Annals of Coloproctology

Case Reports

Malignant disease,Rare disease & stoma,Complication

Colonic Perforation After Treatment With Nivolumab in Esophageal Cancer: A Case Report: Hye Jung Cho, Woo Ram Kim, Joo-Hang Kim, Duk Hwan Kim, Dae Jung Kim, Haeyoun Kang; Ann Coloproctol. 2021;37(Suppl 1):S39-S43. Published online June 24, 2021; DOI: https://doi.org/10.3393/ac.2020.00213.0030

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With the advent of checkpoint inhibitors, it has opened up opportunities for numerous cancer patients. However, as is the case with every treatment, complications need to be weighed. Gastrointestinal adverse effects, such as diarrhea and colitis are well-known complications for checkpoint inhibitors. In severe cases, colitis-induced colonic perforation may occur with an estimation of 1.0% to 1.5% in anti-CTLA-4 antibodies. However, only a handful of cases of such devastating complications have been reported in anti-PD-1 antibodies such as pembrolizumab and nivolumab. We here report a case of intestinal perforation in a patient treated with nivolumab.

Citations

Citations to this article as recorded by

Chemotherapy-associated pneumoperitoneum in cancer patients: a scoping review
Renee M. Maina, Caroline Rader, Jeevan Kypa, Constantine Asahngwa, Hilary M. Jasmin, Nia N. Zalamea, John S. Nelson, Jonathan L. Altomar, Mary Brinson Owens, Clarisse S. Muenyi, Denis A. Foretia
Annals of Medicine & Surgery.2024; 86(5): 2828. CrossRef
Update on immunotherapy‐mediated colitis: Clinical features, mechanisms, and management
Dandan Wang, Yiwei Zhao, Yiyun Zeng, Lanlin Hu, Chuan Xu
Malignancy Spectrum.2024; 1(4): 225. CrossRef
Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System
Zicheng Yu, Haibin Zhu, Hongjun Chen, Lifei Zhu, Xiaolan Liao
Journal of Pharmacy & Pharmaceutical Sciences.2023;[Epub] CrossRef
Gastrointestinal and Hepatobiliary Immune-related Adverse Events: A Histopathologic Review
Zainab I. Alruwaii, Elizabeth A. Montgomery
Advances in Anatomic Pathology.2023; 30(3): 230. CrossRef
An updated review of gastrointestinal toxicity induced by PD-1 inhibitors: from mechanisms to management
Yiyu Cheng, Fangmei Ling, Junrong Li, Yidong Chen, Mingyang Xu, Shuang Li, Liangru Zhu
Frontiers in Immunology.2023;[Epub] CrossRef
Nivolumab

Reactions Weekly.2022; 1892(1): 181. CrossRef
Gastrointestinal and Hepatobiliary Immune-related Adverse Events: A Histopathologic Review
Zainab I. Alruwaii, Elizabeth A. Montgomery
Advances in Anatomic Pathology.2022; 29(4): 183. CrossRef

A Granular Cell Tumor of the Rectum: A Case Report and Review of the Literature: Seung Yoon Yang, Byung Soh Min, Woo Ram Kim; Ann Coloproctol. 2017;33(6):245-248. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.245

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11 Citations

Abstract PDF

A granular cell tumor (GCT) is an uncommon mesenchymal lesion that rarely occurs in the colon and the rectum. We describe the case of 51-year-old man with a 2-cm-sized rectal GCT 10 cm above the anal verge that was incidentally detected after a screening colonoscopy. Preoperative radiologic studies demonstrated a suspicious submucosal rectal mass with mesorectal fat infiltration, but without circumferential resection margin threatening, extramural vessel invasion, and regional lymph-node enlargement. The tumor was resected by using a transanal endoscopic operation (TEO) without immediate postoperative complications. The final pathology revealed that the tumor consisted of a GCT that had invaded the subserosa with clear margins. It had no other risk factors for malignancy according to Fanburg-Smith criteria. We systematically reviewed the English literature by using PubMed and Google Scholar. This report may be the first documented case in the literature to describe a TEO for a GCT that had invaded the subserosa in the rectum.

Citations

Citations to this article as recorded by

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review
Jorge Arche Prats, Diego García Prado, Gonzalo Campaña Villegas, Mónica Martínez Mardónez
Journal of Coloproctology.2024; 44(04): e281. CrossRef
Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection
Michaelia S. Sunderland, Anthony Dakwar, Sowsan Rasheid
The American Surgeon™.2023; 89(4): 1304. CrossRef
Experience of surgical treatment in a granular cell tumor in the qscending colon: a case report
In-Kyeong Kim, Young-Tae Ju, Han-Gil Kim, Jin-Kwon Lee, Dong-Chul Kim, Jae-Myung Kim, Jin Kyu Cho, Ji-Ho Park, Ju-Yeon Kim, Chi-Young Jeong, Soon-Chan Hong, Seung-Jin Kwag
Annals of Coloproctology.2023; 39(3): 275. CrossRef
Granular cell tumour. Case report.
P. Leszczyńska, M. Sobocińska, K. Ustymowicz, W. Romańczyk
Progress in Health Sciences.2023; 13(1): 107. CrossRef
Granular cell tumor of the perineum (clinical case)
R. R. Shakirov, O. Yu. Karpukhin, M. I. Ziganshin, I. S. Raginov
Koloproktologia.2023; 22(4): 121. CrossRef
A case report of rare granular cell tumor of the urinary bladder
Saman Anwar Wahid, Han N. Mohammed Fadhl, Alaa Abbas Ali, Rebaz Karim Mohammed
Urology Case Reports.2022; 42: 102034. CrossRef
Granular cell tumor of the cecum: Case report of mini invasive surgical resection and review of the literature
Roberto Cantella, Giuseppe Evola, Carla Di Stefano, Ezio Trusso Zirna, Marianna Iudica, Luigi Piazza
International Journal of Surgery Case Reports.2021; 87: 106397. CrossRef
Granular Cell Tumor of the Perianal Region
Marina Pérez-Flecha González, Enrique Revilla Sánchez, Carolina Ibarrola de Andrés, Ramón Gómez Sanz
Journal of Gastrointestinal Surgery.2020; 24(4): 907. CrossRef
A Rare Granular Cell Tumor with a Center Ulcer of the Rectum
Jeonghun Lee, Younghye Kim
Case Reports in Gastrointestinal Medicine.2020; 2020: 1. CrossRef
Granular Cell Tumors of the Cecum: Report of Two Cases and Review of Literature
Nam Yeol Cho, Yu-Ah Choi, Gye Sung Lee
Keimyung Medical Journal.2020; 39(2): 86. CrossRef
A rare case of tracheal granular cell tumor in a pediatric patient
Bojiang Chen, Linrui Xu, Min Xie, Weimin Li, Fengming Luo
Pediatric Pulmonology.2019; 54(8): 1101. CrossRef

Original Articles

Single Center Experience With Hyperthermic Intraperitoneal Chemotherapy: Woo Ram Kim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim; Ann Coloproctol. 2017;33(1):16-22. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.16

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4 Citations

Abstract PDF

Purpose

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been proposed for controlling peritoneal seeding metastasis in some kinds of cancers, including those of colorectal origin, but their safety and oncological benefits are subjects of debate. We present our early experience with those procedures.

Methods

Data were retrospectively collected from all patients with peritoneal carcinomatosis (PC) and pseudomyxoma peritonei (PMP) treated using CRS and HIPEC at Yonsei Cancer Center between July 2014 and July 2015. Short-term outcomes and risk factors for postoperative complications were analyzed.

Results

Twenty-three patients with PC (n = 18) and PMP (n = 5) underwent CRS and HIPEC. Median follow-up and age were 2 months and 54 years, respectively. The median peritoneal carcinomatosis index score was 15, and CC0-1 was achieved in 78.3% of all patients. The median operation time and bleeding loss were 590 minutes and 570 mL, respectively. Grade-IIIa/grade-IIIb complications occurred in 4.3% (n = 1)/26.1% (n = 6) of the patients within 30 days postoperatively, and no 30-day mortalities were reported. Factors related to postoperative complications with CRS and HIPEC were number of organ resection (P = 0.013), longer operation time (P < 0.001), and amount of blood loss (P = 0.003). All patients treated with cetuximab for recurred colorectal cancer had grade-III postoperative complication.

Conclusion

Our initial experience with CRS and HIPEC presented about 30% grade-III postoperative complications. Therefore, expert surgeons need to perform those procedures with great caution in selected patients who might benefit from it.

Citations

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Multisocietal Consensus on the Use of Cytoreductive Surgery and HIPEC for the Treatment of Diffuse Malignant Peritoneal Mesothelioma: A GRADE Approach for Evidence Evaluation and Recommendation
Shigeki Kusamura, Michela Cinquini, David Morris, Pompiliu Piso, Hedy Kindler, Andreas Brandl, Edward Levine, Olivier Glehen, Vahan Kepenekian, Olivia Sgarbura, Paul H. Sugarbaker, Dario Baratti, Guaglio Marcello, Deraco Marcello
Journal of Surgical Oncology.2024;[Epub] CrossRef
Pharmacologic Effects of Oxaliplatin Instability in Chloride-Containing Carrier Fluids on the Hyperthermic Intraperitoneal Chemotherapy to Treat Colorectal Cancer In Vitro and In Vivo
Eun Jung Park, Junhyun Ahn, Sharif Md Abuzar, Kyung Su Park, Sung-Joo Hwang, Seung Hyuk Baik
Annals of Surgical Oncology.2022; 29(13): 8583. CrossRef
Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Annals of Coloproctology.2021; 37(6): 425. CrossRef
Is Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy a Safe and Effective Procedure for Treating Patients With a Peritoneal Surface Malignancy?
Dong-Guk Park
Annals of Coloproctology.2017; 33(1): 3. CrossRef

Prognostic Impact of Immunonutritional Status Changes During Preoperative Chemoradiation in Patients With Rectal Cancer: Yong Joon Lee, Woo Ram Kim, Jeonghee Han, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min; Ann Coloproctol. 2016;32(6):208-214. Published online December 31, 2016; DOI: https://doi.org/10.3393/ac.2016.32.6.208

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57 Download
18 Web of Science
14 Citations

Abstract PDF

Purpose

Previous studies have demonstrated the prognostic impact of the prognostic nutritional index (PNI), a proposed indicator of immunonutritional statuses of surgical patients, on patients with various gastrointestinal cancers. Although the prognostic impact of the PNI on patients with colorectal cancer has been well established, its value has not been studied in patients treated with preoperative chemoradiation (pCRT). This study aimed to evaluate the prognostic impact of PNI on patients receiving pCRT for locally advanced rectal cancer (LARC).

Methods

Patients with LARC who underwent curative pCRT followed by surgical resection were enrolled. The PNI was measured in all patients before and after pCRT, and the difference in values was calculated as the PNI difference (dPNI). Patients were classified according to dPNI (<5, 5–10, and >10). Clinicopathologic parameters and long-term oncologic outcomes were assessed according to dPNI classification.

Results

No significant intergroup differences were observed in clinicopathologic parameters such as age, histologic grade, tumor location, tumor-node-metastasis stage, and postoperative complications. Approximately 53% of the patients had a mild dPNI (<5); only 15% had a high dPNI (>10). Univariate and multivariate analyses identified the dPNI as an independent prognostic factor for disease-free status (P < 0.01; hazard ratio [HR], 2.792; 95% confidence interval [CI], 1.577–4.942) and for cancer-specific survival (P = 0.012; HR, 2.469; 95%CI, 1.225–4.978).

Conclusion

The dPNI is predictive of long-term outcomes in pCRT-treated patients with LARC. Further prospective studies should investigate whether immune-nutritional status correction during pCRT would improve oncologic outcomes.

Citations

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Preoperative albumin-to-globulin ratio and prognostic nutritional index predict the prognosis of colorectal cancer: a retrospective study
JunHu Li, Na Zhu, Cheng Wang, LiuPing You, WenLong Guo, ZhiHan Yuan, Shuai Qi, HanZheng Zhao, JiaYong Yu, YueNan Huang
Scientific Reports.2023;[Epub] CrossRef
The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
Atsushi Shimada, Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri, Yoshihiro Kakeji
Scientific Reports.2023;[Epub] CrossRef
Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery
Ali Guner, Minah Cho, Yoo-Min Kim, Jae-Ho Cheong, Woo Jin Hyung, Hyoung-Il Kim
Frontiers in Oncology.2021;[Epub] CrossRef
Pelvimetric and Nutritional Factors Predicting Surgical Difficulty in Laparoscopic Resection for Rectal Cancer Following Preoperative Chemoradiotherapy
Yanwu Sun, Jianhua Chen, Chengwei Ye, Huiming Lin, Xingrong Lu, Ying Huang, Pan Chi
World Journal of Surgery.2021; 45(7): 2261. CrossRef
Inflammation‐nutritional markers of peripheral blood could predict survival in advanced non‐small‐cell lung cancer patients treated with PD‐1 inhibitors
Dan Pu, Qian Xu, Lai‐Yan Zhou, Yu‐Wen Zhou, Ji‐Yan Liu, Xue‐Lei Ma
Thoracic Cancer.2021; 12(21): 2914. CrossRef
Preoperative change of modified Glasgow prognostic score after stenting predicts the long-term outcomes of obstructive colorectal cancer
Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Takaho Okada, Tomoya Abe, Takashi Yazawa, Haruyuki Tsuchiya, Naoya Akazawa, Masaki Sato, Tetsuya Ohira, Yoshihiro Harada, Haruka Okano, Kei Ito, Noriaki Ohuchi, Takashi Tsuchiya
Surgery Today.2020; 50(3): 232. CrossRef
Prognostic impact of preoperative immunonutritional status in rectal mucinous adenocarcinoma
Yanwu Sun, Zhekun Huang, Huiming Lin, Pan Chi
Future Oncology.2020; 16(8): 339. CrossRef
Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy

Yurday Ozdemir, Erkan Topkan, Huseyin Mertsoylu, Ugur Selek
Cancer Management and Research.2020; Volume 12: 1959. CrossRef
Peripheral blood markers predictive of outcome and immune-related adverse events in advanced non-small cell lung cancer treated with PD-1 inhibitors
Lihong Peng, Yong Wang, Fen Liu, Xiaotong Qiu, Xinwei Zhang, Chen Fang, Xiaoyin Qian, Yong Li
Cancer Immunology, Immunotherapy.2020; 69(9): 1813. CrossRef
The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer
Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Takaho Okada, Tomoya Abe, Takashi Yazawa, Haruyuki Tsuchiya, Naoya Akazawa, Masaki Sato, Tetsuya Ohira, Yoshihiro Harada, Haruka Okano, Kei Ito, Takashi Tsuchiya
Surgery Today.2020; 50(10): 1272. CrossRef
Preoperative Fibrinogen-Albumin Ratio Index (FARI) is a Reliable Prognosis and Chemoradiotherapy Sensitivity Predictor in Locally Advanced Rectal Cancer Patients Undergoing Radical Surgery Following Neoadjuvant Chemoradiotherapy

Siyi Lu, Zhenzhen Liu, Xin Zhou, Bingyan Wang, Fei Li, Yanpeng Ma, Wendong Wang, Junren Ma, Yuxia Wang, Hao Wang, Wei Fu
Cancer Management and Research.2020; Volume 12: 8555. CrossRef
Immunonutritional status and pulmonary cavitation in patients with tuberculosis: A revisit with an assessment of neutrophil/lymphocyte ratio
Makoto Nakao, Hideki Muramatsu, Sosuke Arakawa, Yusuke Sakai, Yuto Suzuki, Kohei Fujita, Hidefumi Sato
Respiratory Investigation.2019; 57(1): 60. CrossRef
Temporal changes in immune cell composition and cytokines in response to chemoradiation in rectal cancer
Yong Joon Lee, Sat Byol Lee, Suk Kyung Beak, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
Scientific Reports.2018;[Epub] CrossRef
Impairment of Immunonutritional Status During Treatment is a Factor Associated With Oncologic Outcomes in Patients With Rectal Cancer Treated With Preoperative Chemoradiotherapy
In Ja Park
Annals of Coloproctology.2016; 32(6): 201. CrossRef

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