Annals of Coloproctology

Display

Sort by :

Original Article

Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma: Hyung Ook Kim, Beom Gyu Kim, Seong Jae Cha, Yong Gum Park, Tae Jin Lee; Ann Coloproctol. 2015;31(1):9-15. Published online February 28, 2015; DOI: https://doi.org/10.3393/ac.2015.31.1.9

4,295 View
52 Download
5 Web of Science
4 Citations

Purpose

BRAF mutation and expression of extracellular signal regulated kinase (ERK) are linked with colorectal carcinogenesis through the serrated pathway. BRAF and ERK1/2 play important roles in the activation of mitogen-activated protein (MAP) kinase signaling pathways. The present study investigated the clinicopathologic outcomes of BRAF mutation and ERK1/2 expression in patients with colorectal cancer (CRC) and the possibility of using them as prognostic indicators.

Methods

Dual-priming oligonucleotide-based multiplex polymerase chain reaction for BRAF^V600E mutation and immunohistochemical analysis of ERK1/2 were performed using 65 formalin-fixed, paraffin-embedded samples from patients with CRC. We analyzed the dependences of the clinicopathologic features on BRAF mutation and ERK1/2 expression.

Results

Out of 65 samples from CRC patients, BRAF mutation was detected in 3 (4.6%). The 3 patients with BRAF mutation presented with T3 CRC with lymph node metastasis (stage III) showing moderately or poorly differentiated histology. ERK1 and ERK2 were positively detected in 73.8% and 15.4% of the patients with CRC, respectively. ERK1 expression was significantly correlated with lymph node metastasis (P = 0.049). ERK2 expression was significantly correlated with tumor emboli (P < 0.05), tumor invasion (P = 0.035), lymph node metastasis (P = 0.017), and stage (P = 0.02).

Conclusion

BRAF mutation and ERK1/2 expression may be associated with advanced or more aggressive CRC. These molecular markers might play prognostic roles in CRC developed through the serrated pathway.

Citations

Citations to this article as recorded by

BRAF protein immunoprecipitation, elution, and digestion from cell extract using a microfluidic mixer for mutant BRAF protein quantification by mass spectrometry
Yen-Heng Lin, Heng-Yun Chang, Chia-Chun Wu, Chia-Wei Wu, Kai-Ping Chang, Jau-Song Yu
Analytical and Bioanalytical Chemistry.2019; 411(5): 1085. CrossRef
Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer
Yinying Wu, Yi Li, Xiaoai Zhao, Danfeng Dong, Chunhui Tang, Enxiao Li, Qianqian Geng
Oncology Letters.2017; 13(1): 129. CrossRef
Progression inference for somatic mutations in cancer
Leif E. Peterson, Tatiana Kovyrshina
Heliyon.2017; 3(4): e00277. CrossRef
DoesBRAFMutation and Extracellular Signal Regulated Kinase Expression in Patients With Colorectal Cancer Have Any Prognostic Significance?
Moo Jun Baek
Annals of Coloproctology.2015; 31(1): 1. CrossRef

Case Report

Rhabdoid Carcinoma of the Rectum: Narimantas Evaldas Samalavicius, Rokas Stulpinas, Valdas Gasilionis, Edita Baltruskeviciene, Eduardas Aleknavicius, Ugnius Mickys; Ann Coloproctol. 2013;29(6):252-255. Published online December 31, 2013; DOI: https://doi.org/10.3393/ac.2013.29.6.252

4,611 View
50 Download
12 Citations

Abstract PDF

Rhabdoid colonic tumors are very rare lesions with just a few publications describing such neoplasms. Even more unusual for these lesions are their primary rectal locations, with only two brief case reports having been published on that subject to date. We present a case of a composite rhabdoid rectal carcinoma in a 49-year-old male. The tumor behaved very aggressively, with rapid patient demise despite radical surgery and intensive postoperative chemotherapy (FOLFIRI [folinic acid {leucovorin}, fluorouracil {5-fluorouracil}, and irinotecan] and FOLFOX4 [folinic acid {leucovorin}, fluorouraci {5-fluorouracil}, and oxaliplatin]). Pathologic examination was supportive of a rhabdoid carcinoma, with a compatible immunohistochemical profile, demonstrating synchronous expression of vimentin and epithelial markers in the tumor cells. In addition, BRAF V600E gene mutation, together with a wild-type KRAS gene, was identified, and no evidence of microsatellite instability based on MLH1, MSH2, MSH6, and PMS2 immunophenotypes, i.e., no loss of expression for all 4 markers, was observed. Our reported case confirms previously published observations of the clinical aggressiveness and the poor therapeutic response for rhabdoid tumors.

Citations

Citations to this article as recorded by

Undifferentiated Rhabdoid Carcinoma of the Gastrointestinal Tract: A Rare and Aggressive Malignancy
Justin M Hsieh, Zara Summers, Shinn Yeung
Cureus.2025;[Epub] CrossRef
SMARCB1/INI1-Deficient Poorly Differentiated Carcinoma of the Colon With Rhabdoid Features—A Rare Tumor With Serrated Phenotype: Case Report and Review of Literature
Shivali Maurya, Sujata Yadav, Subham Bhowmik, Jasmine Dhal, Lalita Mehra, Raju Sharma, Asuri Krishna, Atul Sharma, Adarsh Barwad, Prasenjit Das
International Journal of Surgical Pathology.2024; 32(1): 187. CrossRef
Elusive and Aggressive: Unraveling SMARCB1/INI1-Deficient Undifferentiated Carcinoma With Rhabdoid Features Arising From the Colon: A Case Report and Comprehensive Literature Review
Xiaoqin (Lucy) Liu, Diana Agostini-Vulaj
International Journal of Surgical Pathology.2024; 32(8): 1582. CrossRef
A Case of Ascending Colon Carcinoma with Rhabdoid Features
Masanari YAMADA, Masanori ICHINOSE, Atsushi HIRATA, Yoshihiro KURATA, Kimiaki FUKASAWA, Hisahiro MATSUBARA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2024; 85(6): 755. CrossRef
Case report: administration of immune checkpoint inhibitor for SMARCB1 (INI1)-negative rhabdoid carcinoma with microsatellite instability (MSI)-high in the right colon
Toshinori Kobayashi, Yuki Matsui, Hisanori Miki, Masahiko Hatta, Mitsuaki Ishida, Hironaga Satake, Mitsugu Sekimoto
Surgical Case Reports.2023;[Epub] CrossRef
A Rare Case of Undifferentiated Rhabdoid Carcinoma of the Colon
Syed Alishan Nasir, Ronak Patel, Lalaine Ruiz, Michael Bush
Cureus.2022;[Epub] CrossRef
INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature
Masatsugu Kojima, Toru Miyake, Tomoyuki Ueki, Hiroyuki Ohta, Ryoji Kushima, Masanori Shiohara, Hiroo Mizuta, Hiroya Iida, Tsuyoshi Yamaguchi, Sachiko Kaida, Katsushi Takebayashi, Hiromitsu Maehira, Yusuke Nishina, Tomoharu Shimizu, Eiji Mekata, Masaji Tan
Surgical Case Reports.2021;[Epub] CrossRef
BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas
Elena Bolzacchini, Nunzio Digiacomo, Cristina Marrazzo, Nora Sahnane, Roberta Maragliano, Anthony Gill, Luca Albarello, Fausto Sessa, Daniela Furlan, Carlo Capella
Cancers.2019; 11(9): 1252. CrossRef
Pathologic complete response to bevacizumab-FOLFIRI in metastatic colonic undifferentiated carcinoma with rhabdoid features
Tien-Chan Hsieh, Hung-Wei Liu, Chao-Wen Hsu
Journal of Cancer Research and Practice.2019; 6(3): 140. CrossRef
Extraordinary disease-free survival in a rare malignant extrarenal rhabdoid tumor: a case report and review of the literature
Francesco D’Amico, Alessandra Bertacco, Maurizio Cesari, Claudia Mescoli, Giorgio Caturegli, Gabriel Gondolesi, Umberto Cillo
Journal of Medical Case Reports.2018;[Epub] CrossRef
SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior
Jennifer L Sauter, Rondell P Graham, Brandon T Larsen, Sarah M Jenkins, Anja C Roden, Jennifer M Boland
Modern Pathology.2017; 30(10): 1422. CrossRef
Case Report of Rhabdoid Colon Cancer and Review of Literature
Aparna Kalyan, Gurleen Pasricha, Dulabh Monga, Aatur Singhi, Nathan Bahary
Clinical Colorectal Cancer.2015; 14(1): e5. CrossRef

First
Prev
Page of 1
Next
Last

Search