Annals of Coloproctology

Case Report

Benign GI diease,Rare disease & stoma

McKittrick-Wheelock Syndrome: A Case Series: Maureen Elvira P. Villanueva, Mark Augustine S. Onglao, Mayou Martin T. Tampo, Marc Paul J. Lopez; Ann Coloproctol. 2022;38(3):266-270. Published online July 13, 2021; DOI: https://doi.org/10.3393/ac.2020.00745.0106

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McKittrick-Wheelock syndrome is a rare and life-threatening disease characterized by the triad of (1) chronic mucous diarrhea, (2) renal function impairment with hydroelectrolyte imbalance, and (3) a giant colorectal tumor. Often, the tumor is a rectal adenoma. With the mortality being certain, if left untreated, it is important to raise awareness on the presentation, diagnosis, and management of this disease entity. Here, we presented 3 cases of McKittrick-Wheelock syndrome that were successfully managed with surgical resection at the Philippine General Hospital from August 2018 to May 2019. Resolution of their symptoms, reversal of their renal impairment, and correction of their electrolyte depletion were noted after removal of the tumor with a sphincter-saving operation.

Citations

Citations to this article as recorded by

Renal failure due to rectal neoplastic polyp: McKittrick–Wheelock syndrome—a case report
Ivan Valentinov Dimitrov, Theophil Angelov Sedloev, Ivan Petrov Vasilev, Slavyana Slavcheva Usheva, Yavor Asenov Nikolov, Nikolay Metodiev Penkov, Plamen Ivanov Penchev, Maria-Elena Boyadzhieva, Georgi Chavdarov Jelev
Journal of Medical Case Reports.2025;[Epub] CrossRef
A New Perspective on the Management of Giant Rectal Polyps Presenting With McKittrick-Wheelock Syndrome: A Case Report on Treatment With Transanal Excision and Delorme’s Plication
Andrew C Ekwesianya, Abraham V Jesudoss, Manoj Jacob, Mohamad F Badr, Bandipalyam V Praveen
Cureus.2025;[Epub] CrossRef
Mckittrick-Wheelock syndrome as a rare manifestation of villous adenoma of the rectum
V.E. Khoronenko, V.S. Trifanov, N.V. Chebotareva, M.Yu. Meshcheryakova, M.V. Kosogolov
Khirurgiya. Zhurnal im. N.I. Pirogova.2024; (3): 76. CrossRef
McKittrick–Wheelock Syndrome: A Case Report
Kristina Marcinkevičiūtė, Marius Kryžauskas, Tomas Poškus
Medicina.2023; 59(3): 633. CrossRef
Rapid Malignant Transformation of Tubulovillous Adenoma, Initially Presenting as McKittrick-Wheelock Syndrome: A Case Report
Ibnu Purwanto, Benedreky Leo, Bambang Purwanto Utomo, Imam Sofii, Ery Kus Dwianingsih, Neneng Ratnasari
Case Reports in Oncology.2023; 16(1): 818. CrossRef
Giant Villous Adenoma of the Rectum With Prolapse: Case Report
Iurii Munteanu, Munteanu Mihaela, Silvia Popescu, Iulian M Slavu, Anca Oprescu Macovei, Daniel Cochior
Cureus.2023;[Epub] CrossRef
Chronic Kidney Disease, Hypokalemia, and Appendicular Mucocele in a 66-Year-Old Man
Sanda Mrabet, Yosr Chaabouni, Mohamed Ben Hmida
American Journal of Men's Health.2022;[Epub] CrossRef

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