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1 "Jungtak Son"
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Original Article
Malignant disease
Increased Risk of Neoplasms in Adult Patients Undergoing Interval Appendectomy
Jungtak Son, Yong Jun Park, Sung Ryol Lee, Hyung Ook Kim, Kyung Uk Jung
Ann Coloproctol. 2020;36(5):311-315.   Published online January 31, 2020
DOI: https://doi.org/10.3393/ac.2019.10.15.1
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  • 13 Web of Science
  • 13 Citations
AbstractAbstract PDF
Purpose
The low rate of recurrent appendicitis after initial nonsurgical management of complicated appendicitis supports the recently implemented strategy of omitting routine interval appendectomy. However, several reports have suggested an increased incidence rate of neoplasms in these patients. We aimed to identify the risk of neoplasms in the population undergoing interval appendectomy.
Methods
This study retrospectively analyzed consecutive cases of appendicitis that were treated surgically between January 2014 and December 2018 at a single tertiary referral center. Patients were divided into 2 groups depending on whether they underwent immediate or interval appendectomy. Demographics and perioperative clinical and pathologic parameters were analyzed.
Results
All 2,013 adults included in the study underwent surgical treatment because of an initial diagnosis of acute appendicitis. Of these, 5.5% (111 of 2,013) underwent interval appendectomy. Appendiceal neoplasm was identified on pathologic analysis in 36 cases (1.8%). The incidence of neoplasm in the interval group was 12.6% (14 of 111), which was significantly higher than that of the immediate group (1.2% [22 of 1,902], P < 0.001). Conclusion: The incidence rate of neoplasms was significantly higher in patients undergoing interval appendectomy. These findings should be considered when choosing treatment options after successful nonsurgical management of complicated appendicitis.

Citations

Citations to this article as recorded by  
  • Incidental appendiceal neoplasms in a multicenter registry of appendicitis management
    Aksel D. Laudon, Brendin R. Beaulieu-Jones, Swetha Duraiswamy, Frank F. Yang, Elizabeth Chen, Dave R. Flum, Kasey Lerner, Heather L. Evans, Lauren Thompson, Faris K. Azar, Alex Charboneau, Vlad V. Simianu, Victoria Valdes, Chaitan Narsule, Sabrina E. Sanc
    Surgery.2026; 190: 109879.     CrossRef
  • True Incidence of Appendiceal Neoplasms in Patients Presenting with Complicated Appendicitis: A Call for a Revised Management Algorithm
    Laleh Foroutani, Jaeyun Jane Wang, Shreyas Kiran, Han Yin, Joshua Myszewski, Suwayda Ali, Amir Ashraf Ganjouei, Kenzo Hirose, Carlos Corvera, Eric Nakakura, Adnan Alseidi, Mohamed Abdelgadir Adam
    Annals of Surgical Oncology.2026;[Epub]     CrossRef
  • Appendiceal Tumor Prevalence in Patients With Periappendicular Abscess
    Roosa Salminen, Jenny Alajääski, Tero Rautio, Saija Hurme, Pia Nordström, Elisa Mäkäräinen, Elina Lietzén, Tarja Pinta, Marie Grönroos-Korhonen, Tuomo Rantanen, Jan Andersén, Anne Mattila, Jyrki Kössi, Antti Riikola, Hannu Paajanen, Markku Matikainen, Ves
    JAMA Surgery.2025; 160(5): 526.     CrossRef
  • Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract
    Noureldien Darwish, Lynn Guo, Eundong Park, Hwajeong Lee
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Is it Possible to Manage Appendicular Mass Without Surgery?
    Muhammad Albahadili, Saif Mundher Ismael, Monaf Faik Al-Samarraee
    Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2025; 9(2): 46.     CrossRef
  • Can Appendiceal Neoplasms Be Predicted in Patients with Presumed Acute Appendicitis?
    Şevki Pedük
    European Journal of Therapeutics.2024; 30(2): 145.     CrossRef
  • Beyond acute appendicitis: a single-institution experience of unexpected pathology findings after 989 consecutive emergency appendectomy
    Pietro Fransvea, Caterina Puccioni, Gaia Altieri, Luca D’Agostino, Gianluca Costa, Giuseppe Tropeano, Antonio La Greca, Giuseppe Brisinda, Gabriele Sganga
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Exploring the mysterious mucinous appendiceal neoplasm
    Erika Hissong
    Seminars in Diagnostic Pathology.2024; 41(5): 222.     CrossRef
  • High Incidence of Appendiceal Neoplasms in the Elderly: A Critical Concern for Non-Surgical Treatment
    Gizem Issin, Fatih Demir, Irem Guvendir Bakkaloglu, Diren Vuslat Cagatay, Hasan Aktug Simsek, Ismail Yilmaz, Ebru Zemheri
    Medical Principles and Practice.2023; 32(6): 358.     CrossRef
  • Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report
    Suk Jun Lee, Ji Hae Nahm, Jeonghyun Kang, Seung Hyuk Baik, Eun Jung Park
    International Journal of Surgery Case Reports.2022; 99: 107665.     CrossRef
  • Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis
    Roberto Peltrini, Valeria Cantoni, Roberta Green, Ruggero Lionetti, Michele D'Ambra, Carolina Bartolini, Marcello De Luca, Umberto Bracale, Alberto Cuocolo, Francesco Corcione
    The Surgeon.2021; 19(6): e549.     CrossRef
  • Interval appendicectomy for complicated appendicitis: do not let your guard down!
    R Peltrini, M Podda, S Di Saverio, U Bracale, F Corcione
    British Journal of Surgery.2021; 108(9): e288.     CrossRef
  • Modern Management of the Appendix
    CPT Samuel Grasso, LTC Avery Walker
    Surgical Clinics of North America.2021; 101(6): 1023.     CrossRef
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