Inflammatory bowel diseases
- Colorectal surgical management of colitis induced by vasculitis in the absence of inflammatory bowel disease: a case report and literature review
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Jessica A. Paynter, Kirby R. Qin, Georgia Seamer, Ruchira Fernando, Janelle Brennan, Chun Hin Angus Lee
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Ann Coloproctol. 2023;39(3):193-203. Published online November 16, 2022
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DOI: https://doi.org/10.3393/ac.2022.00584.0083
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- Colitis caused by vasculitis is a rare and poorly understood pathology. Little evidence exists on its clinical presentation, path to diagnosis, and surgical management. In this report, we present a case report and literature review. A healthy 20-year-old male patient presented with hemorrhagic colitis requiring total colectomy with end ileostomy. Pathological examination showed pancolitis with multiple ulcers, transmural inflammation, hemorrhage, and microvascular thrombosis. Extensive serological testing revealed elevated cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) and eosinophilia, leading to a diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA) and vasculitis-induced colitis. A literature review was subsequently conducted. Nineteen studies were found documenting vasculitis-induced colitis in the absence of inflammatory bowel disease (IBD). Systemic signs of vasculitis, hemorrhagic colitis, and progression to fulminant colitis were present. Of all patients, 40.0% required colorectal surgery and 62.5% of those patients received a stoma; 25% underwent emergency surgery following failed immunosuppression. All cases relied on clinical correlation with serology and/or histopathology to reach a final diagnosis. We report a case of vasculitis-induced colitis caused by c-ANCA−positive EGPA. The review shows that vasculitis-induced colitis without IBD is an important differential that clinicians should be aware of in patients presenting with colitis.
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- Systemic Lupus Erythematosus Vasculitis Causing Perforation Peritonitis in Miliary Tuberculosis: A Disease in Disguise
Soumyajit Jana, Monika Gureh, Ankur Cheleng, Ayush Vardhan
Cureus.2025;[Epub] CrossRef
Malignant disease,Rare disease & stoma
- Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano
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Jordan Au, Francis M. Hulme-Moir, Andrew Herd, Mathew A. Kozman
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Ann Coloproctol. 2021;37(Suppl 1):S7-S10. Published online November 26, 2019
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DOI: https://doi.org/10.3393/ac.2019.11.19
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3,910
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Web of Science
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- We report a case of a 66-year-old male who presented with a locally advanced primary mucinous adenocarcinoma arising from a fistula-in-ano. The presentation was typical for perianal sepsis and fistula-in-ano with anal pain and chronic discharge. Initial treatments with fistula debridement and seton were performed. Subsequent review of histology revealed underlying adenocarcinoma, while magnetic resonance imaging (MRI) showed local invasion into the prostate. The patient received neoadjuvant chemoradiotherapy followed by pelvic exenteration to maximize the chance of achieving cure. Features of this case are discussed together with its implications, including treatment guidelines and typical MRI findings.
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- Perianal Mucinous Adenocarcinoma: A Case Report and a Systematic Review of the Literature
Ioannis D. Gkegkes, Vassilis Milionis, Nikolaos Goutas, Ioannis Mantzoros, Antonia A. Bourtzinakou, Apostolos P. Stamatiadis
Journal of Gastrointestinal Cancer.2025;[Epub] CrossRef - Perianal Mucinous Adenocarcinoma Found Incidentally From Perianal Mass
Seyed Khalafi, Malini Riddle, Brittany Harper, Vid Fikfak
Cureus.2023;[Epub] CrossRef - Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases: A Focus on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Youngbae Jeon, Eun Jung Park
The Ewha Medical Journal.2023;[Epub] CrossRef