Annals of Coloproctology

Display

Sort by :

Original Articles

Malignant disease,Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer

Prognostic Impact of Carcinoembryonic Antigen Levels in Rectal Cancer Patients Who Had Received Neoadjuvant Chemoradiotherapy: Jung Il Joo, Sang Woo Lim, Bo Young Oh; Ann Coloproctol. 2021;37(3):179-185. Published online May 11, 2021; DOI: https://doi.org/10.3393/ac.2020.11.27

6,025 View
82 Download
8 Web of Science
8 Citations

Purpose
Carcinoembryonic antigen (CEA) is a useful marker for rectal cancer. The aim of this study was to investigate the prognostic impact of CEA level according to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer patients who underwent radical surgery.
Methods
A total of 245 patients with rectal cancer who underwent radical surgery were retrospectively evaluated. Serum CEA level was measured preoperatively and postoperatively. We compared survival outcomes based on CEA level before and after surgery according to nCRT.
Results
Of the 245 patients, elevation of CEA level was observed preoperatively in 79 and postoperatively in 30, respectively. Eighty-seven (35.5%) patients received nCRT, and elevated CEA level was a significant prognostic factor both before and after surgery. In patients who had not received nCRT, an elevated CEA level was a significant prognostic factor before surgery but was not significant after surgery. In a multivariate analysis for prognostic factors, elevation of preoperative CEA level was an independent prognostic factor of disease-free survival (DFS) regardless of nCRT. Postoperative CEA level was an independent prognostic factor of DFS in patients who had received nCRT but was not a factor in patients who had not received nCRT.
Conclusion
Serum CEA level was an independent prognostic factor both preoperatively and postoperatively in rectal cancer patients who had received nCRT.

Citations

Citations to this article as recorded by

Global-local Dirichlet processes for identifying pan-cancer subpopulations using both shared and cancer-specific data
Arhit Chakrabarti, Yang Ni, Debdeep Pati, Bani K. Mallick
The Annals of Applied Statistics.2025;[Epub] CrossRef
Progress of MRI‑based radiomics and deep learning for predicting the prognosis of locally advanced rectal cancer (Review)
Yuting Shi, Qiuhan Huang, Jiali Lyu, Tianjie Dong, Jihong Sun
Oncology Letters.2025; 30(5): 1. CrossRef
Prognostic Value of Dynamic Changes in Immune-Inflammatory and Tumor Biomarkers Following Chemoradiotherapy in Locally Advanced Rectal Cancer
Mahmoud Al-Masri, Yasmin Safi, Mohammad Almasri, Ramiz Kardan, Daliana Mustafa, Osama Alayyan, Bilal Kahalah, Rama AlMasri
Cancers.2025; 17(20): 3383. CrossRef
Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef
Unveiling the profound advantages of total neoadjuvant therapy in rectal cancer: a trailblazing exploration
Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Donghyoun Lee, Chinock Cheong
Annals of Surgical Treatment and Research.2023; 105(6): 341. CrossRef
Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
Minsung Kim, Il Tae Son, Bo Young Oh
The Ewha Medical Journal.2023;[Epub] CrossRef
Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer
Soledad Iseas, Juan M. Sendoya, Juan Robbio, Mariana Coraglio, Mirta Kujaruk, Vanesa Mikolaitis, Mariana Rizzolo, Ana Cabanne, Gonzalo Ruiz, Rubén Salanova, Ubaldo Gualdrini, Guillermo Méndez, Marina Antelo, Marcela Carballido, Cecilia Rotondaro, Julieta
Frontiers in Oncology.2022;[Epub] CrossRef
Carcinoembryonic Antigen, the Most Accessible Test for Predicting Colorectal Cancer Prognosis: Exploring Alternative Roles
Sanghee Kang
Annals of Coloproctology.2021; 37(3): 129. CrossRef

The Prognostic Factors and Severity Index in Fournier's Gangrene.: Kim, Kwang Min , Seong, Seung Hoon , Won, Dal Yeon , Ryu, Hoon , Kim, Ik Yong; J Korean Soc Coloproctol. 2010;26(1):29-33.; DOI: https://doi.org/10.3393/jksc.2010.26.1.29

2,823 View
38 Download
7 Citations

Abstract PDF

PURPOSE
Fournier's disease is polymicrobial necrotizing fasciitis of the perineal, perianal, or genital areas. The objective of this study was to investigate patients with Fournier's gangrene and to determine risk factors that affect mortality.
METHODS
This study was a retrospective clinical study. Clinical presentations and outcomes of surgical treatments were evaluated in 27 patients with Fournier's gangrene that were treated in a single institution from January 2000 to March 2009.
RESULTS
The mean age of patients was 52.8+/-14.4 yr, and the male-to-female ratio was 25:2. Among the predisposing factors, diabetes mellitus was the most common (n=8, 29.6%). The most common infection source was anorectal (n=16, 59.3%). Sepsis on admission was detected in 16 cases (59.3%). Four patients died during treatment, for an overall mortality of 14.8%. A logistic regression test showed a Fournier's gangrene severity index greater than 9 and sepsis on admission to be prognostic factors.
CONCLUSION
The mortality rate was higher in patients with sepsis on admission and with a Fournier's gangrene severity index greater than nine.

Citations

Citations to this article as recorded by

Usefulness of Noninvasive Ventilation with Negative-Pressure Wound Therapy in the Intensive Care Unit: A Case Report
Dongbeen Choi, Ji Young Jang, Kwanhoon Park, Kang Yoon Lee, Hangil Yun, Sungho Lee
Journal of Acute Care Surgery.2024; 14(3): 113. CrossRef
Effect of Sarcopenia on Mortality and Morbidity in Patients With Fournier’s Gangrene
Deniz Tazeoglu, Sami Benli, Ahmet Cem Esmer, Tahsin Colak, Feramuz Demir Apaydin
The American Surgeon™.2023; 89(12): 5527. CrossRef
Biomarkers to predict mortality in patients with Fournier’s gangrene admitted to the intensive care unit after surgery in South Korea
In Sik Shin, Seong Chan Gong, Sanghyun An, Kwangmin Kim
Acute and Critical Care.2023; 38(4): 452. CrossRef
Delta neutrophil index as a prognostic factor for mortality in patients with Fournier's gangrene
In Sik Shin, Seong Chan Gong, Sanghyun An, Kwangmin Kim
International Journal of Urology.2022; 29(11): 1287. CrossRef
Intérêt de l’index de sévérité de la gangrène de Fournier dans la prédiction des facteurs pronostiques de la mortalité
S.M. Moudouni, S. Arza, A. Benhaddou, K.H. Baka, M.A. Lakmichi, Z. Dahami, I. Sarf
African Journal of Urology.2017; 23(4): 347. CrossRef
Prognostic factors and treatment outcomes for patients with Fournier's gangrene: a retrospective study
Kyung Sook Hong, Hee Jung Yi, Ryung‐Ah Lee, Kwang Ho Kim, Soon Sup Chung
International Wound Journal.2017; 14(6): 1352. CrossRef
Clinical Practice Guidelines for Soft Tissue Infections

Infection & Chemotherapy.2012; 44(4): 213. CrossRef

The Relatioships Between Tumor-related Gene Expression and Tumor Budding, Tumor Nodule and Lymph Node Extracapsular Extension in Colorectal Cancer.: Kang, Hyun Jong , Cho, Hang Joo , Kang, Gi Chang , Kim, Kee Hwan , Kang, Won Kyung , Kim, Ji Il , Park, Jong Kyung , Oh, Seungtack , Kim, Jeong Soo , An, Chang Hyeok; J Korean Soc Coloproctol. 2009;25(1):1-7.; DOI: https://doi.org/10.3393/jksc.2009.25.1.1

2,173 View
19 Download

Abstract PDF: PURPOSE
Despite the similar lymph node metastasis observed in patients with advanced colorectal cancer (CRC), there was a different clinical outcome. The relationships between tumor-related gene expression and prognostic factors such as tumor budding, tumor nodule and extracapsular extension (ECE) of lymph nodes in patients with CRC remain unclear yet. The purpose of this study was to evaluate the relationship between expression of molecular markers such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), matrix metalloproteinases (MMPs) and E-cadherin and the tumor budding, tumor nodule and ECE of lymph nodes in patients with stage III CRC.
METHODS
The tissue of 87 patients with stage III CRC were investigated for expressions of molecular markers using immunohistochemical methods.
RESULTS
VEGF and MMP-9 expression in tumor tissue were positively associated with the colorectal cancer prognostic factors such as tumor budding, tumor nodule and extracapsular lymph node extension (P<0.05). But, MMP-2, EGF and E-cadherin expression were of no value with regard to them.
CONCLUSION
Our results suggest that molecular markers, in particular VEGF and MMP-9, may provide additional prognostic information regarding tumor budding, ECE and tumor nodule.

Prognostic Factors for Generalized Peritonitis Secondary to Colonic Perforation.: Kim, Hong , Lee, Kug Jong , Lee, Young Joo , Suh, Kwang Wook; J Korean Soc Coloproctol. 2003;19(4):216-220.

1,312 View
4 Download

Abstract PDF: PURPOSE
The prognosis following colonic perforation is generally regarded as worse than it is for upper gastrointestinal perforation. Moreover, the increasing incidence of colon cancer associated perforation is another reason for the present study of colonic perforation in the present study. We reviewed and analyzed various types of colonic perforations to determine which prognostic factors were still useful for the treatment of colonic perforation.
METHODS
Thirty six patients (mean age, 51.5; 24 males) with generalized peritonitis secondary to a colonic perforation were studied retrospectively. All the patients had undergone an exploratory laparotomy. The severity of the clinical condition was recorded according to the APACHE III scoring system for all the patients when they were first seen. Mortality and morbidity were analyzed for possible prognostic factors, such as age, type of operation, association with malignancy, and APACHE-III score.
RESULTS
Penetrating trauma was the leading cause of perforation (27.8%), and iatrogenic perforations accounted for 19.4% of the total. Among nontraumatic perforations, malignancy was the major pathology (25.0%). The sigmoid colon was the most frequent site of perforation. Types of surgical treatment varied according to the general conditions of the patients. In 22 patients, the operation was finished with primary closure alone. A colonic resection was performed in 14 patients, and a proximal diversion was performed in 19 patients (after either a resection or primary closure). Analysis of the various clinical variables showed that old age (>60), underlying malignancy, and the APACHE III score were significant prognostic factors for the surgical outcome.
CONCLUSIONS
These results suggest that penetrating injuries are still the main cause of colonic perforation and that iatrogenic and malignancy-related perforations are increasing. Among other variables, old age, underlying malignancy and the APACHE III score are significant prognostic factors for the surgical outcome.

Prognostic Factors after Hepatic Resection for Metastatic Colorectal Cancer.: Kim, Hee Cheol , Kim, Chang Nam , Hong, Hyoun Kee , Lee, Dong Hee , Yu, Chang Sik , Lee, Je Hwan , Kim, Tae Won , Kim, Jin Cheon; J Korean Soc Coloproctol. 2000;16(2):87-92.

1,592 View
16 Download

Abstract PDF: Metastases to the liver from carcinoma of the colon and rectum occur as many as 80% of cases. As resection of metastases is proven to enhance survival and to reduce hepatic recurrence, the criteria for selection of patients and surgery type appear to be indispensable. Purpose: The aim of this study was to assess the prognostic factors after hepatic resection for metastatic colorectal cancer and propose the optimal surgical principles for resection of metastatic colorectal cancer. Methods: Sixty-three patients who underwent initial hepatic resection for liver metastases from colorectal cancer between 1989 and 1998 were analyzed regarding clinical and pathologic parameters. Results: Overall 5-year survival rate was 32%. Preoperative serum CEA level and resection margin of metastatic tumors were found to be significant predictors for poor long-term outcome. Resection margin of greater than 5 mm was closely associated with better survival. In multivariate analysis, resection margin alone was an independent prognostic factor.
Conclusions
Preoperative serum CEA level and surgical resection margin may affect the outcome for the patients who underwent hepatic resection for metastatic colorectal cancer. Surgical resection margin must be kept enough to avoid re-recurrence or metastasis during hepatic resection for metastatic colorectal cancer.

First
Prev
Page of 1
Next
Last

Search