Annals of Coloproctology

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Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?: Myung-Kyu Jung, Ui Sup Shin, Young-Jun Ki, Yong-Bae Kim, Sun-Mi Moon, Se-Jin Sung; Ann Coloproctol. 2017;33(6):210-218. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.210

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16 Citations

Purpose

In this study, we investigated both the characteristics of right colon cancer (RTCC) in comparison with those of left colon cancer (LTCC) and the impact of the location of the colon cancer on the prognosis.

Methods

We retrospectively analyzed the cases of 974 patients with nonmetastatic colon cancer who had undergone surgery with a curative intent from January 2001 to December 2011. RTCC was defined as a tumor located proximal to the splenic flexure. The characteristics of RTCC cancer were investigated by using descriptive analyses, and their impacts on the prognosis were assessed by using a Cox multivariate regression.

Results

Compared to LTCC, RTCC showed a female-dominant feature, and an undifferentiated pathology was more frequently observed. The number of lymph nodes retrieved from patients with RTCC was significantly higher than that retrieved from patients with LTCC. During 75 months of follow-up, peritoneal recurrence was more common in patients with RTCC than it was in patients with LTCC, and among the patients with stage III colon cancer, the disease-free and the overall survival rates were significantly worse in patients with RTCC. After adjustments with the other prognostic factors associated with colon cancer had been made, a tumor located at the right colon was found to be independently associated with poor prognosis.

Conclusion

RTCC showed unique clinicopathologic features and was associated with a poorer prognosis.

Citations

Citations to this article as recorded by

Differences in the expression of CMTM3 and SSTR2 genes in right and left colon tumors: A molecular insight into colorectal cancer
Tuğçe Binen, Etem Akbaş, Tahsin Çolak, Tuba Kara, Aslıhan Bakır, Badel İnce
Medical Oncology.2025;[Epub] CrossRef
The relationship between clinical and pathological findings and FDG - PET uptake in metastatic colorectal cancers
Bediz Kurt İnci, Fatih Gürler, Osman Sütcüoğlu, Gözde Tahtacı, Aytuğ Üner, Ahmet Özet, Nazan Günel, Ozan Yazıcı
Indian Journal of Cancer.2024; 61(3): 440. CrossRef
Splenic flexure cancer survival: a 25‐year experience and implications for complete mesocolic excision (CME) and central vascular ligation (CVL)
Krishanth Naidu, Pierre H. Chapuis, Kilian G. M. Brown, Charles Chan, Matthew J. F. X. Rickard, Kheng‐Seong Ng
ANZ Journal of Surgery.2023; 93(7-8): 1861. CrossRef
Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients
Vincent Ho, Liping Chung, Kate Wilkinson, Vivienne Lea, Stephanie H. Lim, Askar Abubakar, Weng Ng, Mark Lee, Tara L. Roberts, Wei Chua, Cheok Soon Lee
Cancers.2023; 15(9): 2438. CrossRef
Colorectal Cancer: Disease Process, Current Treatment Options, and Future Perspectives
Amusa S. Adebayo, Kafilat Agbaje, Simeon K. Adesina, Oluwabukunmi Olajubutu
Pharmaceutics.2023; 15(11): 2620. CrossRef
Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival
Ramón Cantero-Cid, Karla Marina Montalbán-Hernández, Jenny Guevara, Alejandro Pascual-Iglesias, Elisa Pulido, José Carlos Casalvilla, Cristóbal Marcano, Cristina Barragán Serrano, Jaime Valentín, Gloria Cristina Bonel-Pérez, José Avendaño-Ortiz, Verónica
World Journal of Gastrointestinal Oncology.2022; 14(1): 295. CrossRef
Disparities in Healthcare: Evaluation of Equity in Access to Surveillance Colonoscopy After Hemicolectomy in Patients With Colon Cancer During the COVID-19 Pandemic
Ranbir Singh, Eshan Patel
Cureus.2022;[Epub] CrossRef
Comparison of prolonged postoperative ileus between laparoscopic right and left colectomy under enhanced recovery after surgery: a propensity score matching analysis
Zhenmeng Lin, Chunkang Yang, Yi Wang, Mingfang Yan, Huizhe Zheng
World Journal of Surgical Oncology.2022;[Epub] CrossRef
The Prognostic Impact of Primary Tumor Site Differs According to the KRAS Mutational Status
Georgios Antonios Margonis, Neda Amini, Stefan Buettner, Yuhree Kim, Jaeyun Wang, Nikolaos Andreatos, Doris Wagner, Kazunari Sasaki, Andrea Beer, Carsten Kamphues, Daisuke Morioka, Inger Marie Løes, Katsunori Imai, Jin He, Timothy M. Pawlik, Klaus Kaczire
Annals of Surgery.2021; 273(6): 1165. CrossRef
Are right-sided colectomies for neoplastic disease at increased risk of primary postoperative ileus compared to left-sided colectomies? A coarsened exact matched analysis
Richard Garfinkle, Faisal Al-Rashid, Nancy Morin, Gabriela Ghitulescu, Julio Faria, Carol-Ann Vasilevsky, Marylise Boutros
Surgical Endoscopy.2020; 34(12): 5304. CrossRef
Prognostic Heterogeneity of MRE11 Based on the Location of Primary Colorectal Cancer Is Caused by Activation of Different Immune Signals
Chuan-Wen Fan, Maria Kopsida, You-Bin Liu, Hong Zhang, Jing-Fang Gao, Gunnar Arbman, Si-Yu-Wei Cao, Yuan Li, Zong-Guang Zhou, Xiao-Feng Sun
Frontiers in Oncology.2020;[Epub] CrossRef
Early Outcome of Enhanced Recovery Programs Versus Conventional Perioperative Care in Elective Open Left Side Colonic Carcinoma Surgery: Analysis of 80 Cases
Emad M. Abd ElRahman, Mohamed S. Kharoub, Ahmed Shora, Nabil A. Emara, M. Ashraf Balbaa
Indian Journal of Surgical Oncology.2020; 11(3): 372. CrossRef
Evaluating the distribution of the locations of colorectal cancer after appendectomy and cholecystectomy
Szabolcs Ábrahám, Tibor Németh, Ria Benkő, Mária Matuz, Aurél Ottlakán, Dániel Váczi, Attila Paszt, Zsolt Simonka, György Lázár
World Journal of Surgical Oncology.2020;[Epub] CrossRef
Diagnostic and pathologic value of programmed death-ligand 1 expression in colonic carcinoma
DinaO Helmy, MahmoudT El-Sabah Hussein, MohamedS Negm, MinaE Onsy
Egyptian Journal of Pathology.2020; 40(2): 204. CrossRef
Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
Kwangmin Kim, Ernes John T. Castro, Hongjin Shim, John Vincent G. Advincula, Young-Wan Kim
Annals of Coloproctology.2018; 34(6): 280. CrossRef
Laterality: Right-Sided and Left-Sided Colon Cancer
Seong Kyu Baek
Annals of Coloproctology.2017; 33(6): 205. CrossRef

Role of Peritoneal Lavage Cytology and Prediction of Prognosis and Peritoneal Recurrence After Curative Surgery for Colorectal Cancer: Sung Joon Bae, Ui Sup Shin, Young-Jun Ki, Sang Sik Cho, Sun Mi Moon, Sun Hoo Park; Ann Coloproctol. 2014;30(6):266-273. Published online December 31, 2014; DOI: https://doi.org/10.3393/ac.2014.30.6.266

6,379 View
55 Download
13 Web of Science
12 Citations

Abstract PDF

Purpose

In colorectal cancer, the role of detecting free malignant cells from peritoneal lavage is currently unclear. In this study, we investigated the positive rate of free malignant cells in peritoneal lavage fluid and their predictive value for prognosis and peritoneal recurrence after a curative resection.

Methods

From October 2009 to December 2011, in a prospective manner, we performed cytologic examinations of peritoneal lavage fluid obtained just after the abdominal incision from 145 patients who underwent curative surgery for colorectal cancer. We used proportional hazard regression models to analyze the predictive role of positive cytology for peritoneal recurrence and survival.

Results

Among total 145 patients, six patients (4.1%) showed positive cytology. During the median follow-up of 32 months (range, 8-49 months), 27 patients (18.6%) developed recurrence. Among them, 5 patients (3.4%) showed peritoneal carcinomatosis. In the multivariate analysis, positive cytology was an independent predictive factor for peritoneal recurrence (hazard ratio [HR], 136.5; 95% confidence interval [CI], 12.2-1,531.9; P < 0.0001) and an independent poor prognostic factor for overall survival (HR, 11.4; 95% CI, 1.8-72.0; P = 0.009) and for disease-free survival (HR, 11.1; 95% CI, 3.4-35.8; P < 0.0001).

Conclusion

Positive cytology of peritoneal fluid was significantly associated with peritoneal recurrence and worse survival in patients undergoing curative surgery for colorectal cancer. Peritoneal cytology might be a useful tool for selecting patients who need intraperitoneal or systemic chemotherapy.

Citations

Citations to this article as recorded by

Intraoperative flow cytometry in detecting free carcinoma cells in peritoneal lavage fluid of gastric carcinoma cases
Thulasi Raman Ramalingam, Bharaneedharan Marimuthu, Harsha N. Rasheed, Archana Lakshmanan, Swetha Lakshmi Narla, Lakshman Vaidhyanathan, Ajit Pai
Cytometry Part B: Clinical Cytometry.2025;[Epub] CrossRef
Peritoneal Lavage Cytology Predicts Peritoneal Metastasis and is Associated with Poor Prognosis in Patients with Stage II–III Colorectal Cancer
Dewei Kong, Yingjie Li, Shenyi Yin, Yunfei Tan, Boyang Qu, Lei Huang, Jianzhong Jeff Xi, Aiwen Wu
Annals of Surgical Oncology.2025;[Epub] CrossRef
Risk Factors for Positive Peritoneal Lavage Cytology in Stage I to III Colon Cancer: A Prospective Observational Study
Radha Raman Mondal, Subrata Sahu, Sudip Haldar, Samir Bhattacharyya, Arnab Gupta
Indian Journal of Surgical Oncology.2025;[Epub] CrossRef
Development and validation of a nomogram to predict overall survival in patients with incidental gallbladder cancer: A retrospective cohort study
Zhi-Hua Xie, Xuebing Shi, Ming-Qi Liu, Jinghan Wang, Yong Yu, Ji-Xiang Zhang, Kai-Jian Chu, Wei Li, Rui-Liang Ge, Qing-Bao Cheng, Xiao-Qing Jiang
Frontiers in Oncology.2023;[Epub] CrossRef
Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis
Stefanos Bitsianis, Ioannis Mantzoros, Elissavet Anestiadou, Panagiotis Christidis, Christos Chatzakis, Konstantinos Zapsalis, Savvas Symeonidis, Georgios Ntampakis, Kalliopi Domvri, Anastasia Tsakona, Chryssa Bekiari, Orestis Ioannidis, Stamatios Aggelop
Journal of Clinical Medicine.2023; 12(23): 7267. CrossRef
Conventional peritoneal cytology lacks the prognostic significance of detecting local or peritoneal recurrence in colorectal cancer: An Egyptian experience
Mohamed Shalaby, Tarek S El Baradie, Mohamed Salama, Hebat A M Shaaban, Rasha M Allam, Ehab O.A. Hafiz, Mohamed Aly Abdelhamed, Amr Attia
JGH Open.2021; 5(2): 264. CrossRef
Interleukin 10 level in the peritoneal cavity is a prognostic marker for peritoneal recurrence of T4 colorectal cancer
Seung-Yong Jeong, Byeong Geon Jeon, Ji-Eun Kim, Rumi Shin, Hye Seong Ahn, Heejin Jin, Seung Chul Heo
Scientific Reports.2021;[Epub] CrossRef
Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis
Yuanxin Zhang, Xiusen Qin, Wenle Chen, Duo Liu, Jian Luo, Huaiming Wang, Hui Wang
Colorectal Disease.2021; 23(11): 2846. CrossRef
Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Annals of Coloproctology.2021; 37(6): 425. CrossRef
Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum
Lieselotte Lemoine, Paul Sugarbaker, Kurt Van der Speeten
World Journal of Gastroenterology.2016; 22(34): 7692. CrossRef
The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer
Tsuyoshi Ozawa, Soichiro Ishihara, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama, Toshiaki Watanabe
International Journal of Colorectal Disease.2015; 30(9): 1165. CrossRef
Intraoperative Peritoneal Lavage: Limitations of Current Evidence for Clinical Implementation
Duck-Woo Kim
Annals of Coloproctology.2014; 30(6): 248. CrossRef

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