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Ann Coloproctol > Volume 23(6); 2007 > Article
Journal of the Korean Society of Coloproctology 2007;23(6):477-482.
DOI: https://doi.org/10.3393/jksc.2007.23.6.477   
A Comparative Study of Operated and Non-operated Groups in Patients with Hepatic Metastasis from Colorectal Cancer.
Yun, Sang Chul , Kim, Hyung Chul , Chu, Chong Woo , Shin, Eung Jin , Baek, Moo Jun , Cho, Gyu Seok , Choi, Nam Kyu , Jung, Jun Chul , Song, Ok Pyung , Kim, Hyun Jung , Kim, Chan Gyoo , Lee, Joon Hyoek , Park, Seong Jin , Cho, Jun Hee , Lee, Hae Kyung , Kim, Hee Kyung , Koh, Eun Suk
1Department of Surgery, Soonchunhyang University Hospital, Soonchunhyang University, Bucheon, Korea. hchulkim@schbc.ac.kr
2Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University, Bucheon, Korea.
3Department of Radiology, Soonchunhyang University Hospital, Soonchunhyang University, Bucheon, Korea.
4Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University, Bucheon, Korea.
Abstract
PURPOSE
The prognosis for patients with liver metastases (LM) from colorectal cancer is significantly influenced by the clinician's decision. Recently, there have been remarkable advances in treatment of LM, so there can be some changes in therapeutic modalities. We performed a comparative study between operated and non-operated groups of patients with LM to analyze the clinical outcome.
METHODS
From Feb. 2001 to Feb. 2006, 27 patients with LM underwent a hepatectomy, and 113 patients received non-surgical therapy. thirteen hepatectomized cases among the 27 patients had multiple LM. The outcomes of those 13 patients (Group A) were retrospectively compared to those of the non-operated group (Group B, n=21), which had had potentially resectable LM at the initial diagnosis or after chemotherapy, but didn't undergo hepatic resection.
RESULTS
After a median follow-up duration of 31.3 months, the estimated 3-years overall survival (OS) rates were 76.9% and 14.3% in group A and B, respectively (P=0.0001). In the stepwise Cox multivariate regression analysis, factors such as the absence of hepatic resection and a greater diameter of the liver mass independently influenced the poor survival (P=0.005 and P=0.012 respectively). Additionally, two radiologists evaluated the intraoperative ultrasonographic (IOUS) results. IOUS detected new metastatic lesions in 4/13 (30%) patients. There were sub-centimeter metastatic lesions (5~7 mm) and had not been detected in SPIO-enhanced MRI.
CONCLUSIONS
Our results compared to palliative chemotherapy suggest that aggressive surgical resection should be performed to increase the survival rate in patients with LM. Additionally, the treatment plan for LM patients should be discussed with the gastroenterololgist, the radiologist, the oncologist, and the surgeon.
Key Words: Colorectal Cancer, Liver Metastases, Hepatectomy


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