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2 "Jae Ho Park"
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Case Report
Benign GI diease,Rare disease & stoma,Complication
Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report
Sung Hoon Kang, Hee Seok Moon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee, Jae Kyu Sung, Hyun Yong Jeong, Kyung Ha Lee
Ann Coloproctol. 2021;37(Suppl 1):S18-S23.   Published online May 15, 2020
DOI: https://doi.org/10.3393/ac.2020.03.16.1
  • 3,759 View
  • 113 Download
  • 2 Web of Science
  • 4 Citations
AbstractAbstract PDF
Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions. Intestinal perforation in gastrointestinal TB can occur as a paradoxical reaction to antitubercular therapy. A 55-year-old man visited the outpatient department with lower abdominal pain and weight loss. He was diagnosed with intestinal TB and started antitubercular therapy. After 3 months of antitubercular therapy, a colonoscopy revealed improvement of the disease. Three days after the colonoscopy, the patient visited the emergency room complaining of abdominal pain. Abdominal computed tomography revealed extraluminal air-filled spaces in the pelvic cavity. We diagnosed a small bowel perforation and performed an emergency laparotomy and a right hemicolectomy with small bowel resection. This report describes the case of intestinal perforation presenting as a paradoxical reaction to antitubercular and provides a brief literature review.

Citations

Citations to this article as recorded by  
  • Réaction paradoxale tuberculeuse
    L.-D. Azoulay, A.-L. Houist, E. Feredj, W. Vindrios, S. Gallien
    La Revue de Médecine Interne.2024; 45(5): 279.     CrossRef
  • Left hand abscess as a paradoxical reaction during treatment of disseminated tuberculosis in immunocompetent patient: case report and review of literature
    Aisha Alharbi, Aseel Aljahdali, Mohamed Firoze Ahamed, Hassan Almarhabi
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction
    Akira Hokama, Yuiko Oishi, Erika Koga, Sayuri Takehara, Jiro Fujita
    Chonnam Medical Journal.2022; 58(1): 52.     CrossRef
  • Multiple drugs

    Reactions Weekly.2021; 1881(1): 189.     CrossRef
Original Article
Management Outcomes of Colonoscopic Perforations Are Affected by the General Condition of the Patients
Jae Ho Park, Kyung Jong Kim
Ann Coloproctol. 2018;34(1):16-22.   Published online February 28, 2018
DOI: https://doi.org/10.3393/ac.2018.34.1.16
  • 4,463 View
  • 104 Download
  • 1 Web of Science
  • 1 Citations
AbstractAbstract PDF
Purpose

The management of a colonoscopic perforation (CP) varies from conservative to surgical. The objective of this study was to evaluate the outcomes between surgical and conservative treatment of patients with a CP.

Methods

From 2003 to 2016, the medical records of patients with CP were retrospectively reviewed. Patients were divided into 2 groups depending on whether they initially received conservative or surgical treatment.

Results

During the study period, a total of 48 patients with a CP were treated. Among them, 5 patients had underlying colorectal cancer and underwent emergency radical cancer surgery; these patients were excluded. The mean age of the remaining 43 patients was 64.5 years old, and the most common perforation site was the sigmoid colon (15 patients). The initial conservative care group included 16 patients, and the surgery group included 27 patients. In the conservative group, 5 patients required conversion to surgery (failure rate: 5 of 16 [31.3%]). Of the surgery group, laparoscopic surgery was performed on 19 patients and open surgery on 8 patients, including 2 conversion cases. Major postoperative complications developed in 11 patients (34.4%), and postoperative mortality developed in 4 patients (12.5%). The only predictor for poor prognosis after surgery was a high American Society of Anesthesiologists physical status classification.

Conclusion

In this study, conservative treatment for patients with a CP had a relatively high failure rate. Furthermore, surgical treatment showed significant rates of complications and mortality, which depended on the general status of the patients.

Citations

Citations to this article as recorded by  
  • Multicenter retrospective evaluation of ileocecocolic perforations associated with diagnostic lower gastrointestinal endoscopy in dogs and cats
    Vanessa L. Woolhead, Jacqueline C. Whittemore, Sarah A. Stewart
    Journal of Veterinary Internal Medicine.2020; 34(2): 684.     CrossRef
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