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1 "Antitubercular therapy"
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Benign GI diease,Rare disease & stoma,Complication
Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report
Sung Hoon Kang, Hee Seok Moon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee, Jae Kyu Sung, Hyun Yong Jeong, Kyung Ha Lee
Ann Coloproctol. 2021;37(Suppl 1):S18-S23.   Published online May 15, 2020
DOI: https://doi.org/10.3393/ac.2020.03.16.1
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  • 2 Web of Science
  • 4 Citations
AbstractAbstract PDF
Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions. Intestinal perforation in gastrointestinal TB can occur as a paradoxical reaction to antitubercular therapy. A 55-year-old man visited the outpatient department with lower abdominal pain and weight loss. He was diagnosed with intestinal TB and started antitubercular therapy. After 3 months of antitubercular therapy, a colonoscopy revealed improvement of the disease. Three days after the colonoscopy, the patient visited the emergency room complaining of abdominal pain. Abdominal computed tomography revealed extraluminal air-filled spaces in the pelvic cavity. We diagnosed a small bowel perforation and performed an emergency laparotomy and a right hemicolectomy with small bowel resection. This report describes the case of intestinal perforation presenting as a paradoxical reaction to antitubercular and provides a brief literature review.

Citations

Citations to this article as recorded by  
  • Réaction paradoxale tuberculeuse
    L.-D. Azoulay, A.-L. Houist, E. Feredj, W. Vindrios, S. Gallien
    La Revue de Médecine Interne.2024; 45(5): 279.     CrossRef
  • Left hand abscess as a paradoxical reaction during treatment of disseminated tuberculosis in immunocompetent patient: case report and review of literature
    Aisha Alharbi, Aseel Aljahdali, Mohamed Firoze Ahamed, Hassan Almarhabi
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction
    Akira Hokama, Yuiko Oishi, Erika Koga, Sayuri Takehara, Jiro Fujita
    Chonnam Medical Journal.2022; 58(1): 52.     CrossRef
  • Multiple drugs

    Reactions Weekly.2021; 1881(1): 189.     CrossRef
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