Annals of Coloproctology

Case Report

Benign proctology,Rare disease & stoma,Complication

Fournier Gangrene in a Patient With Type 2 Diabetes Mellitus Treated With Dapagliflozin: A Case Report: Jae Young Moon, Min Ro Lee, Jong Hun Kim, Gi Won Ha; Ann Coloproctol. 2021;37(Suppl 1):S48-S50. Published online May 28, 2021; DOI: https://doi.org/10.3393/ac.2020.06.22

4,633 View
156 Download
5 Web of Science
7 Citations

Rare cases of Fournier gangrene (FG) possibly associated with sodium-glucose cotransporter 2 inhibitors have been reported. We present a case of a 66-year-old male patient with type 2 diabetes mellitus on oral metformin, glimepiride, and dapagliflozin therapy. He presented with pain in the perineum and scrotum for 5 days. The clinical finding, computed tomography finding, and laboratory data were matched with FG. Emergency surgical drainage, debridement of necrotic tissue, and diverting loop ileostomy formation were performed by a urologist and a surgeon. The patient had no complications from diabetes before the onset of FG, and serum glucose management was good at the onset of FG. This case shows an FG patient with good glucose management taking dapagliflozin and suggests a possible association between dapagliflozin and FG. Further evaluation and additional research on this relationship are needed.

Citations

Citations to this article as recorded by

Cost-effectiveness analysis and medication use for gangrene treatment in type 2 diabetes patients: A systematic literature review
Entris Sutrisno, Jajang Japar Sodik, Taufik Muhammad Fakih
Pharmacia.2025; 72: 1. CrossRef
Fournier’s Gangrene as an Adverse Event Following Treatment with Sodium Glucose Cotransporter 2 Inhibitors
Ioana-Maria Suciu, Alin Greluș, Alina-Ramona Cozlac, Bogdan-Simion Suciu, Svetlana Stoica, Silvia Luca, Constantin-Tudor Luca, Dan-Ion Gaiță
Medicina.2024; 60(5): 837. CrossRef
A Case of Fournier's Gangrene Following the Initiation of Dapagliflozin
Natalie Shaykh, Avni Agrawal, Melville C O'Brien, Oshin Rai, Vanshika Tripathi, Vishal Jaikaransingh
Cureus.2024;[Epub] CrossRef
Skin-Related Adverse Reactions Induced by Oral Antidiabetic Drugs—A Review of Literature and Case Reports
Justyna Kowalska, Dorota Wrześniok
Pharmaceuticals.2024; 17(7): 847. CrossRef
Cutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors
Alexandra Laura Mederle, Patrick Dumitrescu, Claudia Borza, Nilima Rajpal Kundnani
Journal of Clinical Medicine.2024; 14(1): 188. CrossRef
Management of Fournier’s gangrene during the Covid-19 pandemic era: make a virtue out of necessity
Alessio Paladini, Giovanni Cochetti, Angelica Tancredi, Matteo Mearini, Andrea Vitale, Francesca Pastore, Paolo Mangione, Ettore Mearini
Basic and Clinical Andrology.2022;[Epub] CrossRef
Dapagliflozin

Reactions Weekly.2022; 1926(1): 197. CrossRef

Original Article

Management of Colonic Diverticulitis Tailored to Location and Severity: Comparison of the Right and the Left Colon: Byeoung Hoon Chung, Gi Won Ha, Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2016;32(6):228-233. Published online December 31, 2016; DOI: https://doi.org/10.3393/ac.2016.32.6.228

5,012 View
98 Download
23 Web of Science
23 Citations

Abstract PDF

Purpose

This study assessed optimal management of colonic diverticulitis as functions of disease location and severity and factors associated with complicated diverticulitis.

Methods

This retrospective review analyzed 202 patients diagnosed between 2007 and 2014 at Chonbuk National University Hospital, South Korea, with colonic diverticulitis by using abdominopelvic computed tomography. Diverticulitis location was determined, and disease severity was categorized using the modified Hinchey classification.

Results

Patients included 108 males (53.5%) and 94 females (46.5%); of these, 167 patients (82.7%) were diagnosed with right-sided and 35 (17.3%) with left-sided colonic diverticulitis. Of the 167 patients with right-sided colonic diverticulitis, 12 (7.2%) had complicated and 155 (92.8%) had uncomplicated diverticulitis; of these, 157 patients (94.0%) were successfully managed conservatively. Of the 35 patients with left-sided colonic diverticulitis, 23 (65.7%) had complicated and 12 (34.3%) had uncomplicated diverticulitis; of these, 23 patients (65.7%) were managed surgically. Among patients with right-sided diverticulitis, those with complicated disease were significantly older (54.3 ± 12.7 years vs. 42.5 ± 13.4 years, P = 0.004) and more likely to be smokers (66.7% vs. 32.9%, P = 0.027) than those with uncomplicated disease. However, among patients with left-sided diverticulitis, those with complicated disease had significantly lower body mass index (BMI; 21.9 ± 4.7 kg/m² vs. 25.8 ± 4.3 kg/m², P = 0.021) than those with uncomplicated disease.

Conclusion

Conservative management may be effective in patients with right-sided diverticulitis and patients with uncomplicated left-sided colonic diverticulitis. Surgical management may be required for patients with complicated left-sided diverticulitis. Factors associated with complicated diverticulitis include older age, smoking and lower BMI.

Citations

Citations to this article as recorded by

Right‐sided acute diverticulitis in a North African country: Presentation and management in one surgical center
Laila Jedidi, Aymen Mabrouk, Hela Ghali, Anis Ben Dhaou, Senda Ben Lahouel, Sami Daldoul, Houyem Said Latiri, Mounir Ben Moussa
World Journal of Surgery.2024; 48(6): 1509. CrossRef
Current diagnosis and management of acute colonic diverticulitis: What you need to know
Lisa M. Kodadek, Kimberly A. Davis
Journal of Trauma and Acute Care Surgery.2024; 97(1): 1. CrossRef
Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study
E. Karam, C. Sabbagh, L. Beyer-Bergeot, P. Zerbib, V. Bridoux, G. Manceau, Y. Panis, E. Buscail, A. Venara, I. Khaoudy, M. Gaillard, M. Viennet, A. Thobie, B. Menahem, C. Eveno, C. Bonnel, J.-Y. Mabrut, B. Badic, C. Godet, Y. Eid, E. Duchalais, Z. Lakkis,
Techniques in Coloproctology.2024;[Epub] CrossRef
Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines
Federico Coccolini, Massimo Sartelli, Robert Sawyer, Kemal Rasa, Bruno Viaggi, Fikri Abu-Zidan, Kjetil Soreide, Timothy Hardcastle, Deepak Gupta, Cino Bendinelli, Marco Ceresoli, Vishal G. Shelat, Richard ten Broek, Gian Luca Baiocchi, Ernest E. Moore, Ib
World Journal of Emergency Surgery.2023;[Epub] CrossRef
Diagnosis and management of acute colonic diverticulitis: results of a survey among Korean gastroenterologists
Jae Gon Lee, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Shin Hee Lee, Myung-Won You, Seong-Eun Kim
The Korean Journal of Internal Medicine.2023; 38(5): 672. CrossRef
Right-sided diverticulitis in a Western population
Adi Rov, Anat Ben-Ari, Eyal Barlev, David Pelcman, Sergio Susmalian, Haim Paran
International Journal of Colorectal Disease.2022; 37(6): 1251. CrossRef
Emergency surgery comparison of right versus left acute colonic diverticulitis: A 10-year outcome analysis
JS Tsang, Chi Chung Foo, Jeremy Yip, Hok Kwok Choi, Wai Lun Law, Oswens Siu Hung Lo
The Surgeon.2021; 19(3): 150. CrossRef
Elective surgical management of diverticulitis
Jordan M. Rook, Jill Q. Dworsky, Thomas Curran, Sudeep Banerjee, Mary R. Kwaan
Current Problems in Surgery.2021; 58(5): 100876. CrossRef
Special Situations in the Management of Diverticular Disease
Elizabeth H. Wood, Michael M. Sigman, Dana M. Hayden
Clinics in Colon and Rectal Surgery.2021; 34(02): 121. CrossRef
Routine colonoscopy may be needed for uncomplicated acute right colonic diverticulitis
Kil-yong Lee, Jaeim Lee, Youn Young Park, Seong Taek Oh
BMC Gastroenterology.2021;[Epub] CrossRef
WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
Massimo Sartelli, Federico Coccolini, Yoram Kluger, Ervis Agastra, Fikri M. Abu-Zidan, Ashraf El Sayed Abbas, Luca Ansaloni, Abdulrashid Kayode Adesunkanmi, Boyko Atanasov, Goran Augustin, Miklosh Bala, Oussama Baraket, Suman Baral, Walter L. Biffl, Marja
World Journal of Emergency Surgery.2021;[Epub] CrossRef
Right sided diverticulitis in western countries: A review
Angelo Gabriele Epifani, Diletta Cassini, Roberto Cirocchi, Caterina Accardo, Francesca Di Candido, Massimiliano Ardu, Gianandrea Baldazzi
World Journal of Gastrointestinal Surgery.2021; 13(12): 1721. CrossRef
Difference in Clinical Features between Right- and Left-Sided Acute Colonic Diverticulitis
Kil-yong Lee, Jaeim Lee, Youn Young Park, Younglim Kim, Seong Taek Oh
Scientific Reports.2020;[Epub] CrossRef
2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting
Massimo Sartelli, Dieter G. Weber, Yoram Kluger, Luca Ansaloni, Federico Coccolini, Fikri Abu-Zidan, Goran Augustin, Offir Ben-Ishay, Walter L. Biffl, Konstantinos Bouliaris, Rodolfo Catena, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra,
World Journal of Emergency Surgery.2020;[Epub] CrossRef
Clinical Characteristics of Right Colonic Diverticulitis: A Comparison of Ileocecal Diverticulitis and Hepatic Flexure Diverticulitis
Yoshihisa Fujita, Fumihiko Ishikawa, Shigeyuki Kamata
Nippon Daicho Komonbyo Gakkai Zasshi.2020; 73(6): 244. CrossRef
Meta‐analysis of the demographic and prognostic significance of right‐sided versus left‐sided acute diverticulitis
S. Hajibandeh, S. Hajibandeh, N. J. Smart, A. Maw
Colorectal Disease.2020; 22(12): 1908. CrossRef
Long-term outcome and management of right colonic diverticulitis in western countries: Multicentric Retrospective Study
L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
Journal of Visceral Surgery.2019; 156(4): 296. CrossRef
Résultats à long terme et prise en charge des diverticulites du colon droit dans les pays occidentaux : étude rétrospective multicentrique
L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
Journal de Chirurgie Viscérale.2019; 156(4): 322. CrossRef
Prospective randomized clinical trial of uncomplicated right-sided colonic diverticulitis: antibiotics versus no antibiotics
Jeong Yeon Kim, Sung Gil Park, Hee Joon Kang, Young Ah Lim, Kyung Ho Pak, Tae Yoo, Won Tae Cho, Dong Woo Shin, Jong Wan Kim
International Journal of Colorectal Disease.2019; 34(8): 1413. CrossRef
Predictive Factors Affecting the Clinical Course of Patients With Diverticulitis: Who Needs Hospital Management?
Taeyoung Yoo, Keun Ho Yang, Jungbin Kim, Inseok Park, Hyunjin Cho, Geumhee Gwak, Byung Noe Bae, Ki Hwan Kim
Annals of Coloproctology.2018; 34(1): 23. CrossRef
Perforated diverticulitis: is the right and left difference present here too?
Nicholas Yock Teck Soh, Nan Zun Teo, Carrie Jen Hsi Tan, Shivani Rajaraman, Marianne Tsang, Calvin Jian Ming Ong, Ramesh Wijaya
International Journal of Colorectal Disease.2018; 33(5): 525. CrossRef
Clinical Features and Factors Associated With Surgical Treatment in Patients With Complicated Colonic Diverticulitis
Pill Sun Paik, Jung-A Yun
Annals of Coloproctology.2017; 33(5): 178. CrossRef
What is the Difference Between Right- and Left-Sided Colonic Diverticulitis?
Chang-Nam Kim
Annals of Coloproctology.2016; 32(6): 206. CrossRef

Editorial

Colorectal Liver Metastases: A Never Ending Story: Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2016;32(3):87-87. Published online June 30, 2016; DOI: https://doi.org/10.3393/ac.2016.32.3.87

2,787 View
28 Download

PDF

Original Articles

Positron Emission Tomography/Computed Tomography in the Staging of Colon Cancer: Jae Hyung Lee, Min Ro Lee; Ann Coloproctol. 2014;30(1):23-27. Published online February 28, 2014; DOI: https://doi.org/10.3393/ac.2014.30.1.23

952 View
6 Download
18 Citations

Abstract PDF

Purpose
Accurate preoperative staging of colon cancer is essential for providing the optimal treatment strategy and evaluating the expected prognosis. The aim of this study is to assess the value of positron emission tomography/computed tomography (PET/CT) over conventional studies in the staging of colon cancer.
Methods
A total of 266 colon cancer patients diagnosed between January 2008 and December 2010 were assessed with both PET/CT and conventional studies. Discordance with PET/CT and conventional studies were evaluated, and changes in the management strategy were assessed for each stage. Discordant findings were verified by using intraoperative examination, pathology reports, and follow-up imaging studies.
Results
Multidetector computed tomography (MDCT) and PET/CT showed similar accuracy in detecting lymph node metastasis in patients with clinical stage III (36.2% vs. 42%, P = 0.822) and stage IV (60.3% vs. 63.5%, P = 0.509) disease. PET/CT led to a change in management strategy for 1 of 40 patients (2.5%) with clinical stage I, 0 of 25 patients (0%) with stage II, 9 of 138 patients (6.5%) with stage III, and 8 of 63 patients (12.7%) with stage IV disease.
Conclusion
PET/CT changed the management plan in 6.5% of patients with clinical stage III and 12.7% of patients with clinical stage IV colon cancer. Our findings suggest that PET/CT may be considered as a routine staging tool for clinical stage III and IV colon cancers.

Citations

Citations to this article as recorded by

Diagnostic role of F-18 FDG PET/CT in determining preoperative Lymph node status of patients with rectal cancer: a meta-analysis
Weili Ma, Bo Chen, Fandong Zhu, Chen Yang, Jianfeng Yang
Abdominal Radiology.2024; 49(6): 2125. CrossRef
Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
Hyo Seon Ryu, Hyun Jung Kim, Woong Bae Ji, Byung Chang Kim, Ji Hun Kim, Sung Kyung Moon, Sung Il Kang, Han Deok Kwak, Eun Sun Kim, Chang Hyun Kim, Tae Hyung Kim, Gyoung Tae Noh, Byung-Soo Park, Hyeung-Min Park, Jeong Mo Bae, Jung Hoon Bae, Ni Eun Seo, Cha
Annals of Coloproctology.2024; 40(2): 89. CrossRef
Accuracy of pre‐operative 18‐fluoride fluorodeoxyglucose positron emission tomography (FDG‐PET) in predicting lymph node involvement in colon cancer
Chahaya Marc Gauci, Tae Jun Kim, Yijun Gao, Dayashan S. Perera
ANZ Journal of Surgery.2023; 93(11): 2675. CrossRef
Contribution of Metabolic Parameters and Pericolic Fat Stranding on Preoperative 18F-FDG PET/CT in Predicting Post-operative Histopathology and Outcome in Colorectal Cancer
Selin Soyluoglu, Busra Ozdemir Gunay
Nuclear Medicine and Molecular Imaging.2023; 57(5): 223. CrossRef
CT is unreliable in locoregional staging of early colon cancer: A nationwide registry-based study
Erik Wetterholm, Roberto Rosén, Milladur Rahman, Carl-Fredrik Rönnow
Scandinavian Journal of Surgery.2023; 112(1): 33. CrossRef
Diagnostic accuracy of ≥ 16-slice spiral computed tomography for local staging of colon cancer: A systematic review and meta-analysis
Dan Liu, Lin-Mei Sun, Jing-Hua Liang, Lei Song, Xiao-Pei Liu
World Journal of Clinical Cases.2022; 10(19): 6483. CrossRef
Clinical application and research advancement of positron emission tomography/computed tomography in colorectal cancer
Wu Cai-Xia, Wang Rong-Fu
World Chinese Journal of Digestology.2020; 28(18): 925. CrossRef
Is It Time to Introduce PET/CT in Colon Cancer Guidelines?
Anna Margherita Maffione, Domenico Rubello, Paola Caroli, Patrick M. Colletti, Federica Matteucci
Clinical Nuclear Medicine.2020; 45(7): 525. CrossRef
The role of PET/CT with 18F-fluorodeoxyglucose in detecting the progression of colorectal cancer in asymptomatic patients with elevated level of сarcinoembryonic antigen (literature review)
M. B. Dolgushin, A. I. Mikhaylov, S. S. Gordeev
Colorectal Oncology.2019; 9(2): 11. CrossRef
Morphological predictors for lymph node metastases on computed tomography in colon cancer
Erik Rollvén, Lennart Blomqvist, Emma Öistämö, Fredrik Hjern, György Csanaky, Mirna Abraham-Nordling
Abdominal Radiology.2019; 44(5): 1712. CrossRef
Colorectal Cancer:
Nathan C. Hall, Alexander T. Ruutiainen
Surgical Oncology Clinics of North America.2018; 27(2): 289. CrossRef
Assessment and diagnostic accuracy of lymph node status to predict stage III colon cancer using computed tomography
Erik Rollvén, Mirna Abraham-Nordling, Torbjörn Holm, Lennart Blomqvist
Cancer Imaging.2017;[Epub] CrossRef
Diagnostic Accuracy of CT for Local Staging of Colon Cancer: A Systematic Review and Meta-Analysis
Elias Nerad, Max J. Lahaye, Monique Maas, Patty Nelemans, Frans C. H. Bakers, Geerard L. Beets, Regina G. H. Beets-Tan
American Journal of Roentgenology.2016; 207(5): 984. CrossRef
Comparison of 18F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer
Ahmet Kocael, Betül Vatankulu, Osman Şimşek, Mahir Cengiz, Ahu Kemik, Pınar Kocael, Metin Halaç, Kerim Sönmezoğlu, Kenan Ulualp
Tumor Biology.2016; 37(3): 3871. CrossRef
Metabolic Tumor Volume and Total Lesion Glycolysis in PET/CT Correlate With the Pathological Findings of Colorectal Cancer and Allow Its Accurate Staging
Yoshiyuki Suzuki, Koji Okabayashi, Hirotoshi Hasegawa, Masashi Tsuruta, Kohei Shigeta, Koji Murakami, Yuko Kitagawa
Clinical Nuclear Medicine.2016; 41(10): 761. CrossRef
Impact of Fluorodeoxyglucose PET/Computed Tomography on the Management of Patients with Colorectal Cancer
Sander Thomas Laurens, Wim J.G. Oyen
PET Clinics.2015; 10(3): 345. CrossRef
The Role of Positron Emission Tomography/Computed Tomography in the Initial Staging of Colon Cancer
Hyung Jin Kim, Seong Taek Oh
Annals of Coloproctology.2014; 30(1): 3. CrossRef
Preoperative Staging With Positron Emission Tomography in Patients With Colorectal Cancer
Young Wan Kim, Ik Yong Kim
Annals of Coloproctology.2014; 30(6): 247. CrossRef

Diagnostic Accuracy of Elevated Serum Carcinoembryonic Antigen for Recurrence in Postoperative Stage II Colorectal Cancer Patients: Comparison With Stage III: Ho Seung Kim, Min Ro Lee; Ann Coloproctol. 2013;29(4):155-159. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.155

4,807 View
45 Download
9 Citations

Abstract PDF

Purpose

Elevated levels of serum carcinoembryonic antigen (CEA) following a curative resection of colorectal cancer (CRC) indicate recurrence; however, the levels of CEA may be elevated above the normal limit without recurrence. The aim of this study is to analyze the diagnostic accuracy of elevated serum CEA for predicting recurrence in postoperative stage II and stage III CRC patients.

Methods

A total of 336 stage II and stage III CRC patients who underwent a curative resection between January 2005 and October 2009 were enrolled. Sensitivities, specificities, positive predictive values (PPVs), negative predictive values (NPVs), likelihood ratios and post-test probabilities of recurrence associated with elevated CEA were analyzed and compared.

Results

The median follow-up duration was 45 months (36 to 134 months). Twenty-seven of 189 stage II patients (14.3%) and 52 of 147 stage III patients (35.4%) developed recurrence during the follow-up period. Sensitivities, specificities, PPVs, and NPVs of elevated CEA were 37.0%, 91.4%, 41.7%, and 89.7%, respectively, in stage II patients and 46.2%, 90.5%, 72.7%, and 75.4% in stage III patients. Post-test probabilities of recurrence associated with elevated CEA were 41.8% in stage II patients and 71.9% in stage III patients.

Conclusion

The predictive performance of the probability of recurrence associated with elevated serum CEA after a curative resection in stage II CRC patients is lower than that in stage III CRC patients.

Citations

Citations to this article as recorded by

Significance of carcinoembryonic antigen detection in the early diagnosis of colorectal cancer: A systematic review and meta-analysis
Rui Wang, Qin Wang, Pan Li
World Journal of Gastrointestinal Surgery.2023; 15(12): 2907. CrossRef
Diagnostic accuracy of follow‐up tests for detecting colorectal cancer recurrences in primary care: A systematic review and meta‐analysis
Geertje B. Liemburg, Daan Brandenbarg, Marjolein Y. Berger, Saskia F.A. Duijts, Gea A. Holtman, Geertruida H. Bock, Joke C. Korevaar, Annette J. Berendsen
European Journal of Cancer Care.2021;[Epub] CrossRef
Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction
Po-Li Wei, Long-Teng Lee, Li-Ming Tseng, Kai-Wen Huang
Scientific Reports.2018;[Epub] CrossRef
Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
International Journal of Radiation Biology.2017; 93(3): 315. CrossRef
Time to lowest postoperative carcinoembryonic antigen level is predictive on survival outcome in rectal cancer
Huichuan Yu, Yanxin Luo, Xiaolin Wang, Liangliang Bai, Pinzhu Huang, Lei Wang, Meijin Huang, Yanhong Deng, Jianping Wang
Scientific Reports.2016;[Epub] CrossRef
The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence – A systematic review
Caspar G. Sørensen, William K. Karlsson, Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg
International Journal of Surgery.2016; 25: 134. CrossRef
Blood CEA levels for detecting recurrent colorectal cancer
Brian D Nicholson, Bethany Shinkins, Indika Pathiraja, Nia W Roberts, Tim J James, Susan Mallett, Rafael Perera, John N Primrose, David Mant
Cochrane Database of Systematic Reviews.2015;[Epub] CrossRef
Value of Dual Assessment of Carcinoembryonic Antigen and Fluorine-18-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer Recurrence
Saeed Mohammed Bafaraj
European Journal of Basic Medical Sciences.2015; 5(2): 25. CrossRef
Serum Carcinoembryonic Antigen for Recurrence in Colorectal Cancer Patients
Young Jin Kim
Annals of Coloproctology.2013; 29(4): 137. CrossRef

Editorial

What Should Be Done to Increase Survival in Patients With Colorectal Cancer?: Min Ro Lee, Jong Hun Kim; Ann Coloproctol. 2013;29(4):135-135. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.135

2,609 View
21 Download

PDF

Original Article

Multivariate Analysis of the Survival Rate for Treatment Modalities in Incurable Stage IV Colorectal Cancer: Sung Kang Kim, Chang Ho Lee, Min Ro Lee, Jong Hun Kim; J Korean Soc Coloproctol. 2012;28(1):35-41. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.35

4,912 View
38 Download
14 Citations

Abstract PDF

Purpose

The aim of this study was to compare survival in patients that underwent palliative resection treatment versus non-resection for incurable colorectal cancer (ICRC).

Methods

The case records of 201 patients with ICRC between January 2000 and December 2009 were reviewed. Demographics, American Society of Anesthesiologists (ASA) score, carcinoembryonic antigen (CEA) level, the location of the colon cancer, histology, metastasis, treatment options and median survival were analyzed retrospectively. We divided the patients into four groups according to the treatment modalities: resection alone, resection with post-operative chemotherapy, non-resection treatment by chemotherapy alone, and stent or bypass. Median survival times were compared according to each treatment option, and the survival rates were analyzed.

Results

105 patients underwent palliative resection whereas 96 were treated with non-resection modalities. A palliative resection was performed in 44 cases for resection alone and in 61 cases for resection with post-operative chemotherapy. In patients treated with non-resection of the primary tumor, chemotherapy alone was done in 65 cases and stent or bypass in 31 cases. Multivariate analysis showed a median survival of 14 months in patients with palliative resections with post-operative chemotherapy, which was significantly higher than those for chemotherapy alone (8 months), primary tumor resection alone (5 months), and stent or bypass (5 months). Gender, age, ASA score, CEA level, the location of colon cancer, histology and the presence of multiple metastases were not independent factors in association with the median survival rate.

Conclusion

In the treatment of ICRC, palliative resection followed by post-operative chemotherapy shows the most favorable median survival compared to other treatment options.

Citations

Citations to this article as recorded by

Incidence and determinants of mortality among patients with colorectal cancer in oncology centers of Amhara region, Ethiopia, 2024: multicenter retrospective follow up study
Getachew Tesfaw Walle, Tegene Atamenta Kitaw, Seteamlak Adane
BMC Cancer.2025;[Epub] CrossRef
Biopsy sampling during self-expandable metallic stent placement in acute malignant colorectal obstruction: a narrative review
Sigrid Skov Bennedsgaard, Lene Hjerrild Iversen
World Journal of Surgical Oncology.2021;[Epub] CrossRef
National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis
Antonio V. Sterpetti, Umberto Costi, Giuseppe D'Ermo
Surgical Oncology.2020; 33: 11. CrossRef
Primary Tumor Resection in Patients with Incurable Localized or Metastatic Colorectal Cancer: A Systematic Review and Meta‐analysis
Constantinos Simillis, Eliana Kalakouti, Thalia Afxentiou, Christos Kontovounisios, Jason J. Smith, David Cunningham, Michel Adamina, Paris P. Tekkis
World Journal of Surgery.2019; 43(7): 1829. CrossRef
Long-Chain Noncoding RNAPVT1Gene Polymorphisms Are Associated with the Risk and Prognosis of Colorectal Cancer in the Han Chinese Population
Lei Zhang, Jiehong Mao
Genetic Testing and Molecular Biomarkers.2019; 23(10): 728. CrossRef
Meta-analysis of outcomes following resection of the primary tumour in patients presenting with metastatic colorectal cancer
U Nitsche, C Stöß, L Stecher, D Wilhelm, H Friess, G O Ceyhan
Journal of British Surgery.2018; 105(7): 784. CrossRef
A systematic analysis highlighting deficiencies in reported outcomes for patients with stage IV colorectal cancer undergoing palliative resection of the primary tumour
Deena P. Harji, Abigail Vallance, Jenny Selgimann, Simon Bach, Faheez Mohamed, Julia Brown, Nicola Fearnhead
European Journal of Surgical Oncology.2018; 44(10): 1469. CrossRef
Meta-analysis of oncologic effect of primary tumor resection in patients with unresectable stage IV colorectal cancer in the era of modern systemic chemotherapy
Gi Won Ha, Jong Hun Kim, Min Ro Lee
Annals of Surgical Treatment and Research.2018; 95(2): 64. CrossRef
Prognostic Implications of Primary Tumor Resection in Stage IVB Colorectal Cancer in Elderly Patients
Heui-June Ahn, Ho-Suk Oh, Yongchel Ahn, Sang Jin Lee, Hyun Joong Kim, Moon Ho Kim, Dae-Woon Eom, Jae Young Kwak, Myoung Sik Han, Jae Seok Song
Annals of Coloproctology.2014; 30(4): 175. CrossRef
A Meta-Analysis to Determine the Effect of Primary Tumor Resection for Stage IV Colorectal Cancer with Unresectable Metastases on Patient Survival
Cillian Clancy, John P. Burke, Mitchel Barry, Matthew F. Kalady, J. Calvin Coffey
Annals of Surgical Oncology.2014; 21(12): 3900. CrossRef
Palliative laparoscopic bowel resection in stage IV colorectal cancer patients with unresectable metastasis
Kwan Mo Yang, Seok-Byung Lim, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Chang Sik Yu, Jin Cheon Kim
Korean Journal of Clinical Oncology.2013; 9(2): 134. CrossRef
Recent Advances in the Management of Stage IV Colon Cancer
Rani Kanthan, Jenna-Lynn Senger, Shahid Ahmed, Selliah Kanthan
Journal of Cancer Therapy.2012; 03(06): 1104. CrossRef
Kolonstents als «Bridge to Surgery»
Karl E. Grund, Annette Zipfel
Visceral Medicine.2012; 28(6): 412. CrossRef
Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles
Hemant K. Tiwari, Jill Barnholtz-Sloan, Nathan Wineinger, Miguel A. Padilla, Laura K. Vaughan, David B. Allison
Human Heredity.2008; 66(2): 67. CrossRef

Case Report

Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report: Yo Na Kim, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Dong Geun Lee, Ho Lee, Min Ro Lee, Kyung Ryoul Kim; J Korean Soc Coloproctol. 2011;27(3):157-161. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.157

4,080 View
23 Download
9 Citations

Abstract PDF

Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 × 5.1 cm ulcerative fungating lesion, and the other was a 2.8 × 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.

Citations

Citations to this article as recorded by

Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas
Inayat GILL, Christienne SHAMS, Elisa QUIROZ, Subhashree M. KRISHNAN, Susanna GAIKAZIAN
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2021;[Epub] CrossRef
Large cell neuroendocrine carcinoma of the colon with brain metastasis: A case report
Ali Allouch, Mohamad K. Moussa, Ali Dirany, Zahraa Barek, Mohammad Makke, Nizar Bitar
International Journal of Surgery Case Reports.2020; 76: 421. CrossRef
A case of colorectal large cell neuroendocrine carcinoma accompanied by disseminated peritoneal leiomyomatosis
Kunihiko Suga, Hiroomi Ogawa, Makoto Sohda, Chika Katayama, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Takuya Shiraishi, Ryuji Katoh, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki
Surgical Case Reports.2020;[Epub] CrossRef
Colorectal neuroendocrine carcinoma: A case report and review of the literature
Tomoaki Yoshida, Kenya Kamimura, Kazunori Hosaka, Koji Doumori, Hiromitsu Oka, Akito Sato, Yasuo Fukuhara, Shoji Watanabe, Tomomi Sato, Akira Yoshikawa, Takashi Tomidokoro, Shuji Terai
World Journal of Clinical Cases.2019; 7(14): 1865. CrossRef
Neuroendocrine tumor mixed with adenoma in rectum: a case report and literature review
Jiancong Hu, Xiaochuan Chen, Dezheng Lin, Zhaoliang Yu, Juan Li, Xuefeng Guo
International Journal of Surgery Oncology.2019; 4(6): e79. CrossRef
Large Cell Neuroendocrine Carcinoma of the Rectum with Long Recurrence-free Survival after Radical Surgery and Adjuvant Chemotherapy
Kukiko SAKIHAMA, Kinuko NAGAYOSHI, Hayato FUJITA, Shuntaro NAGAI, Yoshinao ODA, Masafumi NAKAMURA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2018; 79(12): 2463. CrossRef
Synchronous Small Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Colon: A Link for Common Stem Cell Origin?
Seth Lipka, Jorge Hurtado-Cordovi, Boris Avezbakiyev, Lester Freedman, Toshimasa Clark, Kaleem Rizvon, Paul Mustacchia
ACG Case Reports Journal.2014; 1(2): 96. CrossRef
Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon
Donggeum Shin, Youngsook Park, Soojung Gong, Seonghwan Kim, Yunju Jo, Sangbong Ahn, Joonkil Han, Eunkyung Kim
Intestinal Research.2013; 11(2): 137. CrossRef
Synchronous Occurrence of Advanced Neuroendocrine Carcinoma and Tubular Adenocarcinoma of the Rectum
Yoshifumi Nakayama, Takayuki Torigoe, Noritaka Minagawa, Toshihito Uehara, Koji Yamaguchi
Case Reports in Gastroenterology.2013; 7(1): 117. CrossRef

First
Prev
Page of 1
Next
Last

Search