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Original Articles
- Malignant Melanoma of the Anorectal Region.
- Kim, Duck Woo , Kang, Sung Bum , Heo, Seung Chul , Park, Kyu Joo , Bang, Yung Jue , Park, Jae Gahb
- J Korean Soc Coloproctol. 2002;18(4):257-261.
- 1,567 View
- 11 Download
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Abstract
PDF - PURPOSE
Anorectal melanoma is an uncommon tumor that comprises less than 1% of all malignancies of the anorectum. Its epidemiologic features, and clinical characteristics have not been well studied. We reviewed our experience in management of malignant melanoma of anorectal region.
METHODS
Eight patients with malignant melanoma of anorectal region were treated at Seoul National University Hospital in the period of 1980-2001. They represented 0.36% of the 2,246 patients with colorectal cancer seen at Seoul National University Hospital during the same period.
RESULTS
Five patients were female. The median age was 60 years. Common presenting symptoms were decreased stool caliber (63%), and anal bleeding (50%). All lesions developed at the area between 2cm and 7cm from anal verge and could be palpated on digital rectal examination. Two patients had multiple hepatic metastases at initial presentation. Of the remaining 6, abdominoperineal resection was performed for 4 patients, and local excision for 2. During the follow-up period with median length of 11 months, local recurrence occurred in 1 patient and distant metastases occurred in 3. Metastatic disease involved lung and/or brain. Five patients died during the follow-up period and the length of mean survival was 12 months.
CONCLUSION
Malignant melanoma of anorectum seems to have a poor prognosis with an appreciable incidence of regional node metastases. Common symptoms were similar to those of common anorectal disease. But all lesions were palpable on digital rectal examination. Increased awareness of this rare condition may lead to early detection and therefore to improved results.
- Primary Malignant Melanoma of the Rectum.
- Yoon, Seung Jae , Shin, Yong Woon , Jang, Cheol Soon , Cho, Byung Kwan , Cho, Yong Bum , Lee, Don , Kwon, Seong Ryul , Kim, Hyun Suk , Kwon, Kye Sook , Cho, Hyun Keun , Kim, Pum Soo , Kim, Young Soo , Kim, Kyung Rae , Min, Soo Kee
- J Korean Soc Coloproctol. 2000;16(6):478-482.
- 1,486 View
- 17 Download
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Abstract
PDF
- Malignant melanoma arising from the mucosal surface is a rare, virulent malignant neoplasm frequently associated with an extremely poor prognosis. The sites of initial presentation include the nose, oral cavity, larynx, vulva, vagina, anal canal and rectum. Primary melanoma of the rectum is extremely rare and its histogenesis is controversial. We present a case of primary malignant melanoma arising from the rectum in a 77-year-old woman who presented with intermittent anal bleeding for 2 months. Colonoscopic examination of the rectum revealed a 3.5 3.0 2.7 cm exophytic tumor with a granular surface in the rectum, 5cm from the anal verge. Black colored pigmentation was detected. Distant metastasis to liver was detected on abdominal CT scan. Light microscopy of tumor revealed malignant melanocytes surrounded by normal mucosa. The tumor cells reacted positively for immunohistochemical staining with S-100 protein and HMB-45. Clinical and laboratory examination excluded the presence of melanoma at sites other than rectum. Local excision of the tumor was performed.
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