Annals of Coloproctology

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Case Report

Malignant disease,Rare disease & stoma

Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano: Jordan Au, Francis M. Hulme-Moir, Andrew Herd, Mathew A. Kozman; Ann Coloproctol. 2021;37(Suppl 1):S7-S10. Published online November 26, 2019; DOI: https://doi.org/10.3393/ac.2019.11.19

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We report a case of a 66-year-old male who presented with a locally advanced primary mucinous adenocarcinoma arising from a fistula-in-ano. The presentation was typical for perianal sepsis and fistula-in-ano with anal pain and chronic discharge. Initial treatments with fistula debridement and seton were performed. Subsequent review of histology revealed underlying adenocarcinoma, while magnetic resonance imaging (MRI) showed local invasion into the prostate. The patient received neoadjuvant chemoradiotherapy followed by pelvic exenteration to maximize the chance of achieving cure. Features of this case are discussed together with its implications, including treatment guidelines and typical MRI findings.

Citations

Citations to this article as recorded by

Perianal Mucinous Adenocarcinoma: A Case Report and a Systematic Review of the Literature
Ioannis D. Gkegkes, Vassilis Milionis, Nikolaos Goutas, Ioannis Mantzoros, Antonia A. Bourtzinakou, Apostolos P. Stamatiadis
Journal of Gastrointestinal Cancer.2025;[Epub] CrossRef
A Rare Presentation of Fournier’s Gangrene: Necrotizing Infection Traveling Through a Fistula From the Rectum to the Corpus Cavernosum
Donald Dennis, Michael Gentry
Cureus.2025;[Epub] CrossRef
Perianal Mucinous Adenocarcinoma Found Incidentally From Perianal Mass
Seyed Khalafi, Malini Riddle, Brittany Harper, Vid Fikfak
Cureus.2023;[Epub] CrossRef
Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases: A Focus on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Youngbae Jeon, Eun Jung Park
The Ewha Medical Journal.2023;[Epub] CrossRef

Original Article

Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer: Sare Hosseini, Ali Mohammad Bananzadeh, Roham Salek, Mohammad Zare-Bandamiri, Ali Taghizadeh Kermani, Mohammad Mohammadianpanah; Ann Coloproctol. 2017;33(2):57-63. Published online April 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.2.57

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15 Citations

Abstract PDF

Purpose

Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer.

Methods

This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013.

Results

Totally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4%) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival.

Conclusion

Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome.

Citations

Citations to this article as recorded by

Comparing the Histopathologic Patterns and Survival Outcomes of Mucinous vs Non-mucinous Colorectal Adenocarcinoma: A Systematic Review and Meta-Analysis
Jane Nnanemere, Akinyele Oladimeji, Sarah Waseem, Ifelunwa M Osanakpo, Aminat D Lawal , Moses C Odoeke, Joshua T Green
Cureus.2026;[Epub] CrossRef
Association between lymphovascular invasion and lymph node metastases in colon cancer: A National Cancer Database analysis
Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Anjelli Wignakumar, Marylise Boutros, Steven D. Wexner
Colorectal Disease.2025;[Epub] CrossRef
Comprehensive Overview of Molecular, Imaging, and Therapeutic Challenges in Rectal Mucinous Adenocarcinoma
Mihaela Berar, Andra Ciocan, Emil Moiș, Luminița Furcea, Călin Popa, Răzvan Alexandru Ciocan, Florin Zaharie, Cosmin Puia, Nadim Al Hajjar, Cosmin Caraiani, Ioana Rusu, Florin Graur
International Journal of Molecular Sciences.2025; 26(2): 432. CrossRef
Clinicopathological and prognostic features of colorectal mucinous adenocarcinomas: a systematic review and meta-analysis
Xiao Wang, Haoran Wang, Haoqing He, Kai Lv, Wenguang Yuan, Jingbo Chen, Hui Yang
BMC Cancer.2024;[Epub] CrossRef
Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis
Yan Zhuang, Hailong Wang, Da Jiang, Ying Li, Lixia Feng, Caijuan Tian, Mingyu Pu, Xiaowei Wang, Jiangyan Zhang, Yuanjing Hu, Pengfei Liu
BMC Cancer.2021;[Epub] CrossRef
Clinicopathological Features and Survival of Signet-Ring Cell Carcinoma and Mucinous Adenocarcinoma of Right Colon, Left Colon, and Rectum
Lili Zhu, Chunrun Ling, Tao Xu, Jinglin Zhang, Yujie Zhang, Yingjie Liu, Chao Fang, Lie Yang, Wen Zhuang, Rui Wang, Jie Ping, Mojin Wang
Pathology and Oncology Research.2021;[Epub] CrossRef
Identification of Potential Biomarkers and Biological Pathways for Poor Clinical Outcome in Mucinous Colorectal Adenocarcinoma
Chang Woo Kim, Jae Myung Cha, Min Seob Kwak
Cancers.2021; 13(13): 3280. CrossRef
Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
Chuanwang Yan, Hui Yang, Lili Chen, Ran Liu, Wei Shang, Wenguang Yuan, Fei Yang, Qing Sun, Lijian Xia
BMC Cancer.2021;[Epub] CrossRef
Incidence and prognosis of pulmonary metastasis in colorectal cancer: a population-based study
Yizhi Ge, Shijun Lei, Bo Cai, Xiang Gao, Guobin Wang, Lin Wang, Zheng Wang
International Journal of Colorectal Disease.2020; 35(2): 223. CrossRef
Association between aberrant dynein cytoplasmic�1 light intermediate chain�1 expression levels, mucins and chemosensitivity in colorectal cancer
Chun‑Chao Chang, Kuo‑Ching Chao, Chi‑Jung Huang, Chih‑Sheng Hung, Yen‑Chieh Wang
Molecular Medicine Reports.2020;[Epub] CrossRef
Clinical impact of non-predominant histopathological subtypes on the long-term prognosis of colorectal cancer patients in Japan
Heita Ozawa, Shinichi Yamauchi, Hiroki Nakanishi, Junichi Sakamoto, Shin Fujita, Kenichi Sugihara
International Journal of Colorectal Disease.2020; 35(12): 2257. CrossRef
Predictive Significance of Mucinous Histology on Pathologic Complete Response Rate Following Capecitabine-Based Neoadjuvant Chemoradiation in Rectal Cancer: a Comparative Study
Sare Hosseini, NamPhong Nguyen, Mohammad Mohammadianpanah, Sepideh Mirzaei, Ali Mohammad Bananzadeh
Journal of Gastrointestinal Cancer.2019; 50(4): 716. CrossRef
Impact of histological subtype on the prognosis of patients undergoing surgery for colon cancer
Fabio Bagante, Gaya Spolverato, Eliza Beal, Katiuscha Merath, Qinyu Chen, Ozgür Akgül, Robert A. Anders, Timothy M. Pawlik
Journal of Surgical Oncology.2018; 117(7): 1355. CrossRef
SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma
Ping Shen, Shu Yang, Haimei Sun, Guilan Li, Bo Wu, Fengqing Ji, Tingyi Sun, Deshan Zhou
International Journal of Molecular Sciences.2018; 19(5): 1541. CrossRef
Mucinous Subtype in Patients With Colorectal Cancer
Hyung Jin Kim
Annals of Coloproctology.2017; 33(2): 44. CrossRef

Case Report

A Case of a Mucinous Adenocarcinoma Arising from a Rectal Diverticulum: Jang Hoon Kwon, Koon Hee Han, Woo-Sung Chang, Ki-Ho Nam, Myoung Sik Han, Jae Hong Ahn, Sang Hak Han, Gab Jin Cheon; J Korean Soc Coloproctol. 2012;28(4):222-224. Published online August 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.4.222

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8 Citations

Abstract PDF

The occurrence of an adenocarcinoma arising from a rectal diverticulum that causes mechanical ileus is very rare. Recently, we diagnosed a case of a mucinous adenocarcinoma in a rectal diverticulum after an emergent abdominal perineal resection and permanent colostomy by laparotomy. Here, we present a case report and a review of the literature.

Citations

Citations to this article as recorded by

Solitary rectal diverticulum: A rare entity mimicking contained perforation – Imaging and surgical correlation
Kassandra G. Tulenko, Samantha H. Epstein, Brett R. Kurpiel, Rachita Khot
Case Reports in Clinical Radiology.2025; 0: 1. CrossRef
Perforated solitary mid-rectal diverticulum diagnosed with colonoscopy: a case report and literature review
Andrej Nikolovski, Vladimir Avramoski, Klaudia Gjinoska, Irena Kostovska, Emil Stoicovski, Zan Mitrev
Journal of Surgical Case Reports.2025;[Epub] CrossRef
A Novel Method of Treating Rectal Diverticulum Using Transanal Minimally Invasive Surgery (TAMIS)
Yui Kaneko, Neil Strugnell
World Journal of Colorectal Surgery.2024; 13(2): 46. CrossRef
A case of solitary rectal diverticulum presenting with a large retrorectal abscess
Stefanos Gorgoraptis, Sofia Xenaki, Elias Athanasakis, Anna Daskalaki, Konstantinos Lasithiotakis, Evangelia Chrysou, Emmanuel Chrysos
Annals of Medicine and Surgery.2020; 49: 57. CrossRef
Mucinous Adenocarcinoma Arising within a Colonic Diverticulum Mimicking a Diverticular Abscess: A Case Report
Goun Choi, Jiyoung Hwang, Seong Sook Hong, Jae Joon Kim, In Ho Choi
Journal of the Korean Society of Radiology.2018; 79(1): 40. CrossRef
Divertículo rectal sintomático
Alvaro Andres Gomez Venegas
Revista Colombiana de Gastroenterología.2018; 33(4): 469. CrossRef
Rectal pseudodiverticulum
Saurabh Singh, Louis Savage
BMJ Case Reports.2014; 2014: bcr2013201888. CrossRef
Rectal Diverticulum after Stapled Transanal Procedures: Surgery Encouraged
Gianluca Pellino
The American Surgeon™.2013; 79(12): 1320. CrossRef

Original Articles

Malignancy Associated with Inflammatory Bowel Disease.: Shin, Ui Sup , Yu, Chang Sik , Kim, Chan Wook , Park, Jin Seok , Jeong, Kwang Yong , Yoon, Sang Nam , Lim, Seok Byung , Song, Joon Seon , Kim, Jin Cheon; J Korean Soc Coloproctol. 2009;25(3):150-156.; DOI: https://doi.org/10.3393/jksc.2009.25.3.150

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5 Citations

Abstract PDF

PURPOSE
As the number of patients with inflammatory bowel disease (IBD) has steadily increased in Korea, IBD-associated cancers are expected to increase in number. This study investigated the clinical features of intestinal cancer in patients with IBD.
METHODS
One hundred five patients with ulcerative colitis (UC) and 270 patients with Crohn's disease (CD) under the care of the Department of Colon and Rectal Surgery, Asan Medical Center, between December 1989 and January 2009 were reviewed retrospectively.
RESULTS
Ten patients of the 105 with UC and 5 patients of the 270 with CD were found to have intestinal cancer. The mean age was 45 yr (+/-8.8), and the mean duration of IBD at the time of diagnosis of the cancer was 12.6 yr (+/-6.0). Six of the 15 cancer patients had no history of treatment for IBD of more than 3 mo before diagnosis of the cancer. Eleven cancers were located in the rectum (7 in UC, 4 in CD), including 1 case of synchronous cancer. One case of small bowel cancer was found in a patient with small bowel CD. Four cases involved a mucinous adenocarcinoma. Eight of the 12 cases of an adenocarcinoma of the colon and rectum were advanced stage.
CONCLUSION
IBD-associated intestinal cancers were found at a relatively young age, were diagnosed at an advanced stage, and had a higher proportion of mucinous adenocarcinomas than in sporadic cancer. Considering the increasing incidence of IBD and the expected increase in the number of IBD-associated cancer in Korea, every effort should be made to prevent intestinal cancer in patients with IBD and to detect it early.

Citations

Citations to this article as recorded by

Rectal Squamous Cell Carcinoma in a Patient with Familial Adenomatous Polyposis
Hye Min Jo, Hyun Jung Kim, Jina Youn, Seong Kyu Park, Dae Sik Hong, A Reum Chun, Hee Kyung Kim
Korean Journal of Medicine.2015; 88(3): 335. CrossRef
Primary Squamous Cell Carcinoma of the Ascending Colon: Report of a Case and Korean Literature Review
Dong-Keun Cho, Sang-Hun Kim, Sung-Bum Cho, Wan-Sik Lee, Young-Eun Joo
The Korean Journal of Gastroenterology.2014; 64(2): 98. CrossRef
Clinical Characteristics of Lower Gastrointestinal Cancer in Crohn's Disease: Case Series of 5 Patients
Ji Min Choi, Changhyun Lee, Yoo Min Han, Minjong Lee, Dong Kee Jang, Jeehye Kwon, Jong Pil Im, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung
Intestinal Research.2013; 11(2): 127. CrossRef
A Case of Squamous Cell Carcinoma of the Breast in a Patient with Crohn's Disease Taking Azathioprine
Kyoung Chan Park, Dong Uk Ju, Seong Wook Heo, Jung Il Ryu, Ju Youn Cho, Eui Jung Kim, Hoon Kyu Oh, Eun Young Kim
The Korean Journal of Gastroenterology.2012; 60(6): 373. CrossRef
Squamous Cell Carcinoma of the Rectum: Report of Two Cases
Na Rae Kim, Dong Hae Chung, Jeong Heum Baek, Yeon Ho Park, Hee Eun Kyung, Mi Sook Roh, Seung-Yeon Ha
Intestinal Research.2010; 8(2): 172. CrossRef

Mucinous Adenocarcinoma of the Colon and Rectum.: Kim, Kab Choong , Kim, Duck Woo , Park, Hyung Chul , Park, Jae Gahb; J Korean Soc Coloproctol. 2007;23(1):60-64.; DOI: https://doi.org/10.3393/jksc.2007.23.1.60

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1 Citations

Abstract PDF

PURPOSE
This study was to evaluate and compare the clinical characteristics of a mucinous adenocarcinoma with those of a non-mucinous adenocarcinoma in colorectal cancer patients.
METHODS
Data were retrospectively reviewed on 3,232 colorectal cancer patients, including 221 mucinous adenocarcinoma patients (6.1%), who received surgery between 1990 and 2003.
RESULTS
The mean tumor size (6.5 cm) of the mucinous adenocarcinomas was bigger than that (5.2 cm) of the non-mucinous adenocarcinomas. The locations of the mucinous adenocarcinomas were 95 (48.2%) in the proximal colon, 35 (17.8%) in the distal colon, and 67 (34.0%) in the rectum whereas those of the non-mucinous adenocarcinomas were 559 (18.9%) in the proximal colon, 861 (29.2%) in the distal colon, and 1,533 (51.9%) in the rectum. Stage distribution was as follows: In mucinous adenocarcinomas, 7 stage A (3.3%), 84 stage B (39.3%), 76 stage C (35.5%), and 47 stage D (21.9%). In non-mucinous adenocarcinomas, 447 stage A (15.2%), 1,036 stage B (35.1%), 997 stage C (33.8%), and 469 stage D (15.9%). In the univariate analysis, the overall 5-year survival rate of patients with a mucinous adenocarcinoma was lower than that of patients with a non-mucinous adenocarcinoma (60% vs. 65%, P=0.016), but survival rates for each stage were not significantly different. The difference in recurrence rates was not statistically significant (33.3% vs. 24.2%, P=0.258). A multivariate analysis showed that the mucinous histologic type was not useful as an independent prognostic factor.
CONCLUSIONS
Mucinous colorectal adenocarcinomas tend to be large, exist in a proximal location, have an advanced stage at diagnosis. The difference in survival rates for each stage was not statistically significant. A mucinous histologic type was not an independent prognostic factor.

Citations

Citations to this article as recorded by

Analysis of Prognosis in Colorectal Mucinous Adenocarcinoma: A Retrospective Analysis with Peritoneal Fluid
Seung Bong Choi, In Kyu Lee, Dae Youn Won, Yoon Suk Lee, Yoon Si, Sang Chul Lee, Won Kyung Kang, Jong Kyung Park, Chang Hyeok Ahn, Jun-Gi Kim, Seong Taek Oh
Journal of the Korean Surgical Society.2010; 79(6): 474. CrossRef

Case Report

Appendiceal Mucinous Adenocarcinoma with Pseudomyxoma Peritonei.: Park, Tae Jin , Jeong, Chi Young , Jung, Eun Jung , Lee, Young Joon , Hong, Soon Chan , Choi, Sang Kyung , Ha, Woo Song , Park, Soon Tae; J Korean Soc Coloproctol. 2004;20(6):420-423.

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Abstract PDF: Pseudomyxoma peritonei is a relatively rare and poorly understood condition in which mucus accumulate within the peritoneal cavity. The presence of cells in the mucin, either inflammatory or neoplastic, distinguishes it from simple acellular mucus ascites caused by mucinous spillage. There are widespread seedings on the peritoneal and omental surfaces with a heavy cancerous glaze. This is principally a complication of borderline or malignant neoplasm of the ovary and/or appendix. We report one female case with pseudomyxoma peritonei from mucinous adenocarcinoma of appendix which was diagnosed incidentally during laparoscopic cholecystectomy.

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