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1Division of Colorectal Surgery, Department of Surgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
2Department of Surgery, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Copyright © 2023 The Korean Society of Coloproctology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICT OF INTEREST
No potential conflict of interest relevant to this article was reported.
FUNDING
None.
Variable | CRTa | CRT + surgeryb | dF | F | P-value |
---|---|---|---|---|---|
Overall | |||||
MRP | 1.114 ± 0.066 | 0.981 ± 0.068 | 0.525 | 2.182 | 0.120 |
MSP | 1.010 ± 0.041 | 0.836 ± 0.043 | 0.961 | 10.971 | < 0.001 |
MRST | 0.928 ± 0.067 | 0.604 ± 0.048 | 5.100 | 24.497 | < 0.001 |
RC | 1.141 ± 0.119 | 1.309 ± 0.298 | 4.240 | 0.974 | 0.340 |
MRP | 1.080 | 4.869 | 0.030 | ||
Handsewn | 1.018 ± 0.157 | 0.667 ± 0.157 | |||
Stapled | 1.136 ± 0.074 | 1.050 ± 0.074 | |||
MSP | 0.181 | 2.096 | 0.130 | ||
Handsewn | 0.874 ± 0.097 | 0.664 ± 0.101 | |||
Stapled | 1.040 ± 0.045 | 0.874 ± 0.047 | |||
MRST | 1.112 | 5.315 | 0.009 | ||
Handsewn | 0.991 ± 0.159 | 0.987 ± 0.104 | |||
Stapled | 0.914 ± 0.075 | 0.520 ± 0.049 | |||
RC | 4.317 | 0.992 | 0.330 | ||
Handsewn | 1.521 ± 0.282 | 1.934 ± 0.702 | |||
Stapled | 1.117 ± 0.132 | 1.172 ± 0.329 |
Values are presented as mean±standard deviation.
CRT, chemoradiation therapy; dF, degree of freedom; MRP, mean resting pressure; MSP, maximal squeezing pressure; MRST, maximum rectal sensory threshold; RC, rectal compliance.
aThe ratio of each manometric value was calculated by dividing the value obtained immediately after CRT by the initial value obtained before CRT.
bThe ratio of each manometric value was calculated by dividing the value obtained at year post-index surgery by the initial value obtained before CRT.
Characteristic | Data |
---|---|
No. of patients | 169 |
Age (yr) | 63.4 ± 10.3 |
Sex | |
Male | 97 (57.4) |
Female | 72 (42.6) |
Body mass index (kg/m2) | 22.8 ± 4.8 |
ASA PS classification | |
I | 60 (35.5) |
II | 104 (61.5) |
III | 5 (3.0) |
Tumor location (cm) | |
≤6 | 82 (48.5) |
6 > and ≤ 12 | 87 (51.5) |
RT type | |
Short-course | 16 (9.5) |
Long-course | 153 (90.5) |
Operation | |
Lap | 156 (92.3) |
Robot | 6 (3.6) |
Open | 6 (3.6) |
Conversion | 1 (0.6) |
Anastomosis | |
Handsewn | 34 (20.1) |
Stapled | 135 (79.9) |
Pathologic stage (yp) | |
TIS/CR | 24 (14.2) |
I | 44 (26.0) |
II | 44 (26.0) |
III | 52 (30.8) |
IV | 5 (3.0) |
Variable | Pre-CRT | Post-CRT | Postoperative 1 year | P-value | |
---|---|---|---|---|---|
Overall cohort | |||||
MRP (mmHg) | 56.56 ± 3.75 | 54.08 ± 3.16 | 44.95 ± 4.27 | 0.067 | |
MSP (mmHg) | 261.49 ± 12.72 | 251.29 ± 13.60 | 197.25 ± 11.20 | < 0.001 | |
MRST (mL) | 165.50 ± 6.48 | 133.90 ± 5.11 | 87.27 ± 6.15 | < 0.001 | |
RC (mL/mmHg) | 0.845 ± 0.072 | 0.742 ± 0.058 | 0.704 ± 0.104 | 0.210 | |
Stapled anastomosis | |||||
MRP (mmHg) | 56.36 ± 4.15 | 52.95 ± 3.50 | 47.90 ± 4.69 | 0.340 | |
MSP (mmHg) | 260.94 ± 30.13 | 254.54 ± 15.07 | 206.17 ± 12.25 | < 0.001 | |
MRST (mL) | 166.14 ± 7.24 | 130.24 ± 5.19 | 75.63 ± 5.52 | < 0.001 | |
RC (mL/mmHg) | 0.832 ± 0.08 | 0.704 ± 0.06 | 0.614 ± 0.08 | 0.170 | |
Handsewn anastomosis | |||||
MRP (mmHg) | 58.38 ± 8.87 | 59.23 ± 7.46 | 31.54 ± 10.01 | 0.007 | |
MSP (mmHg) | 264.94 ± 30.13 | 236.47 ± 32.17 | 156.59 ± 26.15 | 0.006 | |
MRST (mL) | 167.22 ± 14.7 | 154.44 ± 15.28 | 141.11 ± 18.14 | 0.480 | |
RC (mL/mmHg) | 0.907 ± 0.170 | 0.917 ± 0.136 | 1.115 ± 0.242 | 0.670 |
Variable | CRT |
CRT + surgery |
dF | F | P-value |
---|---|---|---|---|---|
Overall | |||||
MRP | 1.114 ± 0.066 | 0.981 ± 0.068 | 0.525 | 2.182 | 0.120 |
MSP | 1.010 ± 0.041 | 0.836 ± 0.043 | 0.961 | 10.971 | < 0.001 |
MRST | 0.928 ± 0.067 | 0.604 ± 0.048 | 5.100 | 24.497 | < 0.001 |
RC | 1.141 ± 0.119 | 1.309 ± 0.298 | 4.240 | 0.974 | 0.340 |
MRP | 1.080 | 4.869 | 0.030 | ||
Handsewn | 1.018 ± 0.157 | 0.667 ± 0.157 | |||
Stapled | 1.136 ± 0.074 | 1.050 ± 0.074 | |||
MSP | 0.181 | 2.096 | 0.130 | ||
Handsewn | 0.874 ± 0.097 | 0.664 ± 0.101 | |||
Stapled | 1.040 ± 0.045 | 0.874 ± 0.047 | |||
MRST | 1.112 | 5.315 | 0.009 | ||
Handsewn | 0.991 ± 0.159 | 0.987 ± 0.104 | |||
Stapled | 0.914 ± 0.075 | 0.520 ± 0.049 | |||
RC | 4.317 | 0.992 | 0.330 | ||
Handsewn | 1.521 ± 0.282 | 1.934 ± 0.702 | |||
Stapled | 1.117 ± 0.132 | 1.172 ± 0.329 |
Values are presented as number only, mean±standard deviation, or number (%). ASA, American Society of Anesthesiologists; PS, physical status; RT, radiation therapy; TIS, tumor in situ; CR, complete response.
Values are presented as mean±standard deviation. CRT, chemoradiation therapy; MRP, mean resting pressure; MSP, maximal squeezing pressure; MRST, maximum rectal sensory threshold; RC, rectal compliance.
Values are presented as mean±standard deviation. CRT, chemoradiation therapy; dF, degree of freedom; MRP, mean resting pressure; MSP, maximal squeezing pressure; MRST, maximum rectal sensory threshold; RC, rectal compliance. The ratio of each manometric value was calculated by dividing the value obtained immediately after CRT by the initial value obtained before CRT. The ratio of each manometric value was calculated by dividing the value obtained at year post-index surgery by the initial value obtained before CRT.