Annals of Coloproctology

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Editor-in-Chief’s Address

Special issue

Dear Authors and Colleagues: Moo-Jun Baek; Ann Coloproctol. 2020;36(2):63-63. Published online April 30, 2020; DOI: https://doi.org/10.3393/ac.2020.04.10

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Original Article

Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer: Han Jo Kim, Moo-Jun Baek, Dong Hyun Kang, Sang-Cheol Lee, Sang Byung Bae, Kyu Taek Lee, Namsu Lee, Hyungjoo Kim, Dongjun Jeong, Tae Sung Ahn, Moon Soo Lee, Dae Sik Hong, Jong-Ho Won; Ann Coloproctol. 2018;34(2):88-93. Published online April 30, 2018; DOI: https://doi.org/10.3393/ac.2017.10.10

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Purpose
Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods
A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results
Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion
Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.

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Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression
Ricella Souza da Silva, Eduardo M. Queiroga, Cynthia de Toledo Osório, Karin S. Cunha, Fabiana P. Neves, Julieth P. Andrade, Eliane P. Dias
Pathobiology.2024; 91(2): 99. CrossRef
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
Giuseppe Floresta, Vincenzo Abbate
Medicinal Research Reviews.2022; 42(4): 1588. CrossRef
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
World Journal of Gastroenterology.2022; 28(26): 3177. CrossRef
The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
Seyed Mostafa Parizadeh, Reza Jafarzadeh‐Esfehani, Danial Fazilat‐Panah, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Majid Khazaei, Seyed Mohammad Reza Parizadeh, Majid Ghayour‐Mobarhan, Gordon A. Ferns, Amir Avan
IUBMB Life.2019; 71(7): 802. CrossRef

Editorial

Limitation and Value of Using the Adenoma Detection Rate for Colonoscopy Quality Assurance: Jun Hur, Moo-Jun Baek; Ann Coloproctol. 2017;33(3):81-81. Published online June 30, 2017; DOI: https://doi.org/10.3393/ac.2017.33.3.81

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Diagnostic Accuracy of Artificial Intelligence and Computer-Aided Diagnosis for the Detection and Characterization of Colorectal Polyps: Systematic Review and Meta-analysis
Scarlet Nazarian, Ben Glover, Hutan Ashrafian, Ara Darzi, Julian Teare
Journal of Medical Internet Research.2021; 23(7): e27370. CrossRef

Original Article

Expressions and Clinical Significances of Angiopoietin-1, Angiopoietin-2, and Tie-2 Receptor in Patients With Colorectal Cancer: Sunghoon Hong, Hae Il Jung, Tae Sung Ahn, Han-Jo Kim, Kyu-Taek Lee, Moo-Jun Baek, Sang-Byung Bae; Ann Coloproctol. 2017;33(1):9-15. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.9

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Abstract PDF

Purpose

Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis in several malignancies. Hence, we estimated the increased expression of Ang-2 relative to Ang-1 in patients with colorectal cancer and correlated our finding with prognosis in order to investigate the relationships between the expressions of Ang-1/Ang-2/Tie-2 receptor and the clinical parameters or overall survival of such patients.

Methods

We retrospectively analyzed 114 tissue samples from patients with colorectal cancer by using immunohistochemistry (IHC) to examine Ang-1, Ang-2, and Tie-2 expressions and to investigate the relationship between those expressions and clinical parameters or overall survival of such patients. A Western blot analysis was used for Ang-2 expression.

Results

IHC staining showed a link between Ang-1 and Tie-2 (P = 0.018), as well as meaningful correlations between Ang-2 and Tie-2 receptor (P = 0.022) and between lymph-node metastasis and Ang-2 (P = 0.025). The stronger the IHC staining for Ang-2 expression was, the shorter the cumulative survival was (P = 0.016).

Conclusion

A relationship was found to exist between Ang-2 and Tie-2 expressions. The Ang-2 was correlated with lymph-node metastasis, and high expression of Ang-2 was indicative of poor overall survival. These findings suggest that Ang-2 is a useful prognostic marker in the management of patients with colorectal cancer. In addition, we suggest that Ang/Tie-2 signaling plays an important role in the progression of colorectal cancer.

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The Impact of the Renin-Angiotensin System on the Development of Chronic Obstructive Pulmonary Disease
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Advances in Clinical Medicine.2025; 15(01): 1396. CrossRef
The BMI1-Angiopoietin-2 axis as an independent prognostic factor in colorectal cancer
Yin-Chou Hsu, Chi-Wen Luo, Shu-Jyuan Chang, Chiao-Ying Lai, Yu-Tzu Yang, Yi-Zi Chen, Mei-Hsiang Hsu, Cheuk-Kwan Sun, Mei-Ren Pan
Experimental Cell Research.2025; 450(1): 114622. CrossRef
Putative Role of Tie2-Expressing Monocytes/Macrophages in Colorectal Cancer Progression Through Enhancement of Angiogenesis and Metastasis
Eman Amin M. Ali, Alaa Muayad Altaie, Iman M. Talaat, Rifat Hamoudi
Cancers.2025; 17(17): 2856. CrossRef
Differential expression of angiogenesis-related genes ‘VEGF’ and ‘angiopoietin-1’ in metastatic and EMAST-positive colorectal cancer patients
Amir Torshizi Esfahani, Somayeh Mohammadpour, Pooya Jalali, Alireza Yaghoobi, Raana Karimpour, Soha Torkamani, Ali Pardakhtchi, Zahra Salehi, Ehsan Nazemalhosseini-Mojarad
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Platelet Angiopoietin-1 Protects Against Murine Models of Tumor Metastasis
Harvey G. Roweth, Isabelle C. Becker, Michael W. Malloy, Emily M. Clarke, Sophie A. Munn, Priya L. Kumar, Ivan Aivasovsky, Kobe Tray, Alec A. Schmaier, Elisabeth M. Battinelli
Arteriosclerosis, Thrombosis, and Vascular Biology.2024; 44(9): 2024. CrossRef
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Kayoko Hosaka, Patrik Andersson, Jieyu Wu, Xingkang He, Qiqiao Du, Xu Jing, Takahiro Seki, Juan Gao, Yin Zhang, Xiaoting Sun, Ping Huang, Yunlong Yang, Minghua Ge, Yihai Cao
Proceedings of the National Academy of Sciences.2023;[Epub] CrossRef
Angiopoietin-2 as a Prognostic Factor in Patients with Incurable Stage IV Colorectal Cancer
Shinya Munakata, Takae Ueyama, Haruna Ishihara, Hiromitsu Komiyama, Ryoichi Tsukamoto, Masaya Kawai, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Kazuhiro Sakamoto
Journal of Gastrointestinal Cancer.2021; 52(1): 237. CrossRef
Dual Antiangiogenesis Agents Bevacizumab Plus Trebananib, without Chemotherapy, in First-line Treatment of Metastatic Colorectal Cancer: Results of a Phase II Study
Jennifer Mooi, Fiona Chionh, Peter Savas, Jessica Da Gama Duarte, Geoffrey Chong, Stephen Brown, Rachel Wong, Timothy J. Price, Alysson Wann, Effie Skrinos, John M. Mariadason, Niall C. Tebbutt
Clinical Cancer Research.2021; 27(8): 2159. CrossRef
6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice
Ebenezer O. Farombi, Babajide O. Ajayi, Isaac A. Adedara
Food and Chemical Toxicology.2020; 142: 111483. CrossRef
High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
Minna Sopo, Hanna Sallinen, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Maarit Anttila, Elizabeth Christie
PLOS ONE.2020; 15(11): e0241484. CrossRef
Evaluation of plasma angiopoietin‐2 and vascular endothelial growth factor in healthy dogs and dogs with systemic inflammatory response syndrome or sepsis
Maya König, Alice Nentwig, Eliane Marti, Jelena Mirkovitch, Katja‐Nicole Adamik, Simone Schuller
Journal of Veterinary Internal Medicine.2019; 33(2): 569. CrossRef
Targeting Receptor Kinases in Colorectal Cancer
Marilina García-Aranda, Maximino Redondo
Cancers.2019; 11(4): 433. CrossRef
Gene expression and promoter methylation of angiogenic and lymphangiogenic factors as prognostic markers in melanoma
Ana Carolina Monteiro, Julienne K. Muenzner, Fernando Andrade, Flávia Eichemberger Rius, Christian Ostalecki, Carol I. Geppert, Abbas Agaimy, Arndt Hartmann, André Fujita, Regine Schneider‐Stock, Miriam Galvonas Jasiulionis
Molecular Oncology.2019; 13(6): 1433. CrossRef
“Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer
Adriano Angelucci, Simona Delle Monache, Alessio Cortellini, Monica Di Padova, Corrado Ficorella
International Journal of Molecular Sciences.2018; 19(1): 299. CrossRef
Angiopoietin-2 (Ang-2) is a useful serum tumor marker for liver cancer in the Chinese population
Yuxin Chen, Yanping Wu, Xiao Zhang, Hong Zeng, Ya Liu, Qi Wu, Yan Chen, GuoQing Zhu, Qiuhui Pan, Lei Jin, Lin Guo, Fenyong Sun
Clinica Chimica Acta.2018; 478: 18. CrossRef
Efforts to Find Targets Involving Angiogenesis: Step to Improve the Efficacy of Target Therapy in the Era of Colorectal Cancer Treatment
In Ja Park
Annals of Coloproctology.2017; 33(1): 1. CrossRef

Editorials

ERCC1 and the Prognosis for Patients With Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy: Moo-Jun Baek; Ann Coloproctol. 2015;31(3):81-81. Published online June 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.3.81

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ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy
Aziza E. Abdelrahman, Doaa Abdelaziz Ibrahim, Ahmed El-Azony, Ahmed A. Alnagar, Amr Ibrahim
Cancer Biomarkers.2020; 27(2): 251. CrossRef

Different Strategies for Treating a Colovesical Fistula: Moo Jun Baek; Ann Coloproctol. 2015;31(2):45-45. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.45

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Does BRAF Mutation and Extracellular Signal Regulated Kinase Expression in Patients With Colorectal Cancer Have Any Prognostic Significance?: Moo Jun Baek; Ann Coloproctol. 2015;31(1):1-2. Published online February 28, 2015; DOI: https://doi.org/10.3393/ac.2015.31.1.1

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Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment
Wei Pan, Qian Sun, Yang Wang, Jian Wang, Shui Cao, Xiubao Ren
Tumor Biology.2015; 36(5): 3159. CrossRef

Preoperative Body Mass Index and Postoperative Complications After Pelvic Exenteration in Recurrent or Locally Advanced Rectal Cancer Patients: Moo-Jun Baek; Ann Coloproctol. 2014;30(2):60-60. Published online April 25, 2014; DOI: https://doi.org/10.3393/ac.2014.30.2.60

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Timing of Adjuvant Chemotherapy in Colorectal Cancer Patients: Moo-Jun Baek; Ann Coloproctol. 2013;29(4):138-138. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.138

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Original Articles

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis: Jeong Yeon Kim, Dongjun Jeong, Tae Sung Ahn, Hyung Ju Kim, Doo San Park, So Yong Park, Sang Byung Bae, Sookyoung Lee, Sung Soo Lee, Moon Soo Lee, Hyun Deuk Cho, Moo Jun Baek; Ann Coloproctol. 2013;29(3):93-99. Published online June 30, 2013; DOI: https://doi.org/10.3393/ac.2013.29.3.93

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Abstract PDF

Purpose

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods

The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results

The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion

These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

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SPARC Induces COL1A1/COL3A1 Expressions Representing Aggressive Molecular Cancer-Associated Fibroblasts Signatures and CSF1-Mediated Cancer Invasion in Colorectal Cancer
Yusuke Nie, Yoshiki Fujiyama, Shumpei Shibaki, Riku Okamoto, Kota Okuno, Keiko Oki, Akiko Watanabe, Yu Kuroda, Takuya Goto, Kazuko Yokota, Keita Kojima, Hiroki Harada, Mikiko Kidachi, Takafumi Soeno, Mitsuo Yokota, Takeshi Kaida, Shuji Nakamoto, Nobuyuki
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CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy
Keishi Yamashita, Yusuke Kumamoto
International Journal of Molecular Sciences.2024; 25(11): 6003. CrossRef
Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun, Raj Kumar Koiri
PLOS ONE.2022; 17(8): e0273317. CrossRef
SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression
Qing Nian, Jingwei Li, ZhongYu Han, Qi Liang, Maoyu Liu, Chan Yang, Fernando Rodrigues-Lima, Tao Jiang, Liyun Zhao, Jinhao Zeng, Chi Liu, Jianyou Shi
Biomedicine & Pharmacotherapy.2022; 153: 113519. CrossRef
Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda Lopez-Moncada, Alexander Herrera, María José Torres, Exequiel Alonso, Norberto Ariel Gandini, Graciela Gigola, Hector R. Contreras, Claudia Gentili
Molecular and Cellular Endocrinology.2021; 530: 111253. CrossRef
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen,
eLife.2021;[Epub] CrossRef
Secreted protein acidic and rich in cysteine gene variants: Impact on susceptibility and survival of hepatocellular carcinoma patients
Samar Kamal Darweesh, Rasha Ahmed Abd Alziz, Heba Omar, Dina Sabry, Wael Fathy
Journal of Gastroenterology and Hepatology.2019; 34(8): 1424. CrossRef
Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy
Fwu‐Long Mi, Thierry Burnouf, Shih‐Yuan Lu, Yu‐Jen Lu, Kun‐Ying Lu, Yi‐Cheng Ho, Chang‐Yi Kuo, Er‐Yuan Chuang
Advanced Healthcare Materials.2017;[Epub] CrossRef
SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy
Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
Cancer Biomarkers.2017; 18(4): 459. CrossRef
Tumor–stroma ratio is an independent predictor for survival in early cervical carcinoma
Jing Liu, Juan Liu, Jinsong Li, Yingling Chen, Xiaoling Guan, Xiaojuan Wu, Chunyan Hao, Yanlin Sun, Yan Wang, Xiao Wang
Gynecologic Oncology.2014; 132(1): 81. CrossRef
Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma
Young Jin Kim
Annals of Coloproctology.2013; 29(3): 87. CrossRef

Expression of Placenta Growth Factor in Colorectal Carcinomas: Chan Yong Sung, Myoung Won Son, Tae Sung Ahn, Dong Jun Jung, Moon Soo Lee, Moo Jun Baek; J Korean Soc Coloproctol. 2012;28(6):315-320. Published online December 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.6.315

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Abstract PDF

Purpose

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. PlGF is implicated in several pathologic processes, including the growth and spread of cancer and tumor angiogenesis. The aim of this study was to evaluate the expression and the clinical implications of PlGF in colorectal cancer.

Methods

In order to ascertain the clinical significance of PlGF expression in colorectal cancer, the researcher analyzed the expression pattern of PlGF by using an immunohistochemical method and attempted to establish if a relationship existed between PlGF expression and microvessel density (MVD), and subsequently between PlGF expression and the predicted prognosis. A total of 83 patients with colorectal cancer were included for immunohistochemical staining. Clinicopathological characteristics were defined according to the tumor-node-metastasis (TNM) criteria of the Union for International Cancer Control. Clinicopathologic factors, such as age, sex, histological types of tumors, tumor cell grade, TNM stage, lymphovascular invasion, and lymph-node metastasis, were reviewed.

Results

In this study, the PlGF protein expression level was significantly correlated with MVD, patient survival, and clinicopathological factors such as lymph-node metastasis, TNM staging, lymphatic invasion and vascular invasion.

Conclusion

PlGF may be an important angiogenic factor in human colorectal cancer, and in this study, PlGF expression level was significantly correlated with positive lymph-node metastases, tumor stage, and patient survival. These findings suggest that PlGF expression correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

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Role of VEGFs/VEGFR-1 Signaling and Its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models
Claudia Ceci, Maria Grazia Atzori, Pedro Miguel Lacal, Grazia Graziani
International Journal of Molecular Sciences.2020; 21(4): 1388. CrossRef
Angiogenesis in 90Y-Radioembolization of Colorectal Liver Metastases
Ahmed A. Alsultan, Maarten W. Barentsz, Maarten L.J. Smits, Miriam Koopman, Marnix G.E.H. Lam, Charlotte E.N.M. Rosenbaum
Seminars in Nuclear Medicine.2019; 49(3): 204. CrossRef
Synchronous vascular endothelial growth factor protein profiles in both tissue and serum identify metastasis and poor survival in colorectal cancer
Chien-Chih Yeh, Li-Jane Shih, Junn-Liang Chang, Yi-Wei Tsuei, Chang-Chieh Wu, Cheng-Wen Hsiao, Chih-Pin Chuu, Yung-Hsi Kao
Scientific Reports.2019;[Epub] CrossRef
Using serum placenta growth factor could improve the sensitivity of colorectal cancer screening in fecal occult blood negative population: A multicenter with independent cohort validation study
Shu‐Chen Wei, Po‐Nien Tsao, Yu‐Ting Wang, Been‐Ren Lin, Deng‐Chyang Wu, Wen‐Sy Tsai, Jinn‐Shiun Chen, Jau‐Min Wong
Cancer Medicine.2019; 8(7): 3583. CrossRef
“Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer
Adriano Angelucci, Simona Delle Monache, Alessio Cortellini, Monica Di Padova, Corrado Ficorella
International Journal of Molecular Sciences.2018; 19(1): 299. CrossRef
An apparent clinical pharmacokinetic drug–drug interaction between bevacizumab and the anti-placental growth factor monoclonal antibody RO5323441 via a target-trapping mechanism
Ka Wang, Franziska Schaedeli Stark, Tilman Schlothauer, Angelika Lahr, Valerie Cosson, Jianguo Zhi, Kai Habben, Jean Tessier, Eginhard Schick, Roland F. Staack, Oliver Krieter
Cancer Chemotherapy and Pharmacology.2017; 79(4): 661. CrossRef
Hypoxia activates placental growth factor expression in lymphatic endothelial cells
Laura Tudisco, Augusto Orlandi, Valeria Tarallo, Sandro De Falco
Oncotarget.2017; 8(20): 32873. CrossRef
Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis
Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick
BMC Cancer.2015;[Epub] CrossRef
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial
Josep Tabernero, Heinz-Josef Lenz, Salvatore Siena, Alberto Sobrero, Alfredo Falcone, Marc Ychou, Yves Humblet, Olivier Bouché, Laurent Mineur, Carlo Barone, Antoine Adenis, Takayuki Yoshino, Richard M Goldberg, Daniel J Sargent, Andrea Wagner, Dirk Laure
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Epigenetic control of hypoxia inducible factor-1α-dependent expression of placental growth factor in hypoxic conditions
Laura Tudisco, Floriana Della Ragione, Valeria Tarallo, Ivana Apicella, Maurizio D'Esposito, Maria Rosaria Matarazzo, Sandro De Falco
Epigenetics.2014; 9(4): 600. CrossRef
Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer
Annette K. Larsen, Aimery de Gramont, Virginie Poindessous, Anaïs Bouygues, Mériam Ayadi, Paul Mésange
Current Colorectal Cancer Reports.2013; 9(3): 270. CrossRef

Editorial

Laparoscopic Right Hemicolectomy for Colon Cancer: Technically Feasible and Safe to Perform in Terms of Oncologic Outcomes: Moo Jun Baek; J Korean Soc Coloproctol. 2012;28(1):5-5. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.5

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Procedural and post-operative complications associated with laparoscopic versus open abdominal surgery for right-sided colonic cancer resection
Yong Sheng Li, Fan Chun Meng, Jun Kai Lin
Medicine.2020; 99(40): e22431. CrossRef

Original Articles

Stromal-cell-derived Factor 1-α Promotes Tumor Progression in Colorectal Cancer: Se Jun Park, Tae Sung Ahn, Sung Woo Cho, Chang Jin Kim, Dong Jun Jung, Myung Won Son, Sang Ho Bae, Eung Jin Shin, Moon Soo Lee, Chang Ho Kim, Moo Jun Baek; J Korean Soc Coloproctol. 2012;28(1):27-34. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.27

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Abstract PDF

Purpose

Although stromal-cell-derived factor (SDF)-1α is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1α expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor staging, lymph-node metastasis, vascular invasion (VI), lymphatic invasion (LI) and neural invasion (NI).

Methods

Specimens of 83 primary colorectal cancers were examined immunohistochemically, and the relationships between clinicopathological features and SDF-1α expression were analyzed. To compare the expressions between the normal colon tissue and colorectal cancer tissues, we performed Western blot analyses.

Results

According to the Western blot analyses, SDF-1α was more highly expressed in colorectal carcinoma tissues than in normal colonic mucosa (20/21). According to the immunohistochemical stain, SDF-1α was associated with nodal status, distant metastasis, tumor staging, VI and LI. SDF-1α expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high SDF-1α showed that high SDF-1α expression was associated with a shorter overall survival. However, no association was found between SDF-1α expression and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural invasion.

Conclusion

The expression of SDF-1α might be associated with tumor progression in colorectal cancer. Inhibition of SDF-1α could be a therapeutic option in colorectal cancer patients.

Citations

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Human CD133-positive hematopoietic progenitor cells initiate growth and metastasis of colorectal cancer cells
Chao Zhang, Chang Zhou, Xiao-Jin Wu, Min Yang, Zhao-hui Yang, Han-zhen Xiong, Chun-ping Zhou, Yan-xia Lu, Yuan Li, Xue-nong Li
Carcinogenesis.2014; 35(12): 2771. CrossRef

Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer: Nam Won Kim, Chong Woo Chu, Tae Sung Ahn, Chang Jin Kim, Dong Jun Jung, Myoung Won Son, Sang Ho Bae, Moon Soo Lee, Chang Ho Kim, Moo Jun Baek; J Korean Soc Coloproctol. 2011;27(5):231-236. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.231

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Abstract PDF

Purpose

Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the relation of PRL-3 mRNA level in primary colorectal cancer to the corresponding stage and to other clinicopathologic factors.

Methods

Two hundred forty-five patients with histologically-proven colorectal cancer underwent surgery between January 2004 and December 2006. RNA was extracted and cDNA was prepared by using reverse transcription. Quantification of PRL-3 was done using a real-time polymerase chain reaction.

Results

Eighty-six cases with well-preserved specimens were enrolled: 53 males and 33 females. The mean age was 63.4 years. According to tumour node metastasis (TNM) stage of the American Joint Committee on Cancer (AJCC), stage I was 11 cases, stage II was 38 cases, stage III was 23 cases, and stage IV was 14 cases. Among stage IV cases, one case was combined with liver and lung metastases, and one case was combined with liver metastases and peritoneal dissemination. The remaining stage IV patients were combined with only liver metastases. There was a significant correlation in PRL-3 mRNA expression between primary colorectal cancer and corresponding tumor stage. PRL-3 mRNA expression was increased in the liver metastases cases. Lymphatic and vascular invasion were significantly related with PRL-3 mRNA levels.

Conclusion

Advanced stage prediction may be obtained by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Especially, the risk of liver metastases may be predicted by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Further study is required to confirm these preliminary results.

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Prognostic Role of MMPs in Colorectal Cancer: Moo-Jun Baek; J Korean Soc Coloproctol. 2011;27(3):105-106. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.105

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