Skip Navigation
Skip to contents

Ann Coloproctol : Annals of Coloproctology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Search

Page Path
HOME > Search
24 "Seok-Byung Lim"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
Display
Original Articles
Minimally invasive surgery
Comparative perioperative outcomes of articulated versus conventional straight devices in laparoscopic low anterior resection: a propensity score–matched analysis
Hayoung Lee, Yong Sik Yoon, Young Il Kim, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim
Ann Coloproctol. 2025;41(5):434-442.   Published online October 16, 2025
DOI: https://doi.org/10.3393/ac.2025.00227.0032
  • 636 View
  • 18 Download
AbstractAbstract PDFSupplementary Material
Purpose
Laparoscopic low anterior resection for rectal cancer is technically challenging due to the precision required for mesorectal excision. Articulated instruments were developed to improve precision and oncological safety over conventional instruments. This study compares their perioperative outcomes.
Methods
A retrospective cohort study of 432 patients with colorectal cancer who underwent low anterior resection between August 2022 and February 2024 applied propensity score matching to minimize selection bias. Primary endpoints were circumferential resection margin (CRM), distal resection margin (DRM), and harvested lymph nodes count. Secondary outcomes included postoperative complications.
Results
Following propensity score matching, 84 matched pairs were analyzed. Most patients achieved CRM negativity (>1 mm), with CRM ≥10 mm in 67.9% of the articulated group and 59.5% of the conventional group (P=0.613). Median (interquartile range, IQR) lymph nodes harvests were comparable (20 [14–26] vs. 18 [14–22], P=0.147). The articulated group had a significantly longer DRM (30.0 mm [IQR, 18.0–40.0 mm] vs. 24.0 mm [IQR, 12.0–34.2 mm], P=0.008) and the median operation time (111.0 minutes [IQR, 95.8–125.2 minutes] vs. 99.5 minutes [IQR, 72.0–119.8 minutes], P=0.009). Estimated blood loss, open conversion rates, and postoperative complications, including leakage (7.1% vs. 8.3%, P>0.999) and surgical site infections, (15.5% vs. 9.5%, P=0.383), showed no significant differences.
Conclusion
Articulated laparoscopic instruments demonstrated comparable safety and feasibility to conventional instruments but offered no significant clinical or oncological benefits beyond a longer DRM. Larger studies are needed to evaluate their value in laparoscopic rectal surgery.
Colorectal cancer
Effects of clinical information on the treatment decisions for good responders to neoadjuvant chemoradiotherapy among rectal cancer patients
Eon Bin Kim, In Ja Park, Hwa Jung Kim, Jong Keon Jang, Seong Ho Park, Young Il Kim, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu
Ann Coloproctol. 2025;41(5):473-482.   Published online July 10, 2025
DOI: https://doi.org/10.3393/ac.2024.00276.0039
  • 1,418 View
  • 31 Download
  • 1 Citations
AbstractAbstract PDFSupplementary Material
Purpose
The decision for treatment after neoadjuvant chemoradiotherapy (nCRT) in rectal cancer is intricately linked to tumor response and clinical parameters. This study was designed to elucidate determinants influencing treatment decisions for good responders to nCRT, while concurrently evaluating the ramifications of modifications in magnetic resonance imaging (MRI) tumor response evaluation protocols.
Methods
A survey was constructed with 5 cases of good responder after nCRT based on the magnetic resonance–based tumor regression grade (mrTRG) criteria. A total of 35 colorectal surgeons in Korea participated in the survey via email, and they were introduced to 2 discrete MRI-based tumor response evaluation methodologies: the conventional mrTRG and an emergent complete response (CR)/non-CR classification system. Surgeons were directed to select between total mesorectal excision, local excision, or a watch and wait strategy.
Results
Treatment decisions varied significantly (P<0.01), as gradually more clinical information was provided with mrTRG. The paradigm shift from mrTRG to CR/non-CR evaluation criterion instigated the highest alteration in decision (P<0.01). Even comparing with other sets of information, decision change with different tumor response assessment (i.e., mrTRG vs. CR/non-CR) was statistically significant (P<0.01). Three particular cases consistently displayed a declining predilection for total mesorectal excision, favoring a more pronounced inclination towards watch and wait strategy or local excision. Nonetheless, the magnitude of these decisional shifts oscillated depending on the specific endoscopic imagery present.
Conclusion
Our current findings underscore the significant role of tumor response assessment methods in shaping treatment decisions for rectal cancer patients who respond well to nCRT. This highlights the need for clear and accurate tools to interpret MRI results.

Citations

Citations to this article as recorded by  
  • Clinical implications of radiologic criteria and prognostic factors for lateral lymph node metastasis in low rectal cancer
    Gyung Mo Son
    Annals of Coloproctology.2025; 41(6): 489.     CrossRef
Colorectal cancer
Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older
Byeo Lee Lim, In Ja Park, Jun-Soo Ro, Young Il Kim, Seok-Byung Lim, Chang Sik Yu
Ann Coloproctol. 2025;41(3):198-206.   Published online August 5, 2024
DOI: https://doi.org/10.3393/ac.2023.00367.0052
  • 7,398 View
  • 89 Download
  • 4 Web of Science
  • 6 Citations
AbstractAbstract PDFSupplementary Material
Purpose
The aim of this study was to examine the prognosis and associated risk factors, including adjuvant chemotherapy (CTx), in elderly patients with colon cancer.
Methods
This retrospective study included patients who underwent radical resection for colon cancer between January 2010 and December 2014 at Asan Medical Center. The effects of stage, risk factors, and chemotherapy on overall survival (OS) and recurrence-free survival (RFS) were compared in patients aged ≥70 and <70 years.
Results
Of 3,313 patients, 933 (28.1%) was aged ≥70 years. Of the 1,921 patients indicated for adjuvant CTx, 1,294 of 1,395 patients (92.8%) aged <70 years and 369 of 526 patients (70.2%) aged ≥70 years received adjuvant CTx. Old age (≥70 years) was independently associated with RFS in overall cohort. Among patients aged ≥70 years indicated for adjuvant CTx, the 5-year OS (81.6% vs. 50.4%, P<0.001) and RFS (82.9% vs. 67.4%, P=0.025) rates were significantly higher in those who did than did not receive adjuvant CTx. Additionally, adjuvant CTx was confirmed as independent risk factor of both OS and RFS in patients aged ≥70 years indicated for adjuvant CTx.
Conclusion
Old age was associated with poor RFS and adjuvant CTx had benefits in OS as well as RFS in elderly patients eligible for adjuvant CTx.

Citations

Citations to this article as recorded by  
  • Immunological changes and recovery-related factors in older patients with colon cancer: A pilot trial
    Byeo Lee Lim, Young Il Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Yousun Ko, Kyung Won Kim, In Ja Park
    Journal of Geriatric Oncology.2025; 16(3): 102200.     CrossRef
  • Stage II-III colorectal cancer in geriatric patients: Clinicopathological features and chemotherapy utilization
    Yakup Duzkopru, Özlem Doğan
    Turkish Journal of Clinics and Laboratory.2025; 16(1): 118.     CrossRef
  • Does Oxaliplatin-based Adjuvant Therapy Benefit Older Colorectal Cancer Patients?
    Peter Hofland
    Onco Zine - The International Oncology Network.2025;[Epub]     CrossRef
  • Disease-Free Survival of Patients with Stage II Stroma-Rich Colorectal Adenocarcinomas with Microsatellite Stability
    Ángel Romo-Navarro, Juan Ruiz Martín, Irene García-Camacha Gutiérrez, Mariano Amo-Salas, María Recuero Pradillo, César Sánchez-Muñoz, Cristina María Murillo Lázaro, Esperanza Carabias López, Raquel Sánchez Simón, Carlos Quimbayo-Arcila, Yasmina Hernández
    International Journal of Molecular Sciences.2025; 26(24): 11795.     CrossRef
  • Early detection of anastomotic leakage in colon cancer surgery: the role of early warning score and C-reactive protein
    Gyung Mo Son
    Annals of Coloproctology.2024; 40(5): 415.     CrossRef
  • Efficacy of Neoadjuvant Hypofractionated Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer: A Single-Center Retrospective Analysis
    Jae Seung Kim, Jaram Lee, Hyeung-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
    Cancers.2024; 16(24): 4280.     CrossRef
Colorectal cancer
Partial mesorectal excision can be a primary option for middle rectal cancer: a propensity score–matched retrospective analysis
Ee Jin Kim, Chan Wook Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2024;40(3):253-267.   Published online March 31, 2023
DOI: https://doi.org/10.3393/ac.2022.00689.0098
  • 5,898 View
  • 221 Download
  • 1 Web of Science
  • 2 Citations
AbstractAbstract PDF
Purpose
Although partial mesorectal excision (PME) and total mesorectal excision (TME) is primarily indicated for the upper and lower rectal cancer, respectively, few studies have evaluated whether PME or TME is more optimal for middle rectal cancer.
Methods
This study included 671 patients with middle and upper rectal cancer who underwent robot-assisted PME or TME. The 2 groups were optimized by propensity score matching of sex, age, clinical stage, tumor location, and neoadjuvant treatment.
Results
Complete mesorectal excision was achieved in 617 of 671 patients (92.0%), without showing a difference between the PME and TME groups. Local recurrence rate (5.3% vs. 4.3%, P>0.999) and systemic recurrence rate (8.5% vs. 16.0%, P=0.181) also did not differ between the 2 groups, in patients with middle and upper rectal cancer. The 5-year disease-free survival (81.4% vs. 74.0%, P=0.537) and overall survival (88.0% vs. 81.1%, P=0.847) also did not differ between the PME and TME groups, confined to middle rectal cancer. Moreover, 5-year recurrence and survival rates were not affected by distal resection margins of 2 cm (P=0.112) to 4 cm (P>0.999), regardless of pathological stages. Postoperative complication rate was higher in the TME than in the PME group (21.4% vs. 14.5%, P=0.027). Incontinence was independently associated with TME (odds ratio [OR], 2.009; 95% confidence interval, 1.015–3.975; P=0.045), along with older age (OR, 4.366, P<0.001) and prolonged operation time (OR, 2.196; P=0.500).
Conclusion
PME can be primarily recommended for patients with middle rectal cancer with lower margin of >5 cm from the anal verge.

Citations

Citations to this article as recorded by  
  • Review of definition and treatment of upper rectal cancer
    Elias Karam, Fabien Fredon, Yassine Eid, Olivier Muller, Marie Besson, Nicolas Michot, Urs Giger-Pabst, Arnaud Alves, Mehdi Ouaissi
    Surgical Oncology.2024; 57: 102145.     CrossRef
  • Tumour-specific mesorectal excision for rectal cancer: Systematic review and meta-analysis of oncological and functional outcomes
    Fabio Carbone, Wanda Petz, Simona Borin, Emilio Bertani, Stefano de Pascale, Maria Giulia Zampino, Uberto Fumagalli Romario
    European Journal of Surgical Oncology.2023; 49(11): 107069.     CrossRef
Colorecal cancer
Prognostic significance of lymph node yield on oncologic outcomes according to tumor response after preoperative chemoradiotherapy in rectal cancer patients
Hyo Seon Ryu, In Ja Park, Bo Kyung Ahn, Min Young Park, Min Sung Kim, Young Il Kim, Seok-Byung Lim, Jin Cheon Kim
Ann Coloproctol. 2023;39(5):410-420.   Published online April 28, 2022
DOI: https://doi.org/10.3393/ac.2022.00143.0020
  • 5,489 View
  • 133 Download
  • 6 Web of Science
  • 5 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Purpose
This study aimed to evaluate the predictive value of lymph node yield (LNY) for survival outcomes according to tumor response after preoperative chemoradiotherapy (PCRT) in patients with rectal cancer.
Methods
This study was a retrospective study conducted in a tertiary center. A total of 1,240 patients with clinical stage II or III rectal cancer who underwent curative resection after PCRT between 2007 and 2016 were included. Patients were categorized into the good response group (tumor regression grade [TRG], 0–1) or poor response group (TRG, 2–3). Propensity score matching was performed for age, sex, and pathologic stage between LNY of ≥12 and LNY of <12 within tumor response group. The primary outcome was 5-year disease-free survival (DFS) and overall survival (OS).
Results
LNY and positive lymph nodes were inversely correlated with TRG. In good responders, 5-year DFS and 5-year OS of patients with LNY of <12 were better than those with LNY of ≥12, but there was no statistical significance. In poor responders, the LNY of <12 group had worse survival outcomes than the LNY of ≥12 group, but there was also no statistical significance. LNY of ≥12 was not associated with DFS and OS in multivariate analysis.
Conclusion
LNY of <12 showed contrasting outcomes between the good and poor responders in 5-year DFS and OS. LNY of 12 may not imply adequate oncologic surgery or proper staging in rectal cancer patients treated by PCRT. Furthermore, a decrease in LNY should be comprehended differently according to tumor response.

Citations

Citations to this article as recorded by  
  • Breaking Myths: Comparable Outcomes in Lymph Node Analysis Across Surgical Methods
    Salvatore Pezzino, Tonia Luca, Mariacarla Castorina, Giulia Fuccio Sanzà, Gaetano Magro, Stefano Puleo, Ornella Coco, Sergio Castorina
    Cancers.2025; 17(8): 1312.     CrossRef
  • A predictive nomogram for assessing the likelihood of retrieving 12 lymph nodes after rectal cancer surgery: a single-center study
    Jian Ma, Runyang Hao, Shuai Jiao, Qingmin Chen, Baohong Yang, Xu Guan, Jiale Li, Xinxuan Zhao, Yu Huo, Qingxia Xu, Haiyi Liu, Wen Su, Xishan Wang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Effects of Adjuvant Chemotherapy on Oncologic Outcomes in Patients With Stage ⅡA Rectal Cancer Above the Peritoneal Reflection Who Did Not Undergo Preoperative Chemoradiotherapy
    Hyo Seon Ryu, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Yong Sang Hong, Tae Won Kim, Chang Sik Yu
    Clinical Colorectal Cancer.2024; 23(4): 392.     CrossRef
  • Artificial Intelligence-Driven Volumetric Analysis of Muscle Mass as a Predictor of Tumor Response to Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer
    Minsung Kim, Sang Min Lee, Il Tae Son, Jaewoong Kang, Gyoung Tae Noh, Bo Young Oh
    Journal of Clinical Medicine.2024; 13(23): 7018.     CrossRef
  • Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 203.     CrossRef
Colorectal cancer
Efficacy of preoperative chemoradiotherapy in patients with cT2N0 distal rectal cancer
Min Young Park, Chang Sik Yu, Tae Won Kim, Jong Hoon Kim, Jin-hong Park, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Ann Coloproctol. 2023;39(3):250-259.   Published online April 4, 2022
DOI: https://doi.org/10.3393/ac.2022.00066.0009
  • 5,971 View
  • 161 Download
  • 7 Web of Science
  • 7 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
Purpose
This study was designed to determine the feasibility of preoperative chemoradiotherapy (PCRT) in patients with clinical T2N0 distal rectal cancer.
Methods
Patients who underwent surgery for clinical T2N0 distal rectal cancer between January 2008 and December 2016 were included. Patients were divided into PCRT and non-PCRT groups. Non-PCRT patients underwent radical resection or local excision (LE) according to the surgeon’s decision, and PCRT patients underwent surgery according to the response to PCRT. Patients received 50.0 to 50.4 gray of preoperative radiotherapy with concurrent chemotherapy.
Results
Of 127 patients enrolled, 46 underwent PCRT and 81 did not. The mean distance of lesions from the anal verge was lower in the PCRT group (P=0.004). The most frequent operation was transanal excision and ultralow anterior resection in the PCRT and non-PCRT groups, respectively. Of the 46 patients who underwent PCRT, 21 (45.7%) achieved pathologic complete response, including 15 of the 24 (62.5%) who underwent LE. Rectal sparing rate was significantly higher in the PCRT group (11.1% vs. 52.2%, P<0.001). There were no significant differences in 3- and 5-year overall survival and recurrence-free survival regardless of PCRT or surgical procedures.
Conclusion
PCRT in clinical T2N0 distal rectal cancer patients increased the rectal sparing rate via LE and showed acceptable oncologic outcomes. PCRT may be a feasible therapeutic option to avoid abdominoperineal resection in clinical T2N0 distal rectal cancer.

Citations

Citations to this article as recorded by  
  • Lymph node metastasis following chemoradiotherapy in advanced rectal cancer: ypT2-focused analyses of total mesorectal excision specimens
    A. N. Singhi, T.-G. Lee, H.-M. Ahn, H.-R. Shin, M. J. Choi, M. H. Jo, H.-K. Oh, D.-W. Kim, S.-B. Kang
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Is there a role for total neoadjuvant treatment in early-stage rectal cancer?
    Kamil Erozkan, Metincan Erkaya, Jacob A. Miller, Ali Alipouriani, David Liska, Hermann Kessler, Scott R. Steele, Emre Gorgun
    Langenbeck's Archives of Surgery.2025;[Epub]     CrossRef
  • Effects of clinical information on the treatment decisions for good responders to neoadjuvant chemoradiotherapy among rectal cancer patients
    Eon Bin Kim, In Ja Park, Hwa Jung Kim, Jong Keon Jang, Seong Ho Park, Young Il Kim, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu
    Annals of Coloproctology.2025; 41(5): 473.     CrossRef
  • Performance reporting design in artificial intelligence studies using image-based TNM staging and prognostic parameters in rectal cancer: a systematic review
    Minsung Kim, Taeyong Park, Bo Young Oh, Min Jeong Kim, Bum-Joo Cho, Il Tae Son
    Annals of Coloproctology.2024; 40(1): 13.     CrossRef
  • Comparative analysis of organ preservation attempt and radical surgery in clinical T2N0 mid to low rectal cancer
    Hyeung-min Park, Jaram Lee, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
    International Journal of Colorectal Disease.2024;[Epub]     CrossRef
  • Organ preservation for early rectal cancer using preoperative chemoradiotherapy
    Gyung Mo Son
    Annals of Coloproctology.2023; 39(3): 191.     CrossRef
  • Unveiling the profound advantages of total neoadjuvant therapy in rectal cancer: a trailblazing exploration
    Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Donghyoun Lee, Chinock Cheong
    Annals of Surgical Treatment and Research.2023; 105(6): 341.     CrossRef
Case Report
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer
Late Recurrence in a Rectal Cancer Patient Who Underwent Preoperative Chemoradiotherapy Followed by Local Excision: A Case Report
Jin Soo Han, Seok-Byung Lim, Jin-hong Park, Yong Sang Hong
Ann Coloproctol. 2021;37(Suppl 1):S24-S27.   Published online July 27, 2021
DOI: https://doi.org/10.3393/ac.2020.00073.0010
  • 4,509 View
  • 57 Download
  • 2 Web of Science
  • 2 Citations
AbstractAbstract PDF
Some patients who have undergone preoperative chemoradiotherapy (CRT) following surgery have been diagnosed with late recurrence more than 5 years after treatment, raising questions about the possible benefit extending surveillance beyond the recommended 5 years. In 2011, a 71-year-old male patient was diagnosed with T3N+ low-lying rectal cancer located 3 cm from the anal verge before undergoing long-course preoperative CRT. After CRT, the patient was reexamined and diagnosed with ycT1–2N0 lesion, so local excision (LE) was performed. The patient underwent intensive surveillance for up to 5 years, and no evidence of recurrence was found. At 74 months after surgery, the patient was hospitalized for a hematochezia, and local recurrence at the excision site and peritoneal seeding nodules were identified. Considering the late recurrence in this patient, it might be necessary to long-term follow-up beyond 5 years in patients with preoperative CRT followed by LE.

Citations

Citations to this article as recorded by  
  • Effects of clinical information on the treatment decisions for good responders to neoadjuvant chemoradiotherapy among rectal cancer patients
    Eon Bin Kim, In Ja Park, Hwa Jung Kim, Jong Keon Jang, Seong Ho Park, Young Il Kim, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu
    Annals of Coloproctology.2025; 41(5): 473.     CrossRef
  • Coccygodynia in a Long-Term Cancer Survivor Diagnosed with Metastatic Cancer: A Case Report
    Jung Hyun Park, Seong Jin Park, Dulee Kim, Jae Hoo Park, So Young Kwon
    Medicina.2024; 60(8): 1365.     CrossRef
Original Articles
Malignant disease, Rectal cancer,Colorectal cancer,Epidemiology & etiology
Clinicopathological Characteristics and Surgical Outcomes of Crohn Disease-Associated Colorectal Malignancy
Yoo Na Lee, Jong Lyul Lee, Chang Sik Yu, Jong Beom Kim, Seok-Byung Lim, In Ja Park, Young Sik Yoon, Chan Wook Kim, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park, Jin Cheon Kim
Ann Coloproctol. 2021;37(2):101-108.   Published online April 30, 2021
DOI: https://doi.org/10.3393/ac.2020.11.02
  • 5,399 View
  • 105 Download
  • 4 Web of Science
  • 4 Citations
AbstractAbstract PDFSupplementary Material
Purpose
Carcinoma arising from Crohn disease (CD) is rare, and there is no clear guidance on how to properly screen for at-risk patients and choose appropriate care. This study aimed to evaluate the clinicopathological characteristics, treatment, and oncologic outcomes of CD patients diagnosed with colorectal cancer (CRC).
Methods
Using medical records, we retrospectively enrolled a single-center cohort of 823 patients who underwent abdominal surgery for CD between January 2006 and December 2015. CD-associated CRC patients included those with adenocarcinoma, lymphoma, or neuroendocrine tumors of the colon and rectum.
Results
Nineteen patients (2.3%) underwent abdominal surgery to treat CD-associated CRC. The mean duration of CD in the CD-associated CRC group was significantly longer than that in the benign CD group (124.7 ± 77.7 months vs. 68.9 ± 60.2 months, P = 0.006). The CD-associated CRC group included a higher proportion of patients with a history of perianal disease (73.7% vs. 50.2%, P = 0.035) and colonic location (47.4% vs. 6.5%, P = 0.001). Among 19 CD-associated CRC patients, 17 (89.5%) were diagnosed with adenocarcinoma, and of the 17 cases, 15 (88.2%) were rectal adenocarcinoma. On multivariable analyses for developing CRC, only colonic location was a risk factor (relative risk, 7.735; 95% confidence interval, 2.862–20.903; P = 0.001).
Conclusion
Colorectal malignancy is rare among CD patients, even among patients who undergo abdominal surgery. Rectal adenocarcinoma accounted for most of the CRC, and colonic location was a risk factor for developing CRC.

Citations

Citations to this article as recorded by  
  • Perianal Fistulizing Crohn’s Disease–Associated Anorectal and Fistula Cancers: Systematic Review and Expert Consensus
    Serre-Yu Wong, Cathy Rowan, Elvira Diaz Brockmans, Cindy C.Y. Law, Elisabeth Giselbrecht, Celina Ang, Sergey Khaitov, David Sachar, Alexandros D. Polydorides, Leon Shin-han Winata, Bram Verstockt, Antonino Spinelli, David T. Rubin, Parakkal Deepak, Dermot
    Clinical Gastroenterology and Hepatology.2025; 23(6): 927.     CrossRef
  • Reduced expression of alanyl aminopeptidase is a robust biomarker of non‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer syndrome early‐onset colorectal cancer
    Ye Jin Ha, Yun Jae Shin, Ka Hee Tak, Jong Lyul Park, Jeong Hwan Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seon Young Kim, Jin Cheon Kim
    Cancer Medicine.2023; 12(8): 10091.     CrossRef
  • Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
    Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
    Cancers.2023; 15(20): 5098.     CrossRef
  • Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
    Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
    Annals of Coloproctology.2022; 38(2): 97.     CrossRef
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy
Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy
Seul Gi Oh, In Ja Park, Ji-hyun Seo, Young Il Kim, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2020;36(6):382-389.   Published online June 17, 2020
DOI: https://doi.org/10.3393/ac.2020.06.11
  • 5,731 View
  • 104 Download
  • 7 Web of Science
  • 7 Citations
AbstractAbstract PDF
Purpose
Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol.
Methods
This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection between January 2005 and December 2012. Recurrence was evaluated according to receipt of PCRT; PCRT group (n = 1,258) and no-PCRT group (n = 957). Early recurrence occurred within 1 year of surgery and late recurrence after 3 years. The median follow-up duration was 65.7 ± 29 months.
Results
The overall recurrence rate was similar between the PCRT and no-PCRT group (25.8% vs. 24.9%, P = 0.622). The most common initial recurrence site was the lungs in both groups (50.6% vs. 49.6%, P = 0.864), followed by the liver, which was more common in the no-PCRT group (22.5% vs. 33.6%, P = 0.004). Most of the recurrence occurred within 3 years after surgery in both groups (85.3% vs. 85.8%, P = 0.862). Early recurrence was more common in the PCRT group than in the no-PCRT group (43.1% vs. 32.4%, P = 0.020). Recurrence within the first 6 months after surgery was significantly higher in the PCRT group than in the no-PCRT group (18.8% vs. 7.6%, P = 0.003). Lung (n = 27, 44.3%) and liver (n = 22, 36.1%) were the frequent the first relapsed site within 6 months after surgery in PCRT group.
Conclusion
Early recurrence within the first 1 year after surgery was more common in patients treated with PCRT. This difference would be considered for surveillance protocols and need to be evaluated in further studies.

Citations

Citations to this article as recorded by  
  • Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis
    Wenshu Wang, Runyuan Zhao, Xi Liang, Manjun Liu, Haiyan Bai, Jianli Ge, Binxi Yao, Zheng Zhi, Jianming He
    Oncology Reviews.2025;[Epub]     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
  • Update on Diagnosis and Treatment of Colorectal Cancer
    Chan Wook Kim
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • The watch-and-wait strategy versus radical resection for rectal cancer patients with a good response (≤ycT2) after neoadjuvant chemoradiotherapy
    Chungyeop Lee, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Annals of Surgical Treatment and Research.2022; 103(6): 350.     CrossRef
  • Optimal Postoperative Surveillance Strategies for Colorectal Cancer: A Retrospective Observational Study
    Min-Young Park, In-Ja Park, Hyo-Seon Ryu, Jay Jung, Min-Sung Kim, Seok-Byung Lim, Chang-Sik Yu, Jin-Cheon Kim
    Cancers.2021; 13(14): 3502.     CrossRef
  • Comparison between Local Excision and Radical Resection for the Treatment of Rectal Cancer in ypT0-1 Patients: An Analysis of the Clinicopathological Factors and Survival Rates
    Soo Young Oh, In Ja Park, Young IL Kim, Jong-Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Cancers.2021; 13(19): 4823.     CrossRef
  • Shifting Treatment Strategies to Prevent Early Relapse of Locally Advanced Rectal Cancer After Preoperative Chemoradiotherapy
    Eun Jung Park
    Annals of Coloproctology.2020; 36(6): 357.     CrossRef
Benign GI diease, Inflammatory bowel disease
Clinical Characteristics and Postoperative Outcomes of Patients Presenting With Upper Gastrointestinal Tract Crohn Disease
Joon Suk Moon, Jong Lyul Lee, Chang Sik Yu, Seok-Byung Lim, In Ja Park, Yong Sik Yoon, Chan Wook Kim, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park, Hassan Abdullah Alsaleem, Jin Cheon Kim
Ann Coloproctol. 2020;36(4):243-248.   Published online March 16, 2020
DOI: https://doi.org/10.3393/ac.2019.10.16.1
  • 5,700 View
  • 123 Download
  • 8 Web of Science
  • 7 Citations
AbstractAbstract PDF
Purpose
Upper gastrointestinal (GI) tract involvement in Crohn disease (CD) is rare and effectiveness of surgical treatment is limited. The aim of this study was to evaluate characteristics and surgical outcomes of upper GI CD.
Methods
Medical records of 811 patients who underwent intestinal surgery for CD between January 2006 and December 2015 at a single institution were reviewed. Upper GI CD was defined by involvement of the stomach to the fourth portion of duodenum, with or without concomitant small/large bowel CD involvement according to a modification of the Montreal classification.
Results
We identified 24 patients (21 males, 3 females) who underwent surgery for upper GI CD. The mean age at diagnosis was 27 ± 12 years, the mean age at surgery was 33 ± 11 years, and the mean duration of CD was 73.6 ± 56.6 months. Fifteen patients (62.5%) had history of previous perianal surgery. Ten patients (41.7%) had duodenal or gastric stricture and 14 patients (58.3%) had penetrating fistula; patients with fistula were significantly more likely to develop complications (57.1% vs. 20.0%, P = 0.035). One patient with stricture had surgical recurrence. In seven patients with fistula, fistula was related to previous anastomosis. Patients with fistula had significantly longer hospital stays than those with stricture (16 days vs. 11 days, P = 0.01).
Conclusion
Upper GI CD is rare among CD types (2.96%). In patients with upper GI CD, penetrating fistula was associated with longer hospital stay and more complications.

Citations

Citations to this article as recorded by  
  • Diagnosis and Management of Upper Gastrointestinal Involvement in Adult Patients With Crohn’s Disease: A Systematic Review
    Nathaniel A. Cohen, Neta Sror, Maliha Naseer, Dominik Bettenworth, Cathy Lu, Raneem Khedraki, Maria T. Abreu, Raja Atreya, Badr Al-Bawardy, Susan J. Connor, Geert d’Haens, Iris Dotan, Axel Dignass, Sara El Ouali, Brian Feagan, Roger Feakins, Richard Gearr
    Clinical Gastroenterology and Hepatology.2025;[Epub]     CrossRef
  • Update S2k-Guideline Helicobacter pylori and gastroduodenal ulcer disease of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)
    Wolfgang Fischbach, Jan Bornschein, Jörg C. Hoffmann, Sibylle Koletzko, Alexander Link, Lukas Macke, Peter Malfertheiner, Kerstin Schütte, Dieter-Michael Selgrad, Sebastian Suerbaum, Christian Schulz
    Zeitschrift für Gastroenterologie.2024; 62(02): 261.     CrossRef
  • Aktualisierte S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – Juli 2022 – AWMF-Registernummer: 021–001

    Zeitschrift für Gastroenterologie.2023; 61(05): 544.     CrossRef
  • A systematic review and meta‐analysis of prevalence and clinical features of upper gastrointestinal (UGI) tract Crohn's disease in adults compared to non‐UGI types
    Babak Tamizifar, Peyman Adibi, Maryam Hadipour, Vahid Mohamadi
    JGH Open.2023; 7(5): 325.     CrossRef
  • Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents
    Eun Sil Kim, Mi Jin Kim
    Clinical and Experimental Pediatrics.2022; 65(1): 21.     CrossRef
  • Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn’s disease
    Ranjit Pelia, Suresh Venkateswaran, Jason D. Matthews, Yael Haberman, David J. Cutler, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
    BMC Medical Genomics.2021;[Epub]     CrossRef
  • Surgical Treatment of Upper Gastrointestinal Tract Crohn Disease: A Long Way to Go to Identify the Optimal Method
    Soo Yeun Park
    Annals of Coloproctology.2020; 36(4): 207.     CrossRef
Benign GI diease, Inflammatory bowel disease
Short-term Outcomes of Elective 2-Stage Restorative Proctocolectomy for Ulcerative Colitis in Korea: Does Laparoscopy Have Benefits?
Jun Woo Bong, Yong Sik Yoon, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2020;36(1):41-47.   Published online February 29, 2020
DOI: https://doi.org/10.3393/ac.2019.03.29
  • 5,028 View
  • 87 Download
  • 4 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
This study aimed to compare the short-term outcomes of the open and laparoscopic approaches to 2-stage restorative proctocolectomy (RPC) for Korean patients with ulcerative colitis (UC).
Methods
We retrospectively analyzed the medical records of 73 patients with UC who underwent elective RPC between 2009 and 2016. Patient characteristics, operative details, and postoperative complications within 30 days were compared between the open and laparoscopic groups.
Results
There were 26 cases (36%) in the laparoscopic group, which had a lower mean body mass index (P = 0.025), faster mean time to recovery of bowel function (P = 0.004), less intraoperative blood loss (P = 0.004), and less pain on the first and seventh postoperative days (P = 0.029 and P = 0.027, respectively) compared to open group. There were no deaths, and the overall complication rate was 43.8%. There was no between-group difference in the overall complication rate; however, postoperative ileus was more frequent in the open group (27.7% vs. 7.7%, P = 0.043). Current smoking (odds ratio [OR], 44.4; P = 0.003) and open surgery (OR, 5.4; P = 0.014) were the independent risk factors for postoperative complications after RPC.
Conclusion
Laparoscopic RPC was associated with acceptable morbidity and faster recovery than the open approach. The laparoscopic approach is a feasible and safe option for surgical treatment for UC in selective cases.

Citations

Citations to this article as recorded by  
  • Patient-reported Outcome Measures in Ileoanal Pouch Surgery: a Systematic Review
    Zakary Ismail Warsop, Carlo Alberto Manzo, Natalie Yu, Bilal Yusuf, Christos Kontovounisios, Valerio Celentano
    Journal of Crohn's and Colitis.2024; 18(3): 479.     CrossRef
  • Creation of an institutional preoperative checklist to support clinical risk assessment in patients with ulcerative colitis (UC) considering ileoanal pouch surgery
    Bruno Augusto Alves Martins, Amira Shamsiddinova, Manal Mubarak Alquaimi, Guy Worley, Phil Tozer, Kapil Sahnan, Zarah Perry-Woodford, Ailsa Hart, Naila Arebi, Manmeet Matharoo, Janindra Warusavitarne, Omar Faiz
    Frontline Gastroenterology.2024; 15(3): 203.     CrossRef
  • Benefits of Elective Laparoscopic 2-Stage Restorative Proctocolectomy for Ulcerative Colitis in Korea
    Sun Min Park, Won-Kyung Kang
    Annals of Coloproctology.2020; 36(1): 3.     CrossRef
Original article
Defunctioning Protective Stoma Can Reduce the Rate of Anastomotic Leakage after Low Anterior Resection in Rectal Cancer Patients
Byoung Chul Lee, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Chang Sik Yu, Jin Cheon Kim
Received October 22, 2019  Accepted November 19, 2019  Published online January 16, 2020  
DOI: https://doi.org/10.3393/ac.2019.11.19.1
  • 6,611 View
  • 244 Download
  • 19 Citations
AbstractAbstract PDF
PURPOSE
This study aimed to identify risk factors for anastomotic leakage and to evaluate the impact of protective stoma on the rate of anastomotic leakage and subsequent management.
METHODS
This retrospective study analyzed data from 4,282 patients who underwent low anterior resection between 2007 and 2014. Among these, 1,367 (31.9%) underwent surgery to create protective diverting stoma and 232 (5.4%) experienced anastomotic leakage. At 6-month timepoints, data were evaluated to identify any correlation between the presence of diverting stoma and the incidence of anastomotic leakage. In addition, clinicopathological parameters were investigated to identify risk factors for anastomotic leakage.
RESULTS
Diverting stomas significantly reduced the rate of anastomotic leakage [HR 0.334, 95% CI 0.212

Citations

Citations to this article as recorded by  
  • Application of one-stitch modified ileostomy in laparoscopic low anterior rectal resection: An open-label, randomized clinical trial
    Xin Zhang, Baochuan Yang, Weishuai Song, Benjia Liang, Liangzhao Chen, Quan Yuan, Yitong Wang, Jiayi Li, Jie Liu, Jizhun Zhang
    Surgery.2026; 190: 109860.     CrossRef
  • Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis
    Miao-Ling Tsai, Ji-Shiang Hung, John Huang, Been-Ren Lin
    European Journal of Surgical Oncology.2025; 51(8): 108698.     CrossRef
  • Risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery
    Jia-Rui Liu, Jin Zhang, Xiang-Long Duan
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Risk prediction models for permanence of temporary stoma after radical surgery of rectal cancer: a systematic review
    Wenjing Tan, Shiyin Cai, Juanqin Wu, Wenke Wu, Shan Wang, Yaqiu Li, Lulu Liu, Liping Tang, Ying Cao
    World Journal of Surgical Oncology.2025;[Epub]     CrossRef
  • Machine learning model for prediction of permanent stoma after anterior resection of rectal cancer: A multicenter study
    Yang Su, Yanqi Li, Heng Zhang, Wangshuo Yang, Mengdie Liu, Xuelai Luo, Lu Liu
    European Journal of Surgical Oncology.2024; 50(7): 108386.     CrossRef
  • A nomogram of anastomotic stricture after rectal cancer: a retrospective cohort analysis
    Yifan Cheng, Zhen Tian, Shuyang Gao, Shuai Zhao, Ruiqi Li, Jiajie Zhou, Qiannan Sun, Daorong Wang
    Surgical Endoscopy.2024; 38(7): 3661.     CrossRef
  • Impact of diversion ileostomy on postoperative complications and recovery in the treatment of locally advanced upper-half rectal cancer
    Yangyang Wang, Xiaojie Wang, Shenghui Huang, Heyuan Zhu, Ying Huang
    Scientific Reports.2024;[Epub]     CrossRef
  • The role of transanal drainage tube in preventing the anastomotic leakage in rectal cancer surgery without a defunctioning stoma: A meta-analysis
    Yue-Xin Zhang, Tao Jin, Kun Yang
    The Surgeon.2023; 21(4): e164.     CrossRef
  • Sarcopenic Obesity Is a Risk Factor for Worse Oncological Long-Term Outcome in Locally Advanced Rectal Cancer Patients: A Retrospective Single-Center Cohort Study
    Peter Tschann, Markus P. Weigl, Patrick Clemens, Philipp Szeverinski, Christian Attenberger, Matthias Kowatsch, Tarkan Jäger, Klaus Emmanuel, Thomas Brock, Ingmar Königsrainer
    Nutrients.2023; 15(11): 2632.     CrossRef
  • One Decade of Declining Use of Defunctioning Stomas After Rectal Cancer Surgery in the Netherlands: Are We on the Right Track?
    Erik W. Ingwersen, Paulien J.K. van der Beek, Jan Willem T. Dekker, Susan van Dieren, Freek Daams
    Diseases of the Colon & Rectum.2023; 66(7): 1003.     CrossRef
  • Effects of Neoadjuvant Radiotherapy on Postoperative Complications in Rectal Cancer: A Meta-Analysis
    Jianguo Yang, Yajun Luo, Tingting Tian, Peng Dong, Zhongxue Fu, Irena Ilic
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Tailored Management with Highly-Selective Diversion for Low Colorectal Anastomosis: Biochemical Postoperative Follow-Up and Long-Term Results from a Single-Institution Cohort
    Philippe Rouanet, Marie Selvy, Marta Jarlier, Caroline Bugnon, Guillaume Carrier, Anne Mourregot, Pierre-Emmanuel Colombo, Christophe Taoum
    Annals of Surgical Oncology.2022; 29(4): 2514.     CrossRef
  • Are risk factors for anastomotic leakage influencing long-term oncological outcomes after low anterior resection of locally advanced rectal cancer with neoadjuvant therapy? A single-centre cohort study
    Peter Tschann, Markus P. Weigl, Philipp Szeverinski, Daniel Lechner, Thomas Brock, Stephanie Rauch, Jana Rossner, Helmut Eiter, Paolo N. C. Girotti, Tarkan Jäger, Jaroslav Presl, Klaus Emmanuel, Alexander De Vries, Ingmar Königsrainer, Patrick Clemens
    Langenbeck's Archives of Surgery.2022; 407(7): 2945.     CrossRef
  • Analysis of Risk Factors for Anastomotic Leakage After Laparoscopic Anterior Resection of Rectal Cancer and Construction of a Nomogram Prediction Model
    Keli Wang, Meijiao Li, Rui Liu, Yang Ji, Jin Yan
    Cancer Management and Research.2022; Volume 14: 2243.     CrossRef
  • Preoperative risk factors associated with anastomotic leakage after colectomy for colorectal cancer: a systematic review and meta-analysis
    VINÍCIUS EVANGELISTA DIAS, PEDRO ALVES SOARES VAZ DE CASTRO, HOMERO TERRA PADILHA, LARA VICENTE PILLAR, LAURA BOTELHO RAMOS GODINHO, AUGUSTO CLAUDIO DE ALMEIDA TINOCO, RODRIGO DA COSTA AMIL, ALEIDA NAZARETH SOARES, GERALDO MAGELA GOMES DA CRUZ, JULIANA MA
    Revista do Colégio Brasileiro de Cirurgiões.2022;[Epub]     CrossRef
  • Fatores de risco pré-operatórios associados à fístula anastomótica após colectomia para câncer colorretal: revisão sistemática e metanálise
    VINÍCIUS EVANGELISTA DIAS, PEDRO ALVES SOARES VAZ DE CASTRO, HOMERO TERRA PADILHA, LARA VICENTE PILLAR, LAURA BOTELHO RAMOS GODINHO, AUGUSTO CLAUDIO DE ALMEIDA TINOCO, RODRIGO DA COSTA AMIL, ALEIDA NAZARETH SOARES, GERALDO MAGELA GOMES DA CRUZ, JULIANA MA
    Revista do Colégio Brasileiro de Cirurgiões.2022;[Epub]     CrossRef
  • Risk Factors of Anastomotic Leakage After Anterior Resection for Rectal Cancer Patients
    Xiang-nan Yu, Lu-ming Xu, Ya-wen Bin, Ye Yuan, Shao-bo Tian, Bo Cai, Kai-xiong Tao, Lin Wang, Guo-bin Wang, Zheng Wang
    Current Medical Science.2022; 42(6): 1256.     CrossRef
  • Effect of pelvic drain displacement on anastomotic leakage-related morbidity after rectal cancer surgery
    Ho Yung Lee, Sung Il Kang, So Hyun Kim, Jae-Hwang Kim
    Journal of Minimally Invasive Surgery.2021; 24(3): 158.     CrossRef
  • Preoperative chemoradiotherapy versus surgery alone for advanced low rectal cancer: a large multicenter cohort study in Japan
    Tomonori Akagi, Masafumi Inomata, Hajime Fujishima, Meiki Fukuda, Tsuyoshi Konishi, Shunsuke Tsukamoto, Fuminori Teraishi, Heita Ozawa, Keitaro Tanaka, Koya Hida, Yoshiharu Sakai, Masahiko Watanabe
    Surgery Today.2020; 50(11): 1507.     CrossRef
Original Articles
Sensitivity of Various Evaluating Modalities for Predicting a Pathologic Complete Response After Preoperative Chemoradiation Therapy for Locally Advanced Rectal Cancer
Sungwoo Jung, Anuj Parajuli, Chang Sik Yu, Seong Ho Park, Jong Seok Lee, Ah Young Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Ann Coloproctol. 2019;35(5):275-281.   Published online October 31, 2019
DOI: https://doi.org/10.3393/ac.2019.01.07
  • 6,307 View
  • 87 Download
  • 3 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
We investigated the sensitivity of various evaluating modalities in predicting a pathologic complete response (pCR) after preoperative chemoradiation therapy (PCRT) for locally advanced rectal cancer (LARC).
Methods
From a population of 2,247 LARC patients who underwent PCRT followed by surgery at Asan Medical Center, Seoul, Korea from January 2007 to June 2016, we retrospectively analyzed 313 patients (14.1%) who showed a pCR after surgery. Transrectal ultrasound (TRUS), high-resolution magnetic resonance imaging (MRI), abdominopelvic computed tomography (AP-CT), and endoscopy were performed within 2 weeks prior to surgery.
Results
Of the 313 patients analyzed, 256 (81.8%) had a pCR after radical surgery and 57 (18.2%) showed total regression after local excision. Preoperative TRUS, MRI, and AP-CT were performed in 283, 305, and 139 patients, respectively. Among these 3 groups, a prediction of a pCR of the primary tumor was made in 41 (14.5%), 51 (16.7%), and 27 patients (19.4%), respectively, before surgery. A prediction of a clinical N0 stage was made in 204 patients (88.3%) using TRUS, 130 (52.2%) using MRI, and 78 (65.5%) using AP-CT. Of the 211 patients who underwent endoscopy, 87 (41.2%) had a mention of clinical CR in their records. A prediction of a pathologic CR was made for 124 patients (39.6%) through at least one diagnostic modality.
Conclusion
The various evaluation methods for predicting a pCR after PCRT show a predictive sensitivity of 0.15–0.41 for primary tumors and 0.52–0.88 for lymph nodes. Endoscopy is a relatively superior modality for predicting the pCR of the primary tumor of LARC patients.

Citations

Citations to this article as recorded by  
  • Comparison between Local Excision and Radical Resection for the Treatment of Rectal Cancer in ypT0-1 Patients: An Analysis of the Clinicopathological Factors and Survival Rates
    Soo Young Oh, In Ja Park, Young IL Kim, Jong-Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Cancers.2021; 13(19): 4823.     CrossRef
  • Predicting Neoadjuvant Chemoradiotherapy Response in Locally Advanced Rectal Cancer Using Tumor-Infiltrating Lymphocytes Density
    Yao Xu, Xiaoying Lou, Yanting Liang, Shenyan Zhang, Shangqing Yang, Qicong Chen, Zeyan Xu, Minning Zhao, Zhenhui Li, Ke Zhao, Zaiyi Liu
    Journal of Inflammation Research.2021; Volume 14: 5891.     CrossRef
  • A Nine-Gene Signature for Predicting the Response to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer
    In Ja Park, Yun Suk Yu, Bilal Mustafa, Jin Young Park, Yong Bae Seo, Gun-Do Kim, Jinpyo Kim, Chang Min Kim, Hyun Deok Noh, Seung-Mo Hong, Yeon Wook Kim, Mi-Ju Kim, Adnan Ahmad Ansari, Luigi Buonaguro, Sung-Min Ahn, Chang-Sik Yu
    Cancers.2020; 12(4): 800.     CrossRef
Long-term Transanal Excision Outcomes in Patients With T1 Rectal Cancer: Comparative Analysis of Radical Resection
Yunghuyn Hwang, Yong Sik Yoon, Jun Woo Bong, Hye Yun Choi, In Ho Song, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2019;35(4):194-201.   Published online August 31, 2019
DOI: https://doi.org/10.3393/ac.2018.10.18.2
  • 7,805 View
  • 148 Download
  • 16 Web of Science
  • 18 Citations
AbstractAbstract PDF
Purpose
Transanal excision (TAE) is an alternative surgical procedure for early rectal cancer. This study compared long-term TAE outcomes, in terms of survival and local recurrence (LR), with total mesorectal excision (TME) in patients with pathologically confirmed T1 rectal cancer.
Methods
T1 rectal adenocarcinoma patients who underwent surgery from 1990 to 2011 were retrospectively reviewed. Patients that were suspected to have preoperative lymph node metastasis were excluded. Demographics, recurrence, and survival were analyzed based on TAE and TME surgery.
Results
Of 268 individuals, 61 patients (26%) underwent TAE, which was characterized by proximity to the anus, submucosal invasion depth, and lesion infiltration, compared with TME patients (P < 0.001–0.033). During a median follow-up of 10.4 years, 12 patients had systemic and/or LR. Ten-year cancer-specific survival in the TAE and TME groups was not significantly different (98% vs. 100%). However, the 10-year LR rate in the TAE group was greater than that of TME group (10% vs. 0%, P < 0.001). Although 5 of the 6 TAE patients with LR underwent salvage surgery, one of the patients eventually died. The TAE surgical procedure (hazard ratio, 19.066; P = 0.007) was the only independent risk factor for LR.
Conclusion
Although long-term survival after TAE was comparable to that after TME, TAE had a greater recurrence risk than TME. Thus, TAE should only be considered as an alternative surgical option for early rectal cancer in selected patients.

Citations

Citations to this article as recorded by  
  • Local resection in rectal cancer: When, who and how?
    Jesus Badia-Closa, Juan Pablo Campana, Gustavo Leandro Rossi, Xavier Serra-Aracil
    Cirugía Española (English Edition).2025; 103(4): 244.     CrossRef
  • Resección local en cáncer de recto: ¿cuándo, a quién y cómo?
    Jesus Badia-Closa, Juan Pablo Campana, Gustavo Leandro Rossi, Xavier Serra-Aracil
    Cirugía Española.2025; 103(4): 244.     CrossRef
  • Transanal excision in early rectal cancer
    Marija Nikolić, Nemanja Trifunović, Damir Jašarović, Tanja Abazović, Milica Radivojević, Nebojša Mitrović
    Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma.2025; 30(97): 28.     CrossRef
  • Short- and long-term outcomes of local excision with adjuvant radiotherapy in high-risk T1 rectal cancer patients
    Abdullah Al-Sawat, Jung Hoon Bae, Hyun Ho Kim, Chul Seung Lee, Seung Rim Han, Yoon Suk Lee, Hyeon-Min Cho, Hong Seok Jang, In Kyu Lee
    Annals of Surgical Treatment and Research.2022; 102(1): 36.     CrossRef
  • The Role of Transanal Endoscopic Surgery for Early Rectal Cancer
    Natalie F. Berger, Patricia Sylla
    Clinics in Colon and Rectal Surgery.2022; 35(02): 113.     CrossRef
  • Multidisciplinary treatment strategy for early rectal cancer
    Gyung Mo Son, In Young Lee, Sung Hwan Cho, Byung-Soo Park, Hyun Sung Kim, Su Bum Park, Hyung Wook Kim, Sang Bo Oh, Tae Un Kim, Dong Hoon Shin
    Precision and Future Medicine.2022; 6(1): 32.     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
  • Early-rectal Cancer Treatment: A Decision-tree Making Based on Systematic Review and Meta-analysis
    Ignacio Aguirre-Allende, Jose Maria Enriquez-Navascues, Garazi Elorza-Echaniz, Ane Etxart-Lopetegui, Nerea Borda-Arrizabalaga, Yolanda Saralegui Ansorena, Carlos Placer-Galan
    Cirugía Española.2021; 99(2): 89.     CrossRef
  • Oncological Outcomes of Transanal Endoscopic Microsurgery Plus Adjuvant Chemoradiotherapy for Patients with High-Risk T1 and T2 Rectal Cancer
    Kang Xu, Yulin Liu, Peng Yu, Wei Shang, Yongbo Zhang, Mingwen Jiao, Zhonghui Cui, Lijian Xia, Jingbo Chen
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(9): 1006.     CrossRef
  • Early-rectal Cancer Treatment: A Decision-tree Making Based on Systematic Review and Meta-analysis
    Ignacio Aguirre-Allende, Jose Maria Enriquez-Navascues, Garazi Elorza-Echaniz, Ane Etxart-Lopetegui, Nerea Borda-Arrizabalaga, Yolanda Saralegui Ansorena, Carlos Placer-Galan
    Cirugía Española (English Edition).2021; 99(2): 89.     CrossRef
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer
    Karin M. Hardiman, Seth I. Felder, Garrett Friedman, John Migaly, Ian M. Paquette, Daniel L. Feingold
    Diseases of the Colon & Rectum.2021; 64(5): 517.     CrossRef
  • The risk factors of local recurrence and distant metastasis on pT1/T2N0 mid-low rectal cancer after total mesorectal excision
    I-Li Lai, Jeng-Fu You, Yih-Jong Chern, Wen-Sy Tsai, Jy-Ming Chiang, Pao-Shiu Hsieh, Hsin-Yuan Hung, Yu-Jen Hsu
    World Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • Prognostic Factors and Treatment of Recurrence after Local Excision of Rectal Cancer
    Moon Suk Choi, Jung Wook Huh, Jung Kyong Shin, Yoon Ah Park, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee
    Yonsei Medical Journal.2021; 62(12): 1107.     CrossRef
  • New morphological risk factors for metastasis to regional lymph nodes in rectal cancer with invasion into the submucosa
    O. A. Maynovskaya, E. G. Rybakov, S. V. Chernyshov, Yu. A. Shelygin, S. I. Achkasov
    Koloproktologia.2021; 20(4): 22.     CrossRef
  • Surgical Treatment of Low-Lying Rectal Cancer: Updates
    Cristopher Varela, Nam Kyu Kim
    Annals of Coloproctology.2021; 37(6): 395.     CrossRef
  • Comparison of the transanal surgical techniques for local excision of rectal tumors: a network meta-analysis
    Konstantinos Perivoliotis, Ioannis Baloyiannis, Chamaidi Sarakatsianou, George Tzovaras
    International Journal of Colorectal Disease.2020; 35(7): 1173.     CrossRef
  • What Should Be Considered for Local Excision in Early Rectal Cancer?
    Taesung Ahn
    Annals of Coloproctology.2019; 35(4): 155.     CrossRef
  • Survival analysis of local excision vs total mesorectal excision for middle and low rectal cancer in pT1/pT2 stage and intermediate pathological risk
    I-Li Lai, Jeng-Fu You, Yih-Jong Chern, Wen-Sy Tsai, Jy-Ming Chiang, Pao-Shiu Hsieh, Hsin-Yuan Hung, Chien-Yuh Yeh, Sum-Fu Chiang, Cheng-Chou Lai, Rei-Ping Tang, Jinn-Shiun Chen, Yu-Jen Hsu
    World Journal of Surgical Oncology.2019;[Epub]     CrossRef
Oncologic Outcomes of Organ Preserving Approaches in Patients With Rectal Cancer Treated With Preoperative Chemoradiotherapy
In Ja Park, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2019;35(2):65-71.   Published online April 30, 2019
DOI: https://doi.org/10.3393/ac.2019.03.17
  • 5,805 View
  • 129 Download
  • 14 Web of Science
  • 14 Citations
AbstractAbstract PDF
Purpose
We evaluated the oncologic outcomes of organ-preserving strategies in patients with rectal cancer treated with preoperative chemoradiotherapy (PCRT).
Methods
Between January 2008 and January 2013, 74 patients who underwent wait-and-watch (WW) (n = 42) and local excision (LE) (n = 32) were enrolled. Organ-preserving strategies were determined based on a combination of magnetic resonance imaging, sigmoidoscopy, and physical examination 4–6 weeks after completion of PCRT. The rectum sparing rate, 5-year recurrence-free survival (RFS), and overall survival (OS) were evaluated.
Results
The rectum was more frequently spared in the LE (100% vs. 87.5%, P = 0.018) at last follow-up. Recurrence occurred in 9 (28.1%) WW and 7 (16.7%) LE (P = 0.169). In the WW, 7 patients had only luminal regrowth and 2 had combined lung metastasis. In the LE, 2 (4.8%) had local recurrence only, 4 patients had distant metastasis, and 1 patient had local and distant metastasis. Among 13 patients who indicated salvage surgery (WW, n = 7; LE, n = 11), all in the WW received but all of LE refused salvage surgery (P = 0.048). The 5-year OS and 5-year RFS in overall patients was 92.7% and 76.9%, respectively, and were not different between WW and LE (P = 0.725, P = 0.129).
Conclusion
WW and LE were comparable in terms of 5-year OS and RFS. In the LE group, salvage treatment was performed much less among indicated patients. Therefore, methods to improve the oncologic outcomes of patients indicated for salvage treatment should be considered before local excision.

Citations

Citations to this article as recorded by  
  • Effectiveness of Organ Preservation for Locally Advanced Rectal Cancer With Complete Clinical Response After Neoadjuvant Chemoradiotherapy: Bayesian Network Meta-analysis
    Kaibo Ouyang, Zifeng Yang, Yuesheng Yang, Zejian Lyu, Junjiang Wang, Yong Li
    Diseases of the Colon & Rectum.2025; 68(3): 287.     CrossRef
  • Rectal cancer approach strategies after neoadjuvant treatment – a systematic review and network meta-analysis
    Cong Meng, Wenlong Shu, Liting Sun, Si Wu, Pengyu Wei, Jiale Gao, Jinyao Shi, Yang Li, Zhengyang Yang, Hongwei Yao, Zhongtao Zhang
    International Journal of Surgery.2025; 111(4): 3078.     CrossRef
  • Rectal Sparing Approaches after Neoadjuvant Treatment for Rectal Cancer: A Systematic Review and Meta-Analysis Comparing Local Excision and Watch and Wait
    Quoc Riccardo Bao, Stefania Ferrari, Giulia Capelli, Cesare Ruffolo, Marco Scarpa, Amedea Agnes, Giuditta Chiloiro, Elisa Palazzari, Emanuele Damiano Luca Urso, Salvatore Pucciarelli, Gaya Spolverato
    Cancers.2023; 15(2): 465.     CrossRef
  • Organ preservation for early rectal cancer using preoperative chemoradiotherapy
    Gyung Mo Son
    Annals of Coloproctology.2023; 39(3): 191.     CrossRef
  • Can pretreatment platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios predict long-term oncologic outcomes after preoperative chemoradiation followed by surgery for locally advanced rectal cancer?
    Sang Hyun An, Ik Yong Kim
    Annals of Coloproctology.2022; 38(3): 253.     CrossRef
  • Multidisciplinary treatment strategy for early rectal cancer
    Gyung Mo Son, In Young Lee, Sung Hwan Cho, Byung-Soo Park, Hyun Sung Kim, Su Bum Park, Hyung Wook Kim, Sang Bo Oh, Tae Un Kim, Dong Hoon Shin
    Precision and Future Medicine.2022; 6(1): 32.     CrossRef
  • Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
    Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
    Annals of Coloproctology.2022; 38(2): 97.     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
  • The watch-and-wait strategy versus radical resection for rectal cancer patients with a good response (≤ycT2) after neoadjuvant chemoradiotherapy
    Chungyeop Lee, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Annals of Surgical Treatment and Research.2022; 103(6): 350.     CrossRef
  • Improvement in the Assessment of Response to Preoperative Chemoradiotherapy for Rectal Cancer Using Magnetic Resonance Imaging and a Multigene Biomarker
    Eunhae Cho, Sung Woo Jung, In Ja Park, Jong Keon Jang, Seong Ho Park, Seung-Mo Hong, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Cancers.2021; 13(14): 3480.     CrossRef
  • Comparison between Local Excision and Radical Resection for the Treatment of Rectal Cancer in ypT0-1 Patients: An Analysis of the Clinicopathological Factors and Survival Rates
    Soo Young Oh, In Ja Park, Young IL Kim, Jong-Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Cancers.2021; 13(19): 4823.     CrossRef
  • Functional outcomes after sphincter-preserving surgeries for low-lying rectal cancer: A review
    Eun Jung Park, Seung Hyuk Baik
    Precision and Future Medicine.2021; 5(4): 164.     CrossRef
  • The risk of distant metastases in rectal cancer managed by a watch-and-wait strategy – A systematic review and meta-analysis
    Joanna Socha, Lucyna Kępka, Wojciech Michalski, Karol Paciorek, Krzysztof Bujko
    Radiotherapy and Oncology.2020; 144: 1.     CrossRef
  • From Total Mesorectal Excision to Organ Preservation for the Treatment of Rectal Cancer
    Seong Kyu Baek
    Annals of Coloproctology.2019; 35(2): 51.     CrossRef
Variation in the Height of Rectal Cancers According to the Diagnostic Modalities
Seung-Seop Yeom, In Ja Park, Dong-Hoon Yang, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Sung Ho Park, Hwa Jung Kim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2019;35(1):24-29.   Published online February 28, 2019
DOI: https://doi.org/10.3393/ac.2018.07.31
  • 8,282 View
  • 123 Download
  • 13 Web of Science
  • 13 Citations
AbstractAbstract PDF
Purpose
Although the height of a rectal tumor above the anal verge (tumor height) partly determines the treatment strategy, no practical standard exists for reporting this. We aimed to demonstrate the differences in tumor height according to the diagnostic modality used for its measurement.
Methods
We identified 100 patients with rectal cancers located within 15 cm of the anal verge who had recorded tumor heights measured by using magnetic resonance imaging (MRI), colonoscopy, and digital rectal examination (DRE). Tumor height measured by using MRI was compared with those measured by using DRE and colonoscopy to assess reporting inconsistencies. Factors associated with differences in tumor height among the modalities were also evaluated.
Results
The mean tumor heights were 77.8 ± 3.3, 52.9 ± 2.3, and 68.9 ± 3.1 mm when measured by using MRI, DRE, and colonoscopy, respectively (P < 0.001). Agreement among the 3 modalities in terms of tumor sublocation within the rectum was found in only 39% of the patients. In the univariate and the multivariate analyses, clinical stage showed a possible association with concordance among modalities, but age, sex, and luminal location of the tumor were not associated with differences among modalities.
Conclusion
The heights of rectal cancer differed according to the diagnostic modality. Tumor height has implications for rectal cancer’s surgical planning and for interpreting comparative studies. Hence, a consensus is needed for measuring and reporting tumor height.

Citations

Citations to this article as recorded by  
  • The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study
    Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda
    BMC Surgery.2025;[Epub]     CrossRef
  • Defining the tumor location in rectal cancer – Practice variations and impact on treatment decision making
    Elisabeth P. Goedegebuure, Francesco M. Arico, Max J. Lahaye, Monique Maas, Geerard L. Beets, Femke P. Peters, Monique E. van Leerdam, Regina G.H. Beets-Tan, Doenja M.J. Lambregts
    European Journal of Surgical Oncology.2025; 51(6): 109700.     CrossRef
  • Neoadjuvant Radiotherapy vs Up-Front Surgery for Resectable Locally Advanced Rectal Cancer
    Po-Chuan Chen, Avery Shuei-He Yang, Alessandro Fichera, Mu-Hung Tsai, Yuan-Hua Wu, Yu-Min Yeh, Yu Shyr, Edward Chia-Cheng Lai, Chao-Han Lai
    JAMA Network Open.2025; 8(5): e259049.     CrossRef
  • Standard of practice imaging vs. PET/MR: a comparative prospective study in rectal cancer staging
    Rafał Maksim, Angelika Buczyńska, Iwona Sidorkiewicz, Małgorzata Mojsak, Justyna Śliwowska-Burzyńska, Konrad Zuzda, Patryk Gugnacki, Adam Krętowski, Ewa Sierko
    International Journal of Colorectal Disease.2025;[Epub]     CrossRef
  • Effects of Adjuvant Chemotherapy on Oncologic Outcomes in Patients With Stage ⅡA Rectal Cancer Above the Peritoneal Reflection Who Did Not Undergo Preoperative Chemoradiotherapy
    Hyo Seon Ryu, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Yong Sang Hong, Tae Won Kim, Chang Sik Yu
    Clinical Colorectal Cancer.2024; 23(4): 392.     CrossRef
  • Interrater Agreement of Height Assessment by Rigid Proctoscopy/Rectoscopy for Rectal Carcinoma
    Matthias Kraemer, Sarkhan Nabiyev, Silvia Kraemer, Stephanie Schipmann
    Diseases of the Colon & Rectum.2024; 67(8): 1018.     CrossRef
  • Chinese national clinical practice guidelines on prevention, diagnosis and treatment of early colorectal cancer
    Jingnan Li, Hongwei Yao, Yun Lu, Shutian Zhang, Zhongtao Zhang
    Chinese Medical Journal.2024; 137(17): 2017.     CrossRef
  • Review of definition and treatment of upper rectal cancer
    Elias Karam, Fabien Fredon, Yassine Eid, Olivier Muller, Marie Besson, Nicolas Michot, Urs Giger-Pabst, Arnaud Alves, Mehdi Ouaissi
    Surgical Oncology.2024; 57: 102145.     CrossRef
  • Comparison of flexible endoscopy and magnetic resonance imaging in determining the tumor height in rectal cancer
    Mohammed H. Basendowah, Mohammed A. Ezzat, Aseel H. Khayyat, Eyad Saleh A. Alamri, Turki A. Madani, Anas H. Alzahrani, Rana Y. Bokhary, Arwa O. Badeeb, Hussam A. Hijazi
    Cancer Reports.2023;[Epub]     CrossRef
  • Measuring Rectal Cancer Tumor Height: Concordance Between Clinical Examination and MRI
    Shannon M. Navarro, Shuai Chen, Linda M. Farkas
    Diseases of the Colon & Rectum.2022; 65(4): 497.     CrossRef
  • How do they measure up: Assessing the height of rectal cancer with digital rectal exam, endoscopy, and MRI,,
    Jordan Wlodarczyk, Kshitij Gaur, Nicholas Serniak, Kevin Mertz, Jason Muri, Sarah Koller, Sang W. Lee, Kyle G. Cologne
    Surgery in Practice and Science.2022; 10: 100096.     CrossRef
  • Measurement of rectal tumor height from the anal verge on MRI: a comparison of internal versus external anal sphincter
    David D. B. Bates, James L. Fuqua, Junting Zheng, Marinela Capanu, Jennifer S. Golia Pernicka, Sidra Javed-Tayyab, Viktoriya Paroder, Iva Petkovska, Marc J. Gollub
    Abdominal Radiology.2021; 46(3): 867.     CrossRef
  • Robotic Intersphincteric Resection for Low Rectal Cancer: Technical Controversies and a Systematic Review on the Perioperative, Oncological, and Functional Outcomes
    Guglielmo Niccolò Piozzi, Seon Hahn Kim
    Annals of Coloproctology.2021; 37(6): 351.     CrossRef
Does the Different Locations of Colon Cancer Affect the Oncologic Outcome? A Propensity-Score Matched Analysis
Kwan Mo Yang, In Ja Park, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Na Young Kim, Shinae Hong, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2019;35(1):15-23.   Published online February 28, 2019
DOI: https://doi.org/10.3393/ac.2018.07.25
  • 5,553 View
  • 125 Download
  • 4 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
We evaluate the prognostic value of primary tumor location for oncologic outcomes in patients with colon cancer (CC).
Methods
CC patients treated with curative surgery between 2009 and 2012 were classified into 2 groups: right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Recurrence-free survival (RFS) and overall survival (OS) were examined based on tumor stage. Propensity scores were created using eight variables (age, sex, T stage, N stage, histologic grade, presence of lymphovascular invasion/perineural invasion, and microsatellite instability status).
Results
Overall, 2,329 patients were identified. The 5-year RFSs for RCC and LCC patients were 89.7% and 88.4% (P = 0.328), respectively, and their 5-year OSs were 90.9% and 93.4% (P = 0.062). Multivariate survival analyses were carried out by using the Cox regression proportional hazard model. In the unadjusted analysis, a marginal increase in overall mortality was seen in RCC patients (hazard ratio [HR], 1.297; 95% confidence interval [CI], 0.987–1.704, P = 0.062); however, after multivariable adjustment, similar OSs were observed in those patients (HR, 1.219; 95% CI, 0.91–1.633; P = 0.183). After propensity-score matching with a total of 1,560 patients, no significant difference was identified (P = 0.183). A slightly worse OS was seen for stage III RCC patients (HR, 1.561; 95% CI, 0.967–2.522; P = 0.068) than for stage III LCC patients. The 5-year OSs for patients with stage III RCC and stage III LCC were 85.5% and 90.5%, respectively (P = 0.133).
Conclusion
Although the results are inconclusive, tumor location tended to be associated with OS in CC patients with lymph node metastasis, but it was not related to oncologic outcome.

Citations

Citations to this article as recorded by  
  • Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis
    Hanieh Gholamalizadeh, Nima Zafari, Mahla Velayati, Hamid Fiuji, Mina Maftooh, Elnaz Ghorbani, Seyed Mahdi Hassanian, Majid Khazaei, Gordon A. Ferns, Elham Nazari, Amir Avan
    Clinical and Experimental Medicine.2023; 23(8): 4369.     CrossRef
  • Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation
    Kristian-Christos Ngamsri, Christoph Jans, Rizki A. Putri, Katharina Schindler, Jutta Gamper-Tsigaras, Claudia Eggstein, David Köhler, Franziska M. Konrad
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Left colon as a novel high-risk factor for postoperative recurrence of stage II colon cancer
    Liming Wang, Yasumitsu Hirano, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Nao Obara, Shigeki Yamaguchi
    World Journal of Surgical Oncology.2020;[Epub]     CrossRef
Trephine Transverse Colostomy Is Effective for Patients Who Have Previously Undergone Rectal Surgery
Seung-Seop Yeom, Chan Wook Kim, Sung Woo Jung, Se Heon Oh, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2018;34(2):72-77.   Published online April 30, 2018
DOI: https://doi.org/10.3393/ac.2017.09.29
  • 8,070 View
  • 153 Download
  • 4 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
Colostomy creation is an essential procedure for colorectal surgeons, but the preferred method of colostomy varies by surgeon. We compared the outcomes of trephine colostomy creation with open those for the (laparotomy) and laparoscopic methods and evaluated appropriate indications for a trephine colostomy and the advantages of the technique.
Methods
We retrospectively evaluated 263 patients who had undergone colostomy creation by trephine, open and laparoscopic approaches between April 2006 and March 2016. We compared the clinical features and the operative and postoperative outcomes according to the approach used for stoma creation.
Results
One hundred sixty-three patients (62%) underwent colostomy surgery for obstructive causes and 100 (38%) for fistulous problems. The mean operative time was significantly shorter with the trephine approach (trephine, 46.0 ± 1.9 minutes; open, 78.7 ± 3.9 minutes; laparoscopic, 63.5 ± 5.0 minutes; P < 0.001), as was the time to flatus (1.8 ± 0.1 days, 2.1 ± 0.1 days, 2.2 ± 0.3 days, P = 0.025). Postoperative complications (<30 days) were not different among the 3 approaches (trephine, 4.3%; open, 1.2%; laparoscopic, 0%; P = 0.828). In patients who underwent rectal surgery, a trephine colostomy was feasible for a diversion colostomy (P < 0.001).
Conclusion
The trephine colostomy is safe and can be implemented quickly in various situations, and compared to other colostomy procedures, the patient’s recovery is faster. Previous laparotomy history was not a contraindication for a trephine colostomy, and a trephine transverse colostomy is feasible for patients who have undergone previous rectal surgery.

Citations

Citations to this article as recorded by  
  • Non-operative management of gallstone sigmoid ileus in a patient with a prostatic cancer
    Ahmed M AlMuhsin, Abdulaziz Bazuhair, Omar AlKhlaiwy, Rami O Abu Hajar, Thabit Alotaibi
    Journal of Surgical Case Reports.2023;[Epub]     CrossRef
  • Comparison of blowhole colostomy and loop ostomy for palliation of acute malignant colonic obstruction
    Yongjun Park, Dong Uk Choi, Hyung Ook Kim, Yong Bog Kim, Chungki Min, Jung Tack Son, Sung Ryol Lee, Kyung Uk Jung, Hungdai Kim
    Annals of Coloproctology.2022; 38(4): 319.     CrossRef
  • Minimally invasive colostomy with endoscopy as a novel technique for creation of a trephine stoma
    Teppei Kamada, Hironori Ohdaira, Junji Takahashi, Wataru Kai, Keigo Nakashima, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Yutaka Suzuki
    Scientific Reports.2021;[Epub]     CrossRef
Does Anastomosis Configuration Influence Long-term Outcomes in Patients With Crohn Disease?
Parajuli Anuj, Yong Sik Yoon, Chang Sik Yu, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Ann Coloproctol. 2017;33(5):173-177.   Published online October 31, 2017
DOI: https://doi.org/10.3393/ac.2017.33.5.173
  • 5,893 View
  • 71 Download
  • 10 Web of Science
  • 9 Citations
AbstractAbstract PDF
Purpose

In this study, we evaluated the role of various anastomoses in surgical recurrence for patients with Crohn disease (CD).

Methods

We analyzed data retrospectively from consecutive laparotomy cases involving complicated CD between 1991 and 2008. Clinical data were compared in terms of reoperation-free survival (RFS) according to the types of anastomoses, the materials used for the anastomoses, and the operating surgeon.

Results

Of 233 patients with entero-enteric or entero-colic anastomoses, 199 (85%), 11 (5%), and 23 (10%) experienced side-to-side (SS), side-to-end (SE), and end-to-end (EE) anastomoses, respectively. The SS group had the following characteristics: more extensive bowel involvement, frequent obstruction, and greater stapler use; the SS anastomoses were also frequently made by specialized surgeons (P < 0.001–0.004). EE anastomoses were frequently made by general surgeons using a hand-sewing technique (P < 0.001). No differences in RFS were noted among the 3 groups according to the type of anastomosis and the operating surgeon. However, the hand-sewn group showed better RFS than the stapler group (P = 0.04).

Conclusion

The roles of the anastomotic configuration, the material used, and the operating surgeon were not significantly correlated with reoperations or complications in our retrospective CD cohort, irrespective of the higher risk of anastomosis site stricture for EE anastomoses.

Citations

Citations to this article as recorded by  
  • Anastomosis after Bowel Resection for Crohn's Disease: State of the Art Review
    Carla Newton, Alessandro Fichera
    Clinics in Colon and Rectal Surgery.2025; 38(02): 104.     CrossRef
  • Advances in endoscopy in IBD diagnostics and management
    Joana Roseira, Maria Manuela Estevinho, Beatriz Gros, Irene Marafini, Virginia Solitano, Paula Sousa, Cristina Carretero, Winnie Zou, Nasim Parsa, Aline Charabaty, Lumir Kunovsky
    Best Practice & Research Clinical Gastroenterology.2025; 78: 102055.     CrossRef
  • New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease
    Jong Lyul Lee, Yong Sik Yoon, Hyun Gu Lee, Young Il Kim, Min Hyun Kim, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
    World Journal of Gastrointestinal Surgery.2024; 16(8): 2592.     CrossRef
  • Results of the Eighth Scientific Workshop of ECCO: Pathophysiology and Risk Factors of Postoperative Crohn’s Disease Recurrence after an Ileocolonic Resection
    Pauline Rivière, Gabriele Bislenghi, Nassim Hammoudi, Bram Verstockt, Steven Brown, Melissa Oliveira-Cunha, Willem Bemelman, Gianluca Pellino, Paulo Gustavo Kotze, Gabriele Dragoni, Mariangela Allocca, Nurulamin M Noor, Lieven Pouillon, Míriam Mañosa, Edo
    Journal of Crohn's and Colitis.2023; 17(10): 1557.     CrossRef
  • Ileocolic Resection for Crohn Disease: The Influence of Different Surgical Techniques on Perioperative Outcomes, Recurrence Rates, and Endoscopic Surveillance
    Benjamin Click, Amit Merchea, Dorin T Colibaseanu, Miguel Regueiro, Francis A Farraye, Luca Stocchi
    Inflammatory Bowel Diseases.2022; 28(2): 289.     CrossRef
  • Anastomotic Techniques for Abdominal Crohn's Disease: Tricks and Tips
    Marco Bertucci Zoccali, Alessandro Fichera
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(8): 861.     CrossRef
  • Short-term and long-term outcomes of laparoscopic vs open ileocolic resection in patients with Crohn's disease: Propensity-score matching analysis
    Shin Jeong Pak, Young Il Kim, Yong Sik Yoon, Jong Lyul Lee, Jung Bok Lee, Chang Sik Yu
    World Journal of Gastroenterology.2021; 27(41): 7159.     CrossRef
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surgical Management of Crohn’s Disease
    Amy L. Lightner, Jon D. Vogel, Joseph C. Carmichael, Deborah S. Keller, Samir A. Shah, Uma Mahadevan, Sunanda V. Kane, Ian M. Paquette, Scott R. Steele, • Daniel L. Feingold
    Diseases of the Colon & Rectum.2020; 63(8): 1028.     CrossRef
  • Correlation Between Anastomotic Configuration and Long-term Outcomes in Surgery for Crohn Disease
    Jin-Su Kim, Ji-Yeon Kim
    Annals of Coloproctology.2017; 33(5): 159.     CrossRef
Transanal Minimally-Invasive Surgery for Treating Patients With Regressed Rectal Cancer After Preoperative Chemoradiotherapy
Byoung Chul Lee, Seonok Oh, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Ann Coloproctol. 2017;33(2):52-56.   Published online April 28, 2017
DOI: https://doi.org/10.3393/ac.2017.33.2.52
  • 5,909 View
  • 73 Download
  • 8 Web of Science
  • 8 Citations
AbstractAbstract PDF
Purpose

Although the standard treatment for patients with locally advanced rectal cancer managed by preoperative chemoradiotherapy (CRT) is a radical resection, local excisions are used in highly-selective cases. Recently, transanal minimally-invasive surgery (TAMIS) has emerged as a feasible technique for local excision of midrectal lesions. We assess the feasibility of using TAMIS to treat patients with locally advanced rectal cancer who showed good response to CRT.

Methods

From October 2010 to June 2013, 35 consecutive patients with rectal cancer managed by using preoperative CRT underwent TAMIS. After a single-incision laparoscopic surgery port had been introduced into the anal canal, a full-thickness local excision with conventional laparoscopic instruments was performed. We retrospectively reviewed a prospectively collected database of these cases.

Results

Of the 35 patients analyzed, 18 showed pathologic complete responses and 17 had residual lesions (2 ypTis, 4 ypT1, 9 ypT2, and 2 ypT3); 34 (97.1%) showed clear deep, lateral margins. The median distance of lesions from the anal verge was 5 cm. All procedures were completed laparoscopically, and the median operating time was 84 minutes. No intraoperative events or morbidities were seen in any of the patients, except one with wound dehiscence, who was treated conservatively. The median postoperative hospital stay and follow-up period were 4 days and 36 months, respectively. During the study period, no patients died, but 5 (14.3%) experienced recurrence, including one recurrence at the TAMIS site.

Conclusion

TAMIS seems to be a feasible, safe modality for treating patients with locally advanced rectal cancer who show good response to preoperative CRT.

Citations

Citations to this article as recorded by  
  • TAMIS: New Horizons in Modern Colorectal Surgery
    Nurhilal Kızıltoprak, Jack Aaron, Camila Diez, Sam Atallah
    Turkish Journal of Colorectal Disease.2025; 35(2): 33.     CrossRef
  • Multidisciplinary treatment strategy for early rectal cancer
    Gyung Mo Son, In Young Lee, Sung Hwan Cho, Byung-Soo Park, Hyun Sung Kim, Su Bum Park, Hyung Wook Kim, Sang Bo Oh, Tae Un Kim, Dong Hoon Shin
    Precision and Future Medicine.2022; 6(1): 32.     CrossRef
  • Minimally Invasive Treatment of a Completely Obstructed Rectal Anastomosis by Using a Transanal Plasmakinetic Resectoscope: a Case Report and Review of Literature
    Na Wang, Daguang Wang, Weihua Tong, Jinguo Wang
    Indian Journal of Surgery.2021; 83(5): 1127.     CrossRef
  • Transanal minimally invasive surgery using laparoscopic instruments of the rectum: A review
    Myung Jo Kim, Taek-Gu Lee
    World Journal of Gastrointestinal Surgery.2021; 13(10): 1149.     CrossRef
  • Transanal Minimally Invasive Surgery: A Promising Alternative for Certain Advanced Rectal Cancer Patients
    Hernan A. Sanchez-Trejo, Daniel Hakakian, Terrence Curran, Luca Antonioli, Balazs Csoka, Zoltan H. Nemeth
    Journal of Investigative Surgery.2019; 32(4): 377.     CrossRef
  • Transanal minimally invasive surgery as a treatment option for a completely occluded anastomosis after low anterior resection: A new approach to severe anastomotic stenosis
    Jun Woo Bong, Seok‐Byung Lim
    Asian Journal of Endoscopic Surgery.2019; 12(2): 175.     CrossRef
  • A systematic review and meta-analysis of pT2 rectal cancer spread and recurrence pattern: Implications for target design in radiation therapy for organ preservation
    Joanna Socha, Lucyna Pietrzak, Anna Zawadzka, Anna Paciorkiewicz, Anna Krupa, Krzysztof Bujko
    Radiotherapy and Oncology.2019; 133: 20.     CrossRef
  • Transanal Minimally Invasive Surgery After Chemoradiotherapy: Widening Scope of Indications for Local Excision
    Min Jung Kim, Jae Hwan Oh
    Annals of Coloproctology.2017; 33(2): 43.     CrossRef
Prognostic Factors in Terms of the Number of Metastatic Nodules in Patients With Colorectal Cancer Liver Metastases
Ki Ung Jang, Chan Wook Kim, Ki-Hun Kim, Seok-Byung Lim, Chang Sik Yu, Tae Won Kim, Pyo Nyun Kim, Jong Hoon Kim, Jin Cheon Kim
Ann Coloproctol. 2016;32(3):92-100.   Published online June 30, 2016
DOI: https://doi.org/10.3393/ac.2016.32.3.92
  • 6,649 View
  • 39 Download
  • 17 Web of Science
  • 14 Citations
AbstractAbstract PDF
Purpose

The hepatic resection is the gold-standard treatment for patients with colorectal-cancer liver metastases (CLM). This study aimed to identify prognostic factors in patients with synchronous CLM who underwent a surgical curative (R0) resection with respect to the number of metastatic nodules.

Methods

Of 1,261 CLM patients treated between January 1991 and December 2010, 339 who underwent a R0 resection for synchronous CLM were included in this retrospective analysis. Patients were grouped according to the number of CLM nodules: 1–2 CLM nodules, n = 272 (group 1) and 3–8 CLM nodules, n = 67 (group 2).

Results

The 5-year progression-free survival (PFS) rate in group 1was better than that in group 2 (P = 0.020). The multivariate analysis identified lymph-node metastasis (N2), lymphovascular invasion (LVI), and three or more CLM nodules as independent poor prognostic factors for PFS in all patients and lymph-node metastasis (N2) and LVI as independent poor prognostic factors for patients in group 1. No independent prognostic factors were identified for patients in group 2. CLM treatment method and neoadjuvant chemotherapy were not associated with survival.

Conclusion

Three or more metastatic nodules, lymph-node metastasis (N2), and LVI were independent poor prognostic factors for PFS in patients with synchronous CLM who underwent a R0 resection. The latter 2 factors were also independent prognostic factors for PFS in patients with less than 3 CLM nodules; however, in patients with three or more CLM nodules, the prognosis for PFS may be related only to liver metastasis.

Citations

Citations to this article as recorded by  
  • Association Between Colorectal Cancer Primary Features and Liver Metastases Histological Growth Patterns: Inflammation on the Primary Tumor is Associated with Desmoplastic Growth Pattern
    Ana Margarida Abrantes, Rui Caetano-Oliveira, Bárbara Oliveiros, Maria Augusta Cipriano, José Guilherme Tralhão
    Clinical Colorectal Cancer.2025; 24(2): 239.     CrossRef
  • Constructing a prognostic model for colorectal cancer with synchronous liver metastases after preoperative chemotherapy: a study based on SEER and an external validation cohort
    Yixin Ding, Xiaoxi Han, Shufen Zhao, Shasha Wang, Jing Guo, Chuanyu Leng, Xiangxue Li, Kongjia Wang, Wensheng Qiu, Weiwei Qi
    Clinical and Translational Oncology.2024; 26(12): 3169.     CrossRef
  • Liver-first approach to the treatment of patients with synchronous colorectal liver metastases: a systematic review and meta-analysis
    Bruno Mirandola Bulisani, Milena Arruda de Oliveira Leite, Jaques Waisberg
    einstein (São Paulo).2024;[Epub]     CrossRef
  • More Liver Metastases Detected Intraoperatively Indicates Worse Prognosis for Colorectal Liver Metastases Patients after Resection Combined with Microwave Ablation
    Ling-Min Jiang, Yuan-Ping Zhang, Chen-Wei Wang, Wei-Dong Zhang, Wei He, Ji-Liang Qiu, Yi-Chuan Yuan, Bin-Kui Li, Yun-Fei Yuan, Ren-Chun Lai, Dan-Dan Hu, Yun Zheng, Alessandro Granito
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns
    Gemma Garcia-Vicién, Artur Mezheyeuski, María Bañuls, Núria Ruiz-Roig, David G. Molleví
    International Journal of Molecular Sciences.2021; 22(4): 1544.     CrossRef
  • lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression
    Xiao-Zhan Zhang, Hong-Li Mao, Shi-Jie Zhang, Li Sun, Wen-Jing Zhang, Qing-Zhou Chen, Lei Wang, Hong-Chun Liu
    Life Sciences.2020; 249: 117478.     CrossRef
  • HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis
    Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Mitsuo Shimada
    World Journal of Surgical Oncology.2020;[Epub]     CrossRef
  • Solitary colorectal liver metastasis after curative intent surgery: prognostic factors affecting outcomes and survival
    Heeji Shin, Chan Wook Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok‐Byung Lim, Chang Sik Yu, Jin Cheon Kim
    ANZ Journal of Surgery.2019; 89(1-2): 61.     CrossRef
  • Liver Metastases and Histological Growth Patterns: Biological Behavior and Potential Clinical Implications—Another Path to Individualized Medicine?
    Rui Caetano Oliveira, Henrique Alexandrino, Maria Augusta Cipriano, José Guilherme Tralhão
    Journal of Oncology.2019; 2019: 1.     CrossRef
  • Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer?
    Sung Uk Bae, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
    Cancer Research and Treatment.2018; 50(3): 712.     CrossRef
  • Resection after preoperative chemotherapy versus synchronous liver resection of colorectal cancer liver metastases
    Chan W. Kim, Jong L. Lee, Yong S. Yoon, In J. Park, Seok-Byung Lim, Chang S. Yu, Tae W. Kim, Jin C. Kim
    Medicine.2017; 96(7): e6174.     CrossRef
  • A postoperative scoring system for post-hepatectomy early recurrence of colorectal liver metastases
    Rui Mao, Jian-Jun Zhao, Xin-Yu Bi, Ye-Fan Zhang, Zhi-Yu Li, Jian-Guo Zhou, Xiao-Long Wu, Chen Xiao, Hong Zhao, Jian-Qiang Cai
    Oncotarget.2017; 8(60): 102531.     CrossRef
  • Ongoing Adjuvant/Neoadjuvant Trials in Resectable Metastatic Colorectal Cancer
    Daniel Krell, Rob Glynne-Jones
    Current Colorectal Cancer Reports.2016; 12(6): 303.     CrossRef
  • Colorectal Liver Metastases: A Never Ending Story
    Min Ro Lee, Jong Hun Kim
    Annals of Coloproctology.2016; 32(3): 87.     CrossRef
The Role of Diverting Stoma After an Ultra-low Anterior Resection for Rectal Cancer
Seok In Seo, Chang Sik Yu, Gwon Sik Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jin Cheon Kim
Ann Coloproctol. 2013;29(2):66-71.   Published online April 30, 2013
DOI: https://doi.org/10.3393/ac.2013.29.2.66
  • 9,633 View
  • 52 Download
  • 36 Citations
AbstractAbstract PDF
Purpose

A diverting stoma is known to reduce the consequences of distal anastomotic failure following colorectal surgery. The aim of this study was to evaluate the efficacy of a diverting stoma after an ultra-low anterior resection (uLAR) for rectal cancer.

Methods

Between 2000 and 2007, 836 patients who underwent an uLAR were divided into two groups, depending on the fecal diversion: 246 received fecal diversion, and 590 had no diversion. Patient- and disease-related variables were compared between the two groups.

Results

Thirty-two of the 836 patients (3.8%) had immediate anastomosis-related complications and required reoperation. Anastomosis leakage comprised 72% of the complications (23/32). The overall immediate complication rate was significantly lower in patients with a diverting stoma (0.8%, 2/246) compared to those without a diverting stoma (5.1%, 30/590; P = 0.005). The fecal diversion group had lower tumor location, lower anastomosis level, and more preoperative chemo-radiation therapy (P < 0.001). In total, 12% of patients in the diverting stoma group had complications either in making or reversing the stoma (30/246).

Conclusion

The diverting stoma decreased the rate of immediate anastomosis-related complications. However, the rate of complications associated with the diverting stoma was non-negligible, so strict criteria should be applied when deciding whether to use a diverting stoma.

Citations

Citations to this article as recorded by  
  • Patient selection and operative strategies for laparoscopic intersphincteric resection without diverting stoma
    Gang Hu, Ji Ma, Wen-Long Qiu, Shi-Wen Mei, Meng Zhuang, Jun Xue, Jun-Guang Liu, Jian-Qiang Tang
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Risk factors for permanent stoma following sphincter-preserving anterior resection in rectal cancer: A retrospective multicenter observational study
    Pere Planellas, Nair Fernandes, Sandra Alonso-Gonçalves, Thomas Golda, Júlia Gil, Garazi Elorza, Esther Kreisler, Mayra Rebeka Abad-Camacho, Lidia Cornejo, Franco Marinello
    Cirugía Española (English Edition).2025; 103(6): 800095.     CrossRef
  • Risk factors for permanent stoma following sphincter-preserving anterior resection in rectal cancer: A retrospective multicenter observational study
    Pere Planellas, Nair Fernandes, Sandra Alonso-Gonçalves, Thomas Golda, Júlia Gil, Garazi Elorza, Esther Kreisler, Mayra Rebeka Abad-Camacho, Lidia Cornejo, Franco Marinello
    Cirugía Española.2025; 103(6): 800095.     CrossRef
  • Comparison of hand-sewn anterior repair, resection and hand-sewn anastomosis, resection and stapled anastomosis techniques for the reversal of diverting loop ileostomy after low anterior rectal resection: a randomized clinical trial
    Seyed Mostafa Meshkati Yazd, Reza Shahriarirad, Mohammad Reza Keramati, Mehdi Fallahi, Soheila-sadat Nourmohammadi, Alireza Kazemeini, Mohammad Sadegh Fazeli, Amir Keshvari
    Techniques in Coloproctology.2024;[Epub]     CrossRef
  • Complications Rate and Related Factors After Laparoscopic Sphincter-Preserving Total Mesorectal Excision for Low Rectal Cancer: A Single-Center Study in Vietnam
    Ly Huu Phu, Ho Tat Bang, Ung Van Viet, Hoang Danh Tan, Nguyen Trung Tin
    Cureus.2024;[Epub]     CrossRef
  • Could Stoma Be Avoided after Laparoscopic Low Anterior Resection for Rectal Cancer? Experience with Transanal Tube in 195 Cases
    Antonio Sciuto, Roberto Peltrini, Federica Andreoli, Andrea Gianmario Di Santo Albini, Maria Michela Di Nuzzo, Nello Pirozzi, Marcello Filotico, Federica Lauria, Giuseppe Boccia, Michele D’Ambra, Ruggero Lionetti, Carlo De Werra, Felice Pirozzi, Francesco
    Journal of Clinical Medicine.2022; 11(9): 2632.     CrossRef
  • Cecostomy vs ileostomy for protection of anastomoses in colorectal surgery
    Dan Bratu, Alin Mihețiu, Radu Chicea, Alexandru Sabău
    Romanian Journal of Military Medicine.2022; 125(1): 128.     CrossRef
  • A diversion stoma after anterior resection for rectal cancer
    Yury V. Ivanov, Aishe A. Keshvedinova, Alexander V. Smirnov
    Journal of Clinical Practice.2022; 13(3): 56.     CrossRef
  • Preservation of the Arterial Arc Formed by Left Colic Artery, Proximal Inferior Mesenteric Artery, and the First Branch of Sigmoid Arteries in Anus Saving Treatment of Low Rectal Cancer
    Zakari Shaibu, Zhi-hong Chen, Acquah Theophilus, Said A. S. Mzee
    The American Surgeon™.2021; 87(12): 1956.     CrossRef
  • Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80
    Ali P. Mourad, Marie Shella De Robles, Soni Putnis, Robert D.R. Winn
    Current Oncology.2021; 28(2): 1388.     CrossRef
  • Laparoscopic anterior resection
    Senthil Kumar Ganapathi, Rajapandian Subbiah, Sathiyamoorthy Rudramurthy, Harish Kakkilaya, Parthasarathi Ramakrishnan, Palanivelu Chinnusamy
    Journal of Minimal Access Surgery.2021; 17(3): 356.     CrossRef
  • The multidisciplinary management of rectal cancer
    Deborah S. Keller, Mariana Berho, Rodrigo O. Perez, Steven D. Wexner, Manish Chand
    Nature Reviews Gastroenterology & Hepatology.2020; 17(7): 414.     CrossRef
  • Comparison of anastomotic leakage rate and reoperation rate between transanal tube placement and defunctioning stoma after anterior resection: A network meta-analysis of clinical data
    Fu-Gang Wang, Wen-Mao Yan, Ming Yan, Mao-Min Song
    European Journal of Surgical Oncology.2019; 45(8): 1301.     CrossRef
  • Preventive strategies for anastomotic leakage after colorectal resections: A review
    Mostafa Shalaby, Waleed Thabet, Mosaad Morshed, Mohamed Farid, Pierpaolo Sileri
    World Journal of Meta-Analysis.2019; 7(8): 389.     CrossRef
  • Neutrophil‐to‐lymphocyte ratio predicts anastomotic dehiscence
    Patrick A. Walker, Bindu Kunjuraman, David C. C. Bartolo
    ANZ Journal of Surgery.2018;[Epub]     CrossRef
  • Control Comparison of the New EndoWrist and Traditional Laparoscopic Staplers for Anterior Rectal Resection with the Da Vinci Xi: A Case Study
    Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Matteo Palmeri, Cristina Ceccarelli, Matteo Bianchini, Niccolò Furbetta, Giovanni Caprili, Cristiano D'Isidoro, Andrea Moglia, Franca Melfi, Piero Buccianti, Franco Mosca, Luca Morelli
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2018; 28(12): 1422.     CrossRef
  • Incidence, risk factors and prevention of stoma site incisional hernias: a systematic review and meta‐analysis
    D. P. V. Lambrichts, G. H. J. de Smet, R. D. van der Bogt, L. F. Kroese, A. G. Menon, J. Jeekel, G‐J. Kleinrensink, J. F. Lange
    Colorectal Disease.2018;[Epub]     CrossRef
  • Defunctioning ileostomy reduces leakage rate in rectal cancer surgery - systematic review and meta-analysis
    Magdalena Pisarska, Natalia Gajewska, Piotr Małczak, Michał Wysocki, Jan Witowski, Grzegorz Torbicz, Piotr Major, Magdalena Mizera, Marcin Dembiński, Marcin Migaczewski, Andrzej Budzyński, Michał Pędziwiatr
    Oncotarget.2018; 9(29): 20816.     CrossRef
  • Risk factors for anastomotic leakage after low anterior resection without diversional stomas*
    Xiaolong Chen, Libo Feng, Yu Liu, Xiaolong Wu, Jie Xu, Peng Chen, Zhonglin Zuo, Yi Liu, Qingwei Zou, Qing Liu, Dong Xia
    Oncology and Translational Medicine.2018; 4(3): 101.     CrossRef
  • Fortune of temporary ileostomies in patients treated with laparoscopic low anterior resection for rectal cancer
    Mustafa Haksal, Nuri Okkabaz, Ali Emre Atici, Osman Civil, Yasar Ozdenkaya, Ayhan Erdemir, Nihat Aksakal, Mustafa Oncel
    Annals of Surgical Treatment and Research.2017; 92(1): 35.     CrossRef
  • Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?
    Matthew D. Whealon, John V. Gahagan, Sarath Sujatha-Bhaskar, Michael P. O’Leary, Matthew Selleck, Sinziana Dumitra, Byrne Lee, Maheswari Senthil, Alessio Pigazzi
    Annals of Surgical Oncology.2017; 24(8): 2122.     CrossRef
  • Transanal Inspection and Management of Low Colorectal Anastomosis Performed With a New Technique: the TICRANT Study
    Francesco Crafa, Sebastian Smolarek, Giulia Missori, Mostafa Shalaby, Silvia Quaresima, Adele Noviello, Diletta Cassini, Pasquale Ascenzi, Luana Franceschilli, Paolo Delrio, Giannandrea Baldazzi, Ucchino Giampiero, Jacques Megevand, Giovanni Maria Romano,
    Surgical Innovation.2017; 24(5): 483.     CrossRef
  • Outcomes of patients with abdominoperineal resection (APR) and low anterior resection (LAR) who had very low rectal cancer
    Seung-Seop Yeom, In Ja Park, Sung Woo Jung, Se Heon Oh, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Nayoung Kim, Chang Sik Yu, Jin Cheon Kim
    Medicine.2017; 96(43): e8249.     CrossRef
  • Anastomotic leaks in gastrointestinal surgery and their prevention
    Tomasz Banasiewicz, Adam Dziki, Paweł Lampe, Zbigniew Lorenc, Marek Szczepkowski, Jacek Zieliński, Grzegorz Wallner
    Polish Journal of Surgery.2017; 89(2): 49.     CrossRef
  • ON APPLICATION OF MECHANICAL COLORECTAL ANASTOMOSIS AFTER ANTERIOR RESECTION AND LOW ANTERIOR RECTAL RESECTION
    M. F. Cherkasov, A. V. Dmitriev, V. S. Groshilin, S. V. Pereskokov, S. G. Melikova
    Koloproktologia.2017; (4): 54.     CrossRef
  • Diverting ileostomy in laparoscopic rectal cancer surgery: high price of protection
    Peter Ihnát, Petra Guňková, Matúš Peteja, Petr Vávra, Anton Pelikán, Pavel Zonča
    Surgical Endoscopy.2016; 30(11): 4809.     CrossRef
  • Complications of Diverting Ileostomy after Low Anterior Resection for Rectal Carcinoma
    Sean Maroney, Carlos Chavez De Paz, Marjunphilip Duldulao, Tracey Kim, Mark E. Reeves, Kevork K. Kazanjian, Naveenraj Solomon, Carlos Garberoglio
    The American Surgeon™.2016; 82(10): 1033.     CrossRef
  • Is a diverting ostomy needed in mid-high rectal cancer patients undergoing a low anterior resection after neoadjuvant chemoradiation? An NSQIP analysis
    Evangelos Messaris, Tara M. Connelly, Afif N. Kulaylat, Jennifer Miller, Niraj J. Gusani, Gail Ortenzi, Joyce Wong, Neil Bhayani
    Surgery.2015; 158(3): 686.     CrossRef
  • Meta-analysis of defunctioning stoma in low anterior resection with total mesorectal excision for rectal cancer: evidence based on thirteen studies
    Wen-long Gu, Sheng-wen Wu
    World Journal of Surgical Oncology.2015; 13(1): 9.     CrossRef
  • Low anterior resection combined with a covering stoma in the treatment of rectal cancer reduces the risk of permanent anastomotic failure
    Minna Räsänen, Laura Renkonen-Sinisalo, Monika Carpelan-Holmström, Anna Lepistö
    International Journal of Colorectal Disease.2015; 30(10): 1323.     CrossRef
  • Transanal tube placement for prevention of anastomotic leakage following low anterior resection for rectal cancer: a systematic review and meta-analysis
    Gi Won Ha, Hyun Jung Kim, Min Ro Lee
    Annals of Surgical Treatment and Research.2015; 89(6): 313.     CrossRef
  • Efficacy of transanal tube for prevention of anastomotic leakage following laparoscopic low anterior resection for rectal cancers: a retrospective cohort study in a single institution
    Eiji Hidaka, Fumio Ishida, Shumpei Mukai, Kenta Nakahara, Daisuke Takayanagi, Chiyo Maeda, Yusuke Takehara, Jun-ichi Tanaka, Shin-ei Kudo
    Surgical Endoscopy.2015; 29(4): 863.     CrossRef
  • Morbilidad y mortalidad de la ileostomía derivativa temporal en la cirugía por cáncer de recto
    Lucinda Pérez Domínguez, María Teresa García Martínez, Nieves Cáceres Alvarado, Ángeles Toscano Novella, Antonio Pedro Higuero Grosso, José Enrique Casal Núñez
    Cirugía Española.2014; 92(9): 604.     CrossRef
  • Morbidity and Mortality of Temporary Diverting Ileostomies in Rectal Cancer Surgery
    Lucinda Pérez Domínguez, María Teresa García Martínez, Nieves Cáceres Alvarado, Ángeles Toscano Novella, Antonio Pedro Higuero Grosso, José Enrique Casal Núñez
    Cirugía Española (English Edition).2014; 92(9): 604.     CrossRef
  • Role of protective stoma in low anterior resection for rectal cancer: A meta-analysis
    Sheng-Wen Wu, Cong-Chao Ma, Yu Yang
    World Journal of Gastroenterology.2014; 20(47): 18031.     CrossRef
  • Predictive factors for temporary defunctioning stoma permanence in the treatment of rectal adenocarcinoma
    Fernanda Bellotti Formiga, Sabrina Miotto, Galdino José Sitônio Formiga, Odilon Victor Porto Denardin
    Journal of Coloproctology.2013; 33(04): 196.     CrossRef
Clinicopathologic Factors Affecting Recurrence after Curative Surgery for Stage I Colorectal Cancer
Min Ae Keum, Seok-Byung Lim, Sun A Kim, Yong Sik Yoon, Chan Wook Kim, Chang Sik Yu, Jin Cheon Kim
J Korean Soc Coloproctol. 2012;28(1):49-55.   Published online February 29, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.1.49
  • 6,671 View
  • 49 Download
  • 32 Citations
AbstractAbstract PDF
Purpose

The objective of the current study was to identify the clinicopathological risk factors affecting recurrence after a curative resection for stage I colorectal cancer.

Methods

We retrospectively studied 434 patients who underwent a curative resection for stage I colorectal cancer between January 1999 and December 2004. Postoperative oral chemotherapy was performed in 189 patients (45.3%). The following prognostic factors were correlated with recurrence: age, gender, preoperative carcinoembryonic antigen level, location of tumor, T stage, size of tumor, histologic differentiation, growth pattern, and lymphovascular invasion. The median follow-up duration was 65 months.

Results

The overall recurrence rate was 4.6% (20/434). The median time to recurrence was 33 months. Two-thirds of the recurrence occurred more than two years after surgery. Risk factors associated with recurrence were rectal cancer (P = 0.009), T2 stage (P = 0.010), and infiltrative growth pattern (P = 0.020). A Cox proportional hazards regression analysis demonstrated that the infiltrative growth pattern was an independent predictor for recurrence. Tumor cell budding was observed in all pathologic reviews with recurrence.

Conclusion

Long-term follow-up is necessary for stage I colorectal patients with high risk factors like rectal cancer, T2 stage, and infiltrative growth pattern.

Citations

Citations to this article as recorded by  
  • Is tumour location a dominant risk factor of recurrence in early rectal cancer?
    Roberto Rosén, Henrik Thorlacius, Carl-Fredrik Rönnow
    Surgical Endoscopy.2025; 39(2): 1056.     CrossRef
  • Risk factors for recurrence in stage I colorectal cancer after curative resection: a systematic review and meta-analysis
    Sung Hwan Hwang, Seon-Hi Shin, Yun Jin Kim, Jun Ho Lee
    Annals of Surgical Treatment and Research.2025; 108(1): 39.     CrossRef
  • Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer
    Walaiphorn Woraharn, Ashley McCulloch, Christopher Bigley, Phimmada Hatthakarnkul, Kathryn Pennel, Peter Alexander, Hester van Wyk, Antonia Roseweir, Jennifer Hay, Noori Maka, James Park, Nigel B Jamieson, Joanne Edwards, Campbell SD Roxburgh
    The Journal of Pathology: Clinical Research.2025;[Epub]     CrossRef
  • Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer
    Oluwadunni E. Emiloju, Michael Storandt, Tyler Zemla, Nguyen Tran, Krishan Jethwa, Amit Mahipal, Jessica Mitchell, Cornelius Thiels, Kellie Mathis, Robert McWilliams, Joleen Hubbard, Frank Sinicrope, Qian Shi, Zhaohui Jin
    JCO Precision Oncology.2024;[Epub]     CrossRef
  • Determinants of survival and recurrence in patients with stage I colorectal cancer
    Alimohammad Bananzadeh, Mahshid Bahadori, Mohammad Mohammadianpanah, Faramarz Pakravan, Sara Shojaei-Zarghani, Ali Reza Safarpour
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • A systematic review of population‐based studies on metachronous metastases of colorectal cancer
    Karin Nyström, Louise Olsson
    World Journal of Surgery.2024; 48(6): 1521.     CrossRef
  • Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts
    Qingbin Wu, Pengju Chen, Chi Shu, Lin Chen, Zechuan Jin, Jun Huang, Xin Wang, Xue Li, Mingtian Wei, Tinghan Yang, Xiangbing Deng, Aiwen Wu, Yazhou He, Ziqiang Wang
    BMC Medicine.2023;[Epub]     CrossRef
  • Risk factors of recurrence in TNM stage I colorectal cancer
    Jin-Hee Paik, Chun-Geun Ryu, Dae-Yong Hwang
    Annals of Surgical Treatment and Research.2023; 104(5): 281.     CrossRef
  • Postoperative recurrence in locally advanced rectal cancer: how does neoadjuvant treatment affect recurrence pattern?
    Ryosuke Okamura, Yoshiro Itatani, Yusuke Fujita, Nobuaki Hoshino, Shintaro Okumura, Kazuhiro Nishiyama, Koya Hida, Kazutaka Obama
    World Journal of Surgical Oncology.2023;[Epub]     CrossRef
  • Immediate Adjuvant Chemotherapy in Non-Metastatic Colon Cancer: Phase I Trial Evaluating a Novel Treatment Protocol
    Mehraneh D. Jafari, Joseph C. Carmichael, Farshid Dayyani, Chelsea McKinney, Lari Wenzel, Jason A. Zell, Alessio Pigazzi
    Clinical Colorectal Cancer.2022; 21(2): 114.     CrossRef
  • The clinic factors in evaluating long-term outcomes of patients with stage I colorectal cancer
    Zechuan Jin, Qingbin Wu, Xiangbing Deng, Ziqiang Wang
    Asian Journal of Surgery.2022; 45(11): 2231.     CrossRef
  • Identification of high-risk stage I colon and rectal cancer patients: a retrospective analysis of a large Japanese cohort
    Yudai Fukui, Koya Hida, Nobuaki Hoshino, Daisuke Nishizaki, Ryosuke Okamura, Shinichi Yamauchi, Kenichi Sugihara, Yoshiharu Sakai, I. Takemasa, K. Hakamada, H. Kameyama, Y. Takii, H. Ueno, H. Ozawa, S. Ishihara, K. Takahashi, Y. Kanemitsu, M. Itabashi, T.
    International Journal of Colorectal Disease.2022; 37(6): 1403.     CrossRef
  • Predicting liver metastases growth patterns: Current status and future possibilities
    Rui Caetano Oliveira, Henrique Alexandrino, Maria Augusta Cipriano, Filipe Caseiro Alves, José Guilherme Tralhão
    Seminars in Cancer Biology.2021; 71: 42.     CrossRef
  • Improved Outcomes and Staging in Non-Small-Cell Lung Cancer Guided by A Molecular Assay
    Alexander R Gupta, Gavitt A Woodard, David M Jablons, Michael J Mann, Johannes R Kratz
    Future Oncology.2021; 17(34): 4785.     CrossRef
  • Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
    Hye-Sol Jung, Seung-Bum Ryoo, Han-Ki Lim, Min Jung Kim, Sang Hui Moon, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
    Cancers.2021; 13(21): 5294.     CrossRef
  • High-grade intratumoral tumor budding is a predictor for lymphovascular invasion and adverse outcome in stage II colorectal cancer
    Andreas H Marx, Claudius Mickler, Guido Sauter, Ronald Simon, Luigi M Terracciano, Jakob R Izbicki, Till S Clauditz
    International Journal of Colorectal Disease.2020; 35(2): 259.     CrossRef
  • Factors influencing recurrence of stage I–III rectal cancer in regional Australia
    Lucy Haggstrom, Sharlyn Kang, Robert Winn, Soni Putnis, Elias Nasser, James Chen, Morteza Aghmesheh, Daniel Brungs
    ANZ Journal of Surgery.2020; 90(12): 2490.     CrossRef
  • Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions
    Chihiro Yasue, Akiko Chino, Manabu Takamatsu, Ken Namikawa, Daisuke Ide, Shoichi Saito, Masahiro Igarashi, Junko Fujisaki
    Journal of Gastroenterology.2019; 54(8): 708.     CrossRef
  • Influence of gross tumor morphology on clinicopathological profile of colorectal cancers
    Mudassir Ahmad Khan, Nisar A. Chowdri, Showkat Ali Bhat, Fazl Q. Parray, Rauf A. Wani, Asif Mehraj
    Current Medicine Research and Practice.2019; 9(5): 172.     CrossRef
  • Predictive Nomogram for Recurrence of Stage I Colorectal Cancer After Curative Resection
    Chan Kim, Woo Ram Kim, Ki-Yeol Kim, Hong Jae Chon, Seung Hoon Beom, Hyojoong Kim, Minkyu Jung, Sang Joon Shin, Nam Kyu Kim, Joong Bae Ahn
    Clinical Colorectal Cancer.2018; 17(3): e513.     CrossRef
  • Emergency resection surgery for colorectal cancer: Patterns of recurrent disease and survival
    Joe Littlechild, Muneer Junejo, Anne-Marie Simons, Finlay Curran, Darren Subar
    World Journal of Gastrointestinal Pathophysiology.2018; 9(1): 8.     CrossRef
  • Identification of Recurrence—Predictive Indicators in Stage I Colorectal Cancer
    Jun Ho Lee, Jong Lyul Lee, In Ja Park, Seok‐Byung Lim, Chang Sik Yu, Jin Cheon Kim
    World Journal of Surgery.2017; 41(4): 1126.     CrossRef
  • Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016
    Alessandro Lugli, Richard Kirsch, Yoichi Ajioka, Fred Bosman, Gieri Cathomas, Heather Dawson, Hala El Zimaity, Jean-François Fléjou, Tine Plato Hansen, Arndt Hartmann, Sanjay Kakar, Cord Langner, Iris Nagtegaal, Giacomo Puppa, Robert Riddell, Ari Ristimäk
    Modern Pathology.2017; 30(9): 1299.     CrossRef
  • Tumor budding in colorectal cancer—ready for diagnostic practice?
    Viktor H. Koelzer, Inti Zlobec, Alessandro Lugli
    Human Pathology.2016; 47(1): 4.     CrossRef
  • Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis
    Sun A Kim, Kentaro Inamura, Mai Yamauchi, Reiko Nishihara, Kosuke Mima, Yasutaka Sukawa, Tingting Li, Mika Yasunari, Teppei Morikawa, Kathryn C Fitzgerald, Charles S Fuchs, Kana Wu, Andrew T Chan, Xuehong Zhang, Shuji Ogino, Zhi Rong Qian
    British Journal of Cancer.2016; 114(2): 199.     CrossRef
  • Recurrence in patients with stage I colorectal cancer
    Patrick Ely Teloken, David Ransom, Ian Faragher, Ian Jones, Peter Gibbs, Cameron Platell
    ANZ Journal of Surgery.2016; 86(1-2): 49.     CrossRef
  • Preoperative Carcinoembryonic Antigen and Prognosis of Colorectal Cancer. An Independent Prognostic Factor Still Reliable
    Giovanni Li Destri, Antonio Salvatore Rubino, Rosalia Latino, Fabio Giannone, Raffaele Lanteri, Beniamino Scilletta, Antonio Di Cataldo
    International Surgery.2015; 100(4): 617.     CrossRef
  • Factors affecting sphincter-preserving resection treatment for patients with low rectal cancer
    ZHENQIANG SUN, XIANBO YU, HAIJIANG WANG, MING MA, ZELIANG ZHAO, QISAN WANG
    Experimental and Therapeutic Medicine.2015; 10(2): 484.     CrossRef
  • Tumour border configuration in colorectal cancer: proposal for an alternative scoring system based on the percentage of infiltrating margin
    Eva Karamitopoulou, Inti Zlobec, Viktor Hendrik Koelzer, Rupert Langer, Heather Dawson, Alessandro Lugli
    Histopathology.2015; 67(4): 464.     CrossRef
  • Tumor budding in the clinical management of colon and rectal cancer
    Viktor H Koelzer, Inti Zlobec, Alessandro Lugli
    Colorectal Cancer.2014; 3(4): 387.     CrossRef
  • Clinical Management of Localized Colon Cancer with Capecitabine
    J. Quidde, D. Arnold, A. Stein
    Clinical Medicine Insights: Oncology.2012;[Epub]     CrossRef
  • Early Detection of Colorectal Cancer, Is It a Guarantee for the Cure of Cancer?
    Kang Young Lee
    Journal of the Korean Society of Coloproctology.2012; 28(1): 6.     CrossRef
Surgical Outcomes after Total Colectomy with Ileorectal Anastomosis in Patients with Medically Intractable Slow Transit Constipation
Guiyun Sohn, Chang Sik Yu, Chan Wook Kim, Jae Young Kwak, Tae Young Jang, Kyung Ho Kim, Song Soo Yang, Yong Sik Yoon, Seok-Byung Lim, Jin Cheon Kim
J Korean Soc Coloproctol. 2011;27(4):180-187.   Published online August 31, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.4.180
  • 14,079 View
  • 86 Download
  • 33 Citations
AbstractAbstract PDF
Purpose

The aim of this study was to evaluate outcomes of a total colectomy with ileorectal anastomosis in patients with slow transit constipation.

Methods

A retrospective review of 37 consecutive patients with slow transit constipation who underwent a total colectomy between 1994 and 2008 was undertaken. Preoperative and postoperative Wexner's constipation scores were collected and used to evaluate the outcomes after surgical treatment. Also patients' postoperative satisfaction scores were collected using a 4-point scale.

Results

The 37 patients consisted of 31 women and 6 men, with a median age of 41 years (range, 17 to 71 years). Pre- and post-operative Wexner's scores were collected from 33 patients (89.1%), and the mean preoperative Wexner's score was 19.3 (range, 11 to 24), which decreased to an average post-operative score of 2.3 (range, 0 to 8). Neither intraoperative complications nor postoperative mortalities were noted. Five patients (13.5%) had early postoperative complications, and the most common complication was postoperative ileus (10.8%). Seven patients (18.9%) had late postoperative complications, and postoperative ileus (10.8%) was also the most common. Twenty seven of 33 patients were satisfied with their surgical outcome (81.8%).

Conclusion

A total colectomy with ileorectal anastomosis might be an effective surgical procedure with acceptable morbidity to treat medically intractable slow transit constipation.

Citations

Citations to this article as recorded by  
  • Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment
    Luana Alexandrescu, Ionut Eduard Iordache, Alina Mihaela Stanigut, Laura Maria Condur, Doina Ecaterina Tofolean, Razvan Catalin Popescu, Andreea Nelson Twakor, Eugen Dumitru, Andrei Dumitru, Cristina Tocia, Alexandra Herlo, Ionut Tiberiu Tofolean
    Gastrointestinal Disorders.2025; 7(1): 11.     CrossRef
  • Surgery for chronic idiopathic constipation: pediatric and adult patients – a systematic review
    Kerry A. Swanson, Hannah M. Phelps, William C. Chapman, Sean C. Glasgow, Radhika K. Smith, Shannon Joerger, Elizabeth C. Utterson, Baddr A. Shakhsheer
    Journal of Gastrointestinal Surgery.2024; 28(2): 170.     CrossRef
  • Ileorectal intussusception compared to end-to-end ileorectal anastomosis after laparoscopic total colectomy in slow-transit constipation
    Hong Zhi Geng, Chen Xu, Yongjun Yu, Jiying Cong, Zhao Zhang, Yuwei Li, Qilong Chen
    Current Problems in Surgery.2024; 61(6): 101471.     CrossRef
  • A systematic review of outcomes and quality of life after ileorectal anastomosis for ulcerative colitis
    Mohammed Al-Rashedy, Tanmoy Mukherjee, Alan Askari, Shashank Gurjar
    Arab Journal of Gastroenterology.2023; 24(2): 79.     CrossRef
  • Laparoscopic total colectomy with ileorectal anastomosis and subtotal colectomy with antiperistaltic cecorectal anastomosis for slow transit constipation
    Xiu-Mei Deng, Tian-Yu Zhu, Guo-Jun Wang, Bu-Lang Gao, Rui-Xin Li, Jing-Tao Wang
    Updates in Surgery.2023; 75(4): 871.     CrossRef
  • Single-incision clipless laparoscopic total colectomy for intractable slow transit constipation: a single surgeon’s experience
    Hidejiro Kawahara, Nobuo Omura
    Langenbeck's Archives of Surgery.2022; 407(6): 2585.     CrossRef
  • Idiopathic Megacolon—Short Review
    Adrian Constantin, Florin Achim, Dan Spinu, Bogdan Socea, Dragos Predescu
    Diagnostics.2021; 11(11): 2112.     CrossRef
  • Heterogeneous outcome reporting in adult slow‐transit constipation studies: Systematic review towards a core outcome set
    Stella C M Heemskerk, Adriënne H Rotteveel, Jarno Melenhorst, Stéphanie O Breukink, Merel L Kimman, Carmen D Dirksen
    Journal of Gastroenterology and Hepatology.2020; 35(2): 192.     CrossRef
  • Defecation function and quality of life in patients with slow-transit constipation after colectomy
    Yue Tian, Li Wang, Jing-Wang Ye, Yong Zhang, Hui-Chao Zheng, Hao-De Shen, Fan Li, Bao-Hua Liu, Wei-Dong Tong
    World Journal of Clinical Cases.2020; 8(10): 1897.     CrossRef
  • Laparoscopic subtotal colectomy in the surgical treatment of chronic constipation in patients with dolichocolon
    V.V. Anischenko, D.A. Kim
    Endoskopicheskaya khirurgiya.2020; 26(6): 12.     CrossRef
  • Concurrent total abdominal colectomy and ileorectal anastomosis with transvaginal posterior colporrhaphy for constipation
    Peter Chia Yeh, Francisco Orejuela, Lisa Haubert
    International Urogynecology Journal.2019; 30(3): 501.     CrossRef
  • Percutaneous endoscopic colostomy for adults with chronic constipation: Retrospective case series of 12 patients
    D. Strijbos, D. Keszthelyi, A. A. M. Masclee, L. P. L. Gilissen
    Neurogastroenterology & Motility.2018;[Epub]     CrossRef
  • Searching for a definition for pharmacologically refractory constipation: A systematic review
    Alex Yu Sen Soh, Jin‐Yong Kang, Kewin Tien Ho Siah, Carmelo Scarpignato, Kok‐Ann Gwee
    Journal of Gastroenterology and Hepatology.2018; 33(3): 564.     CrossRef
  • Patient-Reported Outcome After Ostomy Surgery for Chronic Constipation
    Fareed Iqbal, Valerie van der Ploeg, Franklin Adaba, Alan Askari, Jamie Murphy, R. John Nicholls, Carolynne Vaizey
    Journal of Wound, Ostomy & Continence Nursing.2018; 45(4): 319.     CrossRef
  • Surgery for constipation: systematic review and practice recommendations
    C. H. Knowles, U. Grossi, M. Chapman, J. Mason
    Colorectal Disease.2017; 19(S3): 17.     CrossRef
  • Colonic Inertia: approach and treatment
    Ana Sofia Garcês Ferreira Soares, Laura Elisabete Ribeiro Barbosa
    Journal of Coloproctology.2017; 37(01): 063.     CrossRef
  • Bioengineering the gut: future prospects of regenerative medicine
    Khalil N. Bitar, Elie Zakhem
    Nature Reviews Gastroenterology & Hepatology.2016; 13(9): 543.     CrossRef
  • Surgical management of severe constipation due to slow transit and obstructed defecation syndrome
    Venetia Giannakaki, Liliana Bordeianou
    Seminars in Colon and Rectal Surgery.2016; 27(1): 28.     CrossRef
  • Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation
    M. A. Mouchli, M. Camilleri, T. Lee, G. Parthasarathy, P. Vijayvargiya, M. Halland, A. Acosta, A. E. Bharucha
    Neurogastroenterology & Motility.2016; 28(6): 871.     CrossRef
  • Comparison of laparoscopic subtotal colectomy with posterior vaginal suspension and laparoscopic subtotal colectomy with transvaginal repair for patients with slow-transit constipation complicated with rectocele: a non-randomized comparative study in a si
    Si Yu, Jian-zhong Deng, Xiang Peng, Yong-hui Zhou, Long-qing Cheng, Yi-ban Lin, Jia-cheng Zhu, Te-dong Luo
    Surgical Endoscopy.2016; 30(7): 2759.     CrossRef
  • Results of long-term retrograde rectal cleansing in patients with constipation or fecal incontinence
    P. F. Vollebregt, A. K. E. Elfrink, W. J. H. J. Meijerink, R. J. F. Felt-Bersma
    Techniques in Coloproctology.2016; 20(9): 633.     CrossRef
  • Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults
    Ralph Hurley O’Dwyer, Andrés Acosta, Michael Camilleri, Duane Burton, Irene Busciglio, Adil E. Bharucha
    Digestive Diseases and Sciences.2015; 60(8): 2398.     CrossRef
  • Chronic severe constipation
    Nikolaos P. Andromanakos, Stamatis I. Pinis, Alkiviadis I. Kostakis
    European Journal of Gastroenterology & Hepatology.2015; 27(3): 204.     CrossRef
  • Lanreotide Autogel in the Treatment of Persistent Diarrhea following a Total Colectomy
    Patrick Schoeters, Karl De Pooter
    Case Reports in Gastrointestinal Medicine.2015; 2015: 1.     CrossRef
  • Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation
    Yoon Suh Do, Seung-Jae Myung, Sun-Young Kwak, Soohan Cho, Enoch Lee, Min Jeong Song, Chang Sik Yu, Yong Sik Yoon, Hye Kyung Lee
    Journal of Neurogastroenterology and Motility.2015; 21(4): 560.     CrossRef
  • Effect of Different Surgical Options on Curative Effect, Nutrition, and Health Status of Patients with Slow Transit Constipation
    Fan Li, Tao Fu, Weidong Tong, Anping Zhang, Chunxue Li, Yu Gao, Jin Song Wu, Baohua Liu
    International Journal of Colorectal Disease.2014; 29(12): 1551.     CrossRef
  • A modified total colonic exclusion for elderly patients with severe slow transit constipation
    Q. Qian, C. Jiang, Y. Chen, Z. Ding, Y. Wu, K. Zheng, Q. Qin, Z. Liu
    Techniques in Coloproctology.2014; 18(7): 629.     CrossRef
  • Management of Chronic Intractable Constipation in Children
    Basavaraj Kerur, Kanchan Kantekure, Silvana Bonilla, Bruce Orkin, Alejandro F. Flores
    Journal of Pediatric Gastroenterology and Nutrition.2014; 59(6): 754.     CrossRef
  • Comparison of hand‐assisted laparoscopy with open total colectomy for slow transit constipation: A retrospective study
    Qin Song Sheng, Jian Jiang Lin, Wen Bin Chen, Fan Long Liu, Xiang Ming Xu, Han Ju Hua, Cai Zhao Lin, Jin Hai Wang
    Journal of Digestive Diseases.2014; 15(8): 419.     CrossRef
  • The role of hand-assisted laparoscopic surgery in total colectomy for colonic inertia: a retrospective study
    Dan Yang Wang, Jian Jiang Lin, Xiang Ming Xu, Fan Long Liu
    Journal of the Korean Surgical Society.2013; 85(3): 123.     CrossRef
  • The use of prucalopride in real life for the treatment of constipation subtypes: ups and downs
    G. Bassotti, M. Bellini
    Techniques in Coloproctology.2013; 17(5): 475.     CrossRef
  • Colectomy with ileorectal anastomosis has a worse 30‐day outcome when performed for colonic inertia than for a neoplastic indication
    A. Reshef, B. Gurland, M. Zutshi, R. P. Kiran, T. Hull
    Colorectal Disease.2013; 15(4): 481.     CrossRef
  • Long-term Follow-up of the Jinling Procedure for Combined Slow-Transit Constipation and Obstructive Defecation
    Ning Li, Jun Jiang, Xiaobo Feng, Weiwei Ding, Jianlei Liu, Jieshou Li
    Diseases of the Colon & Rectum.2013; 56(1): 103.     CrossRef
  • FirstFirst
  • PrevPrev
  • Page of 1
  • Next Next
  • Last Last
Ann Coloproctol : Annals of Coloproctology Twitter Facebook
© Korean Society of Coloproctology.
TOP