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- Diagnostic Accuracy of Elevated Serum Carcinoembryonic Antigen for Recurrence in Postoperative Stage II Colorectal Cancer Patients: Comparison With Stage III
- Ho Seung Kim, Min Ro Lee
- Ann Coloproctol. 2013;29(4):155-159. Published online August 29, 2013
- DOI: https://doi.org/10.3393/ac.2013.29.4.155
- 8,108 View
- 48 Download
- 9 Citations
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Abstract
PDF Purpose Elevated levels of serum carcinoembryonic antigen (CEA) following a curative resection of colorectal cancer (CRC) indicate recurrence; however, the levels of CEA may be elevated above the normal limit without recurrence. The aim of this study is to analyze the diagnostic accuracy of elevated serum CEA for predicting recurrence in postoperative stage II and stage III CRC patients.
Methods A total of 336 stage II and stage III CRC patients who underwent a curative resection between January 2005 and October 2009 were enrolled. Sensitivities, specificities, positive predictive values (PPVs), negative predictive values (NPVs), likelihood ratios and post-test probabilities of recurrence associated with elevated CEA were analyzed and compared.
Results The median follow-up duration was 45 months (36 to 134 months). Twenty-seven of 189 stage II patients (14.3%) and 52 of 147 stage III patients (35.4%) developed recurrence during the follow-up period. Sensitivities, specificities, PPVs, and NPVs of elevated CEA were 37.0%, 91.4%, 41.7%, and 89.7%, respectively, in stage II patients and 46.2%, 90.5%, 72.7%, and 75.4% in stage III patients. Post-test probabilities of recurrence associated with elevated CEA were 41.8% in stage II patients and 71.9% in stage III patients.
Conclusion The predictive performance of the probability of recurrence associated with elevated serum CEA after a curative resection in stage II CRC patients is lower than that in stage III CRC patients.
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Citations
Citations to this article as recorded by
- Significance of carcinoembryonic antigen detection in the early diagnosis of colorectal cancer: A systematic review and meta-analysis
Rui Wang, Qin Wang, Pan Li
World Journal of Gastrointestinal Surgery.2023; 15(12): 2907. CrossRef - Diagnostic accuracy of follow‐up tests for detecting colorectal cancer recurrences in primary care: A systematic review and meta‐analysis
Geertje B. Liemburg, Daan Brandenbarg, Marjolein Y. Berger, Saskia F.A. Duijts, Gea A. Holtman, Geertruida H. Bock, Joke C. Korevaar, Annette J. Berendsen
European Journal of Cancer Care.2021;[Epub] CrossRef - Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction
Po-Li Wei, Long-Teng Lee, Li-Ming Tseng, Kai-Wen Huang
Scientific Reports.2018;[Epub] CrossRef - Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
International Journal of Radiation Biology.2017; 93(3): 315. CrossRef - Time to lowest postoperative carcinoembryonic antigen level is predictive on survival outcome in rectal cancer
Huichuan Yu, Yanxin Luo, Xiaolin Wang, Liangliang Bai, Pinzhu Huang, Lei Wang, Meijin Huang, Yanhong Deng, Jianping Wang
Scientific Reports.2016;[Epub] CrossRef - The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence – A systematic review
Caspar G. Sørensen, William K. Karlsson, Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg
International Journal of Surgery.2016; 25: 134. CrossRef - Blood CEA levels for detecting recurrent colorectal cancer
Brian D Nicholson, Bethany Shinkins, Indika Pathiraja, Nia W Roberts, Tim J James, Susan Mallett, Rafael Perera, John N Primrose, David Mant
Cochrane Database of Systematic Reviews.2015;[Epub] CrossRef - Value of Dual Assessment of Carcinoembryonic Antigen and Fluorine-18-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer Recurrence
Saeed Mohammed Bafaraj
European Journal of Basic Medical Sciences.2015; 5(2): 25. CrossRef - Serum Carcinoembryonic Antigen for Recurrence in Colorectal Cancer Patients
Young Jin Kim
Annals of Coloproctology.2013; 29(4): 137. CrossRef
- Significance of carcinoembryonic antigen detection in the early diagnosis of colorectal cancer: A systematic review and meta-analysis
- Increase of Plasma TGF-beta1 Level in Colorectal Cancer Patients.
- Lim, Chang Ki , Choi, In Young , Shin, Hoon , Ryu, Min Hee , Sohn, Seung Kook , Jin, Seung Won
- J Korean Soc Coloproctol. 2001;17(3):135-140.
- 1,215 View
- 12 Download
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Abstract
PDF
- PURPOSE
Many kinds of malignant tissues, including colorectal cancer were reported to overexpress transforming growth factor-beta1 (TGF-beta1) gene. However, little work has been done on the circulating TGF-beta1 and the association of TGF-beta1 with progression in patients with malignant tumors. In this study, we measured the plasma level of TGF-beta1 in colorectal cancer patients.
METHODS
Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma TGF-beta1 level in 52 colorectal cancer patients and 290 normal controls. And carcinoembryonic antigen (CEA) as a tumor marker was compared with TGF-beta1 in the aspects of sensitivity and specificity.
RESULTS
The mean plasma TGF-beta1 levels were 1.219 +/- 0.834 (0.272~5.772) ng/mL in normal control and 8.207 +/- 2.428 (1.392~39.241) ng/mL in colorectal cancer. In comparison with CEA, TGF-beta1 is more potent in cancer diagnostic sensitivity.
CONCLUSIONS
The results of this study suggest that the plasma TGF-beta1 level can be a useful tumor marker in colorectal cancer patients.
- Clinical Value of the Change in the Serum Carcinoembryonic Antigen (CEA) Level after Curative Surgery in Colorectal Cancer.
- Kim, Young Hoon , Bae, Byung Noe , Kim, Ki Hwan , Han, Se hwan , Kim, Hong Joo , Kim, Young Duck , Kim, Hong Yong
- J Korean Soc Coloproctol. 2003;19(6):372-378.
- 1,475 View
- 4 Download
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Abstract
PDF
- PURPOSE
This retrospective study was designed to evaluate the clinical value of changes in the serum carcinoembryonic antigen (CEA) level after curative surgery in colorectal cancer patients.
METHODS
The clinical value of preoperative serum CEA and dCEA (postoperative 7-day CEA/preoperative CEA) in 115 patients with colorectal cancer, who underwent curative surgery at our Department of General Surgery from 1994 to 1997, was investigated.
RESULTS
The preoperative CEA level was significantly associated with histologic differentiation (P=0.035) and reccurence (P=0.044), but not gender, tumor size, lymph node metastases, Duke's stage, and vascular invasion. dCEA was significantly associated with lymph-node metastases (P=0.017), histologic differentiation (P=0.024), Duke's stage (P=0.021), recurrence (P=0.008), and survival rate (P=0.0379). Especially, in the abnormal preoperative CEA level (>5 ng/mL) group, if dCEA was more than 0.5, these patients had a very poor prognosis (P=0.0003).
CONCLUSIONS
dCEA was associated with more clinicopathologic prognostic factors than preoperative CEA, especially with survival rate. Therefore, we expect dCEA to be a more useful tool for predicting patient outcome.
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