Annals of Coloproctology

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Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer: Han Jo Kim, Moo-Jun Baek, Dong Hyun Kang, Sang-Cheol Lee, Sang Byung Bae, Kyu Taek Lee, Namsu Lee, Hyungjoo Kim, Dongjun Jeong, Tae Sung Ahn, Moon Soo Lee, Dae Sik Hong, Jong-Ho Won; Ann Coloproctol. 2018;34(2):88-93. Published online April 30, 2018; DOI: https://doi.org/10.3393/ac.2017.10.10

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Purpose
Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods
A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results
Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion
Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.

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Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression
Ricella Souza da Silva, Eduardo M. Queiroga, Cynthia de Toledo Osório, Karin S. Cunha, Fabiana P. Neves, Julieth P. Andrade, Eliane P. Dias
Pathobiology.2024; 91(2): 99. CrossRef
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
Giuseppe Floresta, Vincenzo Abbate
Medicinal Research Reviews.2022; 42(4): 1588. CrossRef
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
World Journal of Gastroenterology.2022; 28(26): 3177. CrossRef
The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
Seyed Mostafa Parizadeh, Reza Jafarzadeh‐Esfehani, Danial Fazilat‐Panah, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Majid Khazaei, Seyed Mohammad Reza Parizadeh, Majid Ghayour‐Mobarhan, Gordon A. Ferns, Amir Avan
IUBMB Life.2019; 71(7): 802. CrossRef

Predictive Factors to Distinguish Between Patients With Noncomplicated Appendicitis and Those With Complicated Appendicitis: Tae Hyung Kim, Byung Sun Cho, Jae Hag Jung, Moon Soo Lee, Je Ho Jang, Chang Nam Kim; Ann Coloproctol. 2015;31(5):192-197. Published online October 31, 2015; DOI: https://doi.org/10.3393/ac.2015.31.5.192

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30 Citations

Abstract PDF

Purpose

Recently, randomized controlled trials have reported that conservative therapy can be a treatment option in patients with noncomplicated appendicitis. However, preoperative diagnosis of noncomplicated appendicitis is difficult. In this study, we determined predictive factors to distinguish patients with noncomplicated appendicitis from those with complicated appendicitis.

Methods

A total of 351 patients who underwent surgical treatment for acute appendicitis from January 2011 to December 2012 were included in this study. We classified patients into noncomplicated or complicated appendicitis groups based on the findings of abdominal computed tomography and pathology. We performed a retrospective analysis to find factors that could be used to discriminate between noncomplicated and complicated appendicitis.

Results

The mean age of the patients in the complicated appendicitis group (54.5 years) was higher than that of the patients in the noncomplicated appendicitis group (40.2 years) (P < 0.001), but the male-to-female ratios were similar. In the univariate analysis, the appendicocecal junction's diameter, appendiceal maximal diameter, appendiceal wall enhancement, periappendiceal fat infiltration, ascites, abscesses, neutrophil proportion, C-reactive protein (CRP), aspartate aminotransferase, and total bilirubin were statistically significant factors. However, in the multivariate analysis, the appendiceal maximal diameter (P = 0.018; odds ratio [OR], 1.129), periappendiceal fat infiltration (P = 0.025; OR, 5.778), ascites (P = 0.038; OR, 2.902), and CRP (P < 0.001; OR, 1.368) were statistically significant.

Conclusion

Several factors can be used to distinguish between noncomplicated and complicated appendicitis. Using these factors, we could more accurately distinguish patients with noncomplicated appendicitis from those with complicated appendicitis.

Citations

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Utilizing non-invasive biomarkers for early and accurate differentiation of uncomplicated and complicated acute appendicitis: a retrospective cohort analysis
Mehmet Torun, İsmail Ege Subaşı, Deniz Kol Özbay, Mehmet Ali Özbay, Hakan Özdemir
Scientific Reports.2025;[Epub] CrossRef
High Diagnostic Accuracy but Persistent Risk of Complicated Appendicitis: A Retrospective Analysis from Hail Province, Saudi Arabia
Alfatih Mohamed Ahmed Aljanib, Faisal Fawaz Alshammari, Fahad Maiyah Alshammari, Ali Ahmed Alqahtani, Bandar Alsaif, Jerold C. Alcantara, Abdulaziz Bin Ali Alshammari, Talal Alharazi
International Journal of Applied & Basic Medical Research.2025; 15(2): 85. CrossRef
Low-keV virtual monoenergetic images with rapid kilovoltage-switching DECT for differentiating complicated from uncomplicated appendicitis in adults
Dhanawin Wongsaengchan, Jitti Chatpuwaphat, Shanigarn Thiravit, Sasima Tongsai, Napakadol Noppakunsomboon, Rathachai Kaewlai
Abdominal Radiology.2025;[Epub] CrossRef
Predictive Value of Clinical and CT Scan Findings for Complicated Appendicitis: A Retrospective Analysis
Ahmed G Alsayaf Alghamdi, Saleh M Alzhrani, Amer Fayraq, Saif A Alzahrani
Cureus.2025;[Epub] CrossRef
Development and Validation of the Scoring System of Appendicitis Severity 2.0
Jochem C. G. Scheijmans, Wouter J. Bom, Umme Habiba Ghori, Anna A. W. van Geloven, Gerjon Hannink, Charles C. van Rossem, Lieke van de Wouw, Peter M. Huisman, Annemiek van Hemert, Rutger J. Franken, Steven J. Oosterling, Camiel Rosman, Lianne Koens, Jaap
JAMA Surgery.2024; 159(6): 642. CrossRef
Oxidative Stress Enzyme NOX1 Is a New and Important Biomarker for Childhood Appendicitis?
Veli Avci, Kemal Ayengin, Zubeyir Huyut, Mehmet Tahir Huyut, Lokman Soysal, Salim Bilici
Indian Journal of Surgery.2023; 85(5): 1139. CrossRef
Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review
Binyamin Sikander, Jacob Rosenberg, Siv Fonnes
The American Journal of Emergency Medicine.2023; 67: 100. CrossRef
Risk factors for prolonged hospitalization and delayed treatment completion after laparoscopic appendectomy in patients with uncomplicated acute appendicitis
Jiyoung Shin, Myong Hoon Ihn, Kyung Sik Kim, Sang Hyun Kim, Jihyoun Lee, Sangchul Yun, Sung Woo Cho
Annals of Coloproctology.2023; 39(1): 50. CrossRef
Application of Artificial Neural Network Models to Differentiate Between Complicated and Uncomplicated Acute Appendicitis
Hui-An Lin, Li-Tsung Lin, Sheng-Feng Lin
Journal of Medical Systems.2023;[Epub] CrossRef
A New Marker In The Diagnosis Of Acute Complicated Appendicitis In Adult Patients: Neutrophil/Albumin Ratio
Serdar SAHİN
Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2023; 56(2): 52. CrossRef
Predicting complicated appendicitis is possible without the use of sectional imaging—presenting the NoCtApp score
Jens Strohäker, Martin Brüschke, You-Shan Feng, Christian Beltzer, Alfred Königsrainer, Ruth Ladurner
International Journal of Colorectal Disease.2023;[Epub] CrossRef
Validation of scoring systems for the prediction of complicated appendicitis in adults using clinical and computed tomographic findings
Rathachai Kaewlai, Sasima Tongsai, Wanwarang Teerasamit, Dhanawin Wongsaengchan, Napakadol Noppakunsomboon, Pramuk Khamman, Anchisa Chatkaewpaisal, Piyaporn Apisarnthanarak
Insights into Imaging.2023;[Epub] CrossRef
Predictive scoring systems to differentiate between simple and complex appendicitis in children (PRE-APP study)
Paul van Amstel, Sarah-May M.L. The, Roel Bakx, Taco S. Bijlsma, Sophie M. Noordzij, Oumaima Aajoud, Ralph de Vries, Joep P.M. Derikx, L.W. Ernest van Heurn, Ramon R. Gorter
Surgery.2022; 171(5): 1150. CrossRef
Negative Appendicectomy Rate: Incidence and Predictors
Khaled Noureldin, Ali Asgar Hatim Ali, Mohamed Issa, Heer Shah, Bolu Ayantunde, Abraham Ayantunde
Cureus.2022;[Epub] CrossRef
Evaluation of radiological and temporal characteristics of acute appendicitis on the non-enhanced computed tomography images
Xuan Gao, Wei-Yong Sheng, Biao Chen, Wei-Yi Cheng, Bing-Qing Ma, Peng Xu, Mellisa Evelyn, Jin-Xiang Zhang
Abdominal Radiology.2022; 47(7): 2279. CrossRef
Meta-analysis of the clinical efficacy of laparoscopic appendectomy in the treatment of acute appendicitis
Guangzhe Zhang, Bo Wu
World Journal of Emergency Surgery.2022;[Epub] CrossRef
Predictors and management outcomes of perforated appendicitis in sub-Saharan African countries: A retrospective cohort study
Dereje Zewdu, Mekete Wondwosen, Temesgen Tantu, Tamiru Tilahun, Tewodros Teshome, Ahmed Hamu
Annals of Medicine & Surgery.2022;[Epub] CrossRef
Periappendiceal fat-stranding models for discriminating between complicated and uncomplicated acute appendicitis: a diagnostic and validation study
Hui-An Lin, Hung-Wei Tsai, Chun-Chieh Chao, Sheng-Feng Lin
World Journal of Emergency Surgery.2021;[Epub] CrossRef
Comparison of Outer Diameter of Appendix, C-reactive Protein, and Serum Bilirubin Levels in Complicated Versus Uncomplicated Appendicitis
Dhanish Parekh, Dinesh Jain, Saurabh Mohite, Deepak Phalgune
Indian Journal of Surgery.2020; 82(3): 314. CrossRef
A simple classification of peritoneal contamination in perforated appendicitis predicts surgery‐related complications
Jia J Wee, Chang J Park, York T Lee, Yee L Cheong, Rambha Rai, Shireen A Nah
Journal of Paediatrics and Child Health.2020; 56(2): 272. CrossRef
Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis
Tae Gyeong Lee, Soomin Nam, Hyung Soon Lee, Jin Ho Lee, Young Ki Hong, Jung Gu Kang
Annals of Coloproctology.2020; 36(1): 30. CrossRef
An observational study of innate immune responses in patients with acute appendicitis
Toon Peeters, Sandrina Martens, Valentino D’Onofrio, Mark H. T. Stappers, Jeroen C. H. van der Hilst, Bert Houben, Ruth Achten, Leo A. B. Joosten, Inge C. Gyssens
Scientific Reports.2020;[Epub] CrossRef
The value of ischemia-modified albumin and oxidative stress markers in the diagnosis of acute appendicitis in adults
Hakan Hakkoymaz, Selçuk Nazik, Muhammed Seyithanoğlu, Özlem Güler, Ahmet Rıza Şahin, Emrah Cengiz, Fatih Mehmet Yazar
The American Journal of Emergency Medicine.2019; 37(11): 2097. CrossRef
Systematic Review and Meta-Analysis of CT Features for Differentiating Complicated and Uncomplicated Appendicitis
Hae Young Kim, Ji Hoon Park, Yoon Jin Lee, Sung Soo Lee, Jong-June Jeon, Kyoung Ho Lee
Radiology.2018; 287(1): 104. CrossRef
Ischemia-modified albumin as a predictor of the severity of acute appendicitis
Murat Özgür Kılıç, Cem Emir Güldoğan, İlhan Balamir, Mesut Tez
The American Journal of Emergency Medicine.2017; 35(1): 92. CrossRef
Increased anatomic severity predicts outcomes
Matthew C. Hernandez, Johnathon M. Aho, Elizabeth B. Habermann, Asad J. Choudhry, David S. Morris, Martin D. Zielinski
Journal of Trauma and Acute Care Surgery.2017; 82(1): 73. CrossRef
Role of hematological parameters in prediction of complicated appendicitis
Hakan Ataş, Murat Ö. Kılıç, Serdar G. Terzioğlu, Bariş Saylam
Wiener klinische Wochenschrift.2017; 129(9-10): 369. CrossRef
International normalized ratio and serum C-reactive protein are feasible markers to predict complicated appendicitis
Maru Kim, Sung-Jeep Kim, Hang Joo Cho
World Journal of Emergency Surgery.2016;[Epub] CrossRef
Prolonged operative time in laparoscopic appendectomy: Predictive factors and outcomes
Byeong Geon Jeon, Hyuk Jung Kim, Kuk Hyun Jung, Sang Wook Kim, Jin Soo Park, Ki Ho Kim, Il Dong Kim, Sang-Jeon Lee
International Journal of Surgery.2016; 36: 225. CrossRef
Change in the Diagnosis of Appendicitis by Using a Computed Tomography Scan and the Necessity for a New Scoring System to Determine the Severity of the Appendicitis
Byung Wook Min
Annals of Coloproctology.2015; 31(5): 174. CrossRef

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis: Jeong Yeon Kim, Dongjun Jeong, Tae Sung Ahn, Hyung Ju Kim, Doo San Park, So Yong Park, Sang Byung Bae, Sookyoung Lee, Sung Soo Lee, Moon Soo Lee, Hyun Deuk Cho, Moo Jun Baek; Ann Coloproctol. 2013;29(3):93-99. Published online June 30, 2013; DOI: https://doi.org/10.3393/ac.2013.29.3.93

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11 Citations

Abstract PDF

Purpose

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods

The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results

The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion

These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

Citations to this article as recorded by

SPARC Induces COL1A1/COL3A1 Expressions Representing Aggressive Molecular Cancer-Associated Fibroblasts Signatures and CSF1-Mediated Cancer Invasion in Colorectal Cancer
Yusuke Nie, Yoshiki Fujiyama, Shumpei Shibaki, Riku Okamoto, Kota Okuno, Keiko Oki, Akiko Watanabe, Yu Kuroda, Takuya Goto, Kazuko Yokota, Keita Kojima, Hiroki Harada, Mikiko Kidachi, Takafumi Soeno, Mitsuo Yokota, Takeshi Kaida, Shuji Nakamoto, Nobuyuki
Annals of Surgical Oncology.2025; 32(12): 9354. CrossRef
CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy
Keishi Yamashita, Yusuke Kumamoto
International Journal of Molecular Sciences.2024; 25(11): 6003. CrossRef
Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun, Raj Kumar Koiri
PLOS ONE.2022; 17(8): e0273317. CrossRef
SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression
Qing Nian, Jingwei Li, ZhongYu Han, Qi Liang, Maoyu Liu, Chan Yang, Fernando Rodrigues-Lima, Tao Jiang, Liyun Zhao, Jinhao Zeng, Chi Liu, Jianyou Shi
Biomedicine & Pharmacotherapy.2022; 153: 113519. CrossRef
Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda Lopez-Moncada, Alexander Herrera, María José Torres, Exequiel Alonso, Norberto Ariel Gandini, Graciela Gigola, Hector R. Contreras, Claudia Gentili
Molecular and Cellular Endocrinology.2021; 530: 111253. CrossRef
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen,
eLife.2021;[Epub] CrossRef
Secreted protein acidic and rich in cysteine gene variants: Impact on susceptibility and survival of hepatocellular carcinoma patients
Samar Kamal Darweesh, Rasha Ahmed Abd Alziz, Heba Omar, Dina Sabry, Wael Fathy
Journal of Gastroenterology and Hepatology.2019; 34(8): 1424. CrossRef
Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy
Fwu‐Long Mi, Thierry Burnouf, Shih‐Yuan Lu, Yu‐Jen Lu, Kun‐Ying Lu, Yi‐Cheng Ho, Chang‐Yi Kuo, Er‐Yuan Chuang
Advanced Healthcare Materials.2017;[Epub] CrossRef
SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy
Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
Cancer Biomarkers.2017; 18(4): 459. CrossRef
Tumor–stroma ratio is an independent predictor for survival in early cervical carcinoma
Jing Liu, Juan Liu, Jinsong Li, Yingling Chen, Xiaoling Guan, Xiaojuan Wu, Chunyan Hao, Yanlin Sun, Yan Wang, Xiao Wang
Gynecologic Oncology.2014; 132(1): 81. CrossRef
Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma
Young Jin Kim
Annals of Coloproctology.2013; 29(3): 87. CrossRef

Expression of Placenta Growth Factor in Colorectal Carcinomas: Chan Yong Sung, Myoung Won Son, Tae Sung Ahn, Dong Jun Jung, Moon Soo Lee, Moo Jun Baek; J Korean Soc Coloproctol. 2012;28(6):315-320. Published online December 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.6.315

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Abstract PDF

Purpose

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. PlGF is implicated in several pathologic processes, including the growth and spread of cancer and tumor angiogenesis. The aim of this study was to evaluate the expression and the clinical implications of PlGF in colorectal cancer.

Methods

In order to ascertain the clinical significance of PlGF expression in colorectal cancer, the researcher analyzed the expression pattern of PlGF by using an immunohistochemical method and attempted to establish if a relationship existed between PlGF expression and microvessel density (MVD), and subsequently between PlGF expression and the predicted prognosis. A total of 83 patients with colorectal cancer were included for immunohistochemical staining. Clinicopathological characteristics were defined according to the tumor-node-metastasis (TNM) criteria of the Union for International Cancer Control. Clinicopathologic factors, such as age, sex, histological types of tumors, tumor cell grade, TNM stage, lymphovascular invasion, and lymph-node metastasis, were reviewed.

Results

In this study, the PlGF protein expression level was significantly correlated with MVD, patient survival, and clinicopathological factors such as lymph-node metastasis, TNM staging, lymphatic invasion and vascular invasion.

Conclusion

PlGF may be an important angiogenic factor in human colorectal cancer, and in this study, PlGF expression level was significantly correlated with positive lymph-node metastases, tumor stage, and patient survival. These findings suggest that PlGF expression correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

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Role of VEGFs/VEGFR-1 Signaling and Its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models
Claudia Ceci, Maria Grazia Atzori, Pedro Miguel Lacal, Grazia Graziani
International Journal of Molecular Sciences.2020; 21(4): 1388. CrossRef
Angiogenesis in 90Y-Radioembolization of Colorectal Liver Metastases
Ahmed A. Alsultan, Maarten W. Barentsz, Maarten L.J. Smits, Miriam Koopman, Marnix G.E.H. Lam, Charlotte E.N.M. Rosenbaum
Seminars in Nuclear Medicine.2019; 49(3): 204. CrossRef
Synchronous vascular endothelial growth factor protein profiles in both tissue and serum identify metastasis and poor survival in colorectal cancer
Chien-Chih Yeh, Li-Jane Shih, Junn-Liang Chang, Yi-Wei Tsuei, Chang-Chieh Wu, Cheng-Wen Hsiao, Chih-Pin Chuu, Yung-Hsi Kao
Scientific Reports.2019;[Epub] CrossRef
Using serum placenta growth factor could improve the sensitivity of colorectal cancer screening in fecal occult blood negative population: A multicenter with independent cohort validation study
Shu‐Chen Wei, Po‐Nien Tsao, Yu‐Ting Wang, Been‐Ren Lin, Deng‐Chyang Wu, Wen‐Sy Tsai, Jinn‐Shiun Chen, Jau‐Min Wong
Cancer Medicine.2019; 8(7): 3583. CrossRef
“Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer
Adriano Angelucci, Simona Delle Monache, Alessio Cortellini, Monica Di Padova, Corrado Ficorella
International Journal of Molecular Sciences.2018; 19(1): 299. CrossRef
An apparent clinical pharmacokinetic drug–drug interaction between bevacizumab and the anti-placental growth factor monoclonal antibody RO5323441 via a target-trapping mechanism
Ka Wang, Franziska Schaedeli Stark, Tilman Schlothauer, Angelika Lahr, Valerie Cosson, Jianguo Zhi, Kai Habben, Jean Tessier, Eginhard Schick, Roland F. Staack, Oliver Krieter
Cancer Chemotherapy and Pharmacology.2017; 79(4): 661. CrossRef
Hypoxia activates placental growth factor expression in lymphatic endothelial cells
Laura Tudisco, Augusto Orlandi, Valeria Tarallo, Sandro De Falco
Oncotarget.2017; 8(20): 32873. CrossRef
Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis
Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick
BMC Cancer.2015;[Epub] CrossRef
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial
Josep Tabernero, Heinz-Josef Lenz, Salvatore Siena, Alberto Sobrero, Alfredo Falcone, Marc Ychou, Yves Humblet, Olivier Bouché, Laurent Mineur, Carlo Barone, Antoine Adenis, Takayuki Yoshino, Richard M Goldberg, Daniel J Sargent, Andrea Wagner, Dirk Laure
The Lancet Oncology.2015; 16(8): 937. CrossRef
Epigenetic control of hypoxia inducible factor-1α-dependent expression of placental growth factor in hypoxic conditions
Laura Tudisco, Floriana Della Ragione, Valeria Tarallo, Ivana Apicella, Maurizio D'Esposito, Maria Rosaria Matarazzo, Sandro De Falco
Epigenetics.2014; 9(4): 600. CrossRef
Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer
Annette K. Larsen, Aimery de Gramont, Virginie Poindessous, Anaïs Bouygues, Mériam Ayadi, Paul Mésange
Current Colorectal Cancer Reports.2013; 9(3): 270. CrossRef

Stromal-cell-derived Factor 1-α Promotes Tumor Progression in Colorectal Cancer: Se Jun Park, Tae Sung Ahn, Sung Woo Cho, Chang Jin Kim, Dong Jun Jung, Myung Won Son, Sang Ho Bae, Eung Jin Shin, Moon Soo Lee, Chang Ho Kim, Moo Jun Baek; J Korean Soc Coloproctol. 2012;28(1):27-34. Published online February 29, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.1.27

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Abstract PDF

Purpose

Although stromal-cell-derived factor (SDF)-1α is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1α expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor staging, lymph-node metastasis, vascular invasion (VI), lymphatic invasion (LI) and neural invasion (NI).

Methods

Specimens of 83 primary colorectal cancers were examined immunohistochemically, and the relationships between clinicopathological features and SDF-1α expression were analyzed. To compare the expressions between the normal colon tissue and colorectal cancer tissues, we performed Western blot analyses.

Results

According to the Western blot analyses, SDF-1α was more highly expressed in colorectal carcinoma tissues than in normal colonic mucosa (20/21). According to the immunohistochemical stain, SDF-1α was associated with nodal status, distant metastasis, tumor staging, VI and LI. SDF-1α expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high SDF-1α showed that high SDF-1α expression was associated with a shorter overall survival. However, no association was found between SDF-1α expression and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural invasion.

Conclusion

The expression of SDF-1α might be associated with tumor progression in colorectal cancer. Inhibition of SDF-1α could be a therapeutic option in colorectal cancer patients.

Citations

Citations to this article as recorded by

Human CD133-positive hematopoietic progenitor cells initiate growth and metastasis of colorectal cancer cells
Chao Zhang, Chang Zhou, Xiao-Jin Wu, Min Yang, Zhao-hui Yang, Han-zhen Xiong, Chun-ping Zhou, Yan-xia Lu, Yuan Li, Xue-nong Li
Carcinogenesis.2014; 35(12): 2771. CrossRef

Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer: Nam Won Kim, Chong Woo Chu, Tae Sung Ahn, Chang Jin Kim, Dong Jun Jung, Myoung Won Son, Sang Ho Bae, Moon Soo Lee, Chang Ho Kim, Moo Jun Baek; J Korean Soc Coloproctol. 2011;27(5):231-236. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.231

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Abstract PDF

Purpose

Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the relation of PRL-3 mRNA level in primary colorectal cancer to the corresponding stage and to other clinicopathologic factors.

Methods

Two hundred forty-five patients with histologically-proven colorectal cancer underwent surgery between January 2004 and December 2006. RNA was extracted and cDNA was prepared by using reverse transcription. Quantification of PRL-3 was done using a real-time polymerase chain reaction.

Results

Eighty-six cases with well-preserved specimens were enrolled: 53 males and 33 females. The mean age was 63.4 years. According to tumour node metastasis (TNM) stage of the American Joint Committee on Cancer (AJCC), stage I was 11 cases, stage II was 38 cases, stage III was 23 cases, and stage IV was 14 cases. Among stage IV cases, one case was combined with liver and lung metastases, and one case was combined with liver metastases and peritoneal dissemination. The remaining stage IV patients were combined with only liver metastases. There was a significant correlation in PRL-3 mRNA expression between primary colorectal cancer and corresponding tumor stage. PRL-3 mRNA expression was increased in the liver metastases cases. Lymphatic and vascular invasion were significantly related with PRL-3 mRNA levels.

Conclusion

Advanced stage prediction may be obtained by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Especially, the risk of liver metastases may be predicted by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Further study is required to confirm these preliminary results.

Citations

Citations to this article as recorded by

Colorectal liver metastasis: molecular mechanism and interventional therapy
Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen, Yu Wen
Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef
A retrospective cohort study of clinical value of PRL-3 in stage III human colorectal cancer
Chuanyuan Liu, Wu Zhong, Laiyang Xia, Chuanfa Fang, Hongquan Liu, Xiaochun Liu
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