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Original Articles
Longer withdrawal time is not associated with increased patient discomfort in colonoscopy: a retrospective observational study
Kenichiro Majima, Yosuke Muraki
Ann Coloproctol. 2023;39(1):71-76.   Published online September 7, 2021
DOI: https://doi.org/10.3393/ac.2021.00388.0055
  • 6,164 View
  • 144 Download
  • 3 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
Withdrawal time of sufficient length is a quality indicator for colonoscopies. Nonetheless, whether extending the withdrawal time contributes to patient discomfort remains unknown. This study aimed to clarify the relationship between colonoscopy withdrawal time and patient discomfort.
Methods
A cohort of consecutive patients who underwent colonoscopy at a single institution from October 2018 to January 2020 was retrospectively analyzed. Initially, the relationship between the mean withdrawal time for each colonoscopist in no-finding examinations and polyp detection rate was investigated in 2,043 patients. Subsequently, the primary outcome of association between withdrawal time and patient discomfort, as determined by patient questionnaire, was assessed for each examination in 481 patients from the initial cohort.
Results
The mean withdrawal time was strongly correlated with polyp detection rate (correlation coefficient, 0.72; P<0.001). In contrast, longer withdrawal time was not associated with increased discomfort; however, there was a weak inverse correlation between patient discomfort and longer withdrawal time (correlation coefficient, –0.25; P<0.001). Similarly, multiple regression analysis adjusted for confounding variables revealed that longer withdrawal time was not associated with increased patient discomfort (regression coefficient, –0.04 for each 1-minute increase in the length of withdrawal time; P=0.45).
Conclusion
This study showed for the first time that longer withdrawal times did not result in increased discomfort, indicating that withdrawal time can be extended to sufficient length for optimal patient examination and polyp detection.

Citations

Citations to this article as recorded by  
  • Association between Examination Time and Discomfort in Unsedated Esophagogastroduodenoscopy: A Prospective Observational Study
    Kenichiro Majima, Takeshi Shimamoto, Yosuke Muraki
    GE - Portuguese Journal of Gastroenterology.2026; 33(1): 367.     CrossRef
  • Impact of withdrawal time on the adenoma detection rate in elderly patients during unsedated colonoscopy: a retrospective multicenter study
    Fu-qiang Liu, Ying-hao He, Han Yan, Jin-wen Liao, Wen-juan Ding, Yu-ting Huang, Zhi-qiang Du, Xiang-rong Zhou, Zheng Jiang
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Does longer withdrawal time increase discomfort?
    Kenichiro Majima, Yosuke Muraki
    Digestive Endoscopy.2024; 36(4): 496.     CrossRef
Effects of Intraoperative Insufflation With Warmed, Humidified CO2 during Abdominal Surgery: A Review
Ju Yong Cheong, Anil Keshava, Paul Witting, Christopher John Young
Ann Coloproctol. 2018;34(3):125-137.   Published online June 30, 2018
DOI: https://doi.org/10.3393/ac.2017.09.26
  • 12,411 View
  • 178 Download
  • 13 Web of Science
  • 14 Citations
AbstractAbstract PDF
Purpose
During a laparotomy, the peritoneum is exposed to the cold, dry ambient air of the operating room (20°C, 0%–5% relative humidity). The aim of this review is to determine whether the use of humidified and/or warmed CO2 in the intraperitoneal environment during open or laparoscopic operations influences postoperative outcomes.
Methods
A review was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The PubMed, OVID MEDLINE, Cochrane Central Register of Controlled Trials and Embase databases were searched for articles published between 1980 and 2016 (October). Comparative studies on humans or nonhuman animals that involved randomized controlled trials (RCTs) or prospective cohort studies were included. Both laparotomy and laparoscopic studies were included. The primary outcomes identified were peritoneal inflammation, core body temperature, and postoperative pain.
Results
The literature search identified 37 articles for analysis, including 30 RCTs, 7 prospective cohort studies, 23 human studies, and 14 animal studies. Four studies found that compared with warmed/humidified CO2, cold, dry CO2 resulted in significant peritoneal injury, with greater lymphocytic infiltration, higher proinflammatory cytokine levels and peritoneal adhesion formation. Seven of 15 human RCTs reported a significantly higher core body temperature in the warmed, humidified CO2 group than in the cold, dry CO2 group. Seven human RCTs found lower postoperative pain with the use of humidified, warmed CO2.
Conclusion
While evidence supporting the benefits of using humidified and warmed CO2 can be found in the literature, a large human RCT is required to validate these findings.

Citations

Citations to this article as recorded by  
  • The effects of warmed carbon dioxide pneumoperitoneum nursing care on core body temperature, acid-base balance, and lymphocytes in older patients with cancer in Korea: a randomized controlled trial
    Hyosun Park, Nayeon Shin, Jeong-Heum Baek
    Journal of Korean Biological Nursing Science.2025; 27(4): 598.     CrossRef
  • Performance of intraoperative surgical smoke management technologies for laparoscopic surgery: A comparative in-vivo pig study
    Daniel Göhler, Levon Aslanyan, Kathrin Oelschlägel, Petru Bucur, Jonathan Buggisch, Nadia Azhari, Andreas Rudolph, Sébastien Roger, Michael Stintz, Dirk Bausch, Cédric Demtröder, Mehdi Ouaissi, Urs Giger-Pabst
    Journal of Aerosol Science.2024; 177: 106309.     CrossRef
  • Does intra‐operative humidification with warmed CO2 reduce surgical site infection in open colorectal surgery? A randomized control trial
    Asiri Arachchi, Alice Lee, Manisha Metlapalli, Ellathios Antoniou, Ruben Rajan, Vignesh Narasimhan, Ashray Rajagopalan, Seraphina Key, William M. K. Teoh, Thang Chien Nguyen, James Tow‐Hing Lim, Hanumant Chouhan, Bruce P. Waxman, Julian A. Smith
    ANZ Journal of Surgery.2023; 93(4): 970.     CrossRef
  • The effects of CO2 pneumoperitoneum at different temperature and humidity on hemodynamic and respiratory parameters and postoperative pain in gynecological laparoscopic surgery: A prospective randomized controlled study
    Ilkben Gunusen, Ali Akdemir, Asuman Sargın, Semra Karaman
    Asian Journal of Surgery.2022; 45(1): 154.     CrossRef
  • Incidence of inadvertent perioperative hypothermia in pediatric laparoscopic surgery: a prospective observational single-center study.
    Recai DAĞLI, Ülgen ÇELTİK, Fatma ÇELİK, Zeynel Abidin ERBESLER, Zeynep KÖYLÜ
    Ahi Evran Medical Journal.2022;[Epub]     CrossRef
  • Effects of Warmed and Humidified CO2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis
    Francesco Marchegiani, Eric Noll, Pietro Riva, Seong-Ho Kong, Paola Saccomandi, Giorgia Vita, Véronique Lindner, Izzie Jacques Namer, Jacques Marescaux, Pierre Diemunsch, Michele Diana
    Surgical Innovation.2021; 28(1): 7.     CrossRef
  • Does the Laminar Airflow System Affect the Development of Perioperative Hypothermia? A Randomized Clinical Trial
    Recai Dagli, Fatma Çelik, Hüseyin Özden, Serdar Şahin
    HERD: Health Environments Research & Design Journal.2021; 14(3): 202.     CrossRef
  • Randomized clinical trial of the effect of intraoperative humidified carbon dioxide insufflation in open laparotomy for colorectal resection
    J. Y. Cheong, B. Chami, G. M. Fong, X. S. Wang, A. Keshava, C. J. Young, P. Witting
    BJS Open.2020; 4(1): 45.     CrossRef
  • The Pathogenesis and Prevention of Port-Site Metastasis in Gynecologic Oncology


    Qianqian Gao, Ling Guo, Bo Wang
    Cancer Management and Research.2020; Volume 12: 9655.     CrossRef
  • Morpheus and the Underworld—Interventions to Reduce the Risks of Opioid Use After Surgery: ORADEs, Dependence, Cancer Progression, and Anastomotic Leakage
    Robert Beaumont Wilson
    Journal of Gastrointestinal Surgery.2019; 23(6): 1240.     CrossRef
  • Effects of a multifaceted individualized pneumoperitoneum strategy in elderly patients undergoing laparoscopic colorectal surgery
    Liping Liu, Na Lv, Chunmiao Hou
    Medicine.2019; 98(14): e15112.     CrossRef
  • Single‐incision laparoscopic reversal of Hartmann's operation through the stoma site: comparative outcomes with conventional laparoscopic and open surgery
    P. Thambi, D. W. Borowski, R. Sathasivam, R.‐B. Obuobi, Y. K. S. Viswanath, T. S. Gill
    Colorectal Disease.2019; 21(7): 833.     CrossRef
  • Clinical effects of warmed humidified carbon dioxide insufflation in infants undergoing major laparoscopic surgery
    Tong Meng-Meng, Xu Xue-Jun, Bao Xiao-Hong
    Medicine.2019; 98(27): e16151.     CrossRef
  • Effect of different carbon dioxide (CO2) insufflation for laparoscopic colorectal surgery in elderly patients
    Rongjuan Jiang, Yan Sun, Huaiming Wang, Min Liang, Xianfeng Xie
    Medicine.2019; 98(41): e17520.     CrossRef
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