Annals of Coloproctology

Case Reports

Multivisceral resection for colonic splenic flexure malakoplakia: a case report of a minimally invasive approach: Andrés Ramiro Lanza Díaz, Santiago Gallardo Pezet, Osvaldo Soto González, Montserrat Guraieb Trueba, Ivan Azael Martínez Alonso, Mario Alberto López Ramirez; Ann Coloproctol. 2023;39(2):178-182. Published online July 21, 2021; DOI: https://doi.org/10.3393/ac.2021.00178.0025

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Malakoplakia is a rare granulomatous inflammatory disorder. Its diagnosis depends on histopathological findings; however, high-quality literature regarding proper medical/surgical treatment is lacking. A 38-year-old diabetic female patient was admitted to the emergency room with a history of lower gastrointestinal hemorrhage. Colonoscopy revealed a lesion in the descending colon, and abdominal computed tomography revealed a splenic flexure mass involving the lower pole of the spleen and upper pole of the left kidney. Biopsies confirmed the diagnosis of malakoplakia. After completing antibiotic treatment, a restaging computed tomography revealed a discrete mass increase; hence, the patient underwent laparoscopic en bloc colectomy and partial nephrectomy. Postoperatively, the patient developed a pancreatic fistula, which was successfully treated with percutaneous drainage and antibiotics. The presence of pathognomonic Michaelis-Gutmann inclusions on histopathology is frequently reported as the key to diagnosing malakoplakia. Herein, we present a successful, minimally invasive surgical treatment for colonic malakoplakia.

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A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea
Medicina.2023; 59(1): 156. CrossRef

Benign proctology,Rare disease & stoma,Complication

Fournier Gangrene in a Patient With Type 2 Diabetes Mellitus Treated With Dapagliflozin: A Case Report: Jae Young Moon, Min Ro Lee, Jong Hun Kim, Gi Won Ha; Ann Coloproctol. 2021;37(Suppl 1):S48-S50. Published online May 28, 2021; DOI: https://doi.org/10.3393/ac.2020.06.22

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Rare cases of Fournier gangrene (FG) possibly associated with sodium-glucose cotransporter 2 inhibitors have been reported. We present a case of a 66-year-old male patient with type 2 diabetes mellitus on oral metformin, glimepiride, and dapagliflozin therapy. He presented with pain in the perineum and scrotum for 5 days. The clinical finding, computed tomography finding, and laboratory data were matched with FG. Emergency surgical drainage, debridement of necrotic tissue, and diverting loop ileostomy formation were performed by a urologist and a surgeon. The patient had no complications from diabetes before the onset of FG, and serum glucose management was good at the onset of FG. This case shows an FG patient with good glucose management taking dapagliflozin and suggests a possible association between dapagliflozin and FG. Further evaluation and additional research on this relationship are needed.

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Cost-effectiveness analysis and medication use for gangrene treatment in type 2 diabetes patients: A systematic literature review
Entris Sutrisno, Jajang Japar Sodik, Taufik Muhammad Fakih
Pharmacia.2025; 72: 1. CrossRef
Fournier’s Gangrene as an Adverse Event Following Treatment with Sodium Glucose Cotransporter 2 Inhibitors
Ioana-Maria Suciu, Alin Greluș, Alina-Ramona Cozlac, Bogdan-Simion Suciu, Svetlana Stoica, Silvia Luca, Constantin-Tudor Luca, Dan-Ion Gaiță
Medicina.2024; 60(5): 837. CrossRef
A Case of Fournier's Gangrene Following the Initiation of Dapagliflozin
Natalie Shaykh, Avni Agrawal, Melville C O'Brien, Oshin Rai, Vanshika Tripathi, Vishal Jaikaransingh
Cureus.2024;[Epub] CrossRef
Skin-Related Adverse Reactions Induced by Oral Antidiabetic Drugs—A Review of Literature and Case Reports
Justyna Kowalska, Dorota Wrześniok
Pharmaceuticals.2024; 17(7): 847. CrossRef
Cutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors
Alexandra Laura Mederle, Patrick Dumitrescu, Claudia Borza, Nilima Rajpal Kundnani
Journal of Clinical Medicine.2024; 14(1): 188. CrossRef
Management of Fournier’s gangrene during the Covid-19 pandemic era: make a virtue out of necessity
Alessio Paladini, Giovanni Cochetti, Angelica Tancredi, Matteo Mearini, Andrea Vitale, Francesca Pastore, Paolo Mangione, Ettore Mearini
Basic and Clinical Andrology.2022;[Epub] CrossRef
Dapagliflozin

Reactions Weekly.2022; 1926(1): 197. CrossRef

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