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Case Report
Pulmonary Sarcoidosis That Developed During the Treatment of a Patient With Crohn Disease by Using Infliximab
Tae Kyun Kim, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong, Hyuk Soo Eun
Ann Coloproctol. 2017;33(2):74-77.   Published online April 28, 2017
DOI: https://doi.org/10.3393/ac.2017.33.2.74
  • 6,664 View
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  • 8 Web of Science
  • 12 Citations
AbstractAbstract PDF

For inflammatory bowel disease (IBD), antitumor necrosis factor treatment offers a new direction for both patients and medical doctors. This treatment has dramatically improved the quality of life for patients with ulcerative colitis and Crohn disease (CD). However, with increasing usage and longer follow-up periods, a wider range of possible adverse effects may be encountered. We report an unusual case of pulmonary sarcoidosis developed during the treatment of a patient with CD by using infliximab. A 30-year-old male who had been treated for CD with infliximab for 18 months was admitted due to abnormal opacities on chest radiography. Chest computed tomography displayed clustered small nodules in both lobes and enlarged multiple lymph nodes. The patient was diagnosed with sarcoidosis from the results of a biopsy of the subcarinal lymph node. Lung lesions were improved five months after infliximab was stopped.

Citations

Citations to this article as recorded by  
  • TNF Inhibitor‐Induced Sarcoidosis‐Like Lesions in Inflammatory Bowel Disease
    Zlata Chkolnaia, Benedicte Lebrun‐Vignes, Aurelien Amiot, Mathieu Uzzan, Nicolas Richard, Maeva Charkaoui, Guillaume Le Cosquer, Carmen Stefanescu, Melanie Serrero, Laurianne Plastaras, Sophie Vieujean, David Laharie, Philippe Seksik
    United European Gastroenterology Journal.2026;[Epub]     CrossRef
  • The Development of Sarcoidosis in an Ulcerative Colitis Patient Treated with Vedolizumab: A Case Report and Review of the Literature
    John K. Triantafillidis, Konstantinos Malgarinos, Loukas Kaklamanis, Emmanouil Kritsotakis, Victoria Polydorou, Konstantinos Pantos, Konstantinos Sfakianoudis, Agni Pantou, Konstantinos Bramis, Manousos M. Konstantoulakis, Apostolos E. Papalois
    Clinics and Practice.2026; 16(2): 44.     CrossRef
  • Anti‐TNF Drug‐Induced Sarcoidosis in Inflammatory Bowel Diseases: Multicentric Case Series and Literature Review
    Patrick Bez, Zlata Chkolnaia, Annalisa Aratari, Marta Ascolani, Péter Bacsur, Andreas Blesl, Philippe Seksik, Sara Nikolic, Savarino Edoardo V., Marcello Rattazzi, Francesco Cinetto, Carla Felice, Yoel A. Klug
    BioMed Research International.2026;[Epub]     CrossRef
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    Ei Swe, Jakob Begun
    Cureus.2025;[Epub]     CrossRef
  • Persistent Constitutional Symptoms and Cholestasis During Anti-TNF Therapy as a Harbinger of a Surprising Condition
    Julio Maria Fonseca Chebli, Rogerio Khalil Akkari Evangelista, Liliana Andrade Chebli
    Gastroenterology.2024; 166(2): e1.     CrossRef
  • Pulmonary toxicity assessment of tumor necrosis factor α inhibitors in the treatment of IBD: a real world study based on US food and drug administration adverse events reporting system (FAERS)
    Sichen Sun, Xuan Shi, Mengling Ouyang, Shupeng Zou, Yazheng Zhao, Qian Cheng
    Expert Opinion on Drug Safety.2024; : 1.     CrossRef
  • Sarcoidosis: federal clinical guidelines for diagnosis and treatment
    A. G. Chuchalin, S. N. Avdeev, Z. R. Aisanov, O. P. Baranova, S. E. Borisov, N. A. Geppe, A. A. Vizel’, I. Yu. Vizel’, A. A. Zaicev, N. Y. Kravchenko, M. M. Ilkovich, O. V. Lovacheva, A. B. Malakhov, A. G. Malyavin, D. V. Petrov, V. V. Romanov, I. V. Sivo
    PULMONOLOGIYA.2022; 32(6): 806.     CrossRef
  • Development of pulmonary sarcoidosis in Crohn’s disease patient under infliximab biosimilar treatment after long-term original infliximab treatment: a case report and literature review
    Shin Kashima, Kentaro Moriichi, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanabe, Sayaka Yuzawa, Mikihiro Fujiya
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • An update on the diagnosis and management of ocular sarcoidosis
    De-Kuang Hwang, Shwu-Jiuan Sheu
    Current Opinion in Ophthalmology.2020; 31(6): 521.     CrossRef
  • Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study
    A. A. Vizel, D. A. Culver, I. Yu. Vizel, G. R. Shakirova, E. A. Bakunina
    Tuberculosis and Lung Diseases.2020; 98(10): 33.     CrossRef
  • Radiological Patterns of Lung Involvement in Inflammatory Bowel Disease
    Diletta Cozzi, Chiara Moroni, Gloria Addeo, Ginevra Danti, Monica Marina Lanzetta, Edoardo Cavigli, Massimo Falchini, Fabio Marra, Claudia Lucia Piccolo, Luca Brunese, Vittorio Miele
    Gastroenterology Research and Practice.2018; 2018: 1.     CrossRef
  • Infliximab

    Reactions Weekly.2017; 1657(1): 238.     CrossRef
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