Annals of Coloproctology

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Distribution of the Colonoscopic Adenoma Detection Rate According to Age: Is Recommending Colonoscopy Screening for Koreans Over the Age of 50 Safe?: Taeseok Bae, Yunhyung Ha, Changkyun Kim, Jihyun Lee, Kwangil Ha, Sanghyun Shin, Youngcheol Lee, Yoonsik Kang; Ann Coloproctol. 2015;31(2):46-51. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.46

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13 Web of Science
15 Citations

Purpose

This study was conducted to determine the distributions of the polyp detection rate (PDR) and the adenoma detection rate (ADR) according to age by analyzing the polypectomy results.

Methods

A total of 10,098 patients who underwent a colonoscopy in 2013 were included in this study. Chi-square and logistic regression statistical analyses were performed using SPSS ver. 19.

Results

The mean age of the patients was 52.7 years old (median, 54 ± 12.52 years; range, 14 to 92 years). A total of 6,459 adenomatous polyps (61.7%) from a total of 10,462 polyps were eliminated. The PDR was 50.9% (5,136/10,098), and the. ADR was 35.4% (3,579/10,098). The male-to-female ratio was 51.3%:48.7%, with a male-to-female ADR ratio of 42.8% : 27.7% (P < 0.001). In the age distribution, the values of the ADR were 0% for patients in their 10's, 6.3% for those in their 20's, 14.0% for those in their 30's, 28.7% for those in their 40's, 38.4% for those in their 50's, 46.2% for those in their 60's, 55.8% for those in their 70's, 56.1% for those in their 80's, and 33.3% for those in their 90's. In males, the values of the ADR were 0%, 9.1%, 17.1%, 37.8%, 48.2%, 53.6%, 61.7%, 59.1%, and 33.3% for the same age distribution, and a steep increase was found between patients in their 30's and patients in their 40's. Significant (P < 0.001) factors influencing the ADR included sex, previous colonoscopy experience, polypectomy method, and age of more than 40 years.

Conclusion

In considering the adenoma carcinoma sequence, 28.7% of people, especially 37.8% of males in their 40's showed adenomatous polyps. Whether an earlier first-time colonoscopy will have better results in preventing colorectal cancer should be investigated and discussed.

Citations

Citations to this article as recorded by

Adenoma Detection Rate in Average-Risk Population: An Observational Consecutive Retrospective Study
Xiaoyan He, Xiangyin Lv, Binbin Zhang, Xiaoxuan Ying, Chiyu Hu, Xiaoying Zhou, Jianwen Hu
Cancer Control.2023;[Epub] CrossRef
Adenoma Detection Rates in 45–49-Year-Old Persons Undergoing Screening Colonoscopy: Analysis From the GIQuIC Registry
Mohammad Bilal, Jennifer Holub, David Greenwald, Mark B. Pochapin, Douglas K. Rex, Aasma Shaukat
American Journal of Gastroenterology.2022; 117(5): 806. CrossRef
Adenoma Detection Rate in Colonoscopic Screening with Ketamine-based Sedation: A Prospective Observational Study
Mirza KOVACEVIC, Nermina RIZVANOVIC, Adisa SABANOVIC ADILOVIC, Nedim BARUCIJA, Anida ABAZOVIC
Medeniyet Medical Journal.2022; 37(1): 79. CrossRef
Gastrointestinal Disease in Patients with Common Variable Immunodeficiency: A Retrospective Observational Study
Rishad Khan, Mohamad Habbal, Michael A Scaffidi, Abbas A Bukhari, Amir Rumman, Sarah Al Ghamdi, Stephen D Betschel, Samir C Grover
Journal of the Canadian Association of Gastroenterology.2020; 3(4): 162. CrossRef
Global patterns and trends in colorectal cancer incidence in young adults
Rebecca L Siegel, Lindsey A Torre, Isabelle Soerjomataram, Richard B Hayes, Freddie Bray, Thomas K Weber, Ahmedin Jemal
Gut.2019; 68(12): 2179. CrossRef
Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population
Suk-young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
Annals of Surgical Treatment and Research.2018; 94(1): 36. CrossRef
An Adjusted Level of Adenoma Detection Rate is Necessary for Adults Below 50 Years Old
Jin Young Yoon, Jae Myung Cha, Jeong Eun Shin, Kyeong Ok Kim, Hyo-Joon Yang, Hyun Gun Kim, Young-Seok Cho, Sun-Jin Boo, Jun Lee, Yunho Jung, Hyun Jung Lee, Hoon Sup Koo, Young-Eun Joo
Journal of Clinical Gastroenterology.2018; 52(8): 703. CrossRef
Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients
Mohammed Hussein Kamareddine, Youssef Ghosn, Karam Karam, Anwar Andrew Nader, Ahmad El-Mahmoud, Naseem Bou-Ayash, Mansour El-Khoury, Said Farhat
BMJ Open Gastroenterology.2018; 5(1): e000253. CrossRef
LINE-1 is preferentially hypomethylated within adenomatous polyps in the presence of synchronous colorectal cancer
Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari, Joshua Melson
Clinical Epigenetics.2017;[Epub] CrossRef
Risks of colorectal advanced neoplasia in young adults versus those of screening colonoscopy in patients aged 50 to 54 years
Kyeong Ok Kim, Hyo‐Joon Yang, Jae Myung Cha, Jeong Eun Shin, Hyun Gun Kim, Young‐Seok Cho, Sun‐Jin Boo, Jun Lee, Yunho Jung, Hyun Jung Lee, Kyu Chan Huh, Young‐Eun Joo, Jongha Park, Chang Mo Moon
Journal of Gastroenterology and Hepatology.2017; 32(11): 1825. CrossRef
Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?
Martin Floer, Tobias Meister
Digestion.2016; 93(3): 202. CrossRef
Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy
Bin-Bin Xu, Xiao-Liang Zhao, Gui-Ping Xu
World Journal of Gastroenterology.2016; 22(24): 5609. CrossRef
Role of Colonoscopy in Patients with Hematochezia
Young Wook Kim, Hwang Choi, Gi Jun Kim, Seung Jee Ryu, Sung Min Park, Joon Sung Kim, Jeong-Seon Ji, Byung-Wook Kim, Bo-in Lee, Myung-Gyu Choi
The Korean Journal of Gastroenterology.2016; 67(2): 87. CrossRef
High prevalence of advanced colorectal neoplasia in the Thai population: a prospective screening colonoscopy of 1,404 cases
Bunchorn Siripongpreeda, Chulabhorn Mahidol, Navara Dusitanond, Tassanee Sriprayoon, Bunlung Muyphuag, Thaniya Sricharunrat, Narongchai Teerayatanakul, Watanya Chaiwong, Wipra Worasawate, Prassanee Sattayarungsee, Juthamas Sangthongdee, Jirapa Prarom, Gai
BMC Gastroenterology.2016;[Epub] CrossRef
Adenoma Detection Rate in Patients Younger Than 50 Years of Age: Relationship of the Adenoma Detection Rate to Interval Cancer
In Ja Park
Annals of Coloproctology.2015; 31(2): 41. CrossRef

Effects of DCA on Cell Cycle Proteins in Colonocytes: Yun-Hyung Ha, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):254-259. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.254

5,397 View
43 Download
12 Citations

Abstract PDF

Purpose

Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous studies have been based on studies on colon cancer cell lines, the effect of DCA on normal colonocytes is unknown.

Methods

Normal colonocytes and Caco-2 and HCT116 cells were treated with 20 µM and 250 µM of DCA, and the effect of different concentrations of DCA was measured based on the expression of cell-cycle-related proteins by using Western blots.

Results

The expressions of CDK2 and cyclin D1 for different concentrations of DCA in normal colonocytes and colon cancer cells were similar, but the expressions of cyclin E and A were significantly different. In HCT116 colon cancer cells, the expression of cyclin E increased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin E was not changed or decreased. In HCT116 colon cancer cells, the expression of cyclin A was not changed or decreased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin A was increased at a DCA concentration of 20 µM.

Conclusion

The effect of DCA on stimulating cell proliferation suggests that DNA synthesis is stimulated by an increased expression of cyclin E in colon cancer cells. Our results suggest that a low dose of DCA induces cellular proliferation through increased expression of cyclin A and that a high dose of DCA induces decreased expression of cyclin E and CDK2 in normal colonocytes.

Citations

Citations to this article as recorded by

Role of Microbiota in Pathogenesis of Gastrointestinal Cancers
Abbes Belkhiri, Nataliya Pidkovka
Open Medicine Journal.2025;[Epub] CrossRef
Implication of gut microbes and its metabolites in colorectal cancer
Arun Kumar, Asgar Ali, Raj Kishore Kapardar, Ghulam Mehdi Dar, Nimisha, Apurva, Abhay Kumar Sharma, Renu Verma, Real Sumayya Abdul Sattar, Ejaj Ahmad, Bhawna Mahajan, Sundeep Singh Saluja
Journal of Cancer Research and Clinical Oncology.2023; 149(1): 441. CrossRef
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer
Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar, Rob Van Houdt
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner
Wei Zhu, Yan Si, Jun Xu, Yu Lin, Jing‐Zi Wang, Mengda Cao, Shanwen Sun, Qiang Ding, Lingjun Zhu, Ji‐Fu Wei
Journal of Cellular and Molecular Medicine.2020; 24(6): 3521. CrossRef
Microbiota in cancer development and treatment
Muhammad Hassan Raza, Kamni Gul, Abida Arshad, Naveeda Riaz, Usman Waheed, Abdul Rauf, Fahad Aldakheel, Shatha Alduraywish, Maqbool Ur Rehman, Muhammad Abdullah, Muhammad Arshad
Journal of Cancer Research and Clinical Oncology.2019; 145(1): 49. CrossRef
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer
Huawei Zeng, Shahid Umar, Bret Rust, Darina Lazarova, Michael Bordonaro
International Journal of Molecular Sciences.2019; 20(5): 1214. CrossRef
Dysbiosis of gut microbiota in promoting the development of colorectal cancer
Shaomin Zou, Lekun Fang, Mong-Hong Lee
Gastroenterology Report.2018; 6(1): 1. CrossRef
Oxidative stress: a key regulator of leiomyoma cell survival
Nicole M. Fletcher, Mohammed S. Abusamaan, Ira Memaj, Mohammed G. Saed, Ayman Al-Hendy, Michael P. Diamond, Ghassan M. Saed
Fertility and Sterility.2017; 107(6): 1387. CrossRef
Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53-mediated pathway
HAI-BO YANG, WEI SONG, MEI-DIE CHENG, HAI-FANG FAN, XU GU, YING QIAO, XIN LU, RUI-HE YU, LAN-YING CHEN
Molecular Medicine Reports.2015; 11(4): 2749. CrossRef
Differential Regulation of EGFR–MAPK Signaling by Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in Colon Cancer
Sara M. Centuori, Jesse D. Martinez
Digestive Diseases and Sciences.2014; 59(10): 2367. CrossRef
Bile acids in the colon, from healthy to cytotoxic molecules
Juan I. Barrasa, Nieves Olmo, Ma Antonia Lizarbe, Javier Turnay
Toxicology in Vitro.2013; 27(2): 964. CrossRef
Sodium deoxycholate inhibits chick duodenal calcium absorption through oxidative stress and apoptosis
María A. Rivoira, Ana M. Marchionatti, Viviana A. Centeno, Gabriela E. Díaz de Barboza, María E. Peralta López, Nori G. Tolosa de Talamoni
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2012; 162(4): 397. CrossRef

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