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Editorials
Lactose Intolerance and Colorectal Cancer
Jong-Woo Kim
Ann Coloproctol. 2017;33(5):157-158.   Published online October 31, 2017
DOI: https://doi.org/10.3393/ac.2017.33.5.157
  • 6,269 View
  • 75 Download
  • 6 Web of Science
  • 7 Citations
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Citations

Citations to this article as recorded by  
  • Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota
    Hoi Kit Matthew Leung, Emily Kwun Kwan Lo, Congjia Chen, Fangfei Zhang, Felicianna, Marsena Jasiel Ismaiah, Hani El-Nezami
    Probiotics and Antimicrobial Proteins.2025; 17(4): 2227.     CrossRef
  • Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study
    Sihao Han, Jiemin Yao, Hajime Yamazaki, Samantha A. Streicher, Jianyu Rao, Roch A. Nianogo, Zuofeng Zhang, Brian Z. Huang
    Nutrients.2024; 16(6): 808.     CrossRef
  • Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer
    Jing Sun, Jianhui Zhao, Siyun Zhou, Xinxuan Li, Tengfei Li, Lijuan Wang, Shuai Yuan, Dong Chen, Philip J Law, Susanna C Larsson, Susan M Farrington, Richard S Houlston, Malcolm G Dunlop, Evropi Theodoratou, Xue Li
    JNCI: Journal of the National Cancer Institute.2024; 116(8): 1303.     CrossRef
  • Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study
    Amanda L. Lumsden, Anwar Mulugeta, Elina Hyppönen
    Clinical Nutrition.2023; 42(1): 1.     CrossRef
  • Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase
    Qing Li, Wei Hu, Wei-Xin Liu, Liu-Yang Zhao, Dan Huang, Xiao-Dong Liu, Hung Chan, Yuchen Zhang, Ju-Deng Zeng, Olabisi Oluwabukola Coker, Wei Kang, Simon Siu Man Ng, Lin Zhang, Sunny Hei Wong, Tony Gin, Matthew Tak Vai Chan, Jian-Lin Wu, Jun Yu, William Ka
    Gastroenterology.2021; 160(4): 1179.     CrossRef
  • NONINVASIVE BREATH TESTS FOR DIAGNOSIS OF SIBO AND LACTOSE INTOLERANCE IN PATIENTS ON CHEMOTHERAPY TREATMENT FOR COLORECTAL AND GASTRIC CÂNCER
    Aline Rufino GONÇALVES, Orlando AMBROGINI JR, Nora Manoukian FORONES
    Arquivos de Gastroenterologia.2021; 58(1): 26.     CrossRef
  • PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ
    Ceren AKAL, Atilla YETİŞMEYEN
    Gıda.2020; 45(2): 380.     CrossRef
Topical Effect of Glutamine for Colorectal Anastomosis
Jong-Woo Kim
Ann Coloproctol. 2015;31(6):207-208.   Published online December 31, 2015
DOI: https://doi.org/10.3393/ac.2015.31.6.207
  • 4,642 View
  • 50 Download
  • 1 Web of Science
  • 1 Citations
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Citations

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  • Ischemic or toxic injury: A challenging diagnosis and treatment of drug-induced stenosis of the sigmoid colon
    Zong-Ming Zhang, Xiang-Chun Lin, Li Ma, An-Qin Jin, Fang-Cai Lin, Zhuo Liu, Li-Min Liu, Chong Zhang, Na Zhang, Li-Juan Huo, Xue-Liang Jiang, Feng Kang, Hong-Jun Qin, Qiu-Yang Li, Hong-Wei Yu, Hai Deng, Ming-Wen Zhu, Zi-Xu Liu, Bai-Jiang Wan, Hai-Yan Yang,
    World Journal of Gastroenterology.2017; 23(21): 3934.     CrossRef
Invasion and Metastasis in the Viewpoint of Cell Adhesive Molecules
Jong-Woo Kim
Ann Coloproctol. 2014;30(2):57-58.   Published online April 25, 2014
DOI: https://doi.org/10.3393/ac.2014.30.2.57
  • 2,950 View
  • 28 Download
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Original Articles
Clinical Characteristics of Colorectal Cancer Patients With a Second Primary Cancer
Jin Woo Lee, Jong Woo Kim, Nam Keun Kim
Ann Coloproctol. 2014;30(1):18-22.   Published online February 28, 2014
DOI: https://doi.org/10.3393/ac.2014.30.1.18
  • 5,260 View
  • 46 Download
  • 22 Web of Science
  • 20 Citations
AbstractAbstract PDF
Purpose

The incidence of colorectal cancer is increasing due to a westernized dietary lifestyle, and improvements in treatment and diagnostic tools have resulted in more patients being confirmed of having multiple primary cancers. However, studies regarding multiple primary cancers are insufficient. In this study, the clinical aspects of patients with primary multiple cancers, including colorectal cancers, were investigated, and the results were compared to those of patients with primary colorectal cancer only.

Methods

Seven hundred eighteen patients who received surgery for colorectal cancer between March 2003 and September 2012 in CHA Medical Center were enrolled. A retrograde cohort was done for comparison of the two groups: those with and those without multiple primary cancer. The analysis was done according to sex, age, tumor location, tumor size, metastatic regional lymph-node number, vascular/lymphatic microinvasion, staging, tumor markers, microsatellite instability, and C/T subgroup of polymorphism in methylenetetrahydrofolate reductase.

Results

Of the 718 subjects, 33 (4.6%) had multiple primary cancers: 12 (36.4%) synchronous and 21 (63.6%) metachronous. The malignancy most frequently accompanying colorectal cancer was gastric cancer, followed by thyroid, prostate, and esophageal malignancies in that order. In the comparison between groups, mean age, tumor location, and microsatellite instability showed statistically significant differences; others parameters did not.

Conclusion

The incidence of multiple primary cancers, including colorectal cancer, is increasing. Therefore, defining the characteristics of patients with multiple primary cancers is crucial, and those characteristics need to be acknowledged in the follow-up of colorectal cancer patients.

Citations

Citations to this article as recorded by  
  • Risk of Gynaecological Cancers as Second Primary in Non-gynaecological Cancer Survivors: A Retrospective Cohort Study
    N. R. Sindhu, Dhanya Susan Thomas, Ajit Sebastian, Anitha Thomas, Rachel Chandy, Sherin Daniel, Vinotha Thomas
    The Journal of Obstetrics and Gynecology of India.2025; 75(S1): 146.     CrossRef
  • Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis
    Ye Kyaw Aung, Ye Zhang, Mark A Jenkins, Aung Ko Win
    JNCI Cancer Spectrum.2025;[Epub]     CrossRef
  • Rare comorbidity of colon cancer, hepatic malignant mesothelioma, and abdominal Ewing’s sarcoma: a case report
    Yanru Li, Lukang Teng, Shupeng Wang, Xudong Wu, Tianchen Huang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • A Case Report of Multiple Primary Malignancies Presenting With Unusual Inguinal Metastasis
    Emre Tunc, Yunus Emre Bolukoglu, Bulent Aksel, Lutfi Dogan
    Cureus.2025;[Epub]     CrossRef
  • Multiple primary malignant neoplasms and long‑term survival: A case report
    Biao Xie, Ke Huang, Shuibo Zhu
    Oncology Letters.2025; 30(6): 1.     CrossRef
  • Synchronous Papillary Thyroid Cancer and Colorectal Cancer in a Young Patient with a CHEK2 Mutation
    Sydney Brooke Hoskins, Leslie Torgerson
    Case Reports in Oncology.2024; 17(1): 524.     CrossRef
  • Influence factors of the survival in colorectal cancer patients with second primary malignancy after surgery: A SEER database analysis
    Liyu Liu, Bolin Chen
    Medicine.2023; 102(40): e35286.     CrossRef
  • A synopsis of modern - day colorectal cancer: Where we stand
    Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(2): 188699.     CrossRef
  • A Single-Center Study of Patients With Synchronous Primary Malignancy: A Case Series
    Abeer I Alsulaimani, Layla M Alkhaldi, Sheikha A AlTawairqi, Arif Khurshid, Hamma A Abdulaziz, Abdulrahman G Alotaibi, Haifa O Alotaibi
    Cureus.2022;[Epub]     CrossRef
  • MicroRNAs expression analysis shows key affirmation of Synaptopodin-2 as a novel prognostic and therapeutic biomarker for colorectal and cervical cancers
    Md. Shahadat Hossain, Mahafujul Islam Quadery Tonmoy, Md. Nur Islam, Md. Sajedul Islam, Ibrahim Khalil Afif, Arpita Singha Roy, Atqiya Fariha, Hasan Al Reza, Newaz Mohammed Bahadur, Md. Mizanur Rahaman
    Heliyon.2021; 7(6): e07347.     CrossRef
  • Multiple Metachronous Malignancies: One Patient with Five Primary Malignancies
    Sung Yun Lee, Byung Ik Kim, Hong Ju Kim, Kwan Joong Joo, Sang Hyuk Lee, Chang Hak Yoo, Dong Hoon Kim
    The Korean Journal of Medicine.2019; 94(1): 114.     CrossRef
  • Synchronous Hodgkin lymphoma and gastric adenocarcinoma
    Hongying Wu, Liyan Wei, Lumei Hao, Xuemei Li, Lei Wang, Chenglu Yuan
    Medicine.2018; 97(3): e9484.     CrossRef
  • Secondary Breast, Ovarian, and Uterine Cancers After Colorectal Cancer: A Nationwide Population-Based Cohort Study in Korea
    Dong Woo Shin, Yoon Jin Choi, Hyun Soo Kim, Kyung-Do Han, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
    Diseases of the Colon & Rectum.2018; 61(11): 1250.     CrossRef
  • Clinical characteristics and survival of lung cancer patients associated with multiple primary malignancies
    Shan Shan, Jun She, Zhi-qiang Xue, Chun-xia Su, Shen-xiang Ren, Feng-ying Wu, Rafael Rosell
    PLOS ONE.2017; 12(9): e0185485.     CrossRef
  • Liver resection for hepatocellular carcinoma in patients with hematological malignancies
    Hui-Chen Lin, Yang-Shen Yang, Chieh-Lin Jerry Teng, Ching-Hui Shen, Yee-Gee Jan, Shao-Bin Cheng, Cheng-Chung Wu, Yi-Ling Lin, Chu-Chun Huang, Fang-Ku P’eng
    World Journal of Surgical Oncology.2017;[Epub]     CrossRef
  • Multiple Primary Malignancies in Patients With Hepatocellular Carcinoma
    Wei Xu, Wenjun Liao, Penglei Ge, Jinjun Ren, Haifeng Xu, Huayu Yang, Xinting Sang, Xin Lu, Yilei Mao
    Medicine.2016; 95(17): e3491.     CrossRef
  • Lessons Learned From a Case of Gastric Cancer After Liver Transplantation for Hepatocellular Carcinoma
    Kun Yang, Hong Zhu, Chong-Cheng Chen, Tian-Fu Wen, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Dong-Jiao Guo, Zong-Guang Zhou, Jian-Kun Hu
    Medicine.2016; 95(7): e2666.     CrossRef
  • An Uncommon Presentation of a Metachronous Primary Gastric Tumor in a Patient with a Resected Colorectal Carcinoma: Case Report and Review of the Literature
    Michalis Galanopoulos, Elisavet Nikolaidou, Christos Liatsos
    Journal of Gastrointestinal Cancer.2015; 46(1): 85.     CrossRef
  • Gastric cancer following a liver transplantation for glycogen storage disease type Ia (von Gierke disease): A case report
    HUA XIAO, JIANMIN BIAN, LEI ZHANG, ZHAOMING WANG, AIXING DING
    Oncology Letters.2014; 8(6): 2803.     CrossRef
  • Second Primary Cancers Following Colorectal Cancer
    Jung Wook Huh
    Annals of Coloproctology.2014; 30(1): 2.     CrossRef
Hyperbilirubinemia Is a Significant Indicator for the Severity of Acute Appendicitis
Young Ran Hong, Chul-Woon Chung, Jong Woo Kim, Chang Il Kwon, Dae Ho Ahn, Sung Won Kwon, Seong Ki Kim
J Korean Soc Coloproctol. 2012;28(5):247-252.   Published online October 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.5.247
  • 6,637 View
  • 74 Download
  • 27 Citations
AbstractAbstract PDF
Purpose

This study aims to reveal more effective clinical or laboratory markers for the diagnosis of acute appendicitis and to score the severity based on a sufficiently large number of patients with acute appendicitis.

Methods

We identified 1,195 patients with acute appendicitis after excluding those with other causes of hyperbilirubinemia among the 1,271 patients that underwent a laparoscopic or an open appendectomy between 2009 and 2010. A retrospective chart review of the medical records, including laboratory and histologic results, was conducted. We then analyzed the data using univariate and multivariate analyses.

Results

Among the 1,195 patients, a laparoscopic appendectomy was performed in 685 cases (57.32%), and an open appendectomy was performed in 510 cases (42.68%). The univariate analysis demonstrated significant differences for white blood cell count (P < 0.0001), segmented neutrophils (P = 0.0035), total bilirubin (P < 0.0001), and systemic inflammatory response syndrome (SIRS) score between groups (P < 0.0001). The multivariate analysis demonstrated that total bilirubin (odds ratio, 1.772; 95% confidence interval, 1.320 to 2.379; P = 0.0001) and SIRS score (odds ratio, 1.583; 95% confidence interval, 1.313 to 1.908; P < 0.0001) have statistically significant diagnostic value for perforated appendicitis.

Conclusion

Hyperbilirubinemia is a statistically significant diagnostic marker for acute appendicitis and the likelihood of perforation.

Citations

Citations to this article as recorded by  
  • Hyperbilirubinemia and acute appendicitis: a cohort study
    Harris BARTIMEUS, Ibrahim LABEDA, Julianus A. UWURATUW, Joko HENDARTO, Prihantono PRIHANTONO, Muhammad I. KUSUMA, Muhammad FARUK
    Chirurgia.2025;[Epub]     CrossRef
  • Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model
    Zeynep Kucukakcali, Sami Akbulut
    World Journal of Clinical Cases.2025;[Epub]     CrossRef
  • Hyperbilirubinemia as a Marker for Complicated Acute Appendicitis: A Systematic Review
    Alicja Czyszczon, Bartosz Maczkowski, Aneta Tkaczyk, Marek Drozdz, Wiktoria Boral, Szymon Mikler, Magdalena Mandyna, Aleksandra Przelaskowska, Jan Pulinski
    Cureus.2025;[Epub]     CrossRef
  • Diagnostic Value of Hematological and Biochemical Markers in Pediatric Appendicitis: A ROC-Based Retrospective Evaluation
    Sevgi Buyukbese Sarsu
    Medical Bulletin of Haseki.2025; 63(5): 236.     CrossRef
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    Qian Zhang, Hongwei Zhao, Fangli Wang, Wenqiang Li, Peng Zhang
    Biomedical Reports.2024;[Epub]     CrossRef
  • Letter to the Editor regarding “A novel Appendicitis TriMOdal prediction Score (ATMOS) for acute appendicitis in pregnancy: a retrospective observational study”
    Rıfat Peksöz, Ferdi Cambaztepe, Sabri Selçuk Atamanalp
    Updates in Surgery.2023; 75(1): 265.     CrossRef
  • Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review
    Binyamin Sikander, Jacob Rosenberg, Siv Fonnes
    The American Journal of Emergency Medicine.2023; 67: 100.     CrossRef
  • Elevated total and direct bilirubin are associated with acute complicated appendicitis: a single-center based study in Saudi Arabia
    Mohammed S. Alfehaid, Ayman M. Babiker, Abdullah Hamad Alkharraz, Hamad yousef Alsaeed, Ali Abdullah Alzunaydi, Adi Abdulaziz Aldubaiyan, Hanan Abdalla Sinyan, Bshayr K. Alkhalaf, Rakan Alshuwaykan, Rehana Khalil, Osama Al-Wutayd
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  • Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis
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    Medical Sciences.2022; 10(3): 36.     CrossRef
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    BMC Gastroenterology.2021;[Epub]     CrossRef
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    P N Sreeramulu, Shashidhar K N, Varsha A
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    Journal of Evidence Based Medicine and Healthcare.2019; 6(48): 3039.     CrossRef
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    Seerwan Hama Shareef, Dara Ahmed Mohammed, Goran Ameer Ahmed
    Kurdistan Journal of Applied Research.2018; : 15.     CrossRef
  • Lack of utility of measuring serum bilirubin concentration in distinguishing perforation status of pediatric appendicitis
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    The American Journal of Emergency Medicine.2017; 35(6): 885.     CrossRef
  • Hyperbilirubinaemia: its utility in non‐perforated appendicitis
    Anna Sandstrom, David A. Grieve
    ANZ Journal of Surgery.2017; 87(7-8): 587.     CrossRef
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    Amish Acharya, Sheraz R. Markar, Melody Ni, George B. Hanna
    Surgical Endoscopy.2017; 31(3): 1022.     CrossRef
  • Hyperbilirubinaemia alone cannot distinguish a perforation in acute appendicitis
    Fábio R. Silva, Maria Inês da Rosa, Bruno R. Silva, Carla Simon, Maria Cecília Alexandre, Lidia R. Medeiros, Fabrício S. Bitencourt, Maria Eduarda Fernandes dos Reis
    ANZ Journal of Surgery.2016; 86(4): 255.     CrossRef
  • Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study
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    International Journal of Surgery.2015; 13: 207.     CrossRef
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    Yahya A. Al-Abed, Nasser Alobaid, Fiona Myint
    The American Journal of Surgery.2015; 209(6): 1043.     CrossRef
  • Diagnostic accuracy of hyperbilirubinaemia in anticipating appendicitis and its severity
    Sven Muller, Claudius Falch, Steffen Axt, Peter Wilhelm, Dirk Hein, Alfred Königsrainer, Andreas Kirschniak
    Emergency Medicine Journal.2015; 32(9): 698.     CrossRef
  • Serum total bilirubin elevation is a predictor of the clinicopathological severity of acute appendicitis
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    Surgery Today.2014; 44(6): 1104.     CrossRef
  • Elevated serum bilirubin in assessing the likelihood of perforation in acute appendicitis: A diagnostic meta-analysis
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    International Journal of Surgery.2013; 11(9): 795.     CrossRef
Editorial
Cyclooxygenase and Prostaglandin in Cancer
Jong-Woo Kim
J Korean Soc Coloproctol. 2012;28(5):226-227.   Published online October 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.5.226
  • 3,029 View
  • 37 Download
PDF
Original Articles
Clinical Characteristics of Ischemic Colitis According to Location
Ho Jin Chang, Chul Woon Chung, Kwang Hyun Ko, Jong Woo Kim
J Korean Soc Coloproctol. 2011;27(6):282-286.   Published online December 31, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.6.282
  • 5,325 View
  • 42 Download
  • 11 Citations
AbstractAbstract PDF
Purpose

The aim of this study was to analyze various clinical characteristics of ischemic colitis according to its location.

Methods

The medical records of 92 cases of gastrointestinal ischemic colitis (IC) diagnosed at Bundang CHA Hospital from 1995 to 2008 were reviewed and analyzed retrospectively. The patients were diagnosed by using colonoscopic biopsies or laparotomy findings. The patients were divided into two groups, right and left, according to the main involvement area of the IC at the embryologic boundary line of the distal transverse colon, and the two groups were compared as to clinical characteristics and co-morbid diseases.

Results

Left IC was present in 59 patients (64.1%) and right IC in 33 patients (35.9%). No differences between the two groups in terms of clinical characteristics, cardiovascular disease and diabetes mellitus were observed. However, in 16 cases with renal failure, 10 patient had right IC and 6 patients had left IC, and this difference had statistical significance (P = 0.014). Among the 16, the 11 patients requiring hemodialysis included 8 with right IC (24.2%) and 3 with left IC (5.1%; P = 0.009). Among the 19 cases of severe IC requiring surgical treatment or involving mortality, irrespective of surgery, 11 patients showed right IC and 8 patients showed left IC (P = 0.024).

Conclusion

Right-side ischemic colitis was significantly associated with renal failure and disease severity, so patients with right-side colon ischemia should be more carefully observed and managed.

Citations

Citations to this article as recorded by  
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    Lorraine I Chong Tai, Syed Ahmed, Rajiv R Chokshi
    Cureus.2023;[Epub]     CrossRef
  • Colitis isquémica. ¿La localización en el colon derecho tiene peor pronóstico?
    Vincenzo Vigorita, Marta Paniagua García-Señoráns, Gianluca Pellino, Paula Troncoso Pereira, Alberto de San Ildefonso Pereira, Enrique Moncada Iribarren, Raquel Sánchez-Santos, Jose Enrique Casal Núñez
    Cirugía Española.2022; 100(2): 74.     CrossRef
  • Ischemic colitis. Does right colon location mean worst prognosis?
    Vincenzo Vigorita, Marta Paniagua García-Señoráns, Gianluca Pellino, Paula Troncoso Pereira, Alberto de San Ildefonso Pereira, Enrique Moncada Iribarren, Raquel Sánchez-Santos, Jose Enrique Casal Núñez
    Cirugía Española (English Edition).2022; 100(2): 74.     CrossRef
  • Real‐world multicentre experience of the pathological features of colonic ischaemia and their relationship to symptom duration, disease distribution and clinical outcome
    M. Fenster, P. Feuerstadt, L. J. Brandt, M. S. Mansoor, T. Huisman, O. C. Aroniadis
    Colorectal Disease.2018; 20(12): 1132.     CrossRef
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    Ayah Oglat, Eamonn M.M. Quigley
    Current Opinion in Gastroenterology.2017; 33(1): 34.     CrossRef
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    D. Sun, C. Wang, L. Yang, M. Liu, F. Chen
    Colorectal Disease.2016; 18(10): 949.     CrossRef
  • ACG Clinical Guideline: Epidemiology, Risk Factors, Patterns of Presentation, Diagnosis, and Management of Colon Ischemia (CI)
    Lawrence J Brandt, Paul Feuerstadt, George F Longstreth, Scott J Boley
    American Journal of Gastroenterology.2015; 110(1): 18.     CrossRef
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    Cinthia Cruz, Hani H. Abujudeh, Rosalynn M. Nazarian, James H. Thrall
    Emergency Radiology.2015; 22(4): 357.     CrossRef
  • CT Findings in Acute, Subacute, and Chronic Ischemic Colitis: Suggestions for Diagnosis
    Francesca Iacobellis, Daniela Berritto, Dominik Fleischmann, Giuliano Gagliardi, Antonio Brillantino, Maria Antonietta Mazzei, Roberto Grassi
    BioMed Research International.2014; 2014: 1.     CrossRef
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    A Reginelli, EA Genovese, S Cappabianca, F Iacobellis, D Berritto, P Fonio, F Coppolino, R Grassi
    Critical Ultrasound Journal.2013;[Epub]     CrossRef
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    Nina Kononowa, Michael J Dickenmann, Min Jeong Kim
    Journal of Medical Case Reports.2013;[Epub]     CrossRef
Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer
Bong Su Kang, Dae Ho Ahn, Nam Keun Kim, Jong Woo Kim
J Korean Soc Coloproctol. 2011;27(2):78-82.   Published online April 30, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.2.78
  • 5,522 View
  • 33 Download
  • 18 Citations
AbstractAbstract PDF
Purpose

There have been studies on the relations between metabolic syndrome and colorectal cancer or on the relations between methylenetetrahydrofolate reductase (MTHFR) polymorphism and colorectal cancer, but reports on the relationship between metabolic syndrome, MTHFR polymorphism and colorectal cancer all together are rare. The aim of this study is to find the interrelation between metabolic syndrome and MTHFR polymorphism in colorectal cancer.

Methods

This study investigated 255 colorectal cancer patients (cancer group) who underwent surgery in our hospital from March 2003 to December 2008 and compared those patients to 488 healthy patients (control group). The diagnostic criterion for metabolic syndrome was based on the National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III), and the MTHFR 677 polymorphism was analyzed.

Results

When colorectal cancer patients and patients in the control group were classified as MTHFR 677 subtypes, there was no difference between the two groups: CC 87 (34.1%), CT 134 (52.6%), and TT 34 (13.3%) for the cancer group and CC 145 (32.4%), CT 238 (53.1%), and TT 65 (14.5%) for the control group. Distributions of MTHFR 677C/T genotype and allele frequencies in the individuals with and without metabolic syndrome in the cancer group showed no differences. Moreover, we could find no differences in distributions of MTHFR 677C/T genotypes in the clinical and the biomedical variables of individuals with and without metabolic syndrome in the cancer group.

Conclusion

Our results show no relation between metabolic syndrome and MTHFR polymorphism in colorectal cancer. However, a further prospective study, based on a precise diagnostic criterion for metabolic syndrome, is needed.

Citations

Citations to this article as recorded by  
  • Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer
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    BMC Cancer.2025;[Epub]     CrossRef
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Editorial
The Clinical Usefulness of the Sentinel Lymph Node in Rectal Cancer: Do We Believe It?
Jong Woo Kim
J Korean Soc Coloproctol. 2011;27(2):51-52.   Published online April 30, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.2.51
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