Annals of Coloproctology

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Intestinal Anastomosis by Use of a Memory-shaped Compression Anastomosis Clip (Hand CAC 30): Early Clinical Experience: Hak-Youn Lee, Jin-Hee Woo, Si-Young Park, Nam-Wook Kang, Ki-Jae Park, Hong-Jo Choi; J Korean Soc Coloproctol. 2012;28(2):83-88. Published online April 30, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.2.83

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Purpose

The safety and the efficacy of the compression anastomosis clip (Hand CAC 30) have been demonstrated by animal studies. This study was designed to evaluate the clinical validity of the Hand CAC 30 in enterocolic side-to-side anastomosis after colonic or enteric resections.

Methods

A non-randomized prospective data collection was performed for patients undergoing a side-to-side anastomosis using the Hand CAC 30. Eligibility criteria for the use of the Hand CAC 30 were for anastomoses between the colon and the ileum or between two small bowels. The primary short-term endpoint was the rate of anastomotic leakage. Other clinical outcomes, including intra- and postoperative complications, length of operation time and hospital stay, and the clip elimination time were recorded.

Results

A total of 63 patients (male, 36) underwent an enteric or right-sided colonic resection followed by a side-to-side anastomosis using the Hand CAC 30. Laparoscopic surgery was performed in 36 patients, in whom one patient who underwent a laparoscopic right hemicolectomy was converted to an open procedure (1/32, 3.1%). One patient with ascending colon cancer showed postoperative anastomotic leakage and died of co-morbid ischemic heart disease. There were no other surgical mortalities. The exact date of expulsion of the clip could not be recorded because most patients were not aware of clip elimination. No patients manifested clinical symptoms of anastomotic stricture.

Conclusion

Short-term evaluation of the Hand CAC 30 anastomosis in patients undergoing enterocolic surgery proved it to be a safe and efficacious alternative to the standard hand-sewn or stapling technique.

Citations

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Comparative early histologic healing quality of magnetic versus stapled small bowel anastomosis
Ana Sofia Ore, Ashley Althoff, David R. Kull, Thomas J. Baldwin, Jeffrey L. Van Eps, Evangelos Messaris
Surgery.2023; 173(4): 1060. CrossRef
An Automatic Suturing Machine for Intestinal Anastomosis: Advantages Compared With Hand-Suturing Technique
Sanaz Mosafer Khoorjestan, Gholamreza Rouhi
Surgical Innovation.2019; 26(2): 209. CrossRef
Biodegradable anastomotic tube prepared from diblock copolymers of mPEG-b-PLA and mPEG-b-PLGA
Xiaodong Zhang, Zuoqian Yu, Feizhao Jiang, Lechi Ye, Jinlei Li, Xingzhao Ye, Chungen Xing
Journal of Macromolecular Science, Part A.2019; 56(7): 667. CrossRef
Anastomosis colorrectales por compresión utilizando el dispositivo NiTi
Quintín Héctor González-Contreras, Mónica de Jesús-Mosso, Jesús Alberto Bahena-Aponte, Omar Aldana-Martínez, Karen Pineda-Solís, Sari Narsil Mejia-Arcadia
Cirugía y Cirujanos.2016; 84(6): 482. CrossRef
Laparoscopic colonic anastomosis using a degradable stent in a porcine model
Liang Ma, Xiu-Jun Cai, Hai-Hong Wang, Yan-Lan Yu, Di-Yu Huang, Guang-Ju Ge, Hai-Yi Hu, Shi-Cheng Yu
World Journal of Gastroenterology.2016; 22(19): 4707. CrossRef
Colorectal anastomosis using a compression device
Quintín Héctor González-Contreras, Mónica de Jesús-Mosso, Jesús Alberto Bahena-Aponte, Omar Aldana-Martínez, Karen Pineda-Solís, Sari Narsil Mejia-Arcadia
Cirugía y Cirujanos (English Edition).2016; 84(6): 482. CrossRef
Long term results of the use of compression anastomosis clips (CAC) in gastrointestinal surgery – the first report
Katarzyna Kuśnierz, Paweł Lampe
Polish Journal of Surgery.2015;[Epub] CrossRef
A nickel–titanium memory-shape device for gastrojejunostomy: comparison of the compression anastomosis clip and a hand-sewn anastomosis
Katarzyna Kusnierz, Zdzislaw Lekston, Dmytro Zhavoronkov, Slawomir Mrowiec, Pawel Lampe
Journal of Surgical Research.2014; 187(1): 94. CrossRef

Adjuvant Chemotherapy Using the FOLFOX Regimen in Colon Cancer: Hyeong-Joon Jeon, Jin-Hee Woo, Hak-Yoon Lee, Ki-Jae Park, Hong-Jo Choi; J Korean Soc Coloproctol. 2011;27(3):140-146. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.140

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14 Citations

Abstract PDF

Purpose

Great progress has been made in the adjuvant treatment of colon cancer. The aim of this study was to evaluate the efficacy of postoperative adjuvant chemotherapy using the FOLFOX regimen in patients with stage III and high-risk stage II colon cancer.

Methods

Eighty-two patients who underwent a potentially curative resection for stage III or high-risk stage II colon cancer were enrolled in this retrospective study. They received FOLFOX4 or modified FOLFOX6. The primary endpoint was disease-free survival.

Results

During the median follow-up of 37 months (range, 21 to 61 months), 14 patients experienced disease relapse. The disease-free survival rate at 3 years was 82.9%: 84.6% for stage II and 82.6% for stage III. At the time of the analysis, 8 patients were dead from recurrence. The probability of overall survival at 5 years was 74.5%: 90% for stage II and 74.6% for stage III. Grade 3 or 4 hematologic adverse events included neutropenia (40.2%), anemia (2.4%), and thrombocytopenia (1.2%). Gastrointestinal toxicities included grade 3 or 4 nausea (4.9%) and stomatitis (2.4%). Peripheral sensory neuropathy was observed in 81.7% of the patients during treatment. Of the 11 patients (13.4%) who had grade 3 peripheral sensory neuropathy during treatment, grade 3 symptoms were persistent in 3 patients with gait disturbance at the time of analysis. No treatment-related deaths were recorded.

Conclusion

Postoperative chemotherapy using the FOLFOX regimen, oxaliplatin in combination with 5-fluorouracil and leucovorin, is effective and tolerable in patients with stage III and high-risk stage II colon cancer.

Citations

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Therapeutic Advances in Medical Oncology.2025;[Epub] CrossRef
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Apoptosis.2025; 30(11-12): 2830. CrossRef
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International Journal of Molecular Sciences.2025; 26(18): 8869. CrossRef
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Shirin Kianersi, Sina Salari, Hamid Rezvani, Mohammad A. Araskhan, Alireza Shirangi, Mohammad R. Fathi, Mahmoud D. Ghorbi
Journal of Education and Health Promotion.2023;[Epub] CrossRef
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Nagy Samy Gobran, Mohammed Reda Kelany, Mohammed Abdallah Fathy
Journal of Cancer Therapy.2020; 11(02): 74. CrossRef
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Cancer Control.2019;[Epub] CrossRef
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Lindsay A. Sceats, Seul Ku, Alanna Coughran, Britainy Barnes, Emily Grimm, Matthew Muffly, David A. Spain, Cindy Kin, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert
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Shelby N. Bess, Gage J. Greening, Timothy J. Muldoon
Cytokine & Growth Factor Reviews.2019; 49: 1. CrossRef
Association of baseline patient characteristics with adjuvant chemotherapy toxicities in stage III colorectal cancer patients
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Medical Oncology.2018;[Epub] CrossRef
Risk Stratification in Patients with Stage II Colon Cancer
Ramzi Amri, Jonathan England, Liliana G. Bordeianou, David L. Berger
Annals of Surgical Oncology.2016; 23(12): 3907. CrossRef
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