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Original Articles
Comparison of colorectal cancer surgery patients in intensive care between rural and metropolitan hospitals in Australia: a national cohort study
Jessica A. Paynter, Zakary Doherty, Chun Hin Angus Lee, Kirby R. Qin, Janelle Brennan, David Pilcher
Received April 21, 2024  Accepted July 28, 2024  Published online January 24, 2025  
DOI: https://doi.org/10.3393/ac.2024.00269.0038    [Epub ahead of print]
  • 175 View
  • 7 Download
AbstractAbstract PDFSupplementary Material
Purpose
A small proportion of colorectal cancer (CRC) surgical patients will require an admission to an intensive care unit (ICU) within the early postoperative period. This study aimed to compare the characteristics and outcomes of patients admitted to an ICU following CRC surgery per hospital type (metropolitan vs. rural) over a decade in Australia.
Methods
A retrospective cohort analysis was undertaken of all adult patients admitted to a participating Australian ICUs following CRC surgery between January 2011 and December 2021. The primary outcome was in-hospital mortality.
Results
Over the 10-year period, 19,611 patients were treated in 122 metropolitan ICUs and 4,108 patients were treated in 42 rural ICUs. Rural ICUs had a lower proportion of annual admissions following CRC surgery (20 vs. 36, P<0.001). Patients admitted to a rural ICU were more likely to have undergone emergency CRC surgery compared to those admitted to a metropolitan cohort (28.5% vs. 13.8%, P<0.001). There was no difference in in-hospital mortality between metropolitan and rural hospitals (odds ratio [OR], 1.03; 95% confidence interval [CI], 0.73–1.35; P=0.500). There was a general trend for lower mortality in later years of the study with the odds of death in the final year of the study (2021) almost half that of the first study year (OR, 0.52; 95% CI, 0.34–0.80; P=0.003).
Conclusion
There was no difference between in-hospital mortality outcomes for CRC surgical patients requiring ICU admission between metropolitan and rural hospitals. These findings may contribute to discussions regarding rural scope of colorectal practice within Australia and globally.
Minimally invasive surgery
New double-stapling technique without staple-crossing line in laparoscopic low anterior resection: effort to reduce anastomotic leakage
Nam Seok Kim, Ji Hoon Kim, Yoon Suk Lee, In Kyu Lee, Won Kyung Kang
Ann Coloproctol. 2024;40(6):573-579.   Published online November 22, 2024
DOI: https://doi.org/10.3393/ac.2022.00409.0058
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  • 67 Download
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Purpose
This study aimed to demonstrate the safety of new double-stapling technique (nDST), without a crossing line and dog ears, by comparing with conventional DST (cDST) in laparoscopic low anterior resection (LAR).
Methods
We retrospectively reviewed 98 consecutive patients who underwent laparoscopic LAR for rectal cancer from January 2018 to December 2020. The inclusion criterion was an anastomosis level below the peritoneal reflection and 4 cm above the anal verge. In the nDST group, the staple line of the linear cutter was sutured using barbed sutures to shorten the staple line before firing the circular stapler. Therefore, there were no crossing lines after firing the circular stapler. A 2:1 propensity score matching was performed between the cDST and nDST groups.
Results
After propensity score matching, 39 patients were in the cDST group and 20 were in the nDST group. There were no significant differences in patient demographics between the 2 groups. There was no difference in the total operation time between the cDST and nDST groups (124.0±26.2 minutes vs. 125.2±20.3 minutes, P=0.853). Morbidity rates were similar between the 2 groups (9 cases [23.1%] vs. 5 cases [25.0%], P=0.855). There was no significant difference in leakage rate (4 cases [10.3%] vs. 1 case [5.0%], P=0.847) and anastomotic bleeding rate (1 case [2.6%] vs. 3 cases [15.0%], P=0.211).
Conclusion
The nDST to eliminate the crossing line and dog ears in laparoscopic LAR is technically feasible and safe. However, more attention should be paid to anastomotic bleeding in such cases.
Colorectal cancer
Lymphovascular invasion in colorectal cancers: can we predict it preoperatively?
Elbrus Zarbaliyev, Nihan Turhan, Sebahattin Çelik, Mehmet Çağlıkülekçi
Ann Coloproctol. 2024;40(3):245-252.   Published online June 25, 2024
DOI: https://doi.org/10.3393/ac.2023.00458.0065
  • 1,523 View
  • 166 Download
AbstractAbstract PDF
Purpose
This study aimed to investigate preoperative predictors of lymphovascular invasion (LVI), which is a poor prognostic factor usually detected postoperatively in patients with colorectal cancer.
Methods
Results for all patients operated on for colorectal cancer between January 1, 2006, and December 31, 2021, were retrospectively analyzed. Potential preoperative factors and postoperative pathology results were recorded. The patients were categorized as those with LVI and those without LVI. Potential factors that may be associated with LVI were compared between the 2 groups.
Results
The study included 335 patients. The incidence of LVI was 3.11 times higher in patients with ascending colon tumors (odds ratio [OR], 3.11; 95% confidence interval [CI], 1.34–7.23; P=0.008) and 4.28 times higher in those with metastatic tumors (OR, 4.28; 95% CI, 2.18–8.39; P<0.001). Diabetes mellitus was inversely related to LVI in colorectal cancer patients; specifically, LVI was 56% less common in colorectal cancer patients with diabetes mellitus, irrespective of its duration (OR, 0.44; 95% CI, 0.25–0.76; P<0.001).
Conclusion
The presence of preoperative LVI in colorectal cancer patients is difficult to predict. In particular, the effect of the effect of factors such as chronic disease accompanied by microvascular pathologies on LVI is still unclear. Advances in the neoadjuvant treatment of colorectal cancer patients, who are becoming more widespread every day, will encourage the investigation of different methods of preoperatively predicting LVI as a poor prognostic factor in these patients.
Malignant disease,Colorectal cancer,Epidemiology & etiology
Clinicopathologic characteristics of early-onset colorectal cancer
Kui Seon Park, Young Ki Hong, Yoon Jung Choi, Jung Gu Kang
Ann Coloproctol. 2022;38(5):362-369.   Published online March 11, 2022
DOI: https://doi.org/10.3393/ac.2021.00976.0139
  • 5,480 View
  • 194 Download
  • 14 Web of Science
  • 15 Citations
AbstractAbstract PDF
Purpose
The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years.
Methods
Between January 2009 and December 2018, 1,126 primary CRC patients were included from National Health Insurance Service Ilsan Hospital. The patients were divided into group 1 (n=111, ≤50 years) and group 2 (n=1,015, >50 years). The clinicopathologic features and prognostic outcomes were compared. In addition, to analyze whether there were any differences of those characteristics in 3 groups, patients aged under 50 years were divided into their 20s, 30s, and 40s.
Results
Group 1 had a slightly higher distribution in the left colon and rectum, lower T stage I and higher T stage IV rate, and a significantly higher distribution in stage N2 than group 2 (30.6%:16.3%, P<0.001). Poor histological differentiation of tumors was significantly high in group 1 (P=0.003). The 5-year survival rate for those in their 30s (69.2%) and 40s (91.6%) was higher than those in their 20s who died immediately after surgery (P<0.001). The 5-year disease-free survival rate was also confirmed to be meaningful for each age group, with 0% in their 20s, 53.8% in their 30s, 79.2% in their 40s (P<0.001).
Conclusion
Although the age was not an independent prognostic factor for overall survival in this study, the early onset group of CRCs is more advanced at the time of diagnosis and has a more aggressive histologic type.

Citations

Citations to this article as recorded by  
  • Multiethnic Trends in Early Onset Colorectal Cancer
    Michelle Nagata, Kohei Miyagi, Brenda Y. Hernandez, Scott K. Kuwada
    Cancers.2024; 16(2): 398.     CrossRef
  • Surgical and survival outcomes of early‐onset colorectal cancer patients: a single‐centre descriptive Australian study
    Celine Garrett, Daniel Steffens, Michael Solomon, Cherry Koh
    ANZ Journal of Surgery.2024; 94(9): 1584.     CrossRef
  • Global epidemiology of early‐onset upper gastrointestinal cancer: trend from the Global Burden of Disease Study 2019
    Pojsakorn Danpanichkul, Thanida Auttapracha, Siwanart Kongarin, Ben Ponvilawan, Daniel M. Simadibrata, Kwanjit Duangsonk, Supitchaya Jaruvattanadilok, Sakditad Saowapa, Kanokphong Suparan, Rashid N. Lui, Suthat Liangpunsakul, Michael B. Wallace, Karn Wija
    Journal of Gastroenterology and Hepatology.2024; 39(9): 1856.     CrossRef
  • Early onset metastatic colorectal cancer in Australia
    A. Jalali, S. Smith, G. Kim, H. Wong, M. Lee, J. Yeung, M. Loft, R. Wong, J.D. Shapiro, S. Kosmider, J. Tie, S. Ananda, B. Ma, M. Burge, R. Jennens, B. Lee, J. Johns, L. Lim, A. Dean, L. Nott, P. Gibbs
    Cancer Treatment and Research Communications.2024; 40: 100827.     CrossRef
  • Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study
    Álvaro Esteban Ruiz-Grajales, Juan Camilo Correa-Cote, Miguel Ángel Sánchez-Zapata, Manuela María Orozco-Puerta, Juan Felipe Baena-García, Esteban Castrillón-Martínez
    Journal of Cancer Research and Clinical Oncology.2024;[Epub]     CrossRef
  • The prognostic significance of clinicopathological characteristics in early-onset versus late-onset colorectal cancer liver metastases
    Yi-Tong Li, Xiang-Yu Wang, Bo Zhang, Bao-Rui Tao, Zhen-Mei Chen, Xiao-Chen Ma, Jia-Hao Han, Chong Zhang, Rui Zhang, Jin-Hong Chen
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Clinical implication of tissue carcinoembryonic antigen expression in association with serum carcinoembryonic antigen in colorectal cancer
    Abdulmohsin Fawzi Aldilaijan, Young Il Kim, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jihun Kim, Jun-Soo Ro, Jin Cheon Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Patients younger than 40 years with colorectal cancer have a similar prognosis to older patients
    Tomoki Abe, Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Takashi Kato, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri, Yoshihiro Kakeji
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Clinical and pathological characteristics of early-onset colorectal cancer in South Korea
    Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
    Saudi Journal of Gastroenterology.2023; 29(6): 358.     CrossRef
  • Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
    Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
    Cancers.2023; 15(20): 5098.     CrossRef
  • Unveiling the profound advantages of total neoadjuvant therapy in rectal cancer: a trailblazing exploration
    Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Donghyoun Lee, Chinock Cheong
    Annals of Surgical Treatment and Research.2023; 105(6): 341.     CrossRef
  • Surgical Techniques for Transanal Local Excision for Early Rectal Cancer
    Gyoung Tae Noh
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus R0 resection for resectable colorectal cancer with peritoneal metastases and low peritoneal cancer index scores: A collaborative observational study from Korea and Japan
    Daichi Kitaguchi, Eun Jung Park, Seung Hyuk Baik, Shoma Sasaki, Yuichiro Tsukada, Masaaki Ito
    International Journal of Surgery.2023;[Epub]     CrossRef
  • Is the oncological impact of vascular invasion more important in right colon cancer?
    Gyung Mo Son
    Journal of Minimally Invasive Surgery.2022; 25(2): 49.     CrossRef
  • Different Oncologic Outcomes in Early-Onset and Late-Onset Sporadic Colorectal Cancer: A Regression Analysis on 2073 Patients
    Caterina Foppa, Annalisa Maroli, Sara Lauricella, Antonio Luberto, Carlotta La Raja, Francesca Bunino, Michele Carvello, Matteo Sacchi, Francesca De Lucia, Giuseppe Clerico, Marco Montorsi, Antonino Spinelli
    Cancers.2022; 14(24): 6239.     CrossRef
Review
Malignant disease,Prognosis and adjuvant therapy,Colorectal cancer,Surgical technique
Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Ann Coloproctol. 2021;37(6):425-433.   Published online December 22, 2021
DOI: https://doi.org/10.3393/ac.2021.00920.0131
  • 6,756 View
  • 200 Download
  • 25 Web of Science
  • 26 Citations
AbstractAbstract PDF
From the perspective of survival outcomes, the cancer survival of colorectal cancer (CRC) in the whole stage has improved. Peritoneal metastasis (PM) is found in approximately 8% to 15% of patients with CRC, with a poorer prognosis than that associated with other sites of metastases. Randomized controlled trials and up-to-date meta-analyses provide firm evidence that cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) could significantly improve overall survival compared with systemic chemotherapy alone in selected patients with CRC-PM. Practical guidelines recommend that the management of CRC-PM should be led by a multidisciplinary team carried out in experienced centers and consider CRS plus HIPEC for selected patients. In this review, we aim to provide the latest results of land mark studies and an overview of recent insights with regard to the management of CRC-PM.

Citations

Citations to this article as recorded by  
  • Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing
    Ye Jin Ha, Seong-Hwan Park, Seon-Kyu Kim, Ka Hee Tak, Jeong-Hwan Kim, Chan Wook Kim, Yong Sik Yoon, Seon-Young Kim, Jong Lyul Lee
    Scientific Data.2025;[Epub]     CrossRef
  • CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer
    Ye Jin Ha, Seong-Hwan Park, Ka Hee Tak, Jong Lyul Lee, Chan Wook Kim, Jeong-Hwan Kim, Seon-Young Kim, Seon-Kyu Kim, Yong Sik Yoon
    Scientific Reports.2024;[Epub]     CrossRef
  • Comparison of EPIC Versus HIPEC in the Treatment of Colorectal Peritoneal Metastases and Appendix Tumors Using Inverse Probability of Treatment Weighting
    Min Hye Jeong, Su Jin Kang, Soo Yeun Park, Sang Gyu Kwak, An Na Seo, Suehyun Park, Jun Seok Park, Hye Jin Kim, Gyu-Seog Choi
    Annals of Surgical Oncology.2024; 31(10): 7111.     CrossRef
  • Albumin Leakage Level during Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Associated with Major Complications
    Hyun-Chang Kim, Dong Woo Han, Eun Jung Park, Yeon Hwa Hong, Young Song
    Cancers.2024; 16(16): 2874.     CrossRef
  • Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment
    Mesut Tez
    World Journal of Clinical Oncology.2024; 15(10): 1264.     CrossRef
  • Analgesic effects of combined transversus abdominis plane block and intramuscular electrical stimulation in patients undergoing cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy: a randomized controlled trial
    Hyun-Chang Kim, Jinyoung Park, Jinyoung Oh, Minjae Kim, Eun Jung Park, Seung Hyuk Baik, Young Song
    International Journal of Surgery.2023; 109(5): 1199.     CrossRef
  • Do Laparoscopic Approaches Ensure Oncological Safety and Prognosis for Serosa-Exposed Colon Cancer? A Comparative Study against the Open Approach
    Ji-Hyun Seo, In-Ja Park
    Cancers.2023; 15(21): 5211.     CrossRef
  • Fluorescence-guided colorectal surgery: applications, clinical results, and protocols
    Jin-Min Jung, In Ja Park, Eun Jung Park, Gyung Mo Son
    Annals of Surgical Treatment and Research.2023; 105(5): 252.     CrossRef
  • Improving nanochemoimmunotherapy efficacy by boosting “eat-me” signaling and downregulating “don't-eat-me” signaling with Ganoderma lucidum polysaccharide-based drug delivery
    Guibin Pang, Siqi Wei, Jian Zhao, Fu-Jun Wang
    Journal of Materials Chemistry B.2023; 11(48): 11562.     CrossRef
  • Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis
    Stefanos Bitsianis, Ioannis Mantzoros, Elissavet Anestiadou, Panagiotis Christidis, Christos Chatzakis, Konstantinos Zapsalis, Savvas Symeonidis, Georgios Ntampakis, Kalliopi Domvri, Anastasia Tsakona, Chryssa Bekiari, Orestis Ioannidis, Stamatios Aggelop
    Journal of Clinical Medicine.2023; 12(23): 7267.     CrossRef
  • Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies
    Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak
    Cancers.2023; 15(24): 5791.     CrossRef
  • Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases: A Focus on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
    Youngbae Jeon, Eun Jung Park
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Influence of the COVID-19 Pandemic on the Treatment Patterns and Outcomes of Colorectal Cancer
    In Ja Park
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus R0 resection for resectable colorectal cancer with peritoneal metastases and low peritoneal cancer index scores: A collaborative observational study from Korea and Japan
    Daichi Kitaguchi, Eun Jung Park, Seung Hyuk Baik, Shoma Sasaki, Yuichiro Tsukada, Masaaki Ito
    International Journal of Surgery.2023;[Epub]     CrossRef
  • The Onset of In-Vivo Dehydration in Gas -Based Intraperitoneal Hyperthermia and Its Cytotoxic Effects on Colon Cancer Cells
    Agata Diakun, Tanja Khosrawipour, Agata Mikolajczyk-Martinez, Jakub Nicpoń, Zdzisław Kiełbowicz, Przemysław Prządka, Bartłomiej Liszka, Wojciech Kielan, Kacper Zielinski, Pawel Migdal, Hien Lau, Shiri Li, Veria Khosrawipour
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Patients with Metachronous Peritoneal Metastatic Mucinous Colorectal Adenocarcinoma Benefit More from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) than Their Synchronous Counterparts
    Zoltan Herold, Miklos Acs, Attila Marcell Szasz, Katalin Olasz, Jana Hussong, Max Mayr, Magdolna Dank, Pompiliu Piso
    Cancers.2022; 14(16): 3978.     CrossRef
  • ASO Author Reflections: Is it Correct to Use 5% Dextrose Solution as a Carrier Fluid for Oxaliplatin-based HIPEC?
    Eun Jung Park, Sung-Joo Hwang, Seung Hyuk Baik
    Annals of Surgical Oncology.2022; 29(13): 8593.     CrossRef
  • Pharmacologic Effects of Oxaliplatin Instability in Chloride-Containing Carrier Fluids on the Hyperthermic Intraperitoneal Chemotherapy to Treat Colorectal Cancer In Vitro and In Vivo
    Eun Jung Park, Junhyun Ahn, Sharif Md Abuzar, Kyung Su Park, Sung-Joo Hwang, Seung Hyuk Baik
    Annals of Surgical Oncology.2022; 29(13): 8583.     CrossRef
  • Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report
    Suk Jun Lee, Ji Hae Nahm, Jeonghyun Kang, Seung Hyuk Baik, Eun Jung Park
    International Journal of Surgery Case Reports.2022; 99: 107665.     CrossRef
  • Molecular analyses of peritoneal metastasis from colorectal cancer
    Chang Hyun Kim
    Journal of the Korean Medical Association.2022; 65(9): 586.     CrossRef
  • Surgical treatment for metastatic colorectal cancer
    Eun Jung Park, Seung Hyuk Baik
    Journal of the Korean Medical Association.2022; 65(9): 568.     CrossRef
  • Direction of diagnosis and treatment improvement in colorectal cancer
    In Ja Park
    Journal of the Korean Medical Association.2022; 65(9): 540.     CrossRef
  • Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version
    Eun Jung Park, Seung Hyuk Baik
    Journal of the Anus, Rectum and Colon.2022; 6(4): 213.     CrossRef
  • Molecular Analyses in Peritoneal Metastasis from Colorectal Cancer: A Review-An English Version
    Chang Hyun Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 197.     CrossRef
  • Update on Diagnosis and Treatment of Colorectal Cancer
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    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • It Is a Pleasure to Announce the Issue Titled “Master Class 2021” in Annals of Coloproctology
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    Annals of Coloproctology.2021; 37(6): 349.     CrossRef
Original Articles
Malignant disease,Prognosis and adjuvant therapy,Colorectal cancer
Comparison of the oncological outcomes of stenting as a bridge to surgery and surgery alone in stages II to III obstructive colorectal cancer: a retrospective study
Hiroaki Uehara, Toshiyuki Yamazaki, Akira Iwaya, Hitoshi Kameyama, Masaru Komatsu, Motoharu Hirai
Ann Coloproctol. 2022;38(3):235-243.   Published online July 13, 2021
DOI: https://doi.org/10.3393/ac.2020.01067.0152
  • 5,258 View
  • 203 Download
  • 7 Web of Science
  • 8 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Purpose
We evaluated the oncological outcomes of bridge to surgery (BTS) using stent compared with surgery alone for obstructive colorectal cancer.
Methods
Consecutive patients who underwent curative resection for stages II to III obstructive colorectal cancer at our institution from January 2009 to March 2020, were registered retrospectively and divided into 43 patients in the BTS group and 65 patients in the surgery alone group. We compared the surgical and oncological outcomes between the 2 groups.
Results
Stent-related perforation did not occur. One patient in whom the stent placement was unsuccessful underwent emergency surgery with poor decompression (clinical success rate, 97.7%). The pathological characteristics were not significantly different between the groups. The following surgical outcomes in the BTS group were superior to those in the surgery alone group; nonemergency surgery (P<0.001), surgical approach (P=0.006), and length of hospital stay (P=0.020). The median follow-up time was 44.9 months (range, 1.1–126.5 months). The 3-year relapse-free survival rates were 68.4% and 58.2% (P=0.411), and the overall survival rates were 78.3% and 88.2% (P=0.255) in the surgery alone and BTS groups, respectively. The 3-year locoregional recurrence rates were 10.2% and 8.0% (P=0.948), and distant metastatic recurrence rates were 13.3% and 30.4% (P=0.035) in the surgery alone and BTS groups, respectively.
Conclusion
This study revealed that BTS with stent may be associated with a higher frequency of distant metastatic recurrence. Stent for stages II to III obstructive colorectal cancer potentially worsens oncological outcomes.

Citations

Citations to this article as recorded by  
  • Complete Obstruction, a Real Risk Factor: A Comprehensive Study on Obstruction in Stage IIA Colon Cancer With Propensity Score Matching Analysis
    Soo Young Oh, Chan Wook Kim, Seonok Kim, Min Hyun Kim, Young Il Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu
    Clinical Colorectal Cancer.2024; 23(2): 135.     CrossRef
  • Is it possible to use colon stenting as part of the implementation of the early rehabilitation after surgery concept in the surgical treatment of patients with colon cancer complicated by obstructive intestinal obstruction? Review
    Saday A. Aliyev, Emil S. Aliyev
    Russian Journal of Oncology.2024;[Epub]     CrossRef
  • Oncologic impact of colonic stents for obstructive left-sided colon cancer
    Hideyuki Suzuki, Shingo Tsujinaka, Yoshihiro Sato, Tomoya Miura, Chikashi Shibata
    World Journal of Clinical Oncology.2023; 14(1): 1.     CrossRef
  • 5-year oncological outcomes in left-sided malignant colonic obstruction: stent as bridge to surgery
    Noura S Alhassan, Sulaiman A AlShammari, Razan N AlRabah, Amirah M AlZahrani, Maha-Hamadien Abdulla, Thamer A Bin Traiki, Ahmad M Zubaidi, Omar A Al-Obeed, Khayal A Alkhayal
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
    Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
    Cancers.2023; 15(20): 5098.     CrossRef
  • Do Laparoscopic Approaches Ensure Oncological Safety and Prognosis for Serosa-Exposed Colon Cancer? A Comparative Study against the Open Approach
    Ji-Hyun Seo, In-Ja Park
    Cancers.2023; 15(21): 5211.     CrossRef
  • Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies
    Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak
    Cancers.2023; 15(24): 5791.     CrossRef
  • Colonic stent for bridge to surgery for acute left-sided malignant colonic obstruction: A review of the literature after 2020
    Margherita Binetti, Augusto Lauro, Valeria Tonini
    World Journal of Clinical Oncology.2022; 13(12): 957.     CrossRef
Malignant disease, Rectal cancer,Colorectal cancer,Biomarker & risk factor
Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery
Jiwei Guo, Aik Yong Chok, Hui Jun Lim, Wei Xuan Tay, Weng Kit Lye, Lasitha Bhagya Samarakoon, Emile John Tan, Ronnie Mathew
Ann Coloproctol. 2021;37(3):159-165.   Published online May 28, 2021
DOI: https://doi.org/10.3393/ac.2020.05.25
  • 4,241 View
  • 74 Download
  • 2 Web of Science
  • 3 Citations
AbstractAbstract PDFSupplementary Material
Purpose
Neutrophil-to-lymphocyte ratio (NLR) has been reported to predict adverse survival outcomes among patients with colorectal cancer (CRC). This study evaluates the prognostic value of NLR among patients with obstructing CRC who successfully underwent stenting before curative surgery.
Methods
We retrospectively reviewed patients who underwent stenting before surgery. Patient demographics, tumor characteristics, perioperative outcomes, recurrence-free survival (RFS), and overall survival (OS) were analyzed. NLR was calculated from the differential white blood cell counts at least 4 days after successful stenting, before elective surgery. Optimal cutoff to dichotomize NLR was obtained by maximizing log-rank test statistic with recursive partitioning of KaplanMeier RFS and OS curves. The optimal cutoff for high NLR was ≥ 5 at presentation before stenting, and ≥ 4 after stenting.
Results
Fifty-seven patients with localized obstructing CRC underwent successful endoscopic stenting before curative surgery. High NLR was associated with lymphovascular invasion (P = 0.006) and apical lymph node involvement (P = 0.034). Major perioperative complication(s) (hazard ratio [HR], 11.34; 95% confidence interval [CI], 2.49 to 51.56; P < 0.01) and high NLR (HR, 3.69; 95% CI, 1.46 to 9.35; P < 0.01) negatively impacted OS on univariate and multivariate analyses. High NLR negatively impacted RFS on univariate analysis (HR, 2.91; 95% CI, 1.29 to 6.60; P = 0.01).
Conclusion
NLR of ≥ 4 after stenting is an independent prognostic factor among patients with obstructing localized CRC who are successfully decompressed by endoscopic stenting before curative surgery.

Citations

Citations to this article as recorded by  
  • Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
    Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
    Cancers.2023; 15(20): 5098.     CrossRef
  • Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
    Minsung Kim, Il Tae Son, Bo Young Oh
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
    Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
    Annals of Coloproctology.2022; 38(2): 97.     CrossRef
Malignant disease, Rectal cancer
First Feasibility Study and Short-term Outcomes of Laparoscopic-Assisted Anterior Resection in Colorectal Cancer in Malaysia
Henry Chor Lip Tan, Jih Huei Tan, Nur Akmalrudin Nur Dzainuddin, Koon Khee Chan
Ann Coloproctol. 2020;36(2):94-101.   Published online March 16, 2020
DOI: https://doi.org/10.3393/ac.2019.05.10
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AbstractAbstract PDF
Purpose
The purpose of this study was to demonstrate the feasibility and safety of laparoscopic-assisted anterior resection (LAAR) for colorectal cancer in a local Asian population.
Methods
This is a retrospective review of all patients with colorectal cancer operated from November 2017 to October 2018. Main variables of interest were demography, type and surgery, length of stay (LOS), and the involvement of proximal and distal doughnut. Postoperative complications were analysed using chi-square or Fisher exact and Mann-Whitney tests.
Results
There were 23 patients with a mean age of 62.5 ± 12.2 years. The mean time from diagnosis to surgery was 97.1 ± 154.84 days. There were 12 patients in the LAAR group and 11 in the open anterior resection (OAR) group. Duration of surgery was shorter in OAR (129.58 ± 51.38 minutes) compared to LAAR (147.91 ± 39.37 minutes). Mean LOS was shorter in the LAAR group with 5±1.5 days compared to the OAR group of 7.42 ± 4.25 days. However, there was no significant P-value for both duration of surgery (P = 0.322) or LOS (P = 0.87). A total of 3 complications were recorded after OAR and 2 after LAAR. Both groups had clear proximal and distal margins with 16 (12–18.5) harvested lymph nodes in LAAR and 18 (16–22) in OAR, which were equal (P = 0.155).
Conclusion
This study reports a shorter LOS in the minimally invasive group of 2 days with similar oncologic resection outcomes. This shows that LAAR is feasible in Malaysia and has potential outcome benefits.

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  • Perforated caecal carcinoma within a strangulated inguinal hernia
    Wick Champ Lai, Mogaraj Sellapan, Novinth Kumar Raja Ram, Henry Tan Chor Lip
    ANZ Journal of Surgery.2022; 92(6): 1512.     CrossRef
  • Low Anterior Resection Syndrome: Pathophysiology, Risk Factors, and Current Management
    Seung Mi Yeo, Gyung Mo Son
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • Critical adjustments and trauma surgery trends in adaptation to COVID-19 pandemic in Malaysia
    Henry Tan Chor Lip, Tan Jih Huei, Yuzaidi Mohamad, Rizal Imran Alwi, Tuan Nur' Azmah Tuan Mat
    Chinese Journal of Traumatology.2020; 23(4): 207.     CrossRef
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy
Effect of Age on Laparoscopic Surgery and Postoperative Chemotherapy in Elderly Patients With Colorectal Cancer
Hyun Hee Kim, Myong Hoon Ihn, Yun Hee Lee, Jihyoun Lee, Sangchul Yun, Sung Woo Cho
Ann Coloproctol. 2020;36(4):229-242.   Published online January 31, 2020
DOI: https://doi.org/10.3393/ac.2019.10.03
  • 4,125 View
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  • 10 Web of Science
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AbstractAbstract PDFSupplementary Material
Purpose
We aimed to evaluate the postoperative complications of laparoscopic colorectal cancer (CRC) surgery and the adverse events of postoperative chemotherapy in elderly patients compared to younger patients and to identify the factors influencing the termination of postoperative chemotherapy.
Methods
Between June 2015 and May 2018, 188 patients with CRC underwent laparoscopic surgery with curative intent. Patients aged ≥ 70 were defined as elderly. Postoperative complications and adverse events of chemotherapy were assessed by using the Clavien-Dindo classification and the Common Terminology Criteria for Adverse Events, respectively. The clinicopathological factors were analyzed retrospectively.
Results
Seventy-eight patients were considered elderly with a mean age of 77.5 ± 5.5 years. Overall postoperative complications occurred in 68 patients (36.2%). Age and primary tumor location were independent predictors of overall postoperative complications. Smoking history was the only independent predictor of major postoperative complications. Of 113 patients who were recommended postoperative chemotherapy, 90 patients (79.6%) received postoperative chemotherapy. Overall adverse events occurred in 40 patients (44.4%). The American Society of Anesthesiologists physical status classification and chemotherapy regimen were significantly associated with overall adverse events. The chemotherapy regimen was the only factor significantly associated with severe adverse events. Of 90 patients, postoperative chemotherapy could not be completed in 11 (12.2%). Age was the only factor significantly associated with stopping postoperative chemotherapy (P = 0.003).
Conclusion
This study shows that laparoscopic CRC surgery and postoperative chemotherapy were feasible in elderly patients. Further efforts are needed to ensure that elderly patients have the opportunity to make informed decisions regarding postoperative chemotherapy.

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Citations to this article as recorded by  
  • Survival Benefits of Postoperative Chemotherapy in Patients With Colorectal Mucinous Adenocarcinoma: An Analysis Utilizing Propensity Score Matching From the Surveillance, Epidemiology, and End Results Database
    Jun Rong, Wensheng Deng
    The American Surgeon™.2024; 90(11): 2969.     CrossRef
  • Nutritional Status Indicators Predict Tolerability to Adjuvant Chemotherapy in Patients with Stage II/III Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy
    Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Hiroyuki Matsuzaki, Yuzo Nagai, Takahide Shinagawa, Hirofumi Sonoda, Soichiro Ishihara
    Digestion.2024; 105(5): 345.     CrossRef
  • Abdominal Aortic Calcification as a Predictor of Incomplete Adjuvant Chemotherapy in Stage III Colorectal Cancer: A Retrospective Cohort Study
    Kouki Imaoka, Manabu Shimomura, Hiroshi Okuda, Takuya Yano, Shintaro Akabane, Masahiro Ohira, Yuki Imaoka, Tetsuya Mochizuki, Minoru Hattori, Hideki Ohdan
    Cureus.2024;[Epub]     CrossRef
  • Effect of continuous wound infiltration on patients using intravenous patient-controlled analgesia for pain management after reduced-port laparoscopic colorectal surgery
    Hyeon Deok Choi, Sung Uk Bae
    Annals of Coloproctology.2024; 40(6): 564.     CrossRef
  • Differences in prognosis and underuse of adjuvant chemotherapy between elderly and non‐elderly patients in stage III colorectal cancer
    Takuya Shiraishi, Hiroomi Ogawa, Ikuma Shioi, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Makoto Sohda, Ken Shirabe, Hiroshi Saeki
    Annals of Gastroenterological Surgery.2023; 7(1): 91.     CrossRef
  • Clinical outcomes and cost comparison of laparoscopic versus open surgery in elderly colorectal cancer patients over 80 years
    Aik Yong Chok, Ivan En-Howe Tan, Yun Zhao, Madeline Yen Min Chee, Hui Lionel Raphael Chen, Kwok Ann Ang, Marianne Kit Har Au, Emile John Kwong Wei Tan
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Association between social background and implementation of postoperative adjuvant chemotherapy for older patients undergoing curative resection of colorectal cancers, sub-analysis of the HiSCO-04 study
    Tomoaki Bekki, Manabu Shimomura, Yasufumi Saito, Masahiro Nakahara, Tomohiro Adachi, Satoshi Ikeda, Yosuke Shimizu, Masatoshi Kochi, Yasuyo Ishizaki, Masanori Yoshimitsu, Yuji Takakura, Wataru Shimizu, Daisuke Sumitani, Shinya Kodama, Masahiko Fujimori, M
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Operative and Survival Outcomes of Robotic-Assisted Surgery for Colorectal Cancer in Elderly and Very Elderly Patients: A Study in a Tertiary Hospital in South Korea
    Hugo Cuellar-Gomez, Siti Mayuha Rusli, María Esther Ocharan-Hernández, Tae-Hoon Lee, Guglielmo Niccolò Piozzi, Seon-Hahn Kim, Cruz Vargas-De-León, Yazhou He
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Multidisciplinary treatment strategy for early colon cancer
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Korean Medical Association.2022; 65(9): 558.     CrossRef
  • Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
    Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 203.     CrossRef
  • Adjuvant Chemotherapy in Elderly Colorectal Cancer Patients
    Bengt Glimelius, Erik Osterman
    Cancers.2020; 12(8): 2289.     CrossRef
Review
A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire Hall, Louise Clarke, Atanu Pal, Pamela Buchwald, Tim Eglinton, Chris Wakeman, Frank Frizelle
Ann Coloproctol. 2019;35(6):294-305.   Published online December 31, 2019
DOI: https://doi.org/10.3393/ac.2019.11.13
  • 13,621 View
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AbstractAbstract PDF
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.

Citations

Citations to this article as recorded by  
  • A fluorescent platform integrated with a “one-pot” nicking endonuclease signal amplification and magnetic separation for simultaneous detection of tumor markers
    Miaomiao Liu, Lie Liu, Mengsi Du, Qilong Li, Shiqi Wu, Shengxiang Su, Ningge Jian, Yongjun Wu, Yilin Wang
    Talanta.2025; 282: 127011.     CrossRef
  • CAR-T cell therapy for breast cancer: Current status and future perspective
    Giuseppe Buono, Monica Capozzi, Roberta Caputo, Vincenzo Di Lauro, Daniela Cianniello, Michela Piezzo, Stefania Cocco, Claudia Martinelli, Annarita Verrazzo, Margherita Tafuro, Claudia Calderaio, Alessandra Calabrese, Francesco Nuzzo, Martina Pagliuca, Mi
    Cancer Treatment Reviews.2025; 133: 102868.     CrossRef
  • A promising role of noble metal NPs@MOFs in chondrosarcoma management
    Ziheng Huang, Keyue Tian, Yiyuan Xue, Feng Luo
    Nanoscale.2025; 17(6): 2961.     CrossRef
  • Electrochemical biosensor based on composite of gold nanoparticle/reduced-graphene oxide/graphitic carbon nitride and a caprolactone polymer for highly sensitive detection of CEA
    Yunpeng Li, Xia Wang, Xinling Wang, Zhe Qin, Chong Li, Jing Yang, Mengmeng Cao
    Bioelectrochemistry.2025; 163: 108897.     CrossRef
  • Advances and challenges of metal-organic frameworks in the diagnosis and treatment of gastric cancer
    Min Ye, Yingqi Lu, Peiyan Zou, Luyi Zhou, Govindhan Maduraiveeran, Yong Huang, Yanqiong Peng
    Materials Today Chemistry.2025; 43: 102517.     CrossRef
  • Preoperative Carcinoembryonic Antigen as a Predictor of 5-Year Survival in Rectal Cancer: Proposing a New Prognostic Cutoff
    Amir Keshvari, Seyed Mohsen Ahmadi Tafti, Mohammad Reza Keramati, Mohammad Sadegh Fazeli, Alireza Kazemeini, Behnam Behboudi, Reza Akbari Asbagh, Anahita Mirzasadeghi
    Journal of Gastrointestinal Cancer.2025;[Epub]     CrossRef
  • Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report
    Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang
    Diabetes, Metabolic Syndrome and Obesity.2025; Volume 18: 233.     CrossRef
  • Nanomaterial-based biosensors for carcinoembryonic antigen (CEA) detection: principles, applications, and perspectives: A review
    Siyuan Zhao, Yuxi Zhang, Yafang Wu, Yinglin Wang, Dezhi Li, Qing Liu
    Microchemical Journal.2025; : 112992.     CrossRef
  • Advancing Immunotherapy in Pancreatic Cancer: A Brief Review of Emerging Adoptive Cell Therapies
    Deepak Sherpally, Ashish Manne
    Cancers.2025; 17(4): 589.     CrossRef
  • Assessing the Diagnostic Value of Oncological Biomarkers for Identifying Primary Malignancies in Skeletal Metastatic Disease
    Sanna Matilainen, Hanna Liikanen, Riitta Lassila, Minna Laitinen
    European Journal of Surgical Oncology.2025; : 109688.     CrossRef
  • Determination of carcinoembryonic antigen (CEA) by surface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)
    Aslı Erkal-Aytemur, Samet Şahin, Zafer Üstündağ, İbrahim Ender Mülazımoğlu, Mustafa Oguzhan Caglayan
    Instrumentation Science & Technology.2024; 52(2): 203.     CrossRef
  • Peptide absent sequences emerging in human cancers
    Georgios Christos Tsiatsianis, Candace S.Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
    European Journal of Cancer.2024; 196: 113421.     CrossRef
  • Electrochemical nanobiosensors for the detection of cancer biomarkers in real samples: Trends and challenges
    Fethi Achi, Aisha M. Attar, Abdellatif Ait Lahcen
    TrAC Trends in Analytical Chemistry.2024; 170: 117423.     CrossRef
  • Biosensor-Based Nanodiagnosis of Carcinoembryonic Antigen (CEA): an Approach to Classification and Precise Detection of Cancer Biomarker
    Maryam Hariri, Vahid Alivirdiloo, Nastaran Safavi Ardabili, Sarah Gholami, Sajjad Masoumi, Mohammad Reza Mehraban, Mahsa Alem, Reza Shah Hosseini, Ahmad Mobed, Farhood Ghazi, Iraj Alipourfard
    BioNanoScience.2024; 14(1): 429.     CrossRef
  • Circulating Tumour Cells in the Prediction of Bone Metastasis
    Siu-Wai Choi, Aria Kaiyuan Sun, Jason Pui-Yin Cheung, Jemmi Ching-Ying Ho
    Cancers.2024; 16(2): 252.     CrossRef
  • Next-Generation CEA-CAR-NK-92 Cells against Solid Tumors: Overcoming Tumor Microenvironment Challenges in Colorectal Cancer
    Alexander Sebastian Franzén, Abdelhadi Boulifa, Clarissa Radecke, Sebastian Stintzing, Martin J. Raftery, Gabriele Pecher
    Cancers.2024; 16(2): 388.     CrossRef
  • Normal CEA Levels After Neoadjuvant Chemotherapy and Cytoreduction with Hyperthermic Intraperitoneal Chemoperfusion Predict Improved Survival from Colorectal Peritoneal Metastases
    Michael M. Wach, Geoffrey Nunns, Ahmed Hamed, Joshua Derby, Mark Jelinek, Curtis Tatsuoka, Matthew P. Holtzman, Amer H. Zureikat, David L. Bartlett, Steven A. Ahrendt, James F. Pingpank, M. Haroon A. Choudry, Melanie Ongchin
    Annals of Surgical Oncology.2024; 31(4): 2391.     CrossRef
  • Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
    Akinrinade George Ayankojo, Jekaterina Reut, Vitali Syritski
    Biosensors.2024; 14(2): 71.     CrossRef
  • Optical fiber sensing probe for detecting a carcinoembryonic antigen using a composite sensitive film of PAN nanofiber membrane and gold nanomembrane
    Jinze Li, Xin Liu, Hao Sun, Jiawei Xi, Chen Chang, Li Deng, Yanxin Yang, Xiang Li
    Optics Express.2024; 32(11): 20024.     CrossRef
  • DNAzyme-based ultrasensitive immunoassay: Recent advances and emerging trends
    Meng Wang, Zhe Liu, Chang Liu, Wanghong He, Dui Qin, Minli You
    Biosensors and Bioelectronics.2024; 251: 116122.     CrossRef
  • Predictive modeling algorithms for liver metastasis in colorectal cancer: A systematic review of the current literature
    Isaac Seow-En, Ye Xin Koh, Yun Zhao, Boon Hwee Ang, Ivan En-Howe Tan, Aik Yong Chok, Emile John Kwong Wei Tan, Marianne Kit Har Au
    Annals of Hepato-Biliary-Pancreatic Surgery.2024; 28(1): 14.     CrossRef
  • Realizing the label-free sensitive detection of carcinoembryogenic antigen (CEA) in blood serum via a MNC-decorated flexible immunosensor
    Daisy Mehta, Sukhjot Kaur, Tharamani C. Nagaiah
    Analytical Methods.2024; 16(10): 1473.     CrossRef
  • Postbiotic butyrate: role and its effects for being a potential drug and biomarker to pancreatic cancer
    Abinaya Elango, Vineeta Debbie Nesam, Padmaja Sukumar, Infancia Lawrence, Arunkumar Radhakrishnan
    Archives of Microbiology.2024;[Epub]     CrossRef
  • Classifying Raman Spectra of Colon Cells Based on Machine Learning Algorithms
    Maria Lasalvia, Crescenzio Gallo, Vito Capozzi, Giuseppe Perna
    Photonics.2024; 11(3): 275.     CrossRef
  • Electrochemical immunosensing of tumor markers
    Venkata Narayana Palakollu, Y. Veera Manohara Reddy, Mehdihasan I. Shekh, S.V. Prabhakar Vattikuti, Jaesool Shim, Rajshekhar Karpoormath
    Clinica Chimica Acta.2024; 557: 117882.     CrossRef
  • Improving CEA detection Sensitivity: Carboxyfluorescein-Loaded liposomes in aptamer sandwich assay
    Mohamed Aimene Benariba, Kanza Hannachi, Yuting Zhang, Xiaoli Wang, Nandi Zhou
    Microchemical Journal.2024; 200: 110463.     CrossRef
  • Targeted Biodegradable Near-Infrared Fluorescent Nanoparticles for Colorectal Cancer Imaging
    Seock-Jin Chung, Kay Hadrick, Md Nafiujjaman, Ehsanul Hoque Apu, Meghan L. Hill, Md Nurunnabi, Christopher H. Contag, Taeho Kim
    ACS Applied Bio Materials.2024; 7(12): 7861.     CrossRef
  • Use of tumor markers in distinguishing lung adenocarcinoma-associated malignant pleural effusion from tuberculous pleural effusion
    Ling Ai, Wenjun Wang, Jingyuan Li, Ting Ye, Yuying Li
    The American Journal of the Medical Sciences.2024; 368(2): 136.     CrossRef
  • Carcinoembryonic antigen in the diagnosis, treatment, and follow-up of focal liver lesions
    Osman Nuri Dilek, Dilara İrem Arslan Kahraman, Gökhan Kahraman
    World Journal of Gastrointestinal Surgery.2024; 16(4): 999.     CrossRef
  • Complex Presentation of Lung Cancer with Obstructive Jaundice
    Ruxandra Oprita, Bogdan Oprita, Ioana Adriana Serban, Lidia Aurelia Stefan, Ciprian Mihai Neacsu, Alice Elena Diaconu, Valentin Enache
    Reports.2024; 7(2): 30.     CrossRef
  • A simplified lateral flow immunosensor for the assay of carcinoembryonic antigen in low-resource settings
    Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios Economou
    Analytical Methods.2024; 16(18): 2921.     CrossRef
  • Relevance of glyco-biomakers and glycan profiles in cancer stem cells
    Rohit Pujari, Shiv Kumar Dubey
    Glycobiology.2024;[Epub]     CrossRef
  • Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers
    Yu-Hang Diao, Si-Qi Rao, Xin-Peng Shu, Yong Cheng, Can Tan, Li-Juan Wang, Dong Peng
    World Journal of Gastrointestinal Surgery.2024; 16(5): 1344.     CrossRef
  • Label-free electrochemical biosensor based on dual amplification of gold nanoparticles and polycaprolactones for CEA detection
    Xia Wang, Zhe Qin, Fei Zhang, Chong Li, Xianxian Yuan, Jing Yang, Huaixia Yang
    Talanta.2024; 278: 126468.     CrossRef
  • Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection
    Sonia Fathi-karkan, Saman Sargazi, Shirin Shojaei, Bahareh Farasati Far, Shekoufeh Mirinejad, Marco Cordani, Arezoo Khosravi, Ali Zarrabi, Saeid Ghavami
    Nanoscale.2024; 16(27): 12750.     CrossRef
  • Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis
    Zewdu Bishaw Aynalem, Abebaw Bires Adal, Temesgien Fentahun Ayele, Gashaw Melkie Bayeh, Almaw Genet Yeshiwas, Tadesse Miretie Dessie, Tilahun Degu Tsega
    BMC Cancer.2024;[Epub]     CrossRef
  • Opto-electrochemical transducers for molecular sensing utilizing nanozyme-based sensing technologies
    Indrani Nandi, Vinay Patel, Rohit Srivastava, Pranjal Chandra
    Microchemical Journal.2024; 205: 111360.     CrossRef
  • Five-Segment THz Refractive Index Metamaterial Biosensor With Perfect Absorption for Carcinoembryonic Antigen Measurement
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    IEEE Sensors Journal.2024; 24(16): 25715.     CrossRef
  • Near-infrared light-enhanced colorimetric signal amplification strategy for tumor marker detection based on MoS2/CuO/Au nanocomposite
    Jiawang Xiang, Bing Zhang, Yuan Yuan, Zhihuan Zhao, Jianying Lin, Jing Li
    Microchimica Acta.2024;[Epub]     CrossRef
  • Development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management
    Min-Yi Liao, Yun-Jie Hao, Ching-Shan Luo, Ching-Mei Chen, Po-Hao Feng, Hsin-Yu Yang, Da-Jeng Yao, Kang-Yun Lee, Fan-Gang Tseng
    The Journal of Liquid Biopsy.2024; 6: 100167.     CrossRef
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    Fang Xie, Jialu Xu, Lina Yan, Xia Xiao, Liang Liu
    Heliyon.2024; 10(18): e37715.     CrossRef
  • Biofilm mediated integrin activation and directing acceleration of colorectal cancer
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    APMIS.2024; 132(10): 688.     CrossRef
  • Comparison of the clinical efficacy of dienogest and drospirone/ethinyl estradiol in the treatment of ovarian endometriosis cysts
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    Microchimica Acta.2024;[Epub]     CrossRef
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    International Journal of Radiation Research.2024; 22(2): 455.     CrossRef
  • Glycosylation in cancer as a source of biomarkers
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  • Diagnostic value of joint detection of serum tumor markers in different pathological types of lung cancer
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  • Prognostic value of carcinoembryonic antigen (CEA) and CA 19-9 levels in patients with obstructive colorectal cancer treated with a self-expandable metallic stent and curative surgery
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    Surgery Today.2024;[Epub]     CrossRef
  • Dual metal–organic-frameworks mediated resonance energy transfer for ultrasensitive electrochemiluminescence immunosensing
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  • Advancements in colorectal cancer detection: The role of immuno‐positron emission tomography, immuno‐single‐photon emission computed tomography, and machine learning applications
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  • Emerging roles of long non-coding RNA FOXP4-AS1 in human cancers: From molecular biology to clinical application
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  • Grading carcinoembryonic antigen levels can enhance the effectiveness of prognostic stratification in patients with colorectal cancer: a single-centre retrospective study
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    BMJ Open.2024; 14(10): e084219.     CrossRef
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    Cancers.2024; 16(24): 4213.     CrossRef
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    Biomedicines.2024; 12(12): 2840.     CrossRef
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    Journal of Cancer Research and Therapeutics.2024; 20(7): 2013.     CrossRef
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    British Journal of Neurosurgery.2023; 37(1): 35.     CrossRef
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    Surfaces and Interfaces.2023; 36: 102596.     CrossRef
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    Jian-Xia Xu, Jin-Bao Hu, Xiao-Yan Yang, Na Feng, Xiao-Shan Huang, Xiao-Zhong Zheng, Qin-Pan Rao, Yu-Guo Wei, Ri-Sheng Yu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment
    Karolina Grzesik, Marcelina Janik, Dorota Hoja-Łukowicz
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(3): 188889.     CrossRef
  • Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer
    Kaisa Lehtomäki, Eetu Heervä, Pirkko-Liisa Kellokumpu-Lehtinen, Harri Mustonen, Tapio Salminen, Heikki Joensuu, Kethe Hermunen, Mogens Karsbøl Boisen, Julia Sidenius Johansen, Caj Haglund, Pia Osterlund
    International Journal of Molecular Sciences.2023; 24(7): 6753.     CrossRef
  • Unexplained increase of serum carcinoembryonic antigen: don’t forget the thyroid!
    Filipe Miguel Montes de Jesus, Luca Giovanella
    Clinical Chemistry and Laboratory Medicine (CCLM).2023; 61(10): e203.     CrossRef
  • The Clinical Significance of Serum Free Light Chains in Bladder Cancer
    Monika Gudowska-Sawczuk, Jacek Kudelski, Michał Olkowicz, Grzegorz Młynarczyk, Piotr Chłosta, Barbara Mroczko
    Journal of Clinical Medicine.2023; 12(9): 3294.     CrossRef
  • Target selection and clinical chimeric antigen receptor T cell activity against solid tumors
    Eric von Hofe, Yanping Yang, Moonsoo M. Jin
    iLABMED.2023; 1(1): 29.     CrossRef
  • Sequence of colorectal and liver resection in patients with surgically-treatable stage IV colorectal cancer
    Calista Harbaugh, Aneel Damle
    Seminars in Colon and Rectal Surgery.2023; 34(3): 100969.     CrossRef
  • CXC ELR-Positive Chemokines as Diagnostic and Prognostic Markers for Breast Cancer Patients
    Joanna Motyka, Aleksandra Kicman, Monika Kulesza, Sławomir Ławicki
    Cancers.2023; 15(12): 3118.     CrossRef
  • Impedimetric aptasensor based on MOF based composite for measuring of carcinoembryonic antigen as a tumor biomarker
    Ping He, Qiang Zhang, Qiwei Liu
    Chemosphere.2023; 338: 139339.     CrossRef
  • Two-dimensional substrate assisted SERS immunosensor for accurate detection of carcinoembryonic antigen
    Dechan Lu, Cairou Chen, PeiPei Xu, Ruiyun You, Zhenzhen Lu, Yudong Lu
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2023; 302: 123142.     CrossRef
  • The Significance of CXCL1 and CXCR1 as Potential Biomarkers of Colorectal Cancer
    Marta Łukaszewicz-Zając, Monika Zajkowska, Sara Pączek, Agnieszka Kulczyńska-Przybik, Kamil Safiejko, Marcin Juchimiuk, Leszek Kozłowski, Barbara Mroczko
    Biomedicines.2023; 11(7): 1933.     CrossRef
  • New luminescent hydrophilic iridium(III) nanoflower at low potential for electrochemiluminescence immunosensing
    Li Song, Guangrong Kuang, Gui Zhang, Jiang Guo, Yingzi Fu
    Chemical Engineering Journal.2023; 472: 144923.     CrossRef
  • MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review
    May R. Ibrahim, Yaser E. Greish
    Molecules.2023; 28(16): 5970.     CrossRef
  • Proteomics-Driven Biomarkers in Pancreatic Cancer
    Luís Ramalhete, Emanuel Vigia, Rúben Araújo, Hugo Pinto Marques
    Proteomes.2023; 11(3): 24.     CrossRef
  • Clinicopathologic Significance of Heat Shock Protein 60 as a Survival Predictor in Colorectal Cancer
    Myunghee Kang, Soyeon Jeong, Jungsuk An, Sungjin Park, Seungyoon Nam, Kwang An Kwon, Debashis Sahoo, Pradipta Ghosh, Jung Ho Kim
    Cancers.2023; 15(16): 4052.     CrossRef
  • Colorimetric immunoassay of carcinoembryonic antigen based on the glucose oxidase/MnO2 nanosheet cascade reaction with self-supplying oxygen
    Yuanzhi Yao, Jinhong Wang, Ziqi Wang, Shenghua Li, Hongliang Tan
    Analytical Methods.2023; 15(40): 5351.     CrossRef
  • Combined effect of serum carcinoembryonic antigen and hepatic steatosis on new-onset ischemic heart disease among middle-aged and older Korean adults: a cohort study
    Ji Won Kwak, Yong Jae Lee, Byoungjin Park, Dong Hyuk Jung
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Digestive cancer surgery in low-mid income countries: analysis of postoperative mortality and complications in a single-center study
    Hamza Sekkat, Hassan Agouzoul, Zineb Loudyi, Jaouad Naddouri, Jihane El Hamzaoui, Samira El Fakir, Mohammed Omari, Youness Bakali, Mouna Mhamdi Alaoui, Mohammed Raiss, Abdelmalek Hrora, Farid Sabbah
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Exploring the Role of Biomarkers Associated with Alveolar Damage and Dysfunction in Idiopathic Pulmonary Fibrosis—A Systematic Review
    Alexandra-Simona Zamfir, Mihai Lucian Zabara, Raluca Ioana Arcana, Tudor Andrei Cernomaz, Andreea Zabara-Antal, Marius Traian Dragoș Marcu, Antigona Trofor, Carmen Lăcrămioara Zamfir, Radu Crișan-Dabija
    Journal of Personalized Medicine.2023; 13(11): 1607.     CrossRef
  • CEA vaccines
    Anchit Bhagat, Herbert K. Lyerly, Michael A. Morse, Zachary C. Hartman
    Human Vaccines & Immunotherapeutics.2023;[Epub]     CrossRef
  • Biomarkers in Cancer Detection, Diagnosis, and Prognosis
    Sreyashi Das, Mohan Kumar Dey, Ram Devireddy, Manas Ranjan Gartia
    Sensors.2023; 24(1): 37.     CrossRef
  • Disparities in post-operative surveillance testing for metastatic recurrence among colorectal cancer survivors
    Janeth I. Sanchez, Veena Shankaran, Joseph M. Unger, Margaret M. Madeleine, Noah Espinoza, Beti Thompson
    Journal of Cancer Survivorship.2022; 16(3): 638.     CrossRef
  • T‐cell surface generation of dual bivalent, bispecific T‐cell engaging, RNA duplex cross‐linked antibodies (dbBiTERs) for re‐directed tumor cell lysis
    Maciej Kujawski, Lin Li, Harry Li, Paul J. Yazaki, Piotr Swiderski, John E. Shively
    Biotechnology Journal.2022;[Epub]     CrossRef
  • Application of Proteomics in Pancreatic Ductal Adenocarcinoma Biomarker Investigations: A Review
    Christina Jane Vellan, Jaime Jacqueline Jayapalan, Boon-Koon Yoong, Azlina Abdul-Aziz, Sarni Mat-Junit, Perumal Subramanian
    International Journal of Molecular Sciences.2022; 23(4): 2093.     CrossRef
  • Biomarkers and Genetic Markers of Hepatocellular Carcinoma and Cholangiocarcinoma—What Do We Already Know
    Jacek Baj, Łukasz Bryliński, Filip Woliński, Michał Granat, Katarzyna Kostelecka, Piotr Duda, Jolanta Flieger, Grzegorz Teresiński, Grzegorz Buszewicz, Marzena Furtak-Niczyporuk, Piero Portincasa
    Cancers.2022; 14(6): 1493.     CrossRef
  • Preparation of a disposable electrochemiluminescence sensor chip based on an MXene-loaded ruthenium luminescent agent and its application in the detection of carcinoembryonic antigens
    Weiwei Luo, Zhuoxin Ye, Pinyi Ma, Qiong Wu, Daqian Song
    The Analyst.2022; 147(9): 1986.     CrossRef
  • Circulating Nucleic Acids as Novel Biomarkers for Pancreatic Ductal Adenocarcinoma
    Ryan McGowan, Áine Sally, Anthony McCabe, Brian Michael Moran, Karen Finn
    Cancers.2022; 14(8): 2027.     CrossRef
  • Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection
    Siew Suan Ng, Hooi Ling Lee, Pandian Bothi Raja, Ruey‐an Doong
    Chemistry – An Asian Journal.2022;[Epub]     CrossRef
  • Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors
    Renyuan Ma, Subash C. B. Gopinath, Thangavel Lakshmipriya, Yeng Chen, Larisa Lvova
    Journal of Analytical Methods in Chemistry.2022; 2022: 1.     CrossRef
  • CEA-regulated Oncolytic Virus Anticancer Therapy: A Promising Strategy for Rare Solid Tumors
    Yuqi Yang, Shuhang Wang, Peiwen Ma, Qiyu Tang, Yandong Li, Yuan Fang, Qi Zhu, Wei Tao, Yan Zha, Ning Li
    Current Cancer Drug Targets.2022; 22(2): 126.     CrossRef
  • Nomogram for Predicting Occult Locally Advanced Esophageal Squamous Cell Carcinoma Before Surgery
    Zhixin Huang, Zhinuan Hong, Ling Chen, Mingqiang Kang
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Predicting the benefit of stereotactic body radiotherapy of colorectal cancer metastases
    Sara Lindberg, Eva Onjukka, Peter Wersäll, Caroline Staff, Rolf Lewensohn, Giuseppe Masucci, Karin Lindberg
    Clinical and Translational Radiation Oncology.2022; 36: 91.     CrossRef
  • Prognostic Value of Carcinoembryonic Antigen Changes Before and After Operation for Esophageal Squamous Cell Carcinoma
    Zhinuan Hong, Zhixin Huang, Zhen Chen, Mingqiang Kang
    World Journal of Surgery.2022; 46(11): 2725.     CrossRef
  • Toxic metals in cement induced hematological and DNA damage as well as carcinogenesis in occupationally-Exposed block-factory workers in Lagos, Nigeria
    Tajudeen Yahaya, Esther Oladele, Titilola Salisu, Esther Orji, Zafira Zakari, Umar Usman Liman, Clement Boniface Gomo, Mustapha Abdullahi
    Egyptian Journal of Basic and Applied Sciences.2022; 9(1): 499.     CrossRef
  • Identification of a Five-MiRNA Expression Assay to Aid Colorectal Cancer Diagnosis
    Matthew G. Davey, Gerard Feeney, Heidi Annuk, Maxwell Paganga, Emma Holian, Aoife J. Lowery, Michael J. Kerin, Nicola Miller
    Gastrointestinal Disorders.2022; 4(3): 190.     CrossRef
  • Label-Free Immunosensor Based on Polyaniline-Loaded MXene and Gold-Decorated β-Cyclodextrin for Efficient Detection of Carcinoembryonic Antigen
    Qi Wang, Huaqian Xin, Zhou Wang
    Biosensors.2022; 12(8): 657.     CrossRef
  • The tumor microenvironment of hepatocellular carcinoma and its targeting strategy by CAR-T cell immunotherapy
    Zhang Guizhen, Ji Guanchang, Liu Liwen, Wang Huifen, Ren Zhigang, Sun Ranran, Yu Zujiang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study
    Chul-Hyun Park, Antonio Diaz Lizarraga, Yong-Taek Lee, Kyung-Jae Yoon, Tae-Kyung Yoo
    Journal of Clinical Medicine.2022; 11(17): 5009.     CrossRef
  • Preoperative albumin–bilirubin score as a prognostic indicator in patients with stage III colon cancer
    Hyun Gu Lee, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Jin Cheon Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • A Novel, Quick, and Reliable Smartphone-Based Method for Serum PSA Quantification: Original Design of a Portable Microfluidic Immunosensor-Based System
    Francisco Gabriel Ortega, Germán E. Gómez, Coral González-Martinez, Teresa Valero, José Expósito-Hernández, Ignacio Puche, Alba Rodriguez-Martinez, María José Serrano, José Antonio Lorente, Martín A. Fernández-Baldo
    Cancers.2022; 14(18): 4483.     CrossRef
  • Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends
    Yanping Wang, Yanfeng Gao, Yujun Song
    ChemMedChem.2022;[Epub]     CrossRef
  • Combined hepatocellular carcinoma-cholangiocarcinoma with a predominant HCC component: better survival and MRI-based prediction
    Yuyao Xiao, Xinde Zheng, Changwu Zhou, Peng Huang, Fei Wu, Chun Yang, Mengsu Zeng
    European Radiology.2022; 33(2): 1412.     CrossRef
  • The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
    Hossein Kamali, Shiva Golmohammadzadeh, Hamed Zare, Rahim Nosrati, Mohammad Fereidouni, Hossein Safarpour
    Journal of Nanobiotechnology.2022;[Epub]     CrossRef
  • The Indicative Value of Serum Tumor Markers for Metastasis and Stage of Non-Small Cell Lung Cancer
    Chunyang Jiang, Mengyao Zhao, Shaohui Hou, Xiaoli Hu, Jinchao Huang, Hongci Wang, Changhao Ren, Xiaoying Pan, Ti Zhang, Shengnan Wu, Shun Zhang, Bingsheng Sun
    Cancers.2022; 14(20): 5064.     CrossRef
  • Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis
    Georgia M. Lorentzen, Paweł Łaniewski, Haiyan Cui, Denise J. Roe, Jamal Mourad, Nichole D. Mahnert, Leslie V. Farland, Melissa M. Herbst-Kralovetz
    iScience.2022; 25(12): 105508.     CrossRef
  • Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer
    Jeesoo Choi, Ho Yeon Cho, Jeongseok Jeon, Kyung-A Kim, Yoon Dae Han, Joong Bae Ahn, Inbal Wortzel, David Lyden, Han Sang Kim
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Old and New Blood Markers in Human Colorectal Cancer
    Jean-Luc Wautier, Marie-Paule Wautier
    International Journal of Molecular Sciences.2022; 23(21): 12968.     CrossRef
  • Adnexal masses in patients with colorectal cancer
    Utku Akgor, Oguzhan Kuru, Burcu Soyak, Ali Can Gunes, Esra Uyanık, Murat Gultekin, Nejat Ozgul, Coskun Salman
    Journal of Gynecology Obstetrics and Human Reproduction.2021; 50(5): 101898.     CrossRef
  • Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Upper Gastrointestinal Cancers: A Systematic Review
    Natalia Calanzani, Paige E. Druce, Claudia Snudden, Kristi M. Milley, Rachel Boscott, Dawnya Behiyat, Smiji Saji, Javiera Martinez-Gutierrez, Jasmeen Oberoi, Garth Funston, Mike Messenger, Jon Emery, Fiona M. Walter
    Advances in Therapy.2021; 38(2): 793.     CrossRef
  • Prognostic value of carcinoembryonic antigen levels before and after curative surgery in colon cancer patients
    Hyun Ryung Kim, Jeong Il Joo, Sang Woo Lim, Bo Young Oh
    Annals of Surgical Treatment and Research.2021; 100(1): 33.     CrossRef
  • Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry
    Laura Pont, Valeriia Kuzyk, Fernando Benavente, Victoria Sanz-Nebot, Oleg A. Mayboroda, Manfred Wuhrer, Guinevere S. M. Lageveen-Kammeijer
    Journal of Proteome Research.2021; 20(3): 1666.     CrossRef
  • A two-tiered targeted proteomics approach to identify pre-diagnostic biomarkers of colorectal cancer risk
    Sophia Harlid, Justin Harbs, Robin Myte, Carl Brunius, Marc J. Gunter, Richard Palmqvist, Xijia Liu, Bethany Van Guelpen
    Scientific Reports.2021;[Epub]     CrossRef
  • The Roadmap of Colorectal Cancer Screening
    Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
    Cancers.2021; 13(5): 1101.     CrossRef
  • Optimizing the diagnosis and management of ductal prostate cancer
    Weranja Ranasinghe, Daniel D. Shapiro, Miao Zhang, Tharakeswara Bathala, Nora Navone, Timothy C. Thompson, Bradley Broom, Ana Aparicio, Shi-Ming Tu, Chad Tang, John W. Davis, Louis Pisters, Brian F. Chapin
    Nature Reviews Urology.2021; 18(6): 337.     CrossRef
  • Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis
    Paige Druce, Natalia Calanzani, Claudia Snudden, Kristi Milley, Rachel Boscott, Dawnya Behiyat, Javiera Martinez-Gutierrez, Smiji Saji, Jasmeen Oberoi, Garth Funston, Mike Messenger, Fiona M. Walter, Jon Emery
    Advances in Therapy.2021; 38(6): 3032.     CrossRef
  • Metachronous pulmonary and pancreatic metastases arising from sigmoid colon cancer: A case report
    Jian Yang, Yu-Chen Tang, Ni Yin, Wei Liu, Zhi-Fei Cao, Xi Li, Xiao Zou, Zi-Xiang Zhang, Jian Zhou
    World Journal of Clinical Cases.2021; 9(15): 3668.     CrossRef
  • Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?
    Robert S O'Neill, Alina Stoita
    World Journal of Gastroenterology.2021; 27(26): 4045.     CrossRef
  • Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression
    Ruidan Xu, Yongfeng Yang, Xiaofeng Zheng
    FEBS Letters.2021; 595(16): 2071.     CrossRef
  • Has the COVID-19 Pandemic Caused Upshifting in Colorectal Cancer Stage?
    Ji Ha Lim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin
    Annals of Coloproctology.2021; 37(4): 253.     CrossRef
  • SERS liquid biopsy: An emerging tool for medical diagnosis
    Vlad Moisoiu, Stefania D. Iancu, Andrei Stefancu, Tudor Moisoiu, Barbara Pardini, Mihnea P. Dragomir, Nicolae Crisan, Lucretia Avram, Dana Crisan, Iulia Andras, Daniela Fodor, Loredana F. Leopold, Carmen Socaciu, Zoltán Bálint, Ciprian Tomuleasa, Florin E
    Colloids and Surfaces B: Biointerfaces.2021; 208: 112064.     CrossRef
  • Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings
    Sophia Harlid, Marc J. Gunter, Bethany Van Guelpen
    Cancers.2021; 13(17): 4406.     CrossRef
  • The Level of Preoperative Plasma KRAS Mutations and CEA Predict Survival of Patients Undergoing Surgery for Colorectal Cancer Liver Metastases
    Jiri Polivka, Jindra Windrichova, Martin Pesta, Katerina Houfkova, Hana Rezackova, Tereza Macanova, Ondrej Vycital, Radek Kucera, David Slouka, Ondrej Topolcan
    Cancers.2020; 12(9): 2434.     CrossRef
  • Thionine-doped nanometer-sized silica conjugated with phenylboronic acid: An innovative recognition/signal element for voltammetric aptasensing of colorectal cancer-related carcinoembryonic antigen
    Liangjie Chi, Chao Xu, Shuyuan Li, Xiangyu Wang, Dianping Tang, Fangqin Xue
    Analytica Chimica Acta.2020; 1136: 91.     CrossRef
  • Molecularly Imprinted Polymers in Biological Applications
    Zahra El-Schich, Yuecheng Zhang, Marek Feith, Sarah Beyer, Louise Sternbæk, Lars Ohlsson, Maria Stollenwerk, Anette Gjörloff Wingren
    BioTechniques.2020; 69(6): 407.     CrossRef
  • Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort
    Noel Pin-Vieito, María José Iglesias, David Remedios, Victoria Álvarez-Sánchez, Fernando Fernández-Bañares, Jaume Boadas, Eva Martínez-Bauer, Rafael Campo, Luis Bujanda, Ángel Ferrández, Virginia Piñol, Daniel Rodríguez-Alcalde, Martín Menéndez-Rodríguez,
    Diagnostics.2020; 10(12): 1036.     CrossRef
Original Articles
Immunological Differences Between Right-Sided and Left-Sided Colorectal Cancers: A Comparison of Embryologic Midgut and Hindgut
Han Deok Kwak, Jae Kyun Ju
Ann Coloproctol. 2019;35(6):342-346.   Published online December 31, 2019
DOI: https://doi.org/10.3393/ac.2019.03.17.1
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AbstractAbstract PDF
Purpose
There are known differences in embryology, clinical symptoms, incidences, molecular pathways involved, and oncologic outcomes of right-sided and left-sided colorectal cancers. However, immunologic study has only been characterized for healthy adults. The present study was designed to identify differences in immune cell populations in patients with right-sided and left-sided colorectal cancers.
Methods
A total of 35 patients who underwent colorectal resection for cancer between November 2016 and August 2017 at a tertiary teaching hospital were enrolled in this study. Patients were excluded if they had a disease affecting their immune system. Populations of immune cells, including mucosal-associated invariant T (MAIT), gamma delta T, invariant natural killer T, T, natural killer, and B cells, were measured in the peripheral blood and cancer tissues using flow cytometry, and then assessed based on the origin of the colorectal cancer.
Results
Fifteen had right-side and 20 had left-side colorectal cancer. There were no significant differences between the 2 cohorts for patient characteristics including pathologic stage. Peripheral blood from patients with right-side colon cancers contained fewer MAIT (0.87% right-side vs. 1.74% left-side, P = 0.028) and gamma delta T cells (1.10% right-side vs. 3.05% left-side, P = 0.002). Although the group with right-side colorectal cancer had more MAIT cells in cancer tissues (1.71% vs. 1.00%), this difference was not statistically significant.
Conclusion
There is a difference in population sizes of immune cells in blood between patients with right-sided and leftsided colon cancers. The immune cell composition was determined to be distinct based on embryologic origin.

Citations

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  • Survival of Patients with Right-Sided and Left-Sided Colon Cancer: Insights from an Iranian Medical Center
    Alimohammad Bananzadeh, Sara Shojaei-Zarghani, Amir Reza Bahadori, Ali Reza Safarpour
    Shiraz E-Medical Journal.2024;[Epub]     CrossRef
  • Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective
    Vaishak Kaviyarasan, Alakesh Das, Dikshita Deka, Biki Saha, Antara Banerjee, Neeta Raj Sharma, Asim K. Duttaroy, Surajit Pathak
    International Journal of Colorectal Disease.2024;[Epub]     CrossRef
  • Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival
    Ramón Cantero-Cid, Karla Marina Montalbán-Hernández, Jenny Guevara, Alejandro Pascual-Iglesias, Elisa Pulido, José Carlos Casalvilla, Cristóbal Marcano, Cristina Barragán Serrano, Jaime Valentín, Gloria Cristina Bonel-Pérez, José Avendaño-Ortiz, Verónica
    World Journal of Gastrointestinal Oncology.2022; 14(1): 295.     CrossRef
  • Epidemiology, risk factors, and prevention of colorectal cancer
    Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
    Journal of the Korean Medical Association.2022; 65(9): 549.     CrossRef
  • Epidemiology, Risk Factors, and Prevention of Colorectal Cancer-An English Version
    Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 231.     CrossRef
  • Variants of creating heterotopic and orthotopic PDX models of human colorectal cancer
    A. A. Kiblitskaya, A. Y. Maksimov, A. S. Goncharova, Ye. M. Nepomnyashchaya, Ye. Y. Zlatnik, G. Y. Yegorov, Ye. A. Lukbanova, Ye. V. Zaikina, A. V. Volkova
    Bulletin of Siberian Medicine.2022; 21(3): 50.     CrossRef
  • Genotypic and Phenotypic Characteristics of Hereditary Colorectal Cancer
    Jin Cheon Kim, Walter F. Bodmer
    Annals of Coloproctology.2021; 37(6): 368.     CrossRef
  • Laterality: Immunological Differences Between Right-Sided and Left-Sided Colon Cancer
    Seong Kyu Baek
    Annals of Coloproctology.2019; 35(6): 291.     CrossRef
Malignant disease, Prognosis and adjuvant therapy
Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery
Chang Kyu Oh, Jung Wook Huh, You Jin Lee, Moon Suk Choi, Dae Hee Pyo, Sung Chul Lee, Seong Mun Park, Jung Kyong Shin, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee
Ann Coloproctol. 2020;36(4):273-280.   Published online November 13, 2019
DOI: https://doi.org/10.3393/ac.2019.10.15
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  • 21 Citations
AbstractAbstract PDF
Purpose
The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.
Methods
From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I–III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared.
Results
Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).
Conclusion
Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.

Citations

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  • Oncologic impact of technical difficulties during the early experience with laparoscopic surgery for colorectal cancer: long-term follow-up results of a prospective cohort study
    Hong-min Ahn, Tae Gyun Lee, Hye-Rim Shin, Jeehye Lee, In Jun Yang, Jung Wook Suh, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang
    Current Problems in Surgery.2025; 63: 101694.     CrossRef
  • Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study
    Lucian Flavius Herlo, Ioana Golu, Alexandra Herlo, Claudia Raluca Balasa Virzob, Ionescu Alin, Stela Iurciuc, Ionut Eduard Iordache, Luana Alexandrescu, Doina Ecaterina Tofolean, Raluca Dumache
    Diseases.2025; 13(1): 16.     CrossRef
  • Accelerated enhanced recovery after colon cancer surgery with discharge within one day after surgery: a systematic review
    Misha A. T. Sier, Anke H. C. Gielen, Thaís T. T. Tweed, Noémi C. van Nie, Tim Lubbers, Jan H. M. B. Stoot
    BMC Cancer.2024;[Epub]     CrossRef
  • Risk Factors of Postoperative Complication and Hospital Mortality after Colorectal Perforation Surgery
    Kensuke Kudou, Shuhei Kajiwara, Takashi Motomura, Takafumi Yukaya, Tomonori Nakanoko, Yosuke Kuroda, Masahiro Okamoto, Tadashi Koga, Yo-Ichi Yamashita
    Journal of the Anus, Rectum and Colon.2024; 8(2): 118.     CrossRef
  • Predictive value of POSSUM scoring system for postoperative complications and mortality in elderly patients with colorectal cancer
    Qiang Li, Yingjun Lu
    Technology and Health Care.2024; 32(6): 4653.     CrossRef
  • Postoperative Complications Result in Poor Oncological Outcomes: What Is the Evidence?
    Anjana Wajekar, Sohan Lal Solanki, Juan Cata, Vijaya Gottumukkala
    Current Oncology.2024; 31(8): 4632.     CrossRef
  • The role of robotic-assisted surgery in the management of rectal cancer: a systematic review and meta-analysis
    Chenxiong Zhang, Hao Tan, Han Xu, Jiaming Ding
    International Journal of Surgery.2024; 110(10): 6282.     CrossRef
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Sentinel Lymph Node Analysis in Colorectal Cancer Patients Using One-Step Nucleic Acid Amplification in Combination With Fluorescence and Indocyanine Green
Francesco Esposito, Adele Noviello, Nicola Moles, Enrico Coppola Bottazzi, Mario Baiamonte, Ina Macaione, Umberto Ferbo, Maria Lepore, Antonio Miro, Francesco Crafa
Ann Coloproctol. 2019;35(4):174-180.   Published online August 31, 2019
DOI: https://doi.org/10.3393/ac.2018.07.21.1
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  • 6 Web of Science
  • 6 Citations
AbstractAbstract PDF
Purpose
Analysis of the sentinel lymph node (SLN) in colorectal cancer (CRC) patients was proposed for more accurate staging and tailored lymphadenectomy. The aim of this study was to assess the ability to predict lymph node (LN) involvement through analysis of the SLN with a one-step nucleic acid (OSNA) technique in combination with peritumoral injection of indocyanine green (ICG) and near-infrared (NIR) lymphangiography in CRC patients.
Methods
A total of 34 patients were enrolled. Overall, 51 LNs were analyzed with OSNA. LNs of 17 patients (50%) were examined simultaneously with hematoxylin and eosin (H&E) and OSNA.
Results
SLN analysis of 17 patients examined with H&E and OSNA revealed that OSNA had a higher sensitivity (1 vs. 0.55), higher negative predictive value (1 vs. 0.66) and higher accuracy (100% vs. 76.4%) in predicting LN involvement. Overall, OSNA showed a sensitivity of 0.69, specificity of 1, accuracy of 88.2%, and stage migration of 8.8%. Compared to those who were OSNA (−), OSNA (+) patients had a greater number of LN metastases (4.8 vs. 0.16, P = 0.04), higher G3 rate (44.4% vs. 4%, P = 0.01), more advanced stage of disease (stage III: 77.8% vs. 16%; P = 0.00) and were more rapidly subjected to adjuvant chemotherapy (39.1 days vs. 50.2 days, P = 0.01).
Conclusion
SLN analysis with OSNA in combination with ICG-NIR lymphangiography is feasible and can detect LN involvement in CRC patients. Furthermore, it allows for more accurate staging reducing the delay between surgery and adjuvant chemotherapy.

Citations

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  • Diagnostic value of one-step nucleic acid amplification for sentinel lymph node metastasis in cytokeratin 19-positive tumors: evidence from bioinformatics and meta-analysis
    Ke Li, Min Meng, Weiwei Zhang, Junyi Li, Yiting Wang, Changhui Zhou
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Non-exposed endoscopic wall-inversion surgery with one-step nucleic acid amplification for early gastrointestinal tumors: Personal experience and literature review
    Francesco Crafa, Serafino Vanella, Aristide Morante, Onofrio A Catalano, Kelsey L Pomykala, Mario Baiamonte, Maria Godas, Alexandra Antunes, Joaquim Costa Pereira, Valentina Giaccaglia
    World Journal of Gastroenterology.2023; 29(24): 3883.     CrossRef
  • Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection
    Francesco Crafa, Serafino Vanella, Onofrio A Catalano, Kelsey L Pomykala, Mario Baiamonte
    World Journal of Gastroenterology.2022; 28(30): 4019.     CrossRef
  • Mapping Lymph Node during Indocyanine Green Fluorescence-Imaging Guided Gastric Oncologic Surgery: Current Applications and Future Directions
    Yiqun Liao, Jiahao Zhao, Yuji Chen, Bin Zhao, Yongkun Fang, Fei Wang, Chen Wei, Yichao Ma, Hao Ji, Daorong Wang, Dong Tang
    Cancers.2022; 14(20): 5143.     CrossRef
  • The advantage of one‐step nucleic acid amplification for the diagnosis of lymph node metastasis in colorectal cancer patients
    Yukiharu Hiyoshi, Takashi Akiyoshi, Yosuke Fukunaga
    Annals of Gastroenterological Surgery.2021; 5(1): 60.     CrossRef
  • The evolving role of one-step nucleic acid amplification (OSNA) for the intra-operative detection of lymph node metastases: A diagnostic accuracy meta-analysis
    Anastasios Tranoulis, Dimitra Georgiou, Jason Yap, Stephen Attard-Montalto, Jeremy Twigg, Ahmed Elattar, Kavita Singh, Janos Balega, Sean Kehoe
    European Journal of Surgical Oncology.2021; 47(6): 1233.     CrossRef
Gland Attenuation, a Novel Morphological Feature of Colorectal Cancer: Evidence for an Epithelial-Mesenchymal Transition
Tae-Hwa Baek, Dong-Wook Kang, Joo-Heon Kim, Hyun-Jin Son
Ann Coloproctol. 2018;34(4):187-196.   Published online August 31, 2018
DOI: https://doi.org/10.3393/ac.2017.12.02
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  • 4 Citations
AbstractAbstract PDF
Purpose
Along the invasive margin, colorectal cancer may show distinctive morphologic changes characterized by an asymmetrically attenuating tumor gland with loss of polarity. The author coined the term ‘gland attenuation (GA)’ for these peculiar changes. The aims of this study were to compare the immunoreactivity of the epithelial-mesenchymal transition (EMT) markers E-cadherin and β-catenin and thus determine whether EMTs occurs at tumor budding (TB) or GA sites and to assess the association of TB and/or GA levels with clinicopathological parameters and prognosis.
Methods
Expression patterns of E-cadherin and β-catenin in the tumor centers at GA and TB sites were examined in 101 patients with well or moderately differentiated CRCs, and the prognostic significance of TB and/or GA was statistically evaluated.
Results
GA foci, as well as TB foci, revealed loss of membranous and cytoplasmic E-cadherin expressions and aberrant β-catenin expression with reduced membranous expression and increased localization to the nucleus, suggesting that EMTs occur in GA as well as in TB. The high-TB and the TB-dominant groups were significantly correlated with advanced invasion depth, presence of lymph node metastasis, advanced pathologic staging and presence of lymphovascular invasion. The high-TB and the TB-dominant groups showed poor overall survival (OS) and recurrence-free survival (RFS), and high TB was an independent prognostic factor in the multivariate analyses for OS and RFS.
Conclusion
This study showed evidence that EMTs occurs at GA sites as well as TB foci. TB is a strong and independent prognostic factor, and TB-dominance may be an indicator of adverse clinical outcome.

Citations

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  • Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers
    Betul Unal, Mennan Yigitcan Celik, Elif Ocak Gedik, Cumhur Ibrahim Bassorgun, Gulsum Ozlem Elpek
    World Journal of Hepatology.2023; 15(6): 775.     CrossRef
  • Identification of a Novel Epithelial–Mesenchymal Transition Gene Signature Predicting Survival in Patients With HNSCC
    Wei Xin, Chaoran Zhao, Longyang Jiang, Dongmei Pei, Lin Zhao, Chengpu Zhang
    Pathology and Oncology Research.2021;[Epub]     CrossRef
  • Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial–mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma
    Shinya Neri, Toshi Menju, Terumasa Sowa, Yojiro Yutaka, Daisuke Nakajima, Masatsugu Hamaji, Akihiro Ohsumi, Toyofumi F. Chen-Yoshikawa, Toshihiko Sato, Makoto Sonobe, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date
    Lung Cancer.2019; 128: 13.     CrossRef
  • MicroRNA‐198‐5p inhibits the migration and invasion of non‐small lung cancer cells by targeting fucosyltransferase 8
    Siyao Wang, Xin Zhang, Chunlu Yang, Shun Xu
    Clinical and Experimental Pharmacology and Physiology.2019; 46(10): 955.     CrossRef
Obstructive Ileocolitis in Patients With Obstructed Colorectal Cancer – A Matched Case Control Study
Ning-Qi Pang, Tian-Zhi Lim, Yuanpei Zhou, Ker-Kan Tan
Ann Coloproctol. 2018;34(4):175-179.   Published online August 31, 2018
DOI: https://doi.org/10.3393/ac.2017.06.14.1
  • 3,599 View
  • 87 Download
  • 1 Web of Science
  • 1 Citations
AbstractAbstract PDF
Purpose
Obstructive ileocolitis is an ulcero-inflammatory condition which typically occurs in the ileum or colon proximal to an obstructing colorectal lesion. If left unresolved, it often leads to intestinal perforation. We present a matched case control study of patients with obstructive ileocolitis caused by colorectal cancer to determine if any factors can predict this condition.
Methods
This is a retrospective review of 21 patients with obstructive colorectal cancer and histologically proven obstructive ileocolitis from 2005 to 2015 matched for age and sex with 21 controls with obstructing colorectal cancer without obstructive ileocolitis.
Results
The 21 patients with obstructive ileocolitis had a median age of 71 years (range, 52–86 years). The most common presenting symptom was abdominal pain (n = 16, 76.2%), followed by vomiting/nausea (n = 14, 66.7%) and abdominal distension (n = 12, 57.1%). Interestingly, the radiological feature of pneumatosis intestinalis was noted in only 1 case. No significant differences were observed in baseline comorbidities, clinical presentations, or tumor characteristics between the 2 groups. Patients with obstructive ileocolitis were found to have a significantly higher total leucocyte count (17.1 ± 9.4×109/L vs. 12.0 ± 6.8×109/L, P = 0.016), lower pCO2 (32.3 ± 8.2 mmHg vs. 34.8 ± 4.9 mmHg, P = 0.013), lower HCO3 (18.8 ± 4.5 mmol/L vs. 23.6 ± 2.7 mmol/L, P < 0.001), lower base excess (-6.53 ± 5.32 mmol/L vs. -0.57 ± 2.99 mmol/L, P < 0.001) and higher serum lactate levels (3.14 ± 2.19 mmol/L vs. 1.19 ± 0.91 mmol/L, P = 0.007) compared to controls. No radiological features were predictive of obstructive ileocolitis.
Conclusion
Patients with obstructive ileocolitis tend to present with metabolic acidosis with respiratory compensation, raised lactate, and worse leucocytosis. Radiological features are not useful for predicting this condition.

Citations

Citations to this article as recorded by  
  • Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery
    Jiwei Guo, Aik Yong Chok, Hui Jun Lim, Wei Xuan Tay, Weng Kit Lye, Lasitha Bhagya Samarakoon, Emile John Tan, Ronnie Mathew
    Annals of Coloproctology.2021; 37(3): 159.     CrossRef

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