| c-Met Expression in Colorectal Carcinoma and Adenomas: Correlation with Clinicopathologic Parameters. |
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Kim, Jin , Kim, Jung Yun , Lee, Won Jin , Cho, Seong Jin , Min, Byoung Wook , Um, Jun Won , Cho, Min Young , Suh, Sung Ock , Moon, Hong Young , Hwang, Cheung Wung |
1Department of General Surgery, College of Medicine, Korea University, Korea. minyoung@korea.ac.kr
2Department of Pathology, College of Medicine, Hallym University, Korea. |
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| Abstract |
PURPOSE
Hepatocyte growth factor (HGF) stimulates proliferation, migration, and morphogenesis of epithelial cells by specifically binding to its receptor c-met.
Abnomalities of the c-met oncogene have been studied in cancers of many organs including thyroid, lung, pancreas, and stomach. However, little is known about the clinical significance of c-met oncogene abnormalities in colorectal carcinomas. In this study, we investigated over- expression of the c-met protein in colorectal adenomas and adenocarcinomas, and analyzed the clinicopathologic significance of this over-expression.
METHODS
Expression of the c-met protein localized in colorectal adenoma and adenocarcinoma tissues was analyzed by using immunohistochemistry. The results were compared with clinicopathologic parameters to find clinical correlation.
RESULTS
c-met protein was detected in 42.5% (17/40) of colorectal cancers and in 10.0% (4/40) of colorectal adenomas (P= 0.001). In colorectal cancer, the proportion of expression of c-met protein was 0% (0/40) in stage I, 47.6% (10/40) in stage II, 53.8% (7/40) in stage III and, 0% (0/40) in stage IV. c-met protein expression was 18.8% (3/40) in tumors with invasion into the muscularis propria (MP), and 58.3% (14/40) in tumors with invasion beyond the MP. The depth of tumor invasion was a statistically significant factor (P=0.022) for c-met expression.
CONCLUSIONS
The c-met protein expression was related to the depth of invasion of colorectal cancer and showed a significant difference in its rate of expression between adenoma and adenocarcinomas. |
| Key Words:
Proto-oncogene protein c-met; Colorectal neoplasms; Adenoma |
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