Annals of Coloproctology

Original Article

Prognostic Significance of Tissue Leptin Expression in Colorectal Cancer Patients: Woon Kyung Jeong, Seong Kyu Baek, Mi Kyung Kim, Sun Young Kwon, Hye Soon Kim; Ann Coloproctol. 2015;31(6):222-227. Published online December 31, 2015; DOI: https://doi.org/10.3393/ac.2015.31.6.222

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Purpose

Leptin is encoded by the ob gene and is involved in the control of food intake and energy expenditure. Recent studies have implicated leptin expression to be an indicator of tumor features and prognosis. The purpose of this study was to investigate the association of tissue expression of leptin with the clinicopathological characteristics and clinical outcomes in colorectal cancer patients.

Methods

Patients who had undergone a curative surgical resection for a colorectal adenocarcinoma from 2000 to 2004 were included in the study. Immunohistochemical analyses of leptin expression were performed, and clinicopathological parameters were evaluated.

Results

Clinical data and tumor tissues of 146 patients were evaluated. The mean age was 68.6 ± 11.3 years, and 61.0% were men. Immunohistochemically, the rates of negative, weak, moderate, and strong leptin expression were 2.7% (4 of 146), 5.5% (8 of 146), 43.2% (63 of 146), and 48.6% (71 of 146), respectively. We compared the negative, weak, and moderate expression group (group A) with the strong expression group (group B). Leptin expression was inversely associated with nodal stage (P = 0.007) between the two groups. Leptin expression was not significantly associated with differentiation (P = 0.37), T stage (P = 0.16), and American Joint Committee on Cancer stage (P = 0.49), and no significant differences in the disease-free and the overall survivals (P = 0.78 and P = 0.61) were observed.

Conclusion

Results demonstrated an inverse association of nodal stage with high leptin expression. Higher leptin expression level might predict better oncologic outcome. However, further studies are warranted to identify the exact role of leptin expression in colorectal cancer.

Citations

Citations to this article as recorded by

CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY
Priyanka PARMESH, Udupi Shastri DINESH, Ajay S KHANDAGALE, Anil Bargale BAPU, Roshni SADASHIV, Pradnya REDDY
Arquivos de Gastroenterologia.2024;[Epub] CrossRef
The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer
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Vanda Marques, Fabiola Arella, Marta B. Afonso, André A. Santos, Cecília M.P. Rodrigues
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Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer
Chunxiang Li, Jichuan Quan, Ran Wei, Zhixun Zhao, Xu Guan, Zheng Liu, Shuangmei Zou, Xishan Wang, Zheng Jiang, Jialiang Yang
BioMed Research International.2020;[Epub] CrossRef
Adipocytokines: Are they the Theory of Everything?
Pierre S. Maximus, Zeina Al Achkar, Pousette F. Hamid, Syeda S. Hasnain, Cesar A. Peralta
Cytokine.2020; 133: 155144. CrossRef
The prognostic and therapeutic role of hormones in colorectal cancer: a review
Stella Nikolaou, Shengyang Qiu, Francesca Fiorentino, Shahnawaz Rasheed, Paris Tekkis, Christos Kontovounisios
Molecular Biology Reports.2019; 46(1): 1477. CrossRef
Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
Saad M. Al-Shibli, Norra Harun, Abdelkader E. Ashour, Mohd Hanif B. Mohd Kasmuri, Shaikh Mizan
PeerJ.2019; 7: e7624. CrossRef
Expression of leptin in colorectal adenocarcinoma showed significant different survival patterns associated with tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease in the western province of Saudi Arabia
Jaudah Ahmed Al-Maghrabi, Imtiaz Ahmad Qureshi, Mohamad Nidal Khabaz
Medicine.2018; 97(34): e12052. CrossRef
Obesity-Related Colorectal Cancer: The Role of Leptin
Hyeong Rok Kim
Annals of Coloproctology.2015; 31(6): 209. CrossRef

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