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1 "Hyperbilirubinemia"
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Original Article
Hyperbilirubinemia Is a Significant Indicator for the Severity of Acute Appendicitis
Young Ran Hong, Chul-Woon Chung, Jong Woo Kim, Chang Il Kwon, Dae Ho Ahn, Sung Won Kwon, Seong Ki Kim
J Korean Soc Coloproctol. 2012;28(5):247-252.   Published online October 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.5.247
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  • 27 Citations
AbstractAbstract PDF
Purpose

This study aims to reveal more effective clinical or laboratory markers for the diagnosis of acute appendicitis and to score the severity based on a sufficiently large number of patients with acute appendicitis.

Methods

We identified 1,195 patients with acute appendicitis after excluding those with other causes of hyperbilirubinemia among the 1,271 patients that underwent a laparoscopic or an open appendectomy between 2009 and 2010. A retrospective chart review of the medical records, including laboratory and histologic results, was conducted. We then analyzed the data using univariate and multivariate analyses.

Results

Among the 1,195 patients, a laparoscopic appendectomy was performed in 685 cases (57.32%), and an open appendectomy was performed in 510 cases (42.68%). The univariate analysis demonstrated significant differences for white blood cell count (P < 0.0001), segmented neutrophils (P = 0.0035), total bilirubin (P < 0.0001), and systemic inflammatory response syndrome (SIRS) score between groups (P < 0.0001). The multivariate analysis demonstrated that total bilirubin (odds ratio, 1.772; 95% confidence interval, 1.320 to 2.379; P = 0.0001) and SIRS score (odds ratio, 1.583; 95% confidence interval, 1.313 to 1.908; P < 0.0001) have statistically significant diagnostic value for perforated appendicitis.

Conclusion

Hyperbilirubinemia is a statistically significant diagnostic marker for acute appendicitis and the likelihood of perforation.

Citations

Citations to this article as recorded by  
  • Hyperbilirubinemia and acute appendicitis: a cohort study
    Harris BARTIMEUS, Ibrahim LABEDA, Julianus A. UWURATUW, Joko HENDARTO, Prihantono PRIHANTONO, Muhammad I. KUSUMA, Muhammad FARUK
    Chirurgia.2025;[Epub]     CrossRef
  • Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model
    Zeynep Kucukakcali, Sami Akbulut
    World Journal of Clinical Cases.2025;[Epub]     CrossRef
  • Hyperbilirubinemia as a Marker for Complicated Acute Appendicitis: A Systematic Review
    Alicja Czyszczon, Bartosz Maczkowski, Aneta Tkaczyk, Marek Drozdz, Wiktoria Boral, Szymon Mikler, Magdalena Mandyna, Aleksandra Przelaskowska, Jan Pulinski
    Cureus.2025;[Epub]     CrossRef
  • Diagnostic Value of Hematological and Biochemical Markers in Pediatric Appendicitis: A ROC-Based Retrospective Evaluation
    Sevgi Buyukbese Sarsu
    Medical Bulletin of Haseki.2025; 63(5): 236.     CrossRef
  • Diagnostic value of laboratory parameters for complicated appendicitis: A two‑center study
    Qian Zhang, Hongwei Zhao, Fangli Wang, Wenqiang Li, Peng Zhang
    Biomedical Reports.2024;[Epub]     CrossRef
  • Letter to the Editor regarding “A novel Appendicitis TriMOdal prediction Score (ATMOS) for acute appendicitis in pregnancy: a retrospective observational study”
    Rıfat Peksöz, Ferdi Cambaztepe, Sabri Selçuk Atamanalp
    Updates in Surgery.2023; 75(1): 265.     CrossRef
  • Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review
    Binyamin Sikander, Jacob Rosenberg, Siv Fonnes
    The American Journal of Emergency Medicine.2023; 67: 100.     CrossRef
  • Elevated total and direct bilirubin are associated with acute complicated appendicitis: a single-center based study in Saudi Arabia
    Mohammed S. Alfehaid, Ayman M. Babiker, Abdullah Hamad Alkharraz, Hamad yousef Alsaeed, Ali Abdullah Alzunaydi, Adi Abdulaziz Aldubaiyan, Hanan Abdalla Sinyan, Bshayr K. Alkhalaf, Rakan Alshuwaykan, Rehana Khalil, Osama Al-Wutayd
    BMC Surgery.2023;[Epub]     CrossRef
  • Significance of laboratory parameters in diagnosing acute appendicitis during pregnancy
    Rıfat Peksöz, Esra Dişçi, Abdulkadir Kaya, Enes Ağırman, Ercan Korkut, Nurhak Aksungur, Necip Altundaş, Salih Kara, Sabri Selçuk Atamanalp
    ANZ Journal of Surgery.2022; 92(1-2): 121.     CrossRef
  • Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis
    Abdullah Shuaib, Nour Alhamdan, Husain Arian, Mohamed Alaa Sallam, Ali Shuaib
    Medical Sciences.2022; 10(3): 36.     CrossRef
  • Evaluation of role of hyperbilirubinemia as a new diagnostic marker of complicated appendicitis
    Sabyasachi Bakshi, Nilay Mandal
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Clinical predictors of gangrenous appendicitis: elevated total bilirubin level and computed tomography scan findings
    Itsuki Naya, Kensuke Adachi, Koichi Takeuchi, Yuno Ariyama, Akihiro Hosaka, Kazuhiro Imamura, Yasuhiro Morita, Shigeki Matsubara, Alan Kawarai Lefor, Hisanaga Horie
    Acute Medicine & Surgery.2021;[Epub]     CrossRef
  • THE UTILITY OF SERUM BILIRUBIN AS A MARKER IN ACUTE ABDOMEN
    P N Sreeramulu, Shashidhar K N, Varsha A
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 16.     CrossRef
  • Acute Appendicitis in the Elderly: A Literature Review on an Increasingly Frequent Surgical Problem
    Sintija Lapsa, Arturs Ozolins, Ilze Strumfa, Janis Gardovskis
    Geriatrics.2021; 6(3): 93.     CrossRef
  • Obstructive-Type Jaundice without Bile Duct Dilatation in Generalized Peritonitis Is a Specific Sign of Spontaneous Gall Bladder Perforation
    Vicky Sumarki Budipramana, Maria Meilita
    Case Reports in Medicine.2020; 2020: 1.     CrossRef
  • Diagnostic accuracy of procalcitonin for overall and complicated acute appendicitis in children: a meta-analysis
    Wei Cui, Haipeng Liu, Hong Ni, Xianhui Qin, Liran Zhu
    Italian Journal of Pediatrics.2019;[Epub]     CrossRef
  • A Prospective Study to Evaluate the Role of Serum Bilirubin in Acute Appendicitis
    Siva Kumar Puligundla, Gandikota Venkata Prakash, Ajay Babu, Boddukura Sahithi Priya, Sreedhar Sreedhar, Anugna Anugna, Sumesh Raja, Tejaswi S.
    Journal of Evidence Based Medicine and Healthcare.2019; 6(48): 3039.     CrossRef
  • Evaluation of Serum Bilirubin as a Predictive Marker for Simple and Complicated Appendicitis in Sulaimani Emergency Teaching Hospital
    Seerwan Hama Shareef, Dara Ahmed Mohammed, Goran Ameer Ahmed
    Kurdistan Journal of Applied Research.2018; : 15.     CrossRef
  • Lack of utility of measuring serum bilirubin concentration in distinguishing perforation status of pediatric appendicitis
    William Bonadio, Santina Bruno, David Attaway, Logesh Dharmar, Derek Tam, Peter Homel
    The American Journal of Emergency Medicine.2017; 35(6): 885.     CrossRef
  • Hyperbilirubinaemia: its utility in non‐perforated appendicitis
    Anna Sandstrom, David A. Grieve
    ANZ Journal of Surgery.2017; 87(7-8): 587.     CrossRef
  • Biomarkers of acute appendicitis: systematic review and cost–benefit trade-off analysis
    Amish Acharya, Sheraz R. Markar, Melody Ni, George B. Hanna
    Surgical Endoscopy.2017; 31(3): 1022.     CrossRef
  • Hyperbilirubinaemia alone cannot distinguish a perforation in acute appendicitis
    Fábio R. Silva, Maria Inês da Rosa, Bruno R. Silva, Carla Simon, Maria Cecília Alexandre, Lidia R. Medeiros, Fabrício S. Bitencourt, Maria Eduarda Fernandes dos Reis
    ANZ Journal of Surgery.2016; 86(4): 255.     CrossRef
  • Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study
    A.C. Chambers, S.L. Bismohun, H. Davies, P. White, A.V. Patil
    International Journal of Surgery.2015; 13: 207.     CrossRef
  • Diagnostic markers in acute appendicitis
    Yahya A. Al-Abed, Nasser Alobaid, Fiona Myint
    The American Journal of Surgery.2015; 209(6): 1043.     CrossRef
  • Diagnostic accuracy of hyperbilirubinaemia in anticipating appendicitis and its severity
    Sven Muller, Claudius Falch, Steffen Axt, Peter Wilhelm, Dirk Hein, Alfred Königsrainer, Andreas Kirschniak
    Emergency Medicine Journal.2015; 32(9): 698.     CrossRef
  • Serum total bilirubin elevation is a predictor of the clinicopathological severity of acute appendicitis
    Satoshi Nomura, Masanori Watanabe, Osamu Komine, Takeshi Shioya, Tetsutaka Toyoda, Hideki Bou, Tetsuo Shibuya, Hideyuki Suzuki, Eiji Uchida
    Surgery Today.2014; 44(6): 1104.     CrossRef
  • Elevated serum bilirubin in assessing the likelihood of perforation in acute appendicitis: A diagnostic meta-analysis
    Salvatore Giordano, Markus Pääkkönen, Paulina Salminen, Juha M. Grönroos
    International Journal of Surgery.2013; 11(9): 795.     CrossRef
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