Annals of Coloproctology

Original Article

Translational/basic research

Effects of angiotensin peptides on colonic motility in rats: Gi Won Ha, Jong Hun Kim, Suhn Hee Kim; Ann Coloproctol. 2023;39(3):267-274. Published online March 30, 2022; DOI: https://doi.org/10.3393/ac.2022.00087.0012

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Purpose
Renin-angiotensin system (RAS) is involved in the pathophysiology of colonic inflammation. The aim of this study was to investigate whether small angiotensins (Angs) peptides play a role in the regulation of colonic motility and their roles are modulated in colitis.
Methods
Experimental colitis was induced by an intake of 5% dextran sulfate sodium (DSS) dissolved in tap water for 7 days in Sprague-Dawley rats. After sacrifice, plasma hormone concentrations and messenger RNAs (mRNAs) for RAS were measured. Functional analysis of colonic motility in response to Angs peptides was performed using Taenia coli.
Results
DSS-treated colon showed an increased necrosis with massive infiltration of inflammatory cells. The mRNA level of colonic angiotensin II receptor type 2 (AT2R) in DSS-treated rats was higher than that in control rats whereas the mRNA levels of angiotensin II converting enzyme (ACE), ACE2, AT1R, AT4R, and Mars receptor were not different from those in control rats. Ang III, Ang IV, and Ang-(1-9) (1, 3 μM) increased the frequency of basal colonic motility. Ang-(1-7) did not cause any significant changes in frequency and amplitude of basal motility. The order of potency for an increased frequency of basal motility seems to be Ang II>>Ang IV>Ang III=Ang-(1-9). The increased frequency of basal motility by Ang-(1-9) but not Ang IV was significantly enhanced in DSS-treated rat colon.
Conclusion
In conclusion, these data suggest that small Angs peptides are partly involved in the pathophysiological regulation of colonic motility in experimental colitis.

Citations

Citations to this article as recorded by

Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions
Nadia Khan, Magdalena Kurnik-Łucka, Gniewomir Latacz, Krzysztof Gil
International Journal of Molecular Sciences.2024; 25(10): 5566. CrossRef

Case Report

Benign proctology,Rare disease & stoma,Complication

Fournier Gangrene in a Patient With Type 2 Diabetes Mellitus Treated With Dapagliflozin: A Case Report: Jae Young Moon, Min Ro Lee, Jong Hun Kim, Gi Won Ha; Ann Coloproctol. 2021;37(Suppl 1):S48-S50. Published online May 28, 2021; DOI: https://doi.org/10.3393/ac.2020.06.22

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7 Citations

Abstract PDF

Rare cases of Fournier gangrene (FG) possibly associated with sodium-glucose cotransporter 2 inhibitors have been reported. We present a case of a 66-year-old male patient with type 2 diabetes mellitus on oral metformin, glimepiride, and dapagliflozin therapy. He presented with pain in the perineum and scrotum for 5 days. The clinical finding, computed tomography finding, and laboratory data were matched with FG. Emergency surgical drainage, debridement of necrotic tissue, and diverting loop ileostomy formation were performed by a urologist and a surgeon. The patient had no complications from diabetes before the onset of FG, and serum glucose management was good at the onset of FG. This case shows an FG patient with good glucose management taking dapagliflozin and suggests a possible association between dapagliflozin and FG. Further evaluation and additional research on this relationship are needed.

Citations

Citations to this article as recorded by

Cost-effectiveness analysis and medication use for gangrene treatment in type 2 diabetes patients: A systematic literature review
Entris Sutrisno, Jajang Japar Sodik, Taufik Muhammad Fakih
Pharmacia.2025; 72: 1. CrossRef
Fournier’s Gangrene as an Adverse Event Following Treatment with Sodium Glucose Cotransporter 2 Inhibitors
Ioana-Maria Suciu, Alin Greluș, Alina-Ramona Cozlac, Bogdan-Simion Suciu, Svetlana Stoica, Silvia Luca, Constantin-Tudor Luca, Dan-Ion Gaiță
Medicina.2024; 60(5): 837. CrossRef
A Case of Fournier's Gangrene Following the Initiation of Dapagliflozin
Natalie Shaykh, Avni Agrawal, Melville C O'Brien, Oshin Rai, Vanshika Tripathi, Vishal Jaikaransingh
Cureus.2024;[Epub] CrossRef
Skin-Related Adverse Reactions Induced by Oral Antidiabetic Drugs—A Review of Literature and Case Reports
Justyna Kowalska, Dorota Wrześniok
Pharmaceuticals.2024; 17(7): 847. CrossRef
Cutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors
Alexandra Laura Mederle, Patrick Dumitrescu, Claudia Borza, Nilima Rajpal Kundnani
Journal of Clinical Medicine.2024; 14(1): 188. CrossRef
Management of Fournier’s gangrene during the Covid-19 pandemic era: make a virtue out of necessity
Alessio Paladini, Giovanni Cochetti, Angelica Tancredi, Matteo Mearini, Andrea Vitale, Francesca Pastore, Paolo Mangione, Ettore Mearini
Basic and Clinical Andrology.2022;[Epub] CrossRef
Dapagliflozin

Reactions Weekly.2022; 1926(1): 197. CrossRef

Original Article

Management of Colonic Diverticulitis Tailored to Location and Severity: Comparison of the Right and the Left Colon: Byeoung Hoon Chung, Gi Won Ha, Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2016;32(6):228-233. Published online December 31, 2016; DOI: https://doi.org/10.3393/ac.2016.32.6.228

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23 Web of Science
23 Citations

Abstract PDF

Purpose

This study assessed optimal management of colonic diverticulitis as functions of disease location and severity and factors associated with complicated diverticulitis.

Methods

This retrospective review analyzed 202 patients diagnosed between 2007 and 2014 at Chonbuk National University Hospital, South Korea, with colonic diverticulitis by using abdominopelvic computed tomography. Diverticulitis location was determined, and disease severity was categorized using the modified Hinchey classification.

Results

Patients included 108 males (53.5%) and 94 females (46.5%); of these, 167 patients (82.7%) were diagnosed with right-sided and 35 (17.3%) with left-sided colonic diverticulitis. Of the 167 patients with right-sided colonic diverticulitis, 12 (7.2%) had complicated and 155 (92.8%) had uncomplicated diverticulitis; of these, 157 patients (94.0%) were successfully managed conservatively. Of the 35 patients with left-sided colonic diverticulitis, 23 (65.7%) had complicated and 12 (34.3%) had uncomplicated diverticulitis; of these, 23 patients (65.7%) were managed surgically. Among patients with right-sided diverticulitis, those with complicated disease were significantly older (54.3 ± 12.7 years vs. 42.5 ± 13.4 years, P = 0.004) and more likely to be smokers (66.7% vs. 32.9%, P = 0.027) than those with uncomplicated disease. However, among patients with left-sided diverticulitis, those with complicated disease had significantly lower body mass index (BMI; 21.9 ± 4.7 kg/m² vs. 25.8 ± 4.3 kg/m², P = 0.021) than those with uncomplicated disease.

Conclusion

Conservative management may be effective in patients with right-sided diverticulitis and patients with uncomplicated left-sided colonic diverticulitis. Surgical management may be required for patients with complicated left-sided diverticulitis. Factors associated with complicated diverticulitis include older age, smoking and lower BMI.

Citations

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Right‐sided acute diverticulitis in a North African country: Presentation and management in one surgical center
Laila Jedidi, Aymen Mabrouk, Hela Ghali, Anis Ben Dhaou, Senda Ben Lahouel, Sami Daldoul, Houyem Said Latiri, Mounir Ben Moussa
World Journal of Surgery.2024; 48(6): 1509. CrossRef
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Journal of Trauma and Acute Care Surgery.2024; 97(1): 1. CrossRef
Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study
E. Karam, C. Sabbagh, L. Beyer-Bergeot, P. Zerbib, V. Bridoux, G. Manceau, Y. Panis, E. Buscail, A. Venara, I. Khaoudy, M. Gaillard, M. Viennet, A. Thobie, B. Menahem, C. Eveno, C. Bonnel, J.-Y. Mabrut, B. Badic, C. Godet, Y. Eid, E. Duchalais, Z. Lakkis,
Techniques in Coloproctology.2024;[Epub] CrossRef
Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines
Federico Coccolini, Massimo Sartelli, Robert Sawyer, Kemal Rasa, Bruno Viaggi, Fikri Abu-Zidan, Kjetil Soreide, Timothy Hardcastle, Deepak Gupta, Cino Bendinelli, Marco Ceresoli, Vishal G. Shelat, Richard ten Broek, Gian Luca Baiocchi, Ernest E. Moore, Ib
World Journal of Emergency Surgery.2023;[Epub] CrossRef
Diagnosis and management of acute colonic diverticulitis: results of a survey among Korean gastroenterologists
Jae Gon Lee, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Shin Hee Lee, Myung-Won You, Seong-Eun Kim
The Korean Journal of Internal Medicine.2023; 38(5): 672. CrossRef
Right-sided diverticulitis in a Western population
Adi Rov, Anat Ben-Ari, Eyal Barlev, David Pelcman, Sergio Susmalian, Haim Paran
International Journal of Colorectal Disease.2022; 37(6): 1251. CrossRef
Emergency surgery comparison of right versus left acute colonic diverticulitis: A 10-year outcome analysis
JS Tsang, Chi Chung Foo, Jeremy Yip, Hok Kwok Choi, Wai Lun Law, Oswens Siu Hung Lo
The Surgeon.2021; 19(3): 150. CrossRef
Elective surgical management of diverticulitis
Jordan M. Rook, Jill Q. Dworsky, Thomas Curran, Sudeep Banerjee, Mary R. Kwaan
Current Problems in Surgery.2021; 58(5): 100876. CrossRef
Special Situations in the Management of Diverticular Disease
Elizabeth H. Wood, Michael M. Sigman, Dana M. Hayden
Clinics in Colon and Rectal Surgery.2021; 34(02): 121. CrossRef
Routine colonoscopy may be needed for uncomplicated acute right colonic diverticulitis
Kil-yong Lee, Jaeim Lee, Youn Young Park, Seong Taek Oh
BMC Gastroenterology.2021;[Epub] CrossRef
WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
Massimo Sartelli, Federico Coccolini, Yoram Kluger, Ervis Agastra, Fikri M. Abu-Zidan, Ashraf El Sayed Abbas, Luca Ansaloni, Abdulrashid Kayode Adesunkanmi, Boyko Atanasov, Goran Augustin, Miklosh Bala, Oussama Baraket, Suman Baral, Walter L. Biffl, Marja
World Journal of Emergency Surgery.2021;[Epub] CrossRef
Right sided diverticulitis in western countries: A review
Angelo Gabriele Epifani, Diletta Cassini, Roberto Cirocchi, Caterina Accardo, Francesca Di Candido, Massimiliano Ardu, Gianandrea Baldazzi
World Journal of Gastrointestinal Surgery.2021; 13(12): 1721. CrossRef
Difference in Clinical Features between Right- and Left-Sided Acute Colonic Diverticulitis
Kil-yong Lee, Jaeim Lee, Youn Young Park, Younglim Kim, Seong Taek Oh
Scientific Reports.2020;[Epub] CrossRef
2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting
Massimo Sartelli, Dieter G. Weber, Yoram Kluger, Luca Ansaloni, Federico Coccolini, Fikri Abu-Zidan, Goran Augustin, Offir Ben-Ishay, Walter L. Biffl, Konstantinos Bouliaris, Rodolfo Catena, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra,
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Clinical Characteristics of Right Colonic Diverticulitis: A Comparison of Ileocecal Diverticulitis and Hepatic Flexure Diverticulitis
Yoshihisa Fujita, Fumihiko Ishikawa, Shigeyuki Kamata
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S. Hajibandeh, S. Hajibandeh, N. J. Smart, A. Maw
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L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
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Résultats à long terme et prise en charge des diverticulites du colon droit dans les pays occidentaux : étude rétrospective multicentrique
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Predictive Factors Affecting the Clinical Course of Patients With Diverticulitis: Who Needs Hospital Management?
Taeyoung Yoo, Keun Ho Yang, Jungbin Kim, Inseok Park, Hyunjin Cho, Geumhee Gwak, Byung Noe Bae, Ki Hwan Kim
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Perforated diverticulitis: is the right and left difference present here too?
Nicholas Yock Teck Soh, Nan Zun Teo, Carrie Jen Hsi Tan, Shivani Rajaraman, Marianne Tsang, Calvin Jian Ming Ong, Ramesh Wijaya
International Journal of Colorectal Disease.2018; 33(5): 525. CrossRef
Clinical Features and Factors Associated With Surgical Treatment in Patients With Complicated Colonic Diverticulitis
Pill Sun Paik, Jung-A Yun
Annals of Coloproctology.2017; 33(5): 178. CrossRef
What is the Difference Between Right- and Left-Sided Colonic Diverticulitis?
Chang-Nam Kim
Annals of Coloproctology.2016; 32(6): 206. CrossRef

Editorials

Colorectal Liver Metastases: A Never Ending Story: Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2016;32(3):87-87. Published online June 30, 2016; DOI: https://doi.org/10.3393/ac.2016.32.3.87

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What Should Be Done to Increase Survival in Patients With Colorectal Cancer?: Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2013;29(4):135-135. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.135

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PDF

Original Article

Multivariate Analysis of the Survival Rate for Treatment Modalities in Incurable Stage IV Colorectal Cancer: Sung Kang Kim, Chang Ho Lee, Min Ro Lee, Jong Hun Kim; J Korean Soc Coloproctol. 2012;28(1):35-41. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.35

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14 Citations

Abstract PDF

Purpose

The aim of this study was to compare survival in patients that underwent palliative resection treatment versus non-resection for incurable colorectal cancer (ICRC).

Methods

The case records of 201 patients with ICRC between January 2000 and December 2009 were reviewed. Demographics, American Society of Anesthesiologists (ASA) score, carcinoembryonic antigen (CEA) level, the location of the colon cancer, histology, metastasis, treatment options and median survival were analyzed retrospectively. We divided the patients into four groups according to the treatment modalities: resection alone, resection with post-operative chemotherapy, non-resection treatment by chemotherapy alone, and stent or bypass. Median survival times were compared according to each treatment option, and the survival rates were analyzed.

Results

105 patients underwent palliative resection whereas 96 were treated with non-resection modalities. A palliative resection was performed in 44 cases for resection alone and in 61 cases for resection with post-operative chemotherapy. In patients treated with non-resection of the primary tumor, chemotherapy alone was done in 65 cases and stent or bypass in 31 cases. Multivariate analysis showed a median survival of 14 months in patients with palliative resections with post-operative chemotherapy, which was significantly higher than those for chemotherapy alone (8 months), primary tumor resection alone (5 months), and stent or bypass (5 months). Gender, age, ASA score, CEA level, the location of colon cancer, histology and the presence of multiple metastases were not independent factors in association with the median survival rate.

Conclusion

In the treatment of ICRC, palliative resection followed by post-operative chemotherapy shows the most favorable median survival compared to other treatment options.

Citations

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