Skip Navigation
Skip to contents

Ann Coloproctol : Annals of Coloproctology

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
4 "Carcinoid tumor"
Filter
Filter
Article category
Keywords
Publication year
Authors
Case Reports
Rare disease & stoma
A small, low-grade rectal neuroendocrine tumor with lateral pelvic lymph node metastasis: a case report
Seonhui Shin, Young-In Maeng, Seyun Jung, Chun-Seok Yang
Ann Coloproctol. 2022;38(4):327-331.   Published online March 7, 2022
DOI: https://doi.org/10.3393/ac.2021.00899.0128
  • 3,665 View
  • 172 Download
  • 4 Web of Science
  • 7 Citations
AbstractAbstract PDF
Rectal neuroendocrine tumors (NETs) are typically small lesions that are confined to the submucosa and have favorable behavior at the time of diagnosis. Local endoscopic or surgical resection is recommended because lymph node metastasis is very rare. In this report, we present the case of a 36-year-old male presenting with an incidentally found rectal mass during screening colonoscopy. Pathologic examination of the primary tumor revealed a 9-mm grade 1 NET with submucosal invasion and no significant aggressive factors except for central ulceration. However, radiologic studies revealed a suspected 2.6-cm mesorectal lymph node metastasis and multiple left internal iliac lymph node metastases. We performed laparoscopic intersphincteric resection with left lateral pelvic lymph node dissection. The final pathologic report revealed a metastatic lymph node with low grade, low mitotic count, and low Ki-67 index. We describe an overview of lymph node metastasis of rectal NETs focusing on lateral pelvic lymph node metastasis.

Citations

Citations to this article as recorded by  
  • Risk factors for and prognostic impact of lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a single-center retrospective analysis of 214 cases with radical resection
    Tsubasa Sakurai, Y. Hiyoshi, N. Daitoku, S. Matsui, T. Mukai, T. Nagasaki, T. Yamaguchi, T. Akiyoshi, H. Kawachi, Y. Fukunaga
    Surgery Today.2025; 55(2): 144.     CrossRef
  • Construction and evaluation of the prediction model for advanced disease in well-differentiated colorectal neuroendocrine neoplasms less than 2 cm in diameter
    Hongda Yin, Yanan Chen, Wei Zhao, Fuqiang Zhao, Zhijun Huang, Aimin Yue, Zhijie Wang
    Heliyon.2025; 11(1): e41197.     CrossRef
  • Primary small rectal neuroendocrine tumor with pelvic lateral lymph nodes metastasis: A case report and review of literature
    Lihong Li, Ziyue Chen, Dajian Zhu, Qianbao Lv, Tianpeng Zhang, Jinsong Lai
    International Journal of Surgery Case Reports.2025; 127: 110963.     CrossRef
  • Risk factors for lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a systematic review and meta-analysis
    Ziyue Chen, Dajian Zhu
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Successfully Resected Isolated Lateral Lymph Node Recurrence in a Patient with T1 Lower Rectal Cancer: Case Report and Literature Review
    Kazuma Rifu, Koji Koinuma, Hisanaga Horie, Katsusuke Mori, Daishi Naoi, Mineyuki Tojo, Yuko Homma, Satoshi Murahashi, Atsushi Kihara, Toshiki Mimura, Joji Kitayama, Naohiro Sata
    Journal of the Anus, Rectum and Colon.2024; 8(3): 259.     CrossRef
  • Clinical application of endoscopic ultrasonography in the management of rectal neuroendocrine tumors
    Soo-Young Na, Seong Jung Kim, Hyoun Woo Kang
    International Journal of Gastrointestinal Intervention.2023; 12(3): 105.     CrossRef
  • Multiple rectal neuroendocrine tumors: An analysis of 15 cases and literature review
    Shu Pang, Ye Zong, Kun Zhang, Haiying Zhao, Yongjun Wang, Junxiong Wang, Chuntao Liu, Yongdong Wu, Peng Li
    Frontiers in Oncology.2022;[Epub]     CrossRef
Peritoneal Metastatic Goblet-Cell Carcinoid Tumor Treated With Cytoreductive Surgery and Intraperitoneal Chemotherapy
Sang Il Youn, Hwan Namgung, Jeong Seok Yun, Yun Jun Park, Dong-Guk Park
Ann Coloproctol. 2015;31(2):74-78.   Published online April 30, 2015
DOI: https://doi.org/10.3393/ac.2015.31.2.74
  • 4,084 View
  • 43 Download
  • 5 Web of Science
  • 5 Citations
AbstractAbstract PDF

We report a case of a goblet-cell carcinoid tumor of the appendix which metastasized to the peritoneum and was treated by using cytoreductive surgery (CRS) with intraperitoneal chemotherapy. A 47-year-old male presented with chronic constipation and was diagnosed as having a rectal adenocarcinoma with a signet-ring-cell component under colonoscopy. Computed tomography suggested peritoneal metastases with diffuse nodular parietal peritoneal thickening of the entire abdomen and focal invasion of the upper rectum by a seeding mass. CRS with intraperitoneal chemotherapy was done under the diagnosis of a rectal adenocarcinoma with peritoneal metastases. The pathologic diagnosis was a goblet-cell carcinoid tumor of the appendix with peritoneal metastasis. The histological discrepancy between a peritoneal metastatic mass and a rectal mass was due to the mixed histological pattern of a goblet-cell carcinoid tumor. A metastatic mass may not share identical immunohistochemical characteristics from its origin. This histologic discrepancy necessitates caution in diagnosing a distant metastasis of a goblet-cell carcinoid tumor.

Citations

Citations to this article as recorded by  
  • Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report
    Sungchul Lee, Euitae Kim, Dong-Guk Park
    Annals of Coloproctology.2024; 40(Suppl 1): S18.     CrossRef
  • Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum—A Case Report and Brief Review of the Literature
    Alexandra Dinu, Mariana Aşchie, Gabriela Isabela Bălţătescu, Manuela Enciu, Ionuţ Burlacu
    Reports.2024; 8(1): 1.     CrossRef
  • Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall
    Faten Limaiem, Sahir Omrani, Mohamed Hajri
    Clinical Case Reports.2023;[Epub]     CrossRef
  • Mixed Neuroendocrine Non-neuroendocrine Neoplasm of Anorectum with Goblet Cell Morphology
    Sandhya Biswal, Anirban Kundu, Ankit Sahoo, Prakash Kumar Sasmal, Biswajit Sahoo, Suvradeep Mitra
    Journal of Gastrointestinal Cancer.2021; 52(3): 1093.     CrossRef
  • Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
    Santosh Shenoy
    World Journal of Gastrointestinal Surgery.2016; 8(10): 660.     CrossRef
Original Article
Clinical Characteristics of Colorectal Carcinoid Tumors
J Korean Soc Coloproctol. 2011;27(1):17-20.   Published online February 28, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.1.17
  • 4,816 View
  • 49 Download
  • 19 Citations
AbstractAbstract PDF
Purpose

The carcinoid tumor was recently categorized as a malignant disease due to its possibility of metastasis. This study was aimed to investigate the clinical characteristics and the metastatic rate of colorectal carcinoid tumors.

Methods

Charts were reviewed for 502 patients diagnosed with and treated for colorectal carcinoid tumors between January 2006 and December 2009. The location, size, depth and metastatic status of the tumors were collected.

Results

Including 24 synchronous tumors from 12 patients, 514 carcinoid tumors were removed. Most of them were found in the rectum (97.3%). The male-to-female ratio was 1.38 to 1, and mean age was 50.2 ± 11.4 years. The mean tumor size was 5.8 ± 3.6 mm. Less than 10-mm-sized tumors had a 1.95% lymph node metastatic rate; tumors with sizes from 10 mm to 20 mm and larger than 20 mm had 23.5% and 50% lymph node metastatic rates, respectively. Two cases had distant metastasis; one with a 22-mm-sized tumor metastasized to the liver, and the other with a 20-mm-sized tumor metastasized to the peritoneum. Among 414 patients who completed metastatic studies, 93.8% were classified as stage I, 0.9% as stage II, 4.8% as stage III and 0.5% as stage IV.

Conclusion

Colorectal carcinoid tumors smaller than 10 mm have a low rate of lymph node metastasis, but those sized 10 mm or larger incur significant risk. Further investigation regarding additional risk factors should be done to develop proper treatment guidelines for these tumors.

Citations

Citations to this article as recorded by  
  • Clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10–20 mm rectal neuroendocrine tumors: a multicenter, retrospective study of 10-year experience
    Ja Jun Goo, Dong Hoon Baek, Hyung Wook Kim, Hong Sub Lee, Jong Yoon Lee, Su Bum Park, Geun Am Song, Sang Heon Lee, Jong Hoon Lee
    Surgical Endoscopy.2023; 37(7): 5196.     CrossRef
  • Stratification of rate of lymph node metastasis according to risk factors and oncologic outcomes in patients who underwent radical resection for rectal neuroendocrine tumors
    Myung Jae Jin, Sung Sil Park, Dong-Eun Lee, Sung Chan Park, Dong Woon Lee, Kiho Yu, Hee Jin Chang, Chang Won Hong, Dae Kyung Sohn, Kyung Su Han, Bun Kim, Byung Chang Kim, Jae Hwan Oh
    Annals of Coloproctology.2023; 39(6): 467.     CrossRef
  • Risk factors of lymph node metastasis in rectal neuroendocrine tumors*
    Donghong Liang, Zhennan Niu, Xiaofang Sun, Changjuan Meng, Zhuang Liu
    Oncology and Translational Medicine.2022; 8(4): 186.     CrossRef
  • Risk of lymph node metastasis after endoscopic treatment for rectal NETs 10 mm or less
    Yutaka Inada, Naohisa Yoshida, Kohei Fukumoto, Ryohei Hirose, Ken Inoue, Osamu Dohi, Takaaki Murakami, Kiyoshi Ogiso, Akira Tomie, Munehiro Kugai, Hiroyuki Yoriki, Yoshikazu Inagaki, Daisuke Hasegawa, Kotaro Okuda, Takashi Okuda, Yukiko Morinaga, Mitsuo K
    International Journal of Colorectal Disease.2021; 36(3): 559.     CrossRef
  • Grade G2 Rectal Neuroendocrine Tumor Is Much More Invasive Compared With G1 Tumor
    Yi-Wei Li, Yi-Ping He, Fang-Qi Liu, Jun-Jie Peng, San-Jun Cai, Ye Xu, Ming-He Wang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Nodal metastases in small rectal neuroendocrine tumours
    Sarah O’Neill, Amyn Haji, Suzanne Ryan, Dominique Clement, Konstantinos Sarras, Bu Hayee, Nicola Mulholland, John K. Ramage, Rajaventhan Srirajaskanthan
    Colorectal Disease.2021; 23(12): 3173.     CrossRef
  • Analysis of Risk Factors of Lymph Node Metastasis in Rectal Neuroendocrine Neoplasms Using Multicenter Data
    Gengzhou Wei, Xingyu Feng, Wei Wang, Yu Zhang, Yujie Zeng, Minhu Chen, Ye Chen, Jie Chen, Zhiwei Zhou, Yong Li
    Future Oncology.2018; 14(18): 1817.     CrossRef
  • Predictive Factors for Lymph Node Metastasis and Prognostic Factors for Survival in Rectal Neuroendocrine Tumors
    Beonghoon Sohn, Yoomin Kwon, Seung-Bum Ryoo, Inho Song, Yoon-Hye Kwon, Dong Woon Lee, Sang Hui Moon, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
    Journal of Gastrointestinal Surgery.2017; 21(12): 2066.     CrossRef
  • The Clinicopathologic Features and Treatment of 607 Hindgut Neuroendocrine Tumor (NET) Patients at a Single Institution
    Seung Tae Kim, Sang Yun Ha, Jeeyun Lee, Sung No Hong, Dong Kyung Chang, Young Ho Kim, Yoon Ah Park, Jung Wook Huh, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Hee Cheol Kim, Young Suk Park
    Medicine.2016; 95(19): e3534.     CrossRef
  • Comparison of Endoscopic Mucosal Resection With Circumferential Incision and Endoscopic Submucosal Dissection for Rectal Carcinoid Tumor
    Ru Chen, Xiang Liu, Siyu Sun, Sheng Wang, Nan Ge, Guoxin Wang, Jintao Guo
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2016; 26(3): e56.     CrossRef
  • Nonlinear optical microscopy for label-free detection of gastrointestinal neuroendocrine tumors
    Lianhuang Li, Liwei Jiang, Zhifen Chen, Deyong Kang, Zhenrong Yang, Xing Liu, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Yongjian Zhou, Jianxin Chen
    Lasers in Medical Science.2016; 31(7): 1285.     CrossRef
  • Rektale neuroendokrine Tumoren: chirurgische Therapie
    O. Radulova-Mauersberger, S. Stelzner, H. Witzigmannn
    Der Chirurg.2016; 87(4): 292.     CrossRef
  • Hindgut Neuroendocrine Neoplasia
    James D. Smith, Govind Nandakumar
    Indian Journal of Surgical Oncology.2016; 7(1): 73.     CrossRef
  • Are Small Rectal Neuroendocrine Tumors Safe?
    Jae Ho Choi, Jae Myung Cha
    Intestinal Research.2015; 13(2): 103.     CrossRef
  • Rectal carcinoids: a systematic review
    Frank D. McDermott, Anna Heeney, Danielle Courtney, Helen Mohan, Des Winter
    Surgical Endoscopy.2014; 28(7): 2020.     CrossRef
  • Clinicopathological analysis of colorectal carcinoid tumors and patient outcomes
    Hung-Hsin Lin, Jen-Kou Lin, Jeng-Kai Jiang, Chun-Chi Lin, Yuan-Tzu Lan, Shung-Haur Yang, Huann-Sheng Wang, Wei-Shone Chen, Tzu-Chen Lin, Wen-Yih Liang, Shih-Ching Chang
    World Journal of Surgical Oncology.2014;[Epub]     CrossRef
  • Endoscopic submucosal dissection for colorectal tumors—1,000 colorectal ESD cases: one specialized institute’s experiences
    Eun-Jung Lee, Jae Bum Lee, Suk Hee Lee, Do Sun Kim, Doo Han Lee, Doo Seok Lee, Eui Gon Youk
    Surgical Endoscopy.2013; 27(1): 31.     CrossRef
  • Factors Associated with Lymph Node Metastasis in Radically Resected Rectal Carcinoids: a Systematic Review and Meta-analysis
    Xin Zhou, Haiting Xie, Lingduo Xie, Jing Li, Wei Fu
    Journal of Gastrointestinal Surgery.2013; 17(9): 1689.     CrossRef
  • Variable Clinical Classifications and Diagnostic Coding Systems of Colorectal Neuroendocrine Tumor
    Byung Chang Kim, Cheol Hee Park, Tae Il Kim, Suck-Ho Lee, Jin-Oh Kim, Hyun Soo Kim, Dong-Hoon Yang, Bora Keum, Sung Pil Hong, Seong-Eun Kim, Hyun Gun Kim, Jeong Eun Shin, Jae Myung Cha, Young Eun Joo, Dong Il Park, Hwang Choi, Kyu Chan Huh, Seung-Jae Myun
    Intestinal Research.2013; 11(1): 14.     CrossRef
Case Report
A Case of Appendiceal Carcinoid Tumor.
Bae, Jong Dae , Bae, Jung Min , Jung, Ki Hoon , Jung, Byung Ook , Bae, Sung Han
J Korean Soc Coloproctol. 2003;19(2):108-111.
  • 1,137 View
  • 12 Download
AbstractAbstract PDF
Carcinoid is the most common tumor in the appendix and most often occurs in young patient. A case of mesoappendiceal invasion of carcinoid of appendix in presented and the literature review for indications for right hemicolectomy. A 38-year-old man was admitted to hospital after 3 day with right lower quadrant pain. The appendectomy was performed. At gross pathologic examination the appendix measured 7.5 cm in length and 1.6 cm in diameter. The serosal surface is congested and covered with yellow white fibrinoid material. The cut surface revealed a focal thickening of wall, measured 0.7 x 0.5 cm at 2 cm from tip of the appendix. Light microscopy revealed a typical carcinoid tumors infiltrating periappendiceal fat tissue. The patient was readmitted 4 weeks postoperatively for an elective right hemicolectomy. At exploratory laparotomy, there were no palpable lymph nodes. Exploration of the distal ileum, small bowel, and remaining abdomen did reveal any other carcinoid tumors.
  • FirstFirst
  • PrevPrev
  • Page of 1
  • Next Next
  • Last Last

Ann Coloproctol : Annals of Coloproctology Twitter Facebook
TOP