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Ann Coloproctol > Volume 23(1); 2007 > Article
Journal of the Korean Society of Coloproctology 2007;23(1):34-40.
DOI: https://doi.org/10.3393/jksc.2007.23.1.34   
Prognostic Significance of p27(kip1) Expression in Node Negative Colorectal Carcinoma.
Song, Sang Hyun , Bae, Byung Noe , Lee, Woo Yong , Yang, Keun Ho , Kim, Ki Hwan , Han, Se Hwan , Kim, Hong Ju , Kim, Young Duk , Kim, Hong Yong , Kim, Jung Yeon
1Department of Surgery, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. bnbae@dreamwiz.com
2Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Abstract
PURPOSE
Dukes' A & B colorectal cancer patients are often excluded from adjuvant chemotherapy following potentially curative surgery because they are expected to have good long-term survival. However, actually 20 ~ 30% of these patients suffer from recurrent disease, so it would be helpful for these patients of recurrent disease to be able to select a high risk group.
METHODS
In 78 Dukes' A & B colorectal cancers, we investigated by immunohistochemistry the role of molecular markers, such as p27(kip1), p53, Ki-67, and Skp2, in identifying high-risk patients.
RESULTS
Patients with low p27(kip1) expression showed poor overall survival compared to those with high p27(kip1) expressions (55.3 versus 66.7 months, P=0.018). The only significant factor associated with p27(kip1) expression was p53 expression. The low p27(kip1) expression and positive p53 expression group had poor overall survival (54.3 months, P=0.036). CONCLISIONS: In a node-negative colorectal carcinoma, the molecular marker p27(kip1) does not play an independent prognostic role, but it may have prognostic significance in correlation with other markers such as p53, Ki-67, and Skp2. The assessment of molecular alterations may be useful to node-negative colorectal patients in identifying the high risk group that may benefit from adjuvant chemotherapy.
Key Words: Colorectal cancer; p27(kip1); Skp2; Prognosis


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