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Original Article
Oncologic Outcomes of Postoperative Chemoradiotherapy Versus Chemotherapy Alone in Stage II and III Upper Rectal Cancer
Ji Eun Yoon, Soo Young Lee, Han Duk Kwak, Seung Seop Yeom, Chang Hyun Kim, Jae Kyun Joo, Hyeong Rok Kim, Young Jin Kim
Ann Coloproctol. 2019;35(3):137-143.   Published online June 30, 2019
DOI: https://doi.org/10.3393/ac.2018.09.28
  • 3,909 View
  • 106 Download
  • 4 Web of Science
  • 4 Citations
AbstractAbstract PDF
Purpose
The aim of this study was to assess oncological outcomes of postoperative radiotherapy plus chemotherapy (CRT) versus chemotherapy alone (CTx) in stage II or III upper rectal cancer patients who underwent curative surgery.
Methods
We retrospectively reviewed 263 consecutive patients with pathologic stage II or III upper rectal cancer who underwent primary curative resection with postoperative CRT or CTx from January 2008 to December 2014 at Chonnam National University Hwasun Hospital. Multivariate and propensity score matching analyses were used to reduce selection bias.
Results
Median follow-up was 48.1 months for the entire cohort and 53.5 months for the matched cohort. In subgroup analysis of the propensity score matched cohort, the 3-year local recurrence-free survival was 94.1% (95% confidence interval [CI], 87.8%–100%) in the CRT group and 90.1% (95% CI, 82.8%–97.9%) in the CTx group (P = 0.370). No significant difference in disease-free survival was observed according to treatment type. On multivariate analysis, circumferential resection margin involvement (hazard ratio [HR], 2.386; 95% CI, 1.190–7.599; P = 0.032), N stage (HR, 6.262; 95% CI, 1.843–21.278, P = 0.003), and T stage (HR, 5.896, 95% CI, 1.298–6.780, P = 0.021) were identified as independent risk factors for local recurrence of tumors of the upper rectum.
Conclusion
Omission of radiotherapy in an adjuvant treatment setting may not jeopardize oncologic outcomes in stages II and III upper rectal cancer.

Citations

Citations to this article as recorded by  
  • Is radiotherapy necessary for upper rectal cancer underwent curative resection? A retrospective study of 363 patients
    Zhiwei Ma, Jumei Zhou, Ke Liu, Sisi Chen, Qinghui Wu, Lin Peng, Wei Zhao, Suyu Zhu
    Radiation Oncology.2024;[Epub]     CrossRef
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer 2023 Supplement
    Sean J. Langenfeld, Bradley R. Davis, Jon D. Vogel, Jennifer S. Davids, Larissa K.F. Temple, Kyle G. Cologne, Samantha Hendren, Steven Hunt, Julio Garcia Aguilar, Daniel L. Feingold, Amy L. Lightner, Ian M. Paquette
    Diseases of the Colon & Rectum.2023;[Epub]     CrossRef
  • Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation?
    Xian Hua Gao, Bai Zhi Zhai, Juan Li, Jean Luc Tshibangu Kabemba, Hai Feng Gong, Chen Guang Bai, Ming Lu Liu, Shao Ting Zhang, Fu Shen, Lian Jie Liu, Wei Zhang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Role of adjuvant (chemo)radiotherapy for resected extrahepatic cholangiocarcinoma: a meta-analysis
    Xin-qi Shi, Jing-yu Zhang, Hua Tian, Ling-na Tang, Ai-lin Li
    Journal of Zhejiang University-SCIENCE B.2020; 21(7): 549.     CrossRef
Case Report
Xanthogranulomatous Appendicitis Mimicking Residual Burkitt's Lymphoma After Chemotherapy
Soomin Nam, Jeonghyun Kang, Sung-Eun Choi, Yu Ri Kim, Seung Hyuk Baik, Seung-Kook Sohn
Ann Coloproctol. 2016;32(2):83-86.   Published online April 30, 2016
DOI: https://doi.org/10.3393/ac.2016.32.2.83
  • 3,799 View
  • 43 Download
  • 4 Web of Science
  • 8 Citations
AbstractAbstract PDF

The case of a 23-year-old female treated with aggressive high-dose therapy for Burkitt's lymphoma is reported. A positron emission tomography and computed tomography scan after completion of chemotherapy revealed a residual hypermetabolic lesion in the right pelvic cavity. A pelvic magnetic resonance imaging scan showed circumferential wall thickening at the tip of the appendix. A laparoscopic exploration and appendectomy were performed, and a pathologic examination of the resected appendix revealed xanthogranulomatous appendicitis. This is a rare case of a xanthogranulomatous appendicitis mimicking remnant Burkitt's lymphoma after completion of chemotherapy.

Citations

Citations to this article as recorded by  
  • Xanthogranulomatous appendicitis presenting asymptomatically 3 years after surgery for hilar cholangiocarcinoma: A case report
    Nobuhisa Tanioka, Michio Kuwahara, Takashi Sakai, Yuzuko Nokubo, Makoto Hiroi, Toyokazu Akimori
    International Journal of Surgery Case Reports.2024; 120: 109800.     CrossRef
  • A case of xanthogranulomatous appendicitis that was difficult to diagnose
    Yusaku WATANABE, Shingo SHIOYA, Tetsuhito ARIKIZONO, Syuzou TASHIMA, Toshiyuki CHOSA, Hiroshi SUGITA, Kyouko MIZUKAMI, Kentaro TOKUDOME, Kaoru HIJIKURO, Kouichirou SHIGETA
    Choonpa Igaku.2023; 50(2): 121.     CrossRef
  • Focal Xanthogranulomatous Pyelonephritis on FDG PET/CT
    Yong Liu, Guansheng Tong, Zhe Wen
    Clinical Nuclear Medicine.2022; 47(9): e611.     CrossRef
  • Xanthogranulomatous appendicitis misdiagnosed as a malignant tumor: A case report
    Subo Wang, Tingchong Jiang, Xiaoxuan Zhou, Xiaoming Mao
    Asian Journal of Surgery.2022; 45(8): 1650.     CrossRef
  • A Case of Laparoscopic Cecectomy for Xanthogranulomatous Appendicitis
    Marina ISOKAWA, Aya SATO, Ken IMAIZUMI, Kentaro SATO, Hiroyuki KASAJIMA, Hanae KUSHIBIKI, Norihiko SHIMOYAMA, Kazuaki NAKANISHI
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(11): 1948.     CrossRef
  • Xanthogranulomatous appendicitis: A comprehensive literature review
    Sami Akbulut, Khaled Demyati, Cemalettin Koc, Adem Tuncer, Emrah Sahin, Mehmet Ozcan, Emine Samdanci
    World Journal of Gastrointestinal Surgery.2021; 13(1): 76.     CrossRef
  • A Case of Xanthogranulomatous Appendicitis That Was Difficult to Differentiate from Appendiceal Mucocele
    Hirofumi Doi, Kazuhiro Toyota, Satoshi Hirahara, Yuta Kuhara, Kenji Shirakawa, Tetsuhiro Hara, Hironori Kobayashi, Yoshihiro Sakashita, Motoki Ninomiya, Fumio Shimamoto, Katsunari Miyamoto
    The Japanese Journal of Gastroenterological Surgery.2021; 54(3): 208.     CrossRef
  • A Case of Xanthogranulomatous Appendicitis
    Shoichiro NAKAJO, HoMin KIM, Ryoji NONAKA, Jun KAJIHARA, Masami IMAKITA, Toshikazu ITO, Masahiro TANEMURA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2019; 80(12): 2233.     CrossRef
Original Article
Treatment of Right Colonic Diverticulitis: The Role of Nonoperative Treatment
Ma Ru Kim, Bong-Hyeon Kye, Hyung Jin Kim, Hyeon-Min Cho, Seong Taek Oh, Jun-Gi Kim
J Korean Soc Coloproctol. 2010;26(6):402-406.   Published online December 31, 2010
DOI: https://doi.org/10.3393/jksc.2010.26.6.402
  • 3,695 View
  • 39 Download
  • 24 Citations
AbstractAbstract PDF
Purpose

The purpose of this study is to evaluate the value of nonoperative treatment for right-sided colonic diverticulitis.

Methods

One hundred fifty-eight patients with right-sided colonic diverticulitis were evaluated. Clinical history, physical and radiologic findings, and treatments were reviewed retrospectively. Also, additional episodes and treatment modalities were checked.

Results

Our patients were classified according to treatment modality; 135 patients (85.4%) underwent conservative treatment, including antibiotics and bowel rest, and 23 patients (14.6%) underwent surgery. The mean follow-up length was 37.3 months, and 17 patients (17.5%) underwent recurrent right-sided colonic diverticulitis. Based on treatment modality, including surgery and antibiotics, no significant differences in the clinical features and the recurrence rates were noted between the two groups.

Conclusion

Conservative management with bowel rest and antibiotics could be considered as a safe and effective option for treating right-sided colonic diverticulitis. This treatment option for right-sided colonic diverticulitis, even if the disease is complicated, may be the treatment of choice.

Citations

Citations to this article as recorded by  
  • Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study
    E. Karam, C. Sabbagh, L. Beyer-Bergeot, P. Zerbib, V. Bridoux, G. Manceau, Y. Panis, E. Buscail, A. Venara, I. Khaoudy, M. Gaillard, M. Viennet, A. Thobie, B. Menahem, C. Eveno, C. Bonnel, J.-Y. Mabrut, B. Badic, C. Godet, Y. Eid, E. Duchalais, Z. Lakkis,
    Techniques in Coloproctology.2024;[Epub]     CrossRef
  • Right-sided diverticulitis in a Western population
    Adi Rov, Anat Ben-Ari, Eyal Barlev, David Pelcman, Sergio Susmalian, Haim Paran
    International Journal of Colorectal Disease.2022; 37(6): 1251.     CrossRef
  • Investigation of the clinical features and recurrence patterns of acute right-sided colonic diverticulitis: A retrospective cohort study
    Moon Young Oh, Rumi Shin, Seung Chul Heo, Han-Ki Lim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
    Annals of Medicine and Surgery.2022; 81: 104431.     CrossRef
  • Emergency surgery comparison of right versus left acute colonic diverticulitis: A 10-year outcome analysis
    JS Tsang, Chi Chung Foo, Jeremy Yip, Hok Kwok Choi, Wai Lun Law, Oswens Siu Hung Lo
    The Surgeon.2021; 19(3): 150.     CrossRef
  • Conservative treatment of uncomplicated right-sided diverticulitis: a systematic review and meta-analysis
    Jun Ho Lee, Byung Kyu Ahn, Kang Hong Lee
    International Journal of Colorectal Disease.2021; 36(8): 1791.     CrossRef
  • Conventional-Dose CT Versus 2-mSv CT for Right Colonic Diverticulitis as an Alternate Diagnosis of Appendicitis: Secondary Analysis of Large Pragmatic Randomized Trial Data
    Hae Young Kim, Seungjae Lee, Dong Hwan Kim, Yousun Ko, Ji Hoon Park, Ara Ko, Seok Min Jeong, Sung Bin Park, Kyoung Ho Lee
    American Journal of Roentgenology.2021; 217(5): 1113.     CrossRef
  • Laparoscopic diverticulectomy versus non-operative treatment for uncomplicated right colonic diverticulitis
    Le Huy Luu, Nguyen Lam Vuong, Vo Thi Hong Yen, Do Thi Thu Phuong, Bui Khac Vu, Nguyen Viet Thanh, Nguyen Thien Khanh, Nguyen Van Hai
    Surgical Endoscopy.2020; 34(5): 2019.     CrossRef
  • Diverticulitis aguda del ángulo hepático simulando un cuadro de colecistitis aguda
    M. Gonzalez-Urquijo, A. Baca-Arzaga, G. Lozano-Balderas
    Revista de Gastroenterología de México.2020; 85(4): 484.     CrossRef
  • Short‐ and Long‐Term Outcomes of Right‐Sided Diverticulitis: Over 15 Years of North American Experience
    Jesse Zuckerman, Richard Garfinkle, Carol‐Ann Vasilevksy, Gabriela Ghitulescu, Julio Faria, Nancy Morin, Marylise Boutros
    World Journal of Surgery.2020; 44(6): 1994.     CrossRef
  • Acute diverticulitis of the hepatic flexure mimicking acute cholecystitis
    M. Gonzalez-Urquijo, A. Baca-Arzaga, G. Lozano-Balderas
    Revista de Gastroenterología de México (English Edition).2020; 85(4): 484.     CrossRef
  • Laparoscopic repair of perforated cecal diverticulitis
    K. Spacil, J. Meyer, M. Stehr, M. Schäfer
    Journal of Pediatric Surgery Case Reports.2019; 42: 17.     CrossRef
  • Long-term outcome and management of right colonic diverticulitis in western countries: Multicentric Retrospective Study
    L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
    Journal of Visceral Surgery.2019; 156(4): 296.     CrossRef
  • Résultats à long terme et prise en charge des diverticulites du colon droit dans les pays occidentaux : étude rétrospective multicentrique
    L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
    Journal de Chirurgie Viscérale.2019; 156(4): 322.     CrossRef
  • A Rare Case of Acute Right-Sided Colonic Diverticulitis Presenting as Pancreatitis
    Maria de Lourdes Ladino Sturchler, Evan A. Rusoja, Arun Nagdev, Barry C. Simon
    The Journal of Emergency Medicine.2018; 54(4): e77.     CrossRef
  • Efficacy of conservative management in patients with right colonic diverticulitis
    Gi Won Ha, Min Ro Lee, Jong Hun Kim
    ANZ Journal of Surgery.2017; 87(6): 467.     CrossRef
  • Intraoperative diagnosis of solitary cecal diverticulum not requiring surgery: is appendectomy indicated?
    Renol M. Koshy, Abdelrahman Abusabeib, Saif Al-Mudares, Mohamed Khairat, Adriana Toro, Isidoro Di Carlo
    World Journal of Emergency Surgery.2016;[Epub]     CrossRef
  • Diagnosis and Management of Right Colonic Diverticular Disease: A Review
    Francesco Ferrara, Jesús Bollo, Letizia V. Vanni, Eduardo M. Targarona
    Cirugía Española (English Edition).2016; 94(10): 553.     CrossRef
  • Diagnóstico y tratamiento de la enfermedad diverticular del colon derecho: revisión de conjunto
    Francesco Ferrara, Jesús Bollo, Letizia V Vanni, Eduardo M Targarona
    Cirugía Española.2016; 94(10): 553.     CrossRef
  • Diverticular Disease: Guidelines of the German Society for Gastroenterology, Digestive and Metabolic Diseases and the German Society for General and Visceral Surgery
    Wolfgang Kruis, Christoph-Thomas Germer, Ludger Leifeld
    Digestion.2014; 90(3): 190.     CrossRef
  • Non-operative treatment of right-sided colonic diverticulitis has good long-term outcome: a review of 226 patients
    Ker-Kan Tan, Jiayi Wong, Richard Sim
    International Journal of Colorectal Disease.2013; 28(6): 849.     CrossRef
  • Visceral Obesity as a Risk Factor for Left-Sided Diverticulitis in Japan: A Multicenter Retrospective Study
    Eiji Yamada, Hidenori Ohkubo, Takuma Higurashi, Eiji Sakai, Hiroki Endo, Hirokazu Takahashi, Eri Uchida, Emi Tanida, Nobuyoshi Izumi, Akira Kanesaki, Yasuo Hata, Tetsuya Matsuura, Nobutaka Fujisawa, Kazuto Komatsu, Shin Maeda, Atsushi Nakajima
    Gut and Liver.2013; 7(5): 532.     CrossRef
  • Risk Factors for Severe Diverticulitis in Computed Tomography-Confirmed Acute Diverticulitis in Korea
    Nark-Soon Park, Yoon Tae Jeen, Hyuk Soon Choi, Eun Sun Kim, Young Jin Kim, Bora Keum, Yeon Seok Seo, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu
    Gut and Liver.2013; 7(4): 443.     CrossRef
  • The Clinical Factors for Predicting Severe Diverticulitis in Korea: A Comparison with Western Countries
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    Gut and Liver.2012; 6(1): 78.     CrossRef
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    Yoori Lee, Todd Francone
    Seminars in Colon and Rectal Surgery.2011; 22(3): 180.     CrossRef
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