Case Reports.2023;[Epub]     CrossRef
  • Imaging features, complications and differential diagnoses of abdominal cystic lymphangiomas
    M. Raufaste Tistet, O. Ernst, M. Lanchou, M. Vermersch, P. Lebert
    Abdominal Radiology.2020; 45(11): 3589.     CrossRef
  • Colonic lymphangioma presenting with intermittent pain and intussusception
    Mark M G Ly, Marie Shella De Robles, Catriona Mckenzie, Christopher J Young
    Journal of Surgical Case Reports.2019;[Epub]     CrossRef
  • A Case of Adult Intussusception Secondary to Lymphangioma of the Cecum
    Seong Wook Hwang
    Soonchunhyang Medical Science.2019; 25(2): 139.     CrossRef
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