Warning: fopen(/home/virtual/colon/journal/upload/ip_log/ip_log_2025-11.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 95 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 96 Expression of Cyclooxygenase-2 in Colorectal Adenocarcinoma.
Skip Navigation
Skip to contents

Ann Coloproctol : Annals of Coloproctology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J Korean Soc Coloproctol > Volume 17(5); 2001 > Article
Original Article
Expression of Cyclooxygenase-2 in Colorectal Adenocarcinoma.
Kim, Hyung Suk , Heo, Tae Gil , Hong, Seong Woo , Joo, Mee , Jang, Yeo Gu , Kweon, Do Sung , Paik, In Wook , Lee, Hyucksang
Journal of the Korean Society of Coloproctology 2001;17(5):259-266

1Department of Surgery, Seoul Paik Hospital, Inje University, Seoul, Korea. cosmo021@hanmail.net
2Department of Pathology, Seoul Paik Hospital, Inje University, Seoul, Korea.
prev next
  • 1,212 Views
  • 16 Download
  • 0 Crossref
  • 0 Scopus
Full Article

Download PDF Download PDF

Abstract

PURPOSE
Several studies indicate that nonsteroidal anti-inflammatory drugs including aspirin and sulindac reduce the risk of colon cancer. Futhermore, nonsteroidal anti-inflammatory drugs that inhibit the cyclooxygenase (COX) are shown to inhibit the development colon cancer in animal models of carcinogenesis. COX-1 is constitutively expressed to fulfill its beneficial housekeeping roles. COX-2 is not constitutively expressed by most normal tissues, but it is rapidly induced by certain inflammatory cytokines, tumor promoters, growth factors and oncogenes. The purpose of this study is to evaluate the role of COX-2 in colorectal carcinoma development and the correlation between COX-2 expression and tumor angiogenesis and p53 overexpression.
METHODS
Immunohistochemical analyses using antibodies against COX-2, factor VIII-related antigen, vascular endothelial growth factor (VEGF) and p53 were carried out on archival specimens of 15 colorectal adenoma and 41 adenocarcinoma.
RESULTS
COX-2 expression was increased in 5/15 (33.3%) adenomas and 24/41 (58.5%) adenocarcinomas. COX-2 expression in adenocarcinoma was nearly significantly higher than in adenoma (P=0.050). In adenocarcinoma, COX-2 expression was increased in early cancer (TNM stage) (P=0.028) and well differentiated tumor (P=0.029). COX- 2 expression was not correlated with VEGF expression, microvessel density and p53 overexpression.
CONCLUSIONS
These findings indicate that enhanced expression of COX-2 occurs early during colorectal cancer progression. However, further investigations are needed to evaluate the relationship of COX-2 and tumor angiogenesis using other laboratory methods.

Related articles
Ann Coloproctol : Annals of Coloproctology Twitter Facebook
© Korean Society of Coloproctology.
TOP