Expression of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers.

Choi, Yoon Young; Cho, Hyun Deuk; Park, Dong Guk; Kim, Sung Young; Lee, Moon Soo; Kim, Chang Ho; Cho, Moo Sik; Baek, Moo Jun

doi:10.3393/jksc.2008.24.5.337

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Page Path: HOME > J Korean Soc Coloproctol > Volume 24(5); 2008 > Article

Original Article
Expression of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers.: Choi, Yoon Young , Cho, Hyun Deuk , Park, Dong Guk , Kim, Sung Young , Lee, Moon Soo , Kim, Chang Ho , Cho, Moo Sik , Baek, Moo Jun; Journal of the Korean Society of Coloproctology 2008;24(5):337-344
DOI: https://doi.org/10.3393/jksc.2008.24.5.337

¹Department of Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea. ssurge@sch.ac.kr
²Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
³Department of Surgery, Dan Kook University College of Medicine, Cheonan, Korea.

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Abstract

PURPOSE
Angiogenesis is one of the key steps in solid tumor growth and metastasis. We investigated the prognostic significance of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expressions as markers of angiogenesis in colon cancer.
METHODS
We retrospectively reviewed the medical records of 78 patients with colon or rectal cancer who underwent a surgical resection at Soonchunhyang University Hospital from January 2000 to December 2001, and we evaluated the expression of VEGF and HIF-1alpha in archival tumor tissues by using immunohistochemistry. We recorded the clinical and the pathological characteristics of the patients and analyzed their survival outcomes.
RESULTS
Thirty-four (34) patients were male, and the mean age of all the patients was 66.7 years. HIF-1alpha and VEGF were positive in 56% (44 patients) and 53% (42 patients) of the tumors, respectively. HIF-1alpha expression was significantly associated with several pathological parameters, such as TNM stage (P=0.001), lymph node metastasis (P=0.001). HIF-1alpha expression was also associated with VEGF expression (P=0.032). The survival of patients with HIF-1alpha expression was worse than that of patients with no HIF-1alpha expression (P=0.036). However, VEGF expression was not associated with other pathological characteristics.
CONCLUSIONS
We suggest that, in cases of colorectal cancer, HIF-1alpha expression may be associated with expression of VEGF, progression of tumors, and poor prognosis.

Keywords: Colorectal cancer;HIF-1alpha;VEGF;Angiogenesis

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Expression of LDH-5 in Colorectal Carcinomas: Correlation with Prognosis and Tumor Angiogenesis
Tae Sung Ahn, Chang Jin Kim, Dong Jun Jung, Dong Guk Park, Sung Woo Cho, Sung Young Kim, Moon Soo Lee, Chang Ho Kim, Moo Sik Cho, Moo Jun Baek
Journal of the Korean Society of Coloproctology.2010; 26(1): 62. CrossRef

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