Annals of Coloproctology

Case Reports

Colorectal cancer

Melanocytic nevus of the anal canal and granular cell tumor of the cecum: a case report and literature review of 2 coincidentally co-occurring neurocristopathies: Victoria Sandoval, Jorge Lara-Endara, Javier Rodríguez-Suárez, Williams Arias Garzón, Ligia Redrobán, Nelson Montalvo; Ann Coloproctol. 2024;40(Suppl 1):S23-S26. Published online January 12, 2023; DOI: https://doi.org/10.3393/ac.2022.00444.0063

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Abstract PDF: Granular cell tumors are predominantly benign soft tissue tumors originating from Schwann cells, whereas melanocytic nevi are benign proliferations of melanocytes. We present the case of a patient with the presence of both entities located in the cecum and anal canal, respectively, constituting an extremely rare coincidental finding. A 43-year-old woman was evaluated by colonoscopy for iron-deficiency microcytic anemia that had lasted for 1 year. Colonoscopy demonstrated a macular lesion of 0.3 cm with a melanocytic appearance in the anal canal; at the cecum level, a subepithelial, yellowish, and partially mobile firm nodular lesion measuring 1.3 cm was observed. A histopathological study showed a melanocytic nevus in the anal canal and a granular cell tumor in the cecum. This is the first reported case of a patient with the extremely rare coincidental-incidental finding of these 2 entities at the same time.

Colorectal cancer

Experience of surgical treatment in a granular cell tumor in the ascending colon: a case report: In-Kyeong Kim, Young-Tae Ju, Han-Gil Kim, Jin-Kwon Lee, Dong-Chul Kim, Jae-Myung Kim, Jin Kyu Cho, Ji-Ho Park, Ju-Yeon Kim, Chi-Young Jeong, Soon-Chan Hong, Seung-Jin Kwag; Ann Coloproctol. 2023;39(3):275-279. Published online July 6, 2021; DOI: https://doi.org/10.3393/ac.2020.00836.0119

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Abstract PDF: We report a case about successful surgical treatment of a granular cell tumor in the ascending colon. A 36-year-old man underwent screening colonoscopy. An endoscopic examination revealed a 10-mm yellowish and hemispheric mass in the ascending colon, and lower endoscopic ultrasonography revealed a hypoechoic-to-isoechoic mass invaded the submucosal layer. The mass was suspected to be a colonic carcinoid tumor. Based on the preoperative evaluation, endoscopic complete resection was considered difficult. Therefore, the lesion was removed via laparoscopic right hemicolectomy. Histological examination revealed that the tumor consisted of nests of polygonal cells with abundant granular eosinophilic cytoplasm. Immunohistochemical staining revealed diffuse positivity for S100 and CD68. Therefore, the tumor was diagnosed as a granular cell tumor. We suggest that surgical resection should be considered if it is located in the thin-walled ascending colon prone to perforation, difficult to rule out malignant tumor due to submucosal invasion, or to remove endoscopically.

A Granular Cell Tumor of the Rectum: A Case Report and Review of the Literature: Seung Yoon Yang, Byung Soh Min, Woo Ram Kim; Ann Coloproctol. 2017;33(6):245-248. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.245

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7 Web of Science
11 Citations

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A granular cell tumor (GCT) is an uncommon mesenchymal lesion that rarely occurs in the colon and the rectum. We describe the case of 51-year-old man with a 2-cm-sized rectal GCT 10 cm above the anal verge that was incidentally detected after a screening colonoscopy. Preoperative radiologic studies demonstrated a suspicious submucosal rectal mass with mesorectal fat infiltration, but without circumferential resection margin threatening, extramural vessel invasion, and regional lymph-node enlargement. The tumor was resected by using a transanal endoscopic operation (TEO) without immediate postoperative complications. The final pathology revealed that the tumor consisted of a GCT that had invaded the subserosa with clear margins. It had no other risk factors for malignancy according to Fanburg-Smith criteria. We systematically reviewed the English literature by using PubMed and Google Scholar. This report may be the first documented case in the literature to describe a TEO for a GCT that had invaded the subserosa in the rectum.

Citations

Citations to this article as recorded by

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review
Jorge Arche Prats, Diego García Prado, Gonzalo Campaña Villegas, Mónica Martínez Mardónez
Journal of Coloproctology.2024; 44(04): e281. CrossRef
Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection
Michaelia S. Sunderland, Anthony Dakwar, Sowsan Rasheid
The American Surgeon™.2023; 89(4): 1304. CrossRef
Experience of surgical treatment in a granular cell tumor in the qscending colon: a case report
In-Kyeong Kim, Young-Tae Ju, Han-Gil Kim, Jin-Kwon Lee, Dong-Chul Kim, Jae-Myung Kim, Jin Kyu Cho, Ji-Ho Park, Ju-Yeon Kim, Chi-Young Jeong, Soon-Chan Hong, Seung-Jin Kwag
Annals of Coloproctology.2023; 39(3): 275. CrossRef
Granular cell tumour. Case report.
P. Leszczyńska, M. Sobocińska, K. Ustymowicz, W. Romańczyk
Progress in Health Sciences.2023; 13(1): 107. CrossRef
Granular cell tumor of the perineum (clinical case)
R. R. Shakirov, O. Yu. Karpukhin, M. I. Ziganshin, I. S. Raginov
Koloproktologia.2023; 22(4): 121. CrossRef
A case report of rare granular cell tumor of the urinary bladder
Saman Anwar Wahid, Han N. Mohammed Fadhl, Alaa Abbas Ali, Rebaz Karim Mohammed
Urology Case Reports.2022; 42: 102034. CrossRef
Granular cell tumor of the cecum: Case report of mini invasive surgical resection and review of the literature
Roberto Cantella, Giuseppe Evola, Carla Di Stefano, Ezio Trusso Zirna, Marianna Iudica, Luigi Piazza
International Journal of Surgery Case Reports.2021; 87: 106397. CrossRef
Granular Cell Tumor of the Perianal Region
Marina Pérez-Flecha González, Enrique Revilla Sánchez, Carolina Ibarrola de Andrés, Ramón Gómez Sanz
Journal of Gastrointestinal Surgery.2020; 24(4): 907. CrossRef
A Rare Granular Cell Tumor with a Center Ulcer of the Rectum
Jeonghun Lee, Younghye Kim
Case Reports in Gastrointestinal Medicine.2020; 2020: 1. CrossRef
Granular Cell Tumors of the Cecum: Report of Two Cases and Review of Literature
Nam Yeol Cho, Yu-Ah Choi, Gye Sung Lee
Keimyung Medical Journal.2020; 39(2): 86. CrossRef
A rare case of tracheal granular cell tumor in a pediatric patient
Bojiang Chen, Linrui Xu, Min Xie, Weimin Li, Fengming Luo
Pediatric Pulmonology.2019; 54(8): 1101. CrossRef

A Case of Granular Cell Tumor in the Perianal Region.: Hwang, Do Yeon , Song, Seok Kyu , Lee, Jong Ho , Kim, Hyun Shig , Lee, Jong Kyun , Lee, Jung Dal , Kim, Kwang Yun; J Korean Soc Coloproctol. 2001;17(2):108-111.

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Abstract PDF: Since granular cell tumor was first described by Abrikossoff in 1926, it has been known as a rare disease. The histogenesis of this tumor is still controversial, but the origin is thought to be from a Schwann cell. About one third of the tumors occur in the tongue, and uncommonly in the perianal region. We report a case of granular cell tumor that developed in the perianal region. The tumor grew slowly for 5 years and was removed by a local excision. This tumor showed positive staining with neuron-specific enolase (NSE).

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