Annals of Coloproctology

Display

Sort by :

Original Article

Diagnostic Accuracy of Elevated Serum Carcinoembryonic Antigen for Recurrence in Postoperative Stage II Colorectal Cancer Patients: Comparison With Stage III: Ho Seung Kim, Min Ro Lee; Ann Coloproctol. 2013;29(4):155-159. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.155

8,108 View
48 Download
9 Citations

Purpose

Elevated levels of serum carcinoembryonic antigen (CEA) following a curative resection of colorectal cancer (CRC) indicate recurrence; however, the levels of CEA may be elevated above the normal limit without recurrence. The aim of this study is to analyze the diagnostic accuracy of elevated serum CEA for predicting recurrence in postoperative stage II and stage III CRC patients.

Methods

A total of 336 stage II and stage III CRC patients who underwent a curative resection between January 2005 and October 2009 were enrolled. Sensitivities, specificities, positive predictive values (PPVs), negative predictive values (NPVs), likelihood ratios and post-test probabilities of recurrence associated with elevated CEA were analyzed and compared.

Results

The median follow-up duration was 45 months (36 to 134 months). Twenty-seven of 189 stage II patients (14.3%) and 52 of 147 stage III patients (35.4%) developed recurrence during the follow-up period. Sensitivities, specificities, PPVs, and NPVs of elevated CEA were 37.0%, 91.4%, 41.7%, and 89.7%, respectively, in stage II patients and 46.2%, 90.5%, 72.7%, and 75.4% in stage III patients. Post-test probabilities of recurrence associated with elevated CEA were 41.8% in stage II patients and 71.9% in stage III patients.

Conclusion

The predictive performance of the probability of recurrence associated with elevated serum CEA after a curative resection in stage II CRC patients is lower than that in stage III CRC patients.

Citations

Citations to this article as recorded by

Significance of carcinoembryonic antigen detection in the early diagnosis of colorectal cancer: A systematic review and meta-analysis
Rui Wang, Qin Wang, Pan Li
World Journal of Gastrointestinal Surgery.2023; 15(12): 2907. CrossRef
Diagnostic accuracy of follow‐up tests for detecting colorectal cancer recurrences in primary care: A systematic review and meta‐analysis
Geertje B. Liemburg, Daan Brandenbarg, Marjolein Y. Berger, Saskia F.A. Duijts, Gea A. Holtman, Geertruida H. Bock, Joke C. Korevaar, Annette J. Berendsen
European Journal of Cancer Care.2021;[Epub] CrossRef
Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction
Po-Li Wei, Long-Teng Lee, Li-Ming Tseng, Kai-Wen Huang
Scientific Reports.2018;[Epub] CrossRef
Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
International Journal of Radiation Biology.2017; 93(3): 315. CrossRef
Time to lowest postoperative carcinoembryonic antigen level is predictive on survival outcome in rectal cancer
Huichuan Yu, Yanxin Luo, Xiaolin Wang, Liangliang Bai, Pinzhu Huang, Lei Wang, Meijin Huang, Yanhong Deng, Jianping Wang
Scientific Reports.2016;[Epub] CrossRef
The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence – A systematic review
Caspar G. Sørensen, William K. Karlsson, Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg
International Journal of Surgery.2016; 25: 134. CrossRef
Blood CEA levels for detecting recurrent colorectal cancer
Brian D Nicholson, Bethany Shinkins, Indika Pathiraja, Nia W Roberts, Tim J James, Susan Mallett, Rafael Perera, John N Primrose, David Mant
Cochrane Database of Systematic Reviews.2015;[Epub] CrossRef
Value of Dual Assessment of Carcinoembryonic Antigen and Fluorine-18-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer Recurrence
Saeed Mohammed Bafaraj
European Journal of Basic Medical Sciences.2015; 5(2): 25. CrossRef
Serum Carcinoembryonic Antigen for Recurrence in Colorectal Cancer Patients
Young Jin Kim
Annals of Coloproctology.2013; 29(4): 137. CrossRef

First
Prev
Page of 1
Next
Last

Search