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Colorectal cancer
The role of lateral pelvic lymph node dissection in advanced rectal cancer: a review of current evidence and outcomes
Gyu-Seog Choi, Hye Jin Kim
Ann Coloproctol. 2024;40(4):363-374.   Published online August 30, 2024
DOI: https://doi.org/10.3393/ac.2024.00521.0074
  • 21,219 View
  • 857 Download
  • 13 Web of Science
  • 15 Citations
AbstractAbstract PDF
Metastatic lateral pelvic lymph nodes (LPNs) in rectal cancer significantly impact the prognosis and treatment strategies. Western practices emphasize neoadjuvant chemoradiotherapy (CRT), whereas Eastern approaches often rely on LPN dissection (LPND). This review examines the evolving role of LPND in the context of modern treatments, including total neoadjuvant therapy (TNT), and the impact of CRT on the management of clinically suspicious LPNs. We comprehensively reviewed the key literature comparing the outcomes of LPND versus preoperative CRT for rectal cancer, focusing on recent advancements and ongoing debates. Key studies, including the JCOG0212 trial and recent multicenter trials, were analyzed to assess the efficacy of LPND, particularly in conjunction with preoperative CRT or TNT. Current evidence indicates that LPND can reduce local recurrence rates compared to total mesorectal excision alone in patients not receiving radiation therapy. However, the benefit of LPND in the context of neoadjuvant CRT is influenced by the size and pretreatment characteristics of LPNs. While CRT can effectively control smaller metastatic LPNs, larger or clinically suspicious LPNs may require LPND for optimal outcomes. Advances in surgical techniques, such as robotic-assisted LPND, offer potential benefits but also present challenges and complications. The role of TNT in controlling metastatic LPNs and improving patient outcomes is emerging but remains underexplored. The decision to perform LPND should be individualized based on patient-specific factors, including LPN size, response to neoadjuvant treatment, and surgeon expertise. Future research should focus on optimizing treatment protocols and further evaluating the role of TNT in managing metastatic LPNs.

Citations

Citations to this article as recorded by  
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    Y. Lee
    Techniques in Coloproctology.2025;[Epub]     CrossRef
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    T. Sammour
    Techniques in Coloproctology.2025;[Epub]     CrossRef
  • Laparoscopic Versus Robotic Lateral Pelvic Lymph Node Dissection in Locally‐Advanced Rectal Cancer: A Cohort Study Comparing Perioperative Morbidity and Short‐Term Oncological Outcomes
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    Blas Flor-Lorente, Mario Javier de Miguel Valencia
    Cirugía Española.2025; 103(9): 800202.     CrossRef
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    Blas Flor-Lorente, Mario J. de Miguel-Valencia
    Cirugía Española (English Edition).2025; 103(9): 800202.     CrossRef
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    Colorectal Disease.2025;[Epub]     CrossRef
  • Learning curve for lateral lymph node dissection in rectal cancer – a systematic review of literature
    D. Kehagias, L. Baldari, E. Cassinotti, L. Boni, C. Lampropoulos, I. Kehagias
    Techniques in Coloproctology.2025;[Epub]     CrossRef
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    Asim M. Almughamsi, Yasir Hassan Elhassan
    Surgeries.2025; 6(4): 94.     CrossRef
  • Targeting lateral pelvic lymph nodes in rectal cancer: response to neoadjuvant therapy and artificial intelligence driven clinical decision support
    Ruiqing Liu, Yun Lu, Luca Stocchi
    Intelligent Medicine.2025;[Epub]     CrossRef
  • Clinical implications of radiologic criteria and prognostic factors for lateral lymph node metastasis in low rectal cancer
    Gyung Mo Son
    Annals of Coloproctology.2025; 41(6): 489.     CrossRef
  • From the Editor: Uniting expertise, a new era of global collaboration in coloproctology
    In Ja Park
    Annals of Coloproctology.2024; 40(4): 285.     CrossRef
Malignant disease, Rectal cancer ,Functional outcomes,Colorectal cancer,Minimally invasive surgery
Robotic Intersphincteric Resection for Low Rectal Cancer: Technical Controversies and a Systematic Review on the Perioperative, Oncological, and Functional Outcomes
Guglielmo Niccolò Piozzi, Seon Hahn Kim
Ann Coloproctol. 2021;37(6):351-367.   Published online November 17, 2021
DOI: https://doi.org/10.3393/ac.2021.00836.0119
  • 12,516 View
  • 228 Download
  • 49 Web of Science
  • 51 Citations
AbstractAbstract PDF
Intersphincteric resection (ISR) is the ultimate anus-sparing technique for low rectal cancer and is considered an oncologically safe alternative to abdominoperineal resection. The application of the robotic approach to ISR (RISR) has been described by few specialized surgical teams with several differences regarding approach and technique. This review aims to discuss the technical aspects of RISR by evaluating point by point each surgical controversy. Moreover, a systematic review was performed to report the perioperative, oncological, and functional outcomes of RISR. Postoperative morbidities after RISR are acceptable. RISR allows adequate surgical margins and adequate oncological outcomes. RISR may result in severe bowel and genitourinary dysfunction affecting the quality of life in a portion of patients.

Citations

Citations to this article as recorded by  
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Pelvic Exenteration: Surgical Approaches
Jin Kim
J Korean Soc Coloproctol. 2012;28(6):286-293.   Published online December 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.6.286
  • 10,536 View
  • 178 Download
  • 16 Citations
AbstractAbstract PDF

Although the incidence of local recurrence after curative resection of rectal cancer has decreased due to the understanding of the anatomy of pelvic structures and the adoption of total mesorectal excision, local recurrence in the pelvis still remains a significant and troublesome complication. While surgery for recurrent rectal cancer may offer a chance for a cure, conservative management, including radiation and chemotherapy, remain widely accepted courses of treatment. Recent improvement in imaging modalities, perioperative care, and surgical techniques, including bone resection and wound coverage, have allowed for reductions in operative mortality, though postoperative morbidity still remains high. In this review, the techniques, including surgical approaches, employed for management of locally recurrent rectal cancer are highlighted.

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