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- Short-term Outcomes After Upfront Chemotherapy Followed by Curative Surgery in Metastatic Colon Cancer: A Comparison With Upfront Surgery Patients
- Myung Hyun Han, Youn Young Park, Shiva Pratap, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
- Ann Coloproctol. 2019;35(6):327-334. Published online December 31, 2019
- DOI: https://doi.org/10.3393/ac.2019.03.04.1
- 4,553 View
- 71 Download
- 2 Web of Science
- 2 Citations
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Abstract
PDF - Purpose
Upfront systemic chemotherapy with target agents has been recommended for patients with stage IV colon cancer. Some with partial response are considered for curative resection. There is high risk of developing postoperative complications following upfront systemic chemotherapy. We aimed to evaluate short-term perioperative outcomes of curative surgery after upfront chemotherapy in comparison with upfront surgery in patients with metastatic colon cancer.
Methods
Between January 2010 and October 2015, 146 patients (80 in the surgery first group, 66 in the upfront chemotherapy group) who underwent surgical resection before or after systemic chemotherapy for metastatic colon cancer were included in the present study. All decisions for treatment were made through a multidisciplinary team. Postoperative clinical outcomes and complications were analyzed to compare the groups.
Results
There was no difference between the 2 groups in terms of postoperative clinical outcomes. Overall complication rates were not different between the groups (surgery first group: 46.3% vs. upfront chemotherapy group: 60.6%; P = 0.084). When classified according to the Clavien-Dindo method, there was no difference between the 2 groups in terms of major complications (grade 3 or more) (surgery first group: 18.9% vs. upfront chemotherapy group: 27.5%; P = 0.374).
Conclusion
There was no significant increase in major postoperative complications in metastatic colon cancer patients who received upfront chemotherapy followed by curative surgery. Careful patient selection and treatment planning are important. -
Citations
Citations to this article as recorded by
- Impact of preoperative chemotherapy on perioperative morbidity in combined resection of colon cancer and liver metastases
Joy Z. Done, Angelos Papanikolaou, Miloslawa Stem, Shannon N. Radomski, Sophia Y. Chen, Chady Atallah, Jonathan E. Efron, Bashar Safar
Journal of Gastrointestinal Surgery.2023; 27(11): 2380. CrossRef - Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Annals of Coloproctology.2021; 37(6): 425. CrossRef
- Impact of preoperative chemotherapy on perioperative morbidity in combined resection of colon cancer and liver metastases
- Risk Factors of a Pulmonary Thromboembolism After Colorectal Surgery
- Junyub Kim, Byung-Noe Bae, Hyun Seok Jung, Inseok Park, Hyunjin Cho, Geumhee Gwak, Kiwhan Kim, Hong-Joo Kim, Young Duk Kim
- Ann Coloproctol. 2015;31(5):187-191. Published online October 31, 2015
- DOI: https://doi.org/10.3393/ac.2015.31.5.187
- 5,506 View
- 33 Download
- 3 Web of Science
- 2 Citations
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Abstract
PDF
Purpose Previous studies have revealed that predictors and risk factors of pulmonary thromboembolism (PTE) are malignancy, immobilization, diabetes, and obesity in the postoperative patients. However, in patients undergoing colorectal cancer, studies of PTE have not been enough. Thus, we investigated the risk factors of PTE related to colorectal surgery.
Methods From January 2009 to October 2014, 312 patients received colorectal surgery without other organ resection. The postoperative patients with PTE were 14 (4.5%), and they were classified by sex, age, and stage as a 1:3 paired match to the control group. A multiple logistic regression was performed to identify which factors were associated with PTE.
Results One patient was in stage I, 3 in stage II, 9 in stage III, and 1 in stage IV. In the binary logistic regression analysis, history of diabetes mellitus (odds ratio, 6.498; P = 0.031) and being overweight (odds ratio, 10.018; P = 0.014) were independent risk factors for PTE in patients undergoing colorectal cancer.
Conclusion A history of diabetes mellitus and being overweight were independent risk factors of PTE after colorectal cancer.
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Citations
Citations to this article as recorded by- Could Preoperative Unintended Weight Loss Predispose to Postoperative Thrombosis in Patients Undergoing Colorectal Cancer Surgery? An Analysis of the NSQIP Data
Sally Temraz, Hani Tamim, Aurelie Mailhac, Farah Nassar, Nour Moukalled, Faek Jamali, Ali Taher
Journal of the American College of Nutrition.2021; 40(2): 141. CrossRef - Venous Thromboembolic Complications in Colorectal Surgery
Jung Wook Huh
Annals of Coloproctology.2015; 31(5): 172. CrossRef
- Could Preoperative Unintended Weight Loss Predispose to Postoperative Thrombosis in Patients Undergoing Colorectal Cancer Surgery? An Analysis of the NSQIP Data
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