Annals of Coloproctology

Original Article

Role of β₁-Integrin in Colorectal Cancer: Case-Control Study: Bo-Young Oh, Kwang Ho Kim, Soon Sup Chung, Kyoung Sook Hong, Ryung-Ah Lee; Ann Coloproctol. 2014;30(2):61-70. Published online April 25, 2014; DOI: https://doi.org/10.3393/ac.2014.30.2.61

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Purpose

In the metastatic process, interactions between circulating tumor cells (CTCs) and the extracellular matrix or surrounding cells are required. β₁-Integrin may mediate these interactions. The aim of this study was to investigate whether β₁-integrin is associated with the detection of CTCs in colorectal cancer.

Methods

We enrolled 30 patients with colorectal cancer (experimental group) and 30 patients with benign diseases (control group). Blood samples were obtained from each group, carcinoembryonic antigen (CEA) mRNA for CTCs marker and β₁-integrin mRNA levels were estimated by using reverse transcription-polymerase chain reaction, and the results were compared between the two groups. In the experimental group, preoperative results were compared with postoperative results for each marker. In addition, we analyzed the correlation between the expressions of β₁-integrin and CEA.

Results

CEA mRNA was detected more frequently in colorectal cancer patients than in control patients (P = 0.008). CEA mRNA was significantly reduced after surgery in the colorectal cancer patients (P = 0.032). β₁-Integrin mRNA was detected more in colorectal cancer patients than in the patients with benign diseases (P < 0.001). In colorectal cancer patients, expression of β₁-integrin mRNA was detected more for advanced-stage cancer than for early-stage cancer (P = 0.033) and was significantly decreased after surgery (P < 0.001). In addition, expression of β₁-integrin mRNA was significantly associated with that of CEA mRNA in colorectal cancer patients (P = 0.001).

Conclusion

In conclusion, β₁-integrin is a potential factor for forming a prognosis following surgical resection in colorectal cancer patients. β₁-Integrin may be a candidate for use as a marker for early detection of micrometastatic tumor cells and for monitoring the therapeutic response in colorectal cancer patients.

Citations

Citations to this article as recorded by

A review on mechanobiology of cell adhesion networks in different stages of sporadic colorectal cancer to explain its tumorigenesis
Siti Hawa Ngalim, Norwahida Yusoff, Rayzel Renitha Johnson, Siti Razila Abdul Razak, Xinyue Chen, Jamie K. Hobbs, Yeong Yeh Lee
Progress in Biophysics and Molecular Biology.2022; 175: 63. CrossRef
The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer—Comprehensive Study Based on In Silico Analysis
Huining Kang, Jakub Fichna, Ksenia Matlawska-Wasowska, Damian Jacenik
Cells.2022; 11(23): 3876. CrossRef
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Cuong Cao Le, Amar Bennasroune, Benoit Langlois, Stéphanie Salesse, Camille Boulagnon-Rombi, Hamid Morjani, Stéphane Dedieu, Aline Appert-Collin
Frontiers in Oncology.2020;[Epub] CrossRef
CRISPR/Cas9 in Cancer Immunotherapy: Animal Models and Human Clinical Trials
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Genes.2020; 11(8): 921. CrossRef
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y. Zaytseva, Kathleen L. O’Connor, Craig W. Vander Kooi, Side Liu, Qing-Bai She
Nature Communications.2019;[Epub] CrossRef
Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer
Kyung Sook Hong, Eun-Young Jeon, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee
Cancer Cell International.2018;[Epub] CrossRef
Animal models of colorectal cancer with liver metastasis
Bo Young Oh, Hye Kyung Hong, Woo Yong Lee, Yong Beom Cho
Cancer Letters.2017; 387: 114. CrossRef
A New Size-based Platform for Circulating Tumor Cell Detection in Colorectal Cancer Patients
Bo Young Oh, Jhingook Kim, Woo Yong Lee, Hee Cheol Kim
Clinical Colorectal Cancer.2017; 16(3): 214. CrossRef
Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells
Bo Young Oh, So-Young Kim, Yeo Song Lee, Hye Kyung Hong, Tae Won Kim, Seok Hyung Kim, Woo Yong Lee, Yong Beom Cho
Oncotarget.2016; 7(35): 57066. CrossRef
Expression of L1 protein correlates with cluster of differentiation 24 and integrin β1 expression in gastrointestinal stromal tumors
YUE DU, HAIHONG ZHANG, ZHONGMIN JIANG, GUOWEI HUANG, WENLI LU, HESHENG WANG
Oncology Letters.2015; 9(6): 2595. CrossRef
Correlation between tumor engraftment in patient-derived xenograft models and clinical outcomes in colorectal cancer patients
Bo Young Oh, Woo Yong Lee, Sungwon Jung, Hye Kyung Hong, Do-Hyun Nam, Yoon Ah Park, Jung Wook Huh, Seong Hyeon Yun, Hee Cheol Kim, Ho-Kyung Chun, Yong Beom Cho
Oncotarget.2015; 6(18): 16059. CrossRef
Invasion and Metastasis in the Viewpoint of Cell Adhesive Molecules
Jong-Woo Kim
Annals of Coloproctology.2014; 30(2): 57. CrossRef

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