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Anorectal benign disease
Recent advances in the diagnosis and treatment of complex anal fistula
Pankaj Garg, Kaushik Bhattacharya, Vipul D. Yagnik, G. Mahak
Ann Coloproctol. 2024;40(4):321-335.   Published online August 30, 2024
DOI: https://doi.org/10.3393/ac.2024.00325.0046
  • 6,613 View
  • 565 Download
  • 1 Web of Science
  • 3 Citations
AbstractAbstract PDF
Anal fistula can be a challenging condition to manage, with complex fistulas presenting even greater difficulties. The primary concerns in treating this condition are a risk of damage to the anal sphincters, which can compromise fecal continence, and refractoriness to treatment, as evidenced by a high recurrence rate. Furthermore, the treatment of complex anal fistula involves several additional challenges. Satisfactory solutions to many of these obstacles remain elusive, and no consensus has been established regarding the available treatment options. In summary, complex anal fistula has no established gold-standard treatment, and the quest for effective therapies continues. This review discusses and highlights groundbreaking advances in the management of complex anal fistula over the past decade.

Citations

Citations to this article as recorded by  
  • Understanding the anatomical basis of anorectal fistulas and their surgical management: exploring different types for enhanced precision and safety
    Asim M. Almughamsi, Yasir Hassan Elhassan
    Surgery Today.2025;[Epub]     CrossRef
  • From the Editor: Uniting expertise, a new era of global collaboration in coloproctology
    In Ja Park
    Annals of Coloproctology.2024; 40(4): 285.     CrossRef
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    Si-Ze Wu
    World Journal of Radiology.2024; 16(12): 712.     CrossRef
Original Articles
Expression of the Cancer Stem Cell Markers CD44 and CD133 in Colorectal Cancer: An Immunohistochemical Staining Analysis
Injae Hong, Seong Woo Hong, Yeo Goo Chang, Woo Yong Lee, Byungmo Lee, Yun Kyung Kang, You Sun Kim, In Wook Paik, Hyucksang Lee
Ann Coloproctol. 2015;31(3):84-91.   Published online June 30, 2015
DOI: https://doi.org/10.3393/ac.2015.31.3.84
  • 4,416 View
  • 82 Download
  • 37 Web of Science
  • 29 Citations
AbstractAbstract PDF
Purpose

The aim of this study was to assess the expressions of CD44 and CD133 in colorectal cancer tissue by using immunohistochemical staining and to analyze the clinical significance of the expressions related to other clinicopathological data and survival results.

Methods

One hundred sixty-two patients with a biopsy-proven colorectal adenocarcinoma who were operated on between January 1998 and August 2004 were enrolled in this study. Immunohistochemical staining for CD44 and CD133 was performed on primary colorectal cancer tissue, metastatic lymph nodes, and synchronous and metachronous metastatic tumor tissues if available.

Results

CD44 expression was stronger in the primary tumor than in metastatic lymph nodes (P < 0.001), and CD133 expression tended to be stronger in primary tumor than in metastatic lymph nodes (P = 0.057). No significant correlation was found between the CD44 and the CD133 expressions. The cases with recurrence showed low expression of CD44 (P = 0.017). CD133 expression was lower in cases with elevated CA 19-9 serum levels (P = 0.028) and advanced T stage (P = 0.038). Multivariate analysis proved that low expression of CD44 was an independent prognosis factor for short disease-free survival (P = 0.028).

Conclusion

Low CD44 expression was correlated with increased tumor recurrence and short disease-free survival, and low CD133 expression was associated with advanced tumor stage. We suggest that further studies be performed to evaluate whether the immunohistochemical method for determining the CD44 and the CD133 expressions is appropriate for exploring cancer stem-cell biology in patients with colorectal cancer.

Citations

Citations to this article as recorded by  
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    Wei Shi, Xiaoqing Xu, Jinyuan Tian, Ziyi Zhang, Zhanjun Liu
    New Journal of Chemistry.2024; 48(9): 3793.     CrossRef
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    Pina Ziranu, Andrea Pretta, Valentina Aimola, Flaviana Cau, Stefano Mariani, Alessandra Pia D’Agata, Claudia Codipietro, Daiana Rizzo, Veronica Dell’Utri, Giorgia Sanna, Giusy Moledda, Andrea Cadoni, Eleonora Lai, Marco Puzzoni, Valeria Pusceddu, Massimo
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    V. O. Novosad, D. V. Maltseva
    Bulletin of Experimental Biology and Medicine.2023; 175(1): 144.     CrossRef
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    Sweta Suman, Subhransu Kumar Hota, Pranati Misra, Nageswar Sahu, Subrat Sahu
    Cureus.2023;[Epub]     CrossRef
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    Mehran Pashirzad, Thozhukat Sathyapalan, Afsana Sheikh, Prashant Kesharwani, Amirhossein Sahebkar
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    Hassan Ehteram, Fatemeh Aslanbeigi, Ebrahim Ghoochani Khorasani, Mohammad Tolouee, Hamed Haddad Kashani
    Oncology and Therapy.2022; 10(2): 451.     CrossRef
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    Guanglin Cui, Ziqi Wang, Hanzhe Liu, Zhigang Pang
    Frontiers in Immunology.2022;[Epub]     CrossRef
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    Himanshi Bhanu, Ruchi Mittal, Sarojini Raman
    Clinical Cancer Investigation Journal.2022; 11(6): 9.     CrossRef
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    Yuan-Chang Dai, Chuan-Yin Fang, Hsin-Yi Yang, Yi-Jun Jian, Shou-Chieh Wang, Yi-Wen Liu, Frédéric André
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    Melanie M. Ivancic, Bryant W. Megna, Yuriy Sverchkov, Mark Craven, Mark Reichelderfer, Perry J. Pickhardt, Michael R. Sussman, Gregory D. Kennedy
    Journal of Surgical Research.2020; 246: 160.     CrossRef
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    Aging.2020; 12(11): 10337.     CrossRef
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    Journal of Gastrointestinal Cancer.2019; 50(4): 824.     CrossRef
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    Current Pharmaceutical Design.2019; 25(8): 833.     CrossRef
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    Rongyong Huang, Dan Mo, Junrong Wu, Huaying Ai, Yiping Lu
    Medicine.2018; 97(23): e10446.     CrossRef
  • DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma
    Phaik-Leng Cheah, Jing Li, Lai-Meng Looi, Kean-Hooi Teoh, Diana Bee-Lan Ong, Mark J. Arends
    PeerJ.2018; 6: e5530.     CrossRef
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    Rania ES. Wasfy, Dina M. El-Guindy
    Egyptian Journal of Pathology.2017; 37(1): 204.     CrossRef
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    Tumor Biology.2017; 39(10): 101042831773469.     CrossRef
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    Zhan Yu, Zhen Chen, Jian Wu, Zhong Li, Yugang Wu, Surinder K. Batra
    PLOS ONE.2017; 12(11): e0188139.     CrossRef
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    Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
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    Hoda H. Abou Gabal, Riham M. Abu-Zeid, Maissa N. El-Maraghy
    Egyptian Journal of Pathology.2016; 36(2): 194.     CrossRef
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    Oncotarget.2016; 7(9): 10023.     CrossRef
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    Pu Xia, Xiao-Yan Xu
    Oncotarget.2016; 7(29): 45538.     CrossRef
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    Hungdai Kim
    Annals of Coloproctology.2015; 31(3): 79.     CrossRef
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    Mei Guo, Jun Dou
    Biomedicine & Pharmacotherapy.2015; 76: 107.     CrossRef
Adipose-tissue-derived Stem Cells Enhance the Healing of Ischemic Colonic Anastomoses: An Experimental Study in Rats
Jong Han Yoo, Jae Ho Shin, Min Sung An, Tae Kwun Ha, Kwang Hee Kim, Ki Beom Bae, Tae Hyeon Kim, Chang Soo Choi, Kwan Hee Hong, Jeong Kim, Soo Jin Jung, Sun Hee Kim, Kuk Hwan Rho, Jong Tae Kim, Young Il Yang
J Korean Soc Coloproctol. 2012;28(3):132-139.   Published online June 30, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.3.132
  • 4,301 View
  • 51 Download
  • 19 Citations
AbstractAbstract PDF
Purpose

This experimental study verified the effect of adipose-tissue-derived stem cells (ASCs) on the healing of ischemic colonic anastomoses in rats.

Methods

ASCs were isolated from the subcutaneous fat tissue of rats and identified as mesenchymal stem cells by identification of different potentials. An animal model of colonic ischemic anastomosis was induced by modifying Nagahata's method. Sixty male Sprague-Dawley rats (10-week-old, 370 ± 50 g) were divided into two groups (n = 30 each): a control group in which the anastomosis was sutured in a single layer with 6-0 polypropylene without any treatment and an ASCtreated group (ASC group) in which the anastomosis was sutured as in the control group, but then ASCs were locally transplanted into the bowel wall around the anastomosis. The rats were sacrificed on postoperative day 7. Healing of the anastomoses was assessed by measuring loss of body weight, wound infection, anastomotic leakage, mortality, adhesion formation, ileus, anastomotic stricture, anastomotic bursting pressure, histopathological features, and microvascular density.

Results

No differences in wound infection, anastomotic leakage, or mortality between the two groups were observed. The ASC group had significantly more favorable anastomotic healing, including less body weight lost, less ileus, and fewer ulcers and strictures, than the control group. ASCs augmented bursting pressure and collagen deposition. The histopathological features were significantly more favorable in the ASC group, and microvascular density was significantly higher than it was in the control group.

Conclusion

Locally-transplanted ASCs enhanced healing of ischemic colonic anastomoses by increasing angiogenesis. ASCs could be a novel strategy for accelerating healing of colonic ischemic risk anastomoses.

Citations

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