Papillary serous carcinoma of the peritoneum (PSCP) is a primary tumor of peritoneal lining (mesothelioma) of the abdomen and is histologically difficult to differentiate from papillary serous carcinoma of the ovary. It is very rare tumor that involves the surface of the pelvic and/or abdominal peritoneum. Most patients with this tumor have been treated with optimally surgical cytoreduction and postoperative chemotherapy. However, long term survival has not been achieved in many studies. In recent years, platinum-paclitaxel combination therapy was reported as a effective initial therapy for recurrent PSCP. We have experienced one case of recurrent PSCP which was successfully treated with heptaplatin and paclitaxel. We report the toxicity and long term result of the patient.
Papillary serous peritoneal carcinoma(PSPC) is a rare malignancy that arises in the peritoneum and histologically resembles papillary serous carcinoma of the ovary. If peritoneal carcinomatosis occurs in the absence of an obvious primary tumor site and is associated with a papillary serous pathology, we may be dealing with the distinct entity of PSPC of extraovarian origin. Radiological findings suggesting the diagnosis are diffuse microcalcifications in the peritoneum, which occur in relation to psammoma bodies. The Ca-125 is most often abnormal and, not uncommonly, markedly elevated. The diagnosis requires that the surgeon identify grossly normal ovaries or minimal surface involvement. If PSPC is confirmed, a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and aggressive debulking surgery should be carried out, followed by cisplatin-based chemotherapy. We report a case of PSPC arising from the rectum in a 41 year-old woman.